[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obesity-metabolically-benign\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obesity-metabolically-benign":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100510997","small-extracellular-vesicles-and-insulin-action-100510997",false,"NCT05933707","Small Extracellular Vesicles and Insulin Action","Effect of Small Extracellular Vesicles From Adipose Tissue on Insulin Action","SEV","Inclusion Criteria:\n\n* Metabolically healthy lean subjects must have a BMI ≥18.5 and ≤24.9 kg\u002Fm²; Subjects with obesity must have a BMI ≥30.0 and ≤50.0 kg\u002Fm²\n* Metabolically healthy lean and people with metabolically healthy obesity must have intrahepatic triglyceride (IHTG) content ≤5%; fasting plasma glucose concentration \\\u003C100 mg\u002Fdl, 2-hr oral glucose tolerance plasma glucose concentration \\\u003C140 mg\u002Fdl, hemoglobin A 1C (HbA1c) ≤5.6% and HOMA-IR \\\u003C2.5.\n* People with metabolically unhealthy obesity must have intrahepatic triglyceride (IHTG) content ≥5.6%; HOMA-IR ≥2.5, and HbA1c 5.7%-6.4%, or fasting plasma glucose concentration ≥100 mg\u002Fdl, or 2-hr oral glucose tolerance test (OGTT) plasma glucose concentration ≥140 mg\u002Fdl.\n\nExclusion Criteria:\n\n* History of diabetes, liver disease other than NAFLD or other serious diseases,\n* Consume excessive amounts of alcohol (\\>21 units\u002Fweek for men and \\>14 units\u002Fweek for women),\n* Take medications that could affect the study outcome measures, engage in regular exercise (\\>120 min\u002Fweek),\n* Are pregnant or lactating",true,"ALL","25 Years","55 Years",{"count":22,"type":23},72,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.",[29,30,31,32],"Obesity","Insulin Resistance","Metabolically Healthy Obesity","Obesity, Metabolically Benign",[29,34,35,36],"Weight Loss","Exosomes","Extracellular vesicles","RECRUITING","2025-07-14",{"date":40,"type":41},"2025-07-17","ACTUAL",{"date":43,"type":41},"2023-06-08",{"date":45,"type":23},"2029-09-01",{"name":47,"class":48},"Washington University School of Medicine","OTHER"]