[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obesity-endocrine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obesity-endocrine":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100557646","neuroendocrine-regulation-of-bone-fat-crosstalk-in-obesity-100557646",false,"NCT06540820","NEUROENDOCRINE REGULATION OF BONE-FAT CROSSTALK IN OBESITY","Inclusion criteria for subjects with pituitary disease:\n\n* Male and female subject \\> 18-year-old (also fertile patients can be included)\n* Patients with prolactinoma or Cushing disease, Acromegaly or hypogonadism\u002Fhypopituitarism\n* BMI ≥30 Kg\u002Fm2\n* Able to sign an informed consent\n\nInclusion criteria for subjects without pituitary disease\n\n* Male and female subject \\> 18-year-old\n* BMI ≥ 30 Kg\u002Fm2\n* Able to sign an informed consent\n\nExclusion Criteria:\n\n* Male and female subject \\\u003C18-year-old\n* pregnant or breastfeeding women\n* Subject unable to sign informed consent\n* BMI \\\u003C 30 Kg\u002Fm2","ALL","18 Years",{"count":18,"type":19},150,"ESTIMATED","OBSERVATIONAL","To study the effect of neuroendocrine dysfunctions on bone health in obesity",[23,24,25],"Obesity; Endocrine","Pituitary Dysfunction","Bone Health","NOT_YET_RECRUITING","2024-08-02",{"date":29,"type":30},"2024-08-06","ACTUAL",{"date":32,"type":19},"2024-09",{"date":34,"type":19},"2025-09",{"name":36,"class":37},"IRCCS San Raffaele","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":64},"100286428","vitamin-d-and-its-metabolites-quantification-in-adipose-tissues-of-obese-and-non-obese-patients-100286428","NCT03008525","Vitamin D and Its Metabolites Quantification in Adipose Tissues of Obese and Non-obese Patients.","Vitamin D and Its Metabolites Quantification in Adipose Tissues of Obese and Non-obese","VITADOSE","Inclusion Criteria:\n\n* Subject with a BMI greater than 35 kg \u002F m2 (group OB) or less than 30 kg \u002F m² (group NO)\n* Subject undergoing bariatric surgery (OB group) or abdominal surgery (group NO)\n\nExclusion Criteria:\n\n* Regular intake of dietary supplements or vitamin supplements in the last three months\n* For the subjects of the group NO:\n\n  * Malnourished patient (BMI \\\u003C18.5 kg \u002F m2, weight loss greater than 5% in 1 month or 10% in 6 months)\n  * Subject with an infection or inflammatory syndrome (CRP\\> 10 mg \u002F L and \u002F or white blood cells\\> 12000 \u002F mm3)\n  * Non-cancerous subject","65 Years",{"count":48,"type":19},60,"INTERVENTIONAL",[51],"NA","Vitamin D (VD) is a pleiotropic hormone, involved in many physiological processes including calcium and phosphorus absorption. The VD metabolism begin to be well-known and involves a hepatic hydroxylation (mediated by enzymes, which belong to the cytochrome P450 family) leading to the production of the 25(OH)D, which corresponds to the circulating form of the VD. After circulation in blood, the 25(OH)D is submitted to a second hydroxylation in the kidney resulting to the generation of 1,25(OH)2D, the active metabolite of VD. Numerous epidemiological studies reported an inverse relationship between obesity and circulation level of 25(OH)D. Several mechanisms could explain the low level of 25(OH)D observed in obese subjects, the more classical evoked being based on sequestration and\u002For dilution of VD in adipose tissue (AT), the main VD storage site. However, this mechanism has never been demonstrated. In order to confirm this hypothesis, the concentration of VD and its metabolites in adipose tissue need to be quantified.\n\nThe objective of this study is to determine the concentration of VD and its metabolites in adipose tissue as well as adipose tissue mass quantification and distribution (visceral or subcutaneous) to highlight putative difference of VD and its metabolites quantities between obese and non-obese patients. A quantification of VD metabolism, inflammation and lipid metabolism gene expression will be realized on biopsies. Correlations between gene expression and quantity of VD in tissue will be carrying out.",[23],"RECRUITING","2023-07-25",{"date":57,"type":30},"2023-07-27",{"date":59,"type":30},"2017-03-17",{"date":61,"type":19},"2026-09-13",{"name":63,"class":37},"Assistance Publique Hopitaux De Marseille",1]