[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obesity-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obesity-prevention":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,47,80,111,142,181,213,245,278,304,338,366,394,423,452,485,506,539,576,599,621],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100571029","advancing-water-security-a-community-participatory-school-based-hydration-intervention-100571029",false,"NCT06714929","Advancing Water Security: A Community Participatory School-Based Hydration Intervention","Inclusion Criteria:\n\n* Lunchroom observations: All students (K-5th \\[Pre-Kindergarten if applicable\\]) who eat lunch in the cafeteria on assessment days are eligible\n* BMI and dental caries assessments: 1) student enrolls in study while in 3rd grade (followed through 5th g)\n* Student surveys: Students in 4th-5th grade are eligible to complete surveys assessing beverage intake and perceptions of hydration practices within their school district.\n* Staff surveys: All staff in the target schools will be eligible to complete the Personnel Survey.\n\nExclusion Criteria:\n\n* Lunchroom observations: None.\n* BMI and dental caries assessments: Students are ineligible if they are unable to complete assessments due to developmental or physical reasons, 2) planning to move in the study duration\n* Student surveys: None.\n* Staff surveys: None.",true,"ALL","4 Years",{"count":19,"type":20},7200,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to determine the effectiveness and sustainability of a community-participatory hydration intervention over 3 years within a district that has newly installed hydration stations and is operating under a policy designed to enhance heathy hydration practices and promote equitable access to drinking water.",[26,27],"Dental Caries","Obesity Prevention",[29,30,31,32,33],"hydration","water","sugar-sweetened beverages","dental caries","overweight and obesity","RECRUITING","2026-06-08",{"date":37,"type":38},"2026-06-10","ACTUAL",{"date":40,"type":38},"2024-08-14",{"date":42,"type":20},"2028-05-31",{"name":44,"class":45},"Virginia Commonwealth University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":15,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100596775","advancing-biopsychosocial-care-training-initiative-100596775","NCT07049861","Advancing Biopsychosocial Care Training Initiative","Increasing Access to USPSTF-Recommended Obesity Care for Youth and Adults Who Are Recipients of Medicaid: Evaluation of a Comprehensive Multidisciplinary Obesity Care Training Program in FQHCs","ABC Initiative","Study Eligibility Criteria - Provider Trainees:\n\n* Provider Trainees must be PCPs, BHPs, RDNs, or CHWs who work at participating clinics.\n\n  * PCPs that are eligible to participate as Provider Trainees can be any of the following: Medical Doctors (MD), Doctor of Osteopathic Medicine (DO), Physician Assistants (PA), or Nurse Practitioners (NP). PCPs must see patients in a primary care setting and be capable of referring patients to IBT and MNT. PCPs must have already completed their residency (when applicable).\n  * BHPs that are eligible to participate as Provider Trainees must be at least one of the following categories (listed with typical credentials): Licensed Clinical Social Worker (LCSW), Licensed Professional Counselor (LPC), Licensed Marriage and Family Therapist (LMFT), Psychologist (PhD\u002FPsyD), Psychiatric Nurse Practitioner, Psychiatrist (MD).\n  * RDNs that are eligible to participate as Provider Trainees must be Registered Dietitians\u002FRegistered Dietitian Nutritionists.\n  * CHWs must work as Community Health Workers, or in functionally similar role, within participating clinics\n\nStudy Eligibility - EHR Patients: Benefit-Eligible Patients from Participating Clinics\n\n* Benefit-Eligible Patients from Participating Clinics can either be youth (ages 5-20) or adults (ages 21+) and must be recipients of Medicaid, eligible for the MO Medicaid benefit (i.e., Medicaid recipients with obesity), and have been seen at participating FQHC clinics.\n\nExclusion Criteria - Provider Trainees:\n\n* Not at a participating clinic\n* PCPs who do not have the ability to refer to IBT or MNT\n* Resident Doctors\n* A doctor specializing in reproductive health (or related fields)\n\nExclusion Criteria - Benefit-Eligible Patients from Participating Clinics:\n\n* Patients without obesity\n* Patients not on Medicaid\n* Youth under the age of 5\n* Not a patient at a participating clinic","5 Years",{"count":57,"type":20},6200,[23],"This project will compare two training approaches for US Preventive Services Task Force recommended obesity care in Federally Qualified Health Centers (FQHC) across four aims. Aim 1 compares patient-level effectiveness \\[i.e., patient relative weight change and the proportion of patients who achieve clinically significant weight loss\\]. Aim 2 compares reach (patient treatment utilization). Aim 3 compares primary care provider (PCP) referrals to USPSTF-recommended care at 12 (adoption) and 24 months (maintenance) and short- and long-term changes in provider obesity care competencies . Aim 4 compares implementation and service costs.",[61,27,62,63,64],"Weight Management","Obesity and Obesity-related Medical Conditions","Obesity and Overweight","Obesity",[66,67,68,69,64,70],"Training","Implementation","Intensive Behavioral Treatment","Family-based Behavioral Treatment","Obesity Care","2026-05-18",{"date":73,"type":38},"2026-05-20",{"date":75,"type":38},"2025-07-14",{"date":77,"type":20},"2028-12-15",{"name":79,"class":45},"Washington University School of Medicine",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":46},"100604903","validation-of-energy-expenditure-measures-study-100604903","NCT07155564","Validation of Energy Expenditure Measures Study","Energy Balance Within a Whole-Room Indirect Calorimeter and Its Relevance for Energy Expenditure Measures","ValEE","Inclusion Criteria:\n\n* Abilty to provide informed consent\n* Written declaration of consent\n* Healthy study participants\n* Able to perform moderate physical exercise using a bike ergometer\n* Women: continuous contraception\u002Ffullicular phase of menstrual cycle\n\nExclusion Criteria:\n\n* Weight change \\> 5 kg or 5% of body weight in the last 3 months\n* Nicotine abuse, Alcohol\u002Fdrug abuse\n* Strenuous physical activity in everyday life \\> 1 h per day\n* Body mass index \\\u003C 18.5 kg\u002Fm² or ≥ 40 kg\u002Fm²\n* Chronic diseases with an impact on energy expenditure\n* Food allergy\u002Fintolerance, vegan diet\n* Circumstances that speak against the application of wearable accelerometers (e.g. silicone contact allergy)\n* Impaired fasting glucose, diabetes mellitus and prediabetes\n* Pregnancy\u002Fbreastfeeding\n* Claustrophobia\n* Refusal to communicate incidental findings","18 Years","40 Years",{"count":91,"type":20},34,"OBSERVATIONAL","The energy that the human body burns and the amount of food consumed determine a person's body weight. If food intake covers the amount of energy burned, body weight remains constant - a state known as energy balance. Achieving an energy balance is not easy in everyday life. This is reflected in the increasing number of people suffering from morbid obesity. To counteract this development, it is important to have a better understanding of how much food a person should eat.\n\nIn this study, the investigators will investigate the amount of food needed to meet a person's energy needs and bring them into energy balance.\n\nPrimary aims of the study are i) to technically and biologically validate two whole-room indirect calorimeters (WRICs) and ii) by using whole-room indirect calorimetry, to achieve a more accurate estimate of a person's emergy balance compared to common approximation formulas.\n\nSecondary study aims:\n\n1. To investigate whether the transfer of a person into energy balance using WRIC has an influence on energy expenditure measures compared to the transfer into energy balance using the usual approximation formula.\n2. To investigate whether the transfer of a person into energy balance using WRIC has an influence on activity-dependent energy expenditure measures compared to the transfer into energy balance using the usual approximation formula.\n3. To investigate whether differences in energy expenditure during energy balance during moderate and strenuous physical activity influence food intake.\n4. To investigate whether energy intake in relation to energy expenditure during energy balance is related to weight development",[27,95],"Healthy",[97,98,99,100,101],"Energy balance","Energy expenditure","Weight change","Energy intake","Indirect calorimetry","2026-04-29",{"date":104,"type":38},"2026-04-30",{"date":106,"type":38},"2025-08-26",{"date":108,"type":20},"2029-01-31",{"name":110,"class":45},"University of Leipzig",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":21,"phases":121,"briefSummary":123,"conditions":124,"keywords":129,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":46},"100578440","phase-2-effects-of-tirzepatide-on-muscle-and-vascular-health-in-obese-older-adults-100578440","NCT06811324","Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults","The Effects of Tirzepatide Use on Muscle and Vascular Function Among Obese Older Adults","Inclusion Criteria\n\n* Men and postmenopausal women aged 50 years or older.\n* Body Mass Index (BMI) ≥30 kg\u002Fm².\n* Untreated HbA1c \\\u003C6.5% at baseline.\n* Willingness and ability to comply with all study procedures, including fasting requirements for certain visits.\n* Able to provide informed consent and participate in all study assessments.\n\nExclusion Criteria\n\n* Active diagnosis of type 2 diabetes mellitus (T2DM), defined by active use of glucose-lowering medications or hemoglobin A1c ≥ 6.5%.\n* Body Mass Index (BMI) ≥ 40 kg\u002Fm².\n* Moderate to severe gastroesophageal reflux disease based on patient history.\n* Inability to comply with the treatment protocol or to understand the consent form.\n* Chronic Kidney Disease (CKD) Stage 4.\n* Aspartate aminotransferase (AST) \\> 33 U\u002FL or alanine aminotransferase (ALT) \\> 36 U\u002FL.\n* Active pregnancy.\n* Personal or family history of medullary thyroid carcinoma.\n* Personal or family history of multiple endocrine neoplasia type 2 syndrome.\n* Personal history of gastroparesis.\n* Personal history of diabetic retinopathy.\n* Known serious hypersensitivity, including anaphylaxis and angioedema, to Tirzepatide or any of its excipients.\n* Known serious hypersensitivity, including anaphylaxis and angioedema, to any GLP-1 receptor agonist class of therapies.\n* Concomitant treatment with GLP-1 receptor agonist therapy","50 Years",{"count":120,"type":20},20,[122],"PHASE2","Obesity and type 2 diabetes mellitus (T2DM) represent major public health concerns in the aging community. Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist recently approved for the treatment of T2DM and obesity has been shown to be effective at reducing weight, improving markers of T2DM control, and improving cardiovascular health. Utilization of tirzepatide among older adults has been on the rise since FDA approval was issued, however the effects of tirzepatide use on functional outcomes in older adults with obesity are not well established. Recent studies show that weight loss caused by tirzepatide may be driven by substantial loss of lean muscle mass, which may contribute to weakness and frailty, particularly among older adults. The proposed pilot study aims to evaluate how treatment with tirzepatide for 6 months affects muscle mass and function among older adults, and if changes in muscle mass are linked to changes in functional status over the same time period.",[27,125,126,127,128],"Sarcopenia in Elderly","Cardiovascular Function","GLP - 1","Weight Loss",[130,131,64,132,126],"Tirzepatide","GLP-1","Sarcopenia","2026-04-10",{"date":135,"type":38},"2026-04-15",{"date":137,"type":38},"2026-04-01",{"date":139,"type":20},"2027-06-01",{"name":141,"class":45},"The University of Texas Health Science Center at San Antonio",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":15,"sex":16,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":21,"phases":154,"briefSummary":155,"conditions":156,"keywords":161,"overallStatus":171,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100632486","sustainable-and-ai-enabled-adolescents-and-youth-centred-interventions-to-upgrade-food-choices-and-promote-healthy-sustainable-diets-100632486","NCT07514312","Sustainable and AI-Enabled Adolescents and Youth-Centred Interventions to Upgrade Food Choices and Promote Healthy, Sustainable Diets","AI-Supported, Context-Aware Digital Nudging Intervention to Reduce Ultra-Processed Food Consumption and Improve Dietary Sustainability Among Adolescents and Young Adults (STAY-UP)","STAY-UP","Inclusion Criteria:\n\n* Adolescents aged 12 to 25 years\n* Ownership of a smartphone or regular access to a digital device\n* Ability to use the digital intervention platform\n* Willingness to provide informed consent (and parental consent where applicable)\n* Regular consumption of ultra-processed foods at baseline\n\nExclusion Criteria:\n\n* Presence of medical conditions requiring a specific therapeutic diet\n* Participation in another dietary or behavioral intervention study\n* Severe cognitive or psychological conditions that may impair participation\n* Inability to use digital tools or applications","12 Years","25 Years",{"count":153,"type":20},1000,[23],"This study aims to evaluate the effectiveness of an artificial intelligence (AI)-supported, context-aware digital nudging intervention designed to reduce ultra-processed food consumption and improve dietary sustainability among adolescents and young adults. The intervention utilizes real-time behavioral data, including image-assisted dietary logging and contextual information, to identify high-risk consumption moments and deliver personalized, non-coercive nudges. The study will assess changes in ultra-processed food intake, contextual consumption patterns, and sustainability-related dietary indicators.",[157,27,158,159,160],"Ultra-Processed Food Consumption","Dietary Behaviour","Unhealthy Diet","Non-Communicable Chronic Diseases",[162,163,164,165,166,167,168,169,170],"Ultra-Processed Food","Digital Intervention","Artificial Intelligence","Dietary Behavior","Adolescents","Young Adults","Nutrition","Sustainability","non-communicable disease","NOT_YET_RECRUITING","2026-03-31",{"date":174,"type":38},"2026-04-07",{"date":176,"type":20},"2026-09-16",{"date":178,"type":20},"2028-06-30",{"name":180,"class":45},"Istanbul Gelisim University",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":118,"enrollmentInfo":190,"targetDuration":4,"studyType":21,"phases":192,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":46},"100582024","improving-health-and-reducing-chronic-disease-risk-in-middle-aged-adults-through-nutrition-100582024","NCT06857929","\"Improving Health and Reducing Chronic Disease Risk in Middle-Aged Adults Through Nutrition\"","Nutritional Approach for the Transformation and Reduction of Chronic Disease Indicators in Middle-aged Adults at High Risk","NUTRI-M-Care","Inclusion Criteria:\n\n* BMI 27-40 Kg\u002Fm2\n* Metabolic syndrome according to International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity\n* Stable weight in the last 3 months (weight changes \\\u003C 4Kg)\n* Be able to give informed consent\n\nExclusion Criteria:\n\n* Have a diagnosed illness that interferes with the recommendations proposed in the intervention.\n* Women with established menopause.\n* Pregnant or breastfeeding women.\n* Serious psychiatric illness\u002Fdisorder.\n* Social, cultural or psychological factors that may affect adherence to the intervention protocol.\n* Inability to communicate with study staff.\n* Inability to follow recommended diet or inability to engage in physical activity.\n* Low likelihood of modifying dietary habits according to the different stages of change according to the Prochaska and DiClemente model.\n* Difficulty attending scheduled appointments within the intervention due to work schedule conflicts, travel plans, scheduled surgeries, among other reasons.\n* Therapeutic non-compliance.\n* Participating in a professionally-led nutritional intervention.\n* Being under medical treatment that affects weight, intake or energy expenditure in the 3 months preceding the start of the study.\n\nSmokers who have changed their smoking habit in the 6 months preceding the start of the study (including starting or stopping smoking).\n\n\\- Participation in another trial that may interfere with this proposed study.","30 Years",{"count":191,"type":20},106,[23],"The goal of this clinical trial is to evaluate the effect of a multifactorial lifestyle intervention combining Mediterranean diet, energy reduction and physical activity on weight loss in middle-aged adults (men and women 30-50 years old) with metabolic syndrome. The main questions it aims to answer are:\n\nIs a multifactorial intervention based on Mediterranean diet, energy reduction and physical activity able to promote weight loss maintenance in middle-aged men and women with metabolic syndrome? syndrome? Which are the sociodemographic barriers to adhere to a multifactorial lifestyle intervention to promote cardiometabolic health? How is the lifestyle pattern of middle-aged Spanish adults with metabolic\n\nResearchers will compare a multifactorial lifestyle intervention combining Mediterranean diet, energy reduction and physical activity to a control intervention based on usual primary healthcare to see if the intervention improve cardiometabolic traits and promote weight loss maintenance after 1 year.\n\nParticipants in the intervention arm will be asked to follow an energy-reduced Mediterranean diet plus a physical activity program with the aim of reducing 5-10% of the initial weight in 6 months and of maintaining the weight lost after 1 year o follow-up.",[195,27,63],"Metabolic Syndrome",[197,198,199,200,201,202,203],"metabolic syndrome","Mediterranean diet","Caloric restriction","Physical activity","Weight loss","Weight","body composition","2026-03-23",{"date":206,"type":38},"2026-03-27",{"date":208,"type":38},"2026-03-01",{"date":210,"type":20},"2028-09-30",{"name":212,"class":45},"IMDEA Food",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":21,"phases":223,"briefSummary":224,"conditions":225,"keywords":228,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":244},"100583694","the-effect-of-dairy-intake-on-body-weight-and-composition-and-metabolic-health-in-adolescents-and-seniors-100583694","NCT06879652","The Effect of Dairy Intake on Body Weight and Composition and Metabolic Health in Adolescents and Seniors","Inclusion Criteria (long-term Study):\n\n* Age 15-18 years old (adolescents) or 60-80 years old (seniors)\n* BMI z-score \\>+1SD, \\\u003C+2SD (adolescents) or BMI 25-34.9 kg\u002Fm2 (seniors)\n* Waist circumference \\> 80 cm for women and \\> 94 cm for men (seniors)\n* FBG 5.6-6.9 mmol\u002FL (prediabetes)\n* Willing to follow Canada's Food Guide\n* Willing to maintain current dietary supplement use throughout the study.\n* Willing to abstain from alcohol consumption for 24 hours before all test visits.\n* Willing to avoid vigorous physical activity for 24 hours before all test visits.\n* Understands the study procedures and is willing to provide informed consent by the parent\u002Fguardian and assent by participant to participate in the study and authorization to release relevant protected health information to the study investigator.\n\nExclusion Criteria:\n\n* Fasting BG ≥ 7 mmol\u002FL\n* Blood pressure systolic ≥ 130mmHg or diastolic ≥ 80mmHg (adolescents) or systolic ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg\n* Smoking (tobacco and\u002For cannabis product use in the last 6 months)\n* Thyroid problems\n* History of CVDs, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, any malabsorption syndrome, pancreatitis, gallbladder, or biliary disease.\n* Presence of gastrointestinal disorder or surgeries within the past year.\n* Use of the prescription or non-prescription drugs, herbal or nutritional supplements known to affect the outcome of the study as per the investigator's judgment (including prebiotics and probiotics).\n* Known to be pregnant, lactating, or not postmenopausal for at least a year and\u002For is taking hormonal treatments\n* Unwillingness or inability to comply with the experimental procedures\n* Known intolerance, sensitivity, or allergy to dairy, gluten, or any other study treatments.\n* Consumption of protein powders\u002Fsupplements\n* Extreme dietary habits (e.g., Atkins diet, very high-protein diets, etc.)\n* Weight gain or loss of \\> 5% in the previous three months.\n* Excessive alcohol intake (more than 2 drinks per day or 9 per week)\n* Restrained eating, identified by a score of ≥11 on the Eating Habits Questionnaire\n\nInclusion Criteria (short-term study):\n\n* Age 14-18 years old (adolescents) or 60-75 years old (older adults)\n* BMI z-score \\>+1SD, \\\u003C+2SD (adolescents) or BMI 25-30 kg\u002Fm2 (older adults)\n* Willing to maintain habitual diet, physical activity pattern, and body weight throughout the study.\n* Willing to maintain current dietary supplement use throughout the study. On study visit days, subject agrees not to take any supplements until dismissal from the Nutrition Intervention Center.\n* Willing to abstain from alcohol consumption for 24hrs prior to all study visits.\n* Willing to avoid vigorous physical activity for 24hrs prior to all study visits.\n* Willing to refrain from cannabis use throughout the entire duration of the study.\n* Willing to refrain from protein supplement use (e.g. protein powder) throughout the entire duration of the study.\n* Understands the study procedures, provides informed consent to participate in the study, and authorizes release of relevant protected health information to the study investigator.\n\nExclusion Criteria (short-term study):\n\n* Smoking\n* Thyroid problems\n* Lactose intolerance and\u002For allergies, intolerances, or sensitivities to study treatments\n* Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, malabsorptive syndrome, pancreatitis, gallbladder or biliary disease\n* Presence of gastrointestinal disorder or surgeries within the past year.\n* Inability to comply with the experimental procedures and follow our safety guidelines\n* Regular breakfast skipping (\\>3 days a week)\n* On a special diet (e.g. ketogenic, Atkins, high protein) or restrained eaters as identified by a score of \\>20 on the Eating Attitudes Questionnaire\n* Difficulties with eating or swallowing\n* Fasting blood glucose \\>5.6mmol\u002FL measured at screening\n* Uncontrolled hypertension (systolic blood pressure \\>120mmHg, diastolic blood pressure \\>80mmHg) as defined by the average blood pressure measured at screening\n* Weight gain or loss of \\>10lbs in previous three months\n* Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect outcome of the study as per investigator's judgement","14 Years","80 Years",{"count":222,"type":20},240,[23],"The goal of this study is to examine how regular dairy intake affects body weight, body composition, and metabolic health in overweight and obese adolescents (ages 15-18) and older adults (ages 60-80) over six months. We are inviting eligible individuals to participate in this study at the Nutrition Intervention Center, Department of Nutritional Sciences, University of Toronto. Participants will be randomly divided into two groups. The intervention (dairy) group will consume three servings of dairy per day (milk, yogurt, and cheese) before breakfast, lunch, and dinner. The control (low-dairy) group will continue their usual diet, keeping dairy intake to less than one serving per day.\n\nParticipants will have biweekly sessions with a registered dietitian to be guided to follow Canada's Food Guide, monitor their dietary intake and ensure compliance with their assigned group. In addition, they will visit the Nutrition Intervention Center at weeks 0, 12, and 24 for anthropometric and body composition assessments (weight, height, waist circumference, blood pressure, lean mass, and fat mass), resting metabolic rate, (gait speed, grip strength, and chair stand test just for older adults) and blood markers (fasting blood glucose, insulin, C-peptide, HbA1c, lipid profiles, and inflammatory markers). Each visit will take approximately 4 hours.\n\nBefore each visit, the participants will be asked to fast overnight for 12 hours, maintain their usual diet and sleep patterns, and avoid exercise and alcohol the day before. The participants will be compensated for their time and travel expenses.\n\nOur secondary objective is to compare the effects of dairy and plant-based alternative products on blood sugar and appetite regulation in adolescents and older adults. Participants will be asked to come to the Nutrition Intervention Center on 3 separate occasions: once for an in-person screening lasting approximately 30 min and 2 times for study visits lasting approximately 2.5 hrs each. The entire study will take at least 2 weeks to complete. You will be asked to fast for 12 hrs (overnight) before each study visit. You will also be instructed to maintain the same dietary and sleep patterns and refrain from exercise and alcohol consumption on the days before the study visits. During these study visits, you will be asked to consume either a dairy or a plant-based alternative product as well as a pizza meal. You will periodically fill out questionnaires rating your feelings and perceptions, and provide blood samples through finger pricks and intravenously through your forearm to measure blood sugar, insulin, hormones, and amino acids. You will be compensated for your time and travel expenses.",[226,227,27],"Dairy Consumption","Metabolic Health",[229,64,230,231,232,233,166,234],"Dairy intake","Type2 Diabetes","HbA1c","BMI z-score","Insulin resistance","Seniors","2026-03-03",{"date":237,"type":38},"2026-03-05",{"date":239,"type":20},"2026-06-01",{"date":241,"type":20},"2028-06",{"name":243,"class":45},"University of Toronto",2,{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":253,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":21,"phases":257,"briefSummary":258,"conditions":259,"keywords":262,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":46},"100578381","brief-behavioral-sleep-intervention-for-obesity-prevention-in-primary-care-100578381","NCT06810557","Brief Behavioral Sleep Intervention for Obesity Prevention in Primary Care","Feasibility and Preliminary Efficacy of a Brief Behavioral Sleep Intervention for Excessive Weight Gain Prevention in Primary Care","Rx SLEEP","Inclusion Criteria:\n\n* Patient at Temple Pediatrics\n* Child age 6-11 years\n* Child time in bed of less than 9 hours per night on most days per week\n* Body Mass Index (BMI) for age and biological sex great than the 10th percentile but less than the 95th percentile\n* Understanding of and ability to complete the protocol\n* Parent age at least 18 years and primary caregiver\n* Willingness to be randomized to either condition\n\nExclusion Criteria:\n\n* Diagnosed sleep disorder\n* Medication use or diagnosis of medical or psychiatric condition that may impact sleep or weight status\n* Current or planned treatment for weight control","6 Years","11 Years",{"count":256,"type":20},50,[23],"The goal of this study is to compare two different approaches to help families with children 6-11 years enhance nighttime sleep: 1) working one-on-one with a nurse to learn effective behavioral strategies to try to improve children's sleep or 2) receiving education on a good night's sleep and its benefits. Participating families will meet with a nurse 6 times or receive 6 educational handouts. Participating families will also complete three assessments (start of the study, 2 months and 6 months) during which study questionnaires will be completed, participating children will wear devices that assess sleep and physical activity, participating families will report on what the child ate on two separate days and will be measured for height and weight.",[260,261,27],"Obesity, Childhood","Short Sleep",[263,264,265,266,267,268],"sleep","behavioral intervention","primary care","obesity prevention","child","pediatric","2026-02-10",{"date":271,"type":38},"2026-02-12",{"date":273,"type":38},"2025-05-15",{"date":275,"type":20},"2027-03-31",{"name":277,"class":45},"Temple University",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":285,"enrollmentInfo":286,"targetDuration":4,"studyType":21,"phases":287,"briefSummary":288,"conditions":289,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":46},"100585101","feasibility-of-a-nutrition-intervention-for-patients-with-prediabetes-at-a-federally-qualified-health-center-100585101","NCT06897982","Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center","One-arm Feasibility and Acceptability Pilot Study of a Community-informed Nutrition Intervention to Recruit, Engage, and Retain Patients Who Are Eligible to Participate in the Diabetes Prevention Program at Two Community Health Centers in Los Angeles","Inclusion Criteria:\n\n* 18+ years old\n* BMI of 25 or higher (23 or higher if Asian)\n* Meet specific blood sugar test criteria indicating prediabetes, such as a fasting plasma glucose level between 110-125 mg\u002FdL or an A1C level between 5.7-6.4%\n* Not be diagnosed with type 1 or type 2 diabetes\n* Moderate to high risk of having prediabetes or a known diagnosis of prediabetes by their medical provider in the last 12 months.\n* Eligible or enrolled in the Diabetes Prevention Program\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* BMI of less than 25 or higher (or under 23 if Asian)\n* Does not meet specific blood sugar test criteria indicating prediabetes, such as a fasting plasma glucose level between 110-125 mg\u002FdL or an A1C level between 5.7-6.4%\n* Currently diagnosed with type 1 or type 2 diabetes\n* Has not been diagnosed as moderate to high risk of having prediabetes or having a known diagnosis of prediabetes by their medical provider in the last 12 months.","99 Years",{"count":120,"type":20},[23],"The purpose of the study is to assess the feasibility and acceptability of incorporating hands-on nutritional demonstrations to enhance the Diabetes Prevention Program (DPP) curriculum among patients who are at-risk for prediabetes",[290,291,292,293,294,27],"Prediabetic State","PreDiabetes","Health Knowledge, Attitudes, Practice","Nutrition, Healthy","Acceptability of Health Care","2026-01-15",{"date":297,"type":38},"2026-01-20",{"date":299,"type":38},"2025-12-08",{"date":301,"type":20},"2027-02-28",{"name":303,"class":45},"Cedars-Sinai Medical Center",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":310,"eligibilityCriteria":311,"healthyVolunteers":15,"sex":16,"minAge":88,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":21,"phases":314,"briefSummary":315,"conditions":316,"keywords":319,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":46},"100576420","optimizing-an-extended-care-intervention-to-promote-weight-loss-maintenance-100576420","NCT06785064","Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance","OPT-X: OPTimizing an EXtended Care Intervention to Promote Weight Loss Maintenance","OPT-X","Inclusion Criteria:\n\n* Age \\>18 years\n* Body mass index (BMI) \\>30 kg\u002Fm2\n* Has regular access to internet (to access Zoom videoconferencing platform)\n* If indicated during screening, willing to obtain medical clearance for exercise from their healthcare provider prior to enrollment\n\nExclusion Criteria:\n\n* Current or recent (past 6 months) use of prescription weight loss medications\n* Weight loss \\>10 pounds in past 6 months (other than postpartum)\n* Pregnancy or anticipating pregnancy\n* Another household member already participating in the study\n* Participation in another randomized research project\n* Uncontrolled hypertension (blood pressure \\>160\u002F100 mm Hg at screening)\n* Any of the following other medical conditions: myocardial infarction or cerebrovascular accident within the last 6 months; unstable angina within the past 6 months; NYHA Class III or IV congestive heart failure; type 1 diabetes; and chronic lung diseases that limit physical activity\n* Unable to identify potential buddy (i.e., adult friend or family member) for extended care intervention phase\n* Residing \\>50 miles from the university (to attend assessment visits)\n* Planning to relocate out of the area in the next 18 months\n* Does not have internet access\n* Unwilling or unable to do any of the following: give informed consent; read\u002Funderstand English; accept random assignment",{"count":313,"type":20},544,[23],"The purpose of this study is to find out what combination of components, if any, offers the best support for keeping weight off after someone loses weight. Long term weight loss maintenance is a challenge for many people who lose weight. There are many strategies, or components, people may use to avoid regain, but investigators do not know if there is a best, or optimal, combination of such components that can be done without adding a lot of cost or other burdens for people.\n\n* The primary goal of this clinical trial is to identify the optimal package that maximizes weight loss maintenance.\n* The study also wants to understand the reasons why these components may work and if certain components help specific sub-groups of people.\n\nParticipants will engage in a 16-week Phase 1 Weight Loss Program. Participants who lose 5% or more of their weight during that program will continue to Phase 2 Extended Care and be randomly assigned to 0, 1, 2, 3, or all of four methods of weight loss maintenance. They will use their assigned package for 12 months. Researchers will compare 16 different possible combinations of components and learn which of the 16 packages offers the best support for keeping weight off.\n\nThe four components participants could be assigned to in Phase 2 are:\n\n1. Reduced Food Variety: Limiting the variety of foods participants eat by having them choose a few high-calorie, low nutrient foods to eat regularly\n2. Home-based Resistance Training: Engaging in exercises that build strength from the comfort of the participant's own home\n3. Buddy Training and Support: Having a friend or \"buddy\" get trained to support the participant\n4. Acceptance and Commitment (ACT) Workshops: Having participants learn skills to handle tough thoughts and feelings about weight control in a healthy way\n\nParticipants will have their weight measured and complete surveys 4 times if they complete both Phase 1 and Phase 2. During Phase 1, participants will attend weekly group sessions and be in touch with a study staff member investigators call a Wellness Coach. During Phase 2, participants will stay in touch with their Wellness Coach, use their assigned package, and answer questions about their experience periodically.",[27,317,128,318],"Weight Change","Weight Loss Maintenance",[320,321,322,323,324,325,326,327,328],"weight loss maintenance","weight loss","weight change","health behavior","reduced food variety","ACT workshop","buddy support","home-based resistance training","weight training","2026-01-06",{"date":331,"type":38},"2026-01-07",{"date":333,"type":38},"2025-12-02",{"date":335,"type":20},"2029-02-28",{"name":337,"class":45},"University of Alabama at Birmingham",{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":15,"sex":16,"minAge":346,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":21,"phases":349,"briefSummary":350,"conditions":351,"keywords":352,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":46},"100578811","healthyw860-pilot-100578811","NCT06816147","HealthyW8_60+ Pilot","Empowering Healthy Lifestyle Behavior Through Personalized Intervention Portfolios to Prevent and Control Obesity in the Elderly","HealthyW8","Inclusion Criteria:\n\nIndividuals aged 60 or older:\n\n* both males\u002Ffemales, general free-living population,\n* residing in Luxembourg,\n* having normal weight or being overweight, i.e., with a BMI between 18.5 ; 30 kg\u002Fm², which is considered a risk factor for developing obesity,\n* owning a smartphone.\n\nExclusion Criteria:\n\n* With known manifest chronic diseases that prohibits participation in the study (e.g., cancer, Parkinson's),\n* Persons with cognitive diseases (Alzheimer's) or those who are not able to lead an independent life,\n* Persons following a strict diet (on their own or advised by their physician),\n* Particular population groups, such as prisoners, the mentally disabled, or groups whose ability to give voluntary informed consent may be in question.","60 Years",{"count":348,"type":20},30,[23],"This pilot study will focus on men and women aged ≥60 years for a period of 3 months during which each participant will use the HLRS. The primary purpose is to study whether the HLRS, reflecting a multi-component intervention, is well accepted by the participant, has a decent adherence (i.e., user time of the app). In addition, investigators will study the feasibility of the design, i.e. whether the overall design is well suited to the participants, in order to improve their lifestyle, e.g., dietary habits and PA, among others. Secondary outcomes related to the feasibility approach include dietary habits, PA patterns, and selected plasma and urinary endpoints. This pilot study will be of longitudinal design without a control group. A later trial that is planned for the following year will focus further on biological endpoints and will be randomized. In this present pilot study, investigators aim to assess mainly the user-friendliness of the HLRS, and gather first evidence that the intervention can indeed produce healthier lifestyle patterns.\n\nThe study's primary objective is to determine whether the developed HLRS can be successfully applied to the target population (men and women aged ≥60 years) and whether they use it frequently during the study and are satisfied with the HLRS.\n\nSecondly, investigators will study whether the assessment of endpoints required for the later and separately planned ensuing long-term study can be well assessed within the study and if, despite the limited time of the intervention duration, the intervention will be able to preliminary improve specific markers related to the risk of obesity and associated comorbidities. This will entail anthropometric measures to assess changes in body mass and body fat in addition to the primary and secondary objectives.",[27],[64,353,354,355],"BMI","overweight","life style recommender solution","2025-12-05",{"date":358,"type":38},"2025-12-12",{"date":360,"type":38},"2025-11-19",{"date":362,"type":20},"2026-12-31",{"name":364,"class":365},"Luxembourg Institute of Health","OTHER_GOV",{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":15,"sex":16,"minAge":373,"maxAge":374,"enrollmentInfo":375,"targetDuration":4,"studyType":21,"phases":377,"briefSummary":378,"conditions":379,"keywords":381,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":389,"leadSponsor":391,"locationsCount":393},"100582527","primary-prevention-of-obesity-in-american-indian-youth-in-rural-tribal-schools-100582527","NCT06864468","Primary Prevention of Obesity in American Indian Youth in Rural Tribal Schools","A School-Based Partnership With Rural Tribal Schools for the Primary Prevention of Obesity Among American Indian Youth (P2)","Inclusion Criteria: students enrolled in the 4th and 3rd grades at one of the participating schools, has parental consent, ability to attend baseline assessment, and the 3-day summer camp -\n\nExclusion Criteria: any student not in either the 3rd or 4th grades, and youth who have not completed an application with any known allergies or limitations to physical activity will not be included\n\n\\-","8 Years","10 Years",{"count":376,"type":20},120,[23],"The goal of this study is to learn if a culturally relevant health promotion curricula prevents obesity among 4th graders in rural tribal schools. The main questions it aims to answer are: 1) Does the health promotion curricula intervention increase diet and physical activity behaviors in 4th grade students? Researchers will compare 4th grade classes who will receive intervention at two intervention schools to 4th grades at two comparison schools who will not receive the intervention.\n\nAll participants will have their skin carotenoids assessed using Veggie Meter, complete 24-hour diet recall via telephone, height and weight measured, body composition, answer two surveys about perceptions of their school environment practices and diet patterns at school, wear accelerometers for 7 days",[27,380],"School Wellness Policy",[382,266,383,384],"school-based","American Indian children and youth","school wellness policy","2025-11-17",{"date":387,"type":38},"2025-11-20",{"date":106,"type":38},{"date":390,"type":20},"2027-05",{"name":392,"class":45},"Northern Arizona University",3,{"id":395,"slug":396,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":398,"acronym":399,"eligibilityCriteria":400,"healthyVolunteers":15,"sex":16,"minAge":253,"maxAge":4,"enrollmentInfo":401,"targetDuration":4,"studyType":21,"phases":403,"briefSummary":404,"conditions":405,"keywords":407,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":46},"100561956","promoting-physical-activity-and-fitness-among-underserved-latino-families-living-in-us-mexico-border-regions-100561956","NCT06596902","Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions","AFL","Inclusion Criteria:\n\n* parents aged ≥18 years\n* children aged 6-11 years\n* living in the target community (within 5 miles of one of targeted community centers)\n\nExclusion Criteria:\n\n* for the parent or child are presence of a medical or physical condition that is contraindicated to participating in sports\u002Fexercise (e.g., negative score on the Physical Activity Readiness Questionnaire (PAR-Q)).",{"count":402,"type":20},290,[23],"This study has the goal to increase physical activity and fitness among Latinos in San Diego, California and Mexicali, Baja California (U.S.-Mexico border) since these cities have similar diseases such as high rates of heart disease and obesity. Therefore there is a need to have physical activity programs for children and their families. We will collaborate with community centers to have this program available.",[27,406],"Heart Disease",[408,409,410,411,412,413],"Fitness","Healthy Lifestyle","Community Based","Family Program","Latino","U.S.-Mexico Border","2025-09-30",{"date":416,"type":38},"2025-10-06",{"date":418,"type":38},"2024-06-24",{"date":420,"type":20},"2029-01",{"name":422,"class":45},"San Diego State University",{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":427,"acronym":428,"eligibilityCriteria":429,"healthyVolunteers":15,"sex":16,"minAge":88,"maxAge":430,"enrollmentInfo":431,"targetDuration":4,"studyType":21,"phases":433,"briefSummary":434,"conditions":435,"keywords":436,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":449,"locationsCount":451},"100602230","better4all-personalized-intervention-pilot-study-100602230","NCT07120802","Better4All Personalized Intervention Pilot Study","BETTER4ALL","Inclusion Criteria:\n\n* Age: Participants aged 18-65 years to represent the adult general population.\n* Body Mass Index (BMI):\n\n  * Overweight or obesity group: BMI ≥ 25 kg\u002Fm².\n  * Normal weight group: BMI 18.5-24.9 kg\u002Fm².\n* Technology Use:\n\n  * Willingness and ability to use wearable devices and an Android mobile application for the duration of the study.\n  * Owning a smartphone device with the Android operating system.\n* Eating utensil technique: dominant hand gestures that correspond to handling of food via a fork or a spoon.\n* Language Proficiency: Ability to read and understand the language in which the mobile app and study materials are provided.\n* Consent: Willing to provide informed consent to participate in the study.\n* Residency: Must be a resident of one of the seven participating countries.\n* Availability: Able to participate for the full three-week duration of the study and comply with the study protocol.\n\nExclusion Criteria:\n\n* Health Conditions: Pregnant or breastfeeding women, as they might have different lifestyle behaviours or health needs.\n* Physical Limitations: Any physical or mental condition that would prevent the participant from using the wearable device or mobile application as intended.\n* Eating utensil technique: eating food with chopsticks on a daily or regular basis.\n* Technical Incompatibility: Individuals who do not own a compatible smartphone or are unable to use the provided wearable devices for technical reasons.","65 Years",{"count":432,"type":20},490,[23],"The BETTER4U project (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you) is funded by the European Union (EU) and involves an international consortium consisting of 28 partners across Europe, Israel, and Australia. The project started in November 2023 and will run until October 2027. The main aim of BETTER4U is to improve weight management through a tailor-made intervention, the \"BETTER4ALL personalized intervention\", using modern monitoring tools and artificial intelligence (AI), including machine learning (ML) practices.\n\nIn the context of the BETTER4U project, the present Pilot Study aims to a) evaluate the usability, feasibility and acceptability of the BETTER4U mobile application (\"BETTER4U App\") and Intervention Platform that will be used to monitor and collect data from participants in the BETTER4ALL personalized intervention (randomized controlled trial; RCT) and b) collect data to evaluate and improve the BETTER4U causal AI models for the prevention of weight gain, before deploying them at large scale, as well as test and identify the optimal ways of delivering the AI-based interventions to the participants. The study will be conducted in seven sites in Cyprus, France, Greece, Poland, Portugal, Spain, and Sweden.\n\nThe BETTER4All Pilot Study will be a longitudinal, correlational, observational study, including a total of n=490 participants, equally distributed among the seven sites (i.e. n=70 per site). Specifically, n=60 (± 3-5) \"general population\" participants (henceforth: \"end-users\" of the wearables and the BETTER4U App) and n=10 (± 3-5) healthcare or other types of providers (henceforth: potential \"implementers\" of the BETTER4U intervention) will constitute each site's sample.\n\nThe study will involve the following two components: a) the administration of the wearables (smartwatches) to the \"end-users\" and their registration to and training on the BETTER4U App, to be used for a total duration of three weeks (21 days). During this period, their lifestyle behaviours (i.e. \"BETTER4U Core Behavioural Indicators - BCBIs\", such as eating occasions, physical activity, sedentary time, sleep etc.) and \"living environment indicators - LEIs\"; (e.g. access to parks in your area, distance from your home to your work place etc.) will be recorded daily, either in an automated way via the wearables or self-reported by the end-users through the App; and b) the registration to and training on the BETTER4U Intervention Platform of the \"implementers\" for a total duration of one week (7 days), during which they will be asked to test the platform's functionalities using synthetic data. The implementers will also be provided with the wearables and the App (similarly to the end-users) for one week only to allow collection of additional data that will help verify the accuracy of the algorithms in the gathered data from the wearables\u002Fmonitoring tools regarding BCBIs and LEIs.\n\nOverall, the outcomes and the findings of the Pilot Study will be used to further refine, optimize, and adjust the tools for the BETTER4ALL RCT, according to the feedback received by both end-users' and implementers' perspectives.",[27],[437,438,439,440,441,442],"weight management","polygenic risk score","artificial intelligence","personalized intervention","obesity","randomized controlled trial","2025-08-06",{"date":445,"type":38},"2025-08-13",{"date":447,"type":38},"2025-06-01",{"date":414,"type":20},{"name":450,"class":45},"Harokopio University",7,{"id":453,"slug":454,"hasResults":11,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":344,"eligibilityCriteria":458,"healthyVolunteers":15,"sex":16,"minAge":459,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":21,"phases":462,"briefSummary":463,"conditions":464,"keywords":467,"overallStatus":171,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":481,"leadSponsor":482,"locationsCount":484},"100593817","empowering-healthy-lifestyle-personalised-intervention-to-prevent-and-control-obesity-the-healthyw8-project-100593817","NCT07011368","Empowering Healthy Lifestyle Personalised Intervention to Prevent and Control Obesity: The HealthyW8 Project","Empowering Healthy Lifestyle Behaviour Through Personalized Intervention Portfolios to Prevent and Control Obesity During Vulnerable Stages of Life: The HealthyW8 Project.","Inclusion Criteria:\n\n* Overweight (BMI between 25-30 kg\u002Fm\\^2)\n* To have a smart phone\n\nExclusion Criteria:\n\n* Individuals with manifest chronic diseases\n* Individuals with cognitive diseases\n* Individuas not able to lead an independent life","7 Years",{"count":461,"type":20},2720,[23],"The goal of the HealthyW8 study (an intervention study) is:\n\nTo assess the usefulness and effects of a digital-based healthy lifestyle recommender system (HRLS) on the prevention of obesity in the following propulations: schoolchildren (5-10 y) and their parents, young adults (18-25 y) and elders (\\>65 y).\n\nThe main questions it aims to answer are:\n\nOutcome 1: To select and validate a tool-assisted 3-mo intervention (mostly digital) by iteratively testing the HLRS on reducing risk of overweight\u002Fobesity among the described age groups.\n\nOutcome 2: To assess the effect of 1-y interventions (mostly digital) with the HLRS described and further iteratively improved previously (outcome 1) on reducing risk of overweight\u002Fobesity at described ages.\n\nResearchers will compare the intervention group before the intervention (baseline) and after it (3-mo intervention trial), or control group (standard care) vs. Intervention group (1-y intervention) to see changes on changes in overweight\u002Fobesity, and related parameters (body composition and biomarkers).\n\nParticipants will follow the HLRS recommendations (meal plans, physical activity and sleep pattern measures and recommendations, assessment of behavioural\u002Fpsychological aspects, and motivational features through digital devices), which will be assessed by means of measurement of body weight, body composition, and biomarkers.",[27,63,62,465,466],"Digital Health","Behavioural Science Interventions to Improve Health Equity",[468,469,470,471,472,473,474,475,476],"Healthy lifestyle recommender system","digital empowerment","health literacy","personalised prevention","pre-obesity biomarkers","mHealth","Human Digital Twin","behavior change techniques","physical activity","2025-06-27",{"date":479,"type":38},"2025-07-01",{"date":479,"type":20},{"date":178,"type":20},{"name":483,"class":365},"Fundació d'investigació Sanitària de les Illes Balears",13,{"id":486,"slug":487,"hasResults":11,"nctId":488,"briefTitle":489,"officialTitle":489,"acronym":428,"eligibilityCriteria":490,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":430,"enrollmentInfo":491,"targetDuration":4,"studyType":21,"phases":493,"briefSummary":494,"conditions":495,"keywords":496,"overallStatus":171,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":451},"100592751","better4all-personalized-intervention-100592751","NCT06997510","Better4All Personalized Intervention","Inclusion Criteria:\n\n* Age: Participant aged 18-65 years\n* Body Mass Index (BMI): BMI ≥ 25 kg\u002Fm² (overweight or obesity)\n* Willingness and ability to use wearable devices and an Android mobile application for the duration of the study\n* Owning a smartphone device with Android operating system\n* Eating utensil technique: dominant hand gestures that correspond to handling of food via a fork or a spoon\n* Language proficiency: participant has the ability to read and understand the language in which the mobile app and study materials are provided\n* Consent: participant is willing to provide informed consent to participate in the study\n* Residency: participant is resident of the country\n* Availability: participant is able to participate for the full three-week duration of the study and comply with the study protocol\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding or intending to get pregnant in the short-term\n* Comorbidities which might affect inflammation levels (i.e. type 1 diabetes, uncontrolled type 2 diabetes, unstable cardiovascular disease, eating disorders, gastrointestinal disorders)\n* Mental illness affecting cognitive and communication skills, lifestyle and\u002For dietary habits\n* History of cancer within 5 years prior to intervention onset\n* Physical Limitations: any physical or mental condition that would prevent the participant from using the wearable device or mobile application as intended\n* Any other criterion which would deem the participant unsuitable, according to the investigator's impression\n* Technical Incompatibility: Individual does not own a compatible smartphone or are unable to use the provided wearable devices for technical reasons\n* Documented and\u002For self-reported rapid changes in body weight in the six months preceding intervention onset, attributed to a diagnosed medical condition\n* Interventional drug treatment in a clinical trial in the period within six months prior to intervention onset, which might affect intervention impact\n* Inability to adhere to the proposed diet regimens, due to medical (i.e. gluten intolerance, allergies, swallowing problems) or religious reasons\n* Medication promoting weight loss\n* Bariatric surgery in the 12 months preceding intervention onset\n* Use of supplements promoting weight loss or sleep quality, mood enhancing supplements, and\u002For consumption of probiotics and medications that influence the microbiome in the last three months preceding intervention onset Participation in a different clinical trial protocol or participation in different programs aiming at weight loss during the six months preceding intervention onset",{"count":492,"type":20},1022,[23],"The BETTER4U (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you) project, funded by the European Union, aims to address obesity through biologically and behaviourally tailored interventions. Obesity is a major public health issue influenced by genetic, metabolic, and lifestyle factors. Despite current weight management interventions, many individuals face challenges due to these varied influences. The BETTER4U project seeks to improve weight management by incorporating artificial intelligence (AI) and polygenic risk scores (PRS) to personalize interventions. The goal is to test the effectiveness of these personalized interventions in improving weight loss compared to standard care, using advanced monitoring tools and AI models.\n\nThe BETTER4ALL personalized intervention is a multicentre, open-label, parallel-group randomized controlled trial (RCT) involving seven study sites across Cyprus, France, Greece, Poland, Portugal, Spain, and Sweden. A total of 1,022 participants with overweight or obesity (BMI ≥ 25 kg\u002Fm²), aged 18-65 years, will be enrolled. Participants will be randomized into two groups: an intervention group receiving personalized lifestyle recommendations based on AI and PRS, and a control group receiving standard care recommendations. The intervention will last six months, followed by a six-month follow-up assessment.\n\nThe intervention's key aspects include wearable devices and a mobile application to monitor participants' behaviour, including physical activity, sleep, and eating habits. The intervention also integrates genetic, metabolic, and environmental data to provide tailored recommendations for weight loss. Participants' outcomes will be assessed regarding BMI, weight loss maintenance, changes in clinical biomarkers, body composition, and other lifestyle parameters.\n\nThis RCT will provide valuable insights into the effectiveness of personalized weight management strategies. AI-driven personalized recommendations and real-time monitoring represent a significant shift from traditional, one-size-fits-all approaches. The results of this study could offer a more effective and sustainable model for obesity management, particularly by accounting for individual genetic predispositions and lifestyle factors. Furthermore, by evaluating the impact of the intervention on a wide range of health outcomes, including biomarkers and psychosocial factors, the study will provide a comprehensive understanding of how personalized interventions can improve overall health and weight management.\n\nIn addition to contributing to the scientific understanding of obesity and its management, this project has the potential to influence public health strategies, offering a more personalized, data-driven approach to obesity prevention and treatment. By integrating genetic, environmental, and lifestyle factors, the BETTER4U intervention could pave the way for future innovations in digital health and obesity management.",[27],[437,438,497,440,441,442],"aritificial intelligence","2025-05-21",{"date":500,"type":38},"2025-05-30",{"date":502,"type":20},"2025-10-01",{"date":504,"type":20},"2027-04-01",{"name":450,"class":45},{"id":507,"slug":508,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":15,"sex":16,"minAge":513,"maxAge":514,"enrollmentInfo":515,"targetDuration":4,"studyType":21,"phases":516,"briefSummary":517,"conditions":518,"keywords":525,"overallStatus":171,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":4},"100584805","team-based-learning-intervention-to-prevent-risk-factors-for-chronic-diseases---a-cluster-randomized-trial-100584805","NCT06894134","Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial","Team-based Learning Intervention in Adolescents to Prevent Risk Factors for Chronic Diseasers - a Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Adolescent students of high school\n* Age ranging from 15 to 19 years old.\n\nExclusion Criteria:\n\n* Cognitive limitations\n* Physical limitations\n* Communication limitations\n* Use of medications that interfere with eating, physical activity, or sleeping habits.","15 Years","19 Years",{"count":222,"type":20},[23],"Background: Chronic diseases, such as cardiovascular diseases, diabetes, and cancer, are a major global health issue. Their modifiable risk factors, including poor diet, physical inactivity, irregular sleep, tobacco use, and excessive alcohol consumption, often emerge during adolescence and persist into adulthood. Early educational interventions can promote healthy habits and reduce their prevalence. Team-Based Learning (TBL), an active teaching method, has demonstrated effectiveness in improving knowledge and behaviors essential for a healthy lifestyle. Objective: evaluate whether a TBL-based educational intervention can improve adolescents' knowledge and habits related to chronic disease risk factors. Methods: A cluster randomized controlled trial (cRCT) will be conducted in public schools in Palmares, Brazil, targeting high school students aged 15-19 years. Fourteen schools will be randomly assigned to intervention and control groups. The intervention, consisting of four TBL modules, will cover healthy eating, physical activity, screen time, sleep, tobacco, and alcohol use, delivered by graduate nursing students under faculty supervision. Data collection will take place at three time points: pre-intervention, post-intervention, and three months later. The control group will continue receiving standard health education. Primary outcomes will assess behavioral changes, while secondary outcomes will analyze body mass index (BMI) and blood pressure. Analysis: Data will be analyzed using SPSS, with descriptive statistics, paired and unpaired t-tests, ANOVA, and chi-square tests. The analysis will account for clustering and be conducted using intention-to-treat analysis. Statistical significance will be set at p\\\u003C0.05. Conclusion: The study will provide evidence on TBL as a scalable tool for preventing risk factors in adolescents, contributing to long-term public health benefits.",[519,27,520,521,522,523,524],"Cardiovascular Diseases","Sedentary Behaviors","Sleep Perception","Alcohol Abuse","Drug Abuse","Physical Inactivity",[526,527,528,529],"team-based learning","adolescents","prevention","chronic diseases","2025-03-25",{"date":532,"type":38},"2025-03-30",{"date":534,"type":20},"2025-09-01",{"date":536,"type":20},"2026-11-30",{"name":538,"class":45},"Professor Fernando Figueira Integral Medicine Institute",{"id":540,"slug":541,"hasResults":11,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":11,"sex":16,"minAge":547,"maxAge":430,"enrollmentInfo":548,"targetDuration":4,"studyType":21,"phases":549,"briefSummary":550,"conditions":551,"keywords":554,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":567,"lastUpdatePostDateStruct":568,"startDateStruct":570,"completionDateStruct":572,"leadSponsor":574,"locationsCount":244},"100572518","maintain-mucosal-ablation-therapy-after-incretins-100572518","NCT06734312","MAINTAIN (Mucosal AblatIoN Therapy After INcretins)","Gastric Fundal Mucosal Ablation for Weight Management in Patients Stopping Glucagon-like Peptide-1 Receptor Agonists","MAINTAIN","Inclusion Criteria:\n\n1. Subjects aged 21-65\n2. Body mass Index (BMI) ≥30 kilograms per square meter (kg\u002Fm²), or ≤45 kg\u002Fm²\n3. Observed ≥ 10% TBWL with semaglutide or tirzepatide use for primary obesity therapy\n4. Subject did not experience \\>50% weight recurrence since discontinuation of semaglutide or tirzepatide\n5. Maintained a stable dose of semaglutide or tirzepatide for a minimum of 12 weeks\n6. Have recently discontinued or are planning to discontinue semaglutide or tirzepatide (≤ 24 weeks from last dose to time of study procedure)\n7. No previous medical history of diabetes mellitus\n8. Willing and able to participate in the study procedures\n9. Understand and voluntarily sign the informed consent\n\nExclusion Criteria:\n\n1. Known diagnosis of type I or type II diabetes or a Hemoglobin A1c \\> 6.5% at time of screening\n2. Use of GLP-1 or GLP-1\u002FGIP medication for the treatment of diabetes, rather than obesity.\n3. Use of anticoagulation, antithrombotic agents, and\u002For NSAIDs that cannot be discontinued for a minimum of 12 weeks\n4. Known bleeding diathesis that cannot be corrected through medical means.\n5. History of decompensated end-organ disease\n6. Unwillingness to abstain from the use of incretin mimetics during the study duration.\n7. Unwillingness to abstain from the use of tobacco during the study duration\n8. Patients on any medications or supplements including those that may influence cholecystokinin (CCK), glucose, growth hormone, insulin and\u002For somatostatin levels\n9. History of any stomach manipulation (including repair of hiatal hernia or fundoplication) deemed unsafe by PI for GFMA\n10. Active disordered eating\n11. Patients who do not give their consent to the enrollment in the study or are incompetent, unconscious or unable to express their consent for any reason\n12. Known diagnosis of gastroparesis or functional dyspepsia\n13. Patients who are pregnant, who plan to become pregnant during study duration, or patients of child-bearing potential who refuse effective birth control methods (as approved by PI)\n14. Active H. pylori infection or history of H pylori without treatment and confirmation of eradication\n15. Active gastric ulceration.\n16. Use of concomitant medications known to induce weight loss (including but not limited to liraglutide, phentermine, phentermine\u002Ftopiramate, bupropion\u002Fnaltrexone, metformin)","21 Years",{"count":120,"type":20},[23],"The purpose of this study is to assess the effect of gastric fundal mucosal ablation (GFMA) on weight trajectory following discontinuation of once-weekly semaglutide or tirzepatide in adults with obesity. In this study, GFMA will be performed on patients who have experienced \\> 10% weight loss with GLP-1 therapy and who plan to discontinue use of GLP-1 medications for the duration of the study.",[62,63,27,552,131,553],"Obesity Recidivism","Ablation Techniques",[441,555,556,557,558,559,560,561,562,321,563,564,565,566],"obesity and overweight","endoscopic bariatric therapy","ablation","gastric mucosal ablation","GMA","GFMA","glp-1","weight loss medications","semaglutide","tirzepatide","hunger","appetite","2025-03-18",{"date":569,"type":38},"2025-03-21",{"date":571,"type":38},"2025-01-01",{"date":573,"type":20},"2026-06",{"name":575,"class":45},"Dr. Christopher McGowan",{"id":577,"slug":578,"hasResults":11,"nctId":579,"briefTitle":580,"officialTitle":580,"acronym":4,"eligibilityCriteria":581,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":582,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":584,"conditions":585,"keywords":586,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":46},"100581353","pennington-generation-cohort-100581353","NCT06849206","Pennington Generation Cohort","Inclusion Criteria:\n\n* Children, adolescents, and young adults (birth through age 24 years) and their nuclear family members\\* and adults age 25+ who are expectant parents or are trying to conceive\n* Self-reported resident of Louisiana\n* Ability to understand instructions and complete all study procedures\n* Able to provide informed consent (adults aged over 18 years)\n* Able to provide assent (children 9 to 17 years)\n* Able to communicate (oral and written) in English\n\nExclusion Criteria:\n\n* Discretion of the Medical Monitor or Principal Investigator",{"count":583,"type":20},3000,"The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role of lifestyle and the environment on the risk of developing obesity and other health outcomes.",[27],[476,441,587,588,589],"diet","nutrition","families","2025-03-13",{"date":592,"type":38},"2025-03-17",{"date":594,"type":38},"2025-02-24",{"date":596,"type":20},"2045-02-24",{"name":598,"class":45},"Pennington Biomedical Research Center",{"id":600,"slug":601,"hasResults":11,"nctId":602,"briefTitle":603,"officialTitle":603,"acronym":604,"eligibilityCriteria":605,"healthyVolunteers":11,"sex":16,"minAge":606,"maxAge":346,"enrollmentInfo":607,"targetDuration":4,"studyType":21,"phases":609,"briefSummary":610,"conditions":611,"keywords":612,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":616,"completionDateStruct":618,"leadSponsor":620,"locationsCount":46},"100567663","revision-of-vsg-with-ablation-of-the-mucosa-procedure-100567663","NCT06671119","REvision of VSG with Ablation of the Mucosa Procedure","REVAMP","Inclusion Criteria:\n\n1. Male and female patients who have:\n\n   1. BMI of 30 kg\u002Fm2 or greater, AND\n   2. regained at least 25% of the total weight lost after initial successful response to sleeve gastrectomy. defined as Excess Weight Loss (EWL) greater than 50% or Total Body Weight Loss (TBWL) exceeding 20%\n2. Must have undergone SG at least three years before the time of enrollment\n3. Age range: 22 - 60 years\n4. Must agree to refrain from using weight loss medications such as Meridia, Saxenda, Januvia, Xenical, Duromine, GLP-1 agonists (e.g., Ozempic, Wegovy) and dual GLP-1\u002FGIP agonists (e.g., Mounjaro, Zepbound), as well as any over-the-counter weight loss medications or supplements throughout the study.\n5. Women of childbearing potential (WOCBP) must agree to use acceptable contraception methods.\n6. Must agree not to donate blood during participation in the study.\n7. Should be able to comply with study requirements, understand, and sign the Informed Consent Form.\n8. Stable weight defined as a fluctuation of less than 5% for at least 3 months prior to the screening visit.\n9. Should have a history of failure to lose weight using conventional diet and lifestyle therapies.\n10. Must have reliable access to wifi and\u002For internet services.\n11. Must express willingness to comply with the substantial lifelong dietary restrictions required by the procedure.\n\nExclusion Criteria:\n\n1. Inadequate response to sleeve gastrectomy\n2. Patients requiring exogenous insulin.\n3. HbA1c \\> 8.5%\n4. Pregnant or breast-feeding or intending to get pregnant during the study.\n5. Unwilling or unable to complete the Visual Analogue Scale for pain assessment, patient questionnaires, or comply with study visits and other study procedures as required per protocol.\n6. History of diabetic ketoacidosis or hyperosmolar nonketotic coma.\n7. Previous use of any types of insulin for \\> 1 month (at any time, except for treatment of gestational diabetes).\n8. Change in diabetic treatment within the last three months.\n9. Use of glucose-lowering drugs for diabetes mellitus treatment with the exception of sulfonylurea (SU), biguanides and sodium-dependent glucose co-transporter 2 (SGLT-2) inhibitors.\n10. GLP-1 use in the preceding 6 months.\n11. Known autoimmune disease, other than autoimmune thyroid disease, which is adequately replaced, including but not limited to celiac disease, or pre-existing symptoms of systemic lupus erythematosus, scleroderma or other autoimmune connective tissue disorder.\n12. Previous endoscopic bariatric procedures or conditions, prior intra-gastric balloon or another gastric implant.\n13. History of diabetic gastroparesis.\n14. Known active hepatitis or active liver disease other than Non-Alcoholic Fatty Liver Disease or Non-Alcoholic Steatohepatitis.\n15. Acute gastrointestinal illness in the previous 7 days.\n16. Known history of irritable bowel syndrome, radiation enteritis, or other inflammatory bowel disease, such as Crohn's disease.\n17. Known history of a structural or functional disorder of the esophagus that may impede passage of the device through the gastrointestinal tract or increase the risk of esophageal damage during an endoscopic procedure, including Barrett's esophagus, esophagitis, dysphagia, achalasia, stricture\u002Fstenosis, esophageal varices, esophageal diverticula, esophageal perforation, or any other disorder of the esophagus.\n18. Known history of a structural or functional disorder of the esophagus, including any swallowing disorder, esophageal chest pain disorders, or drug-refractory esophageal reflux symptoms.\n19. Known history of a structural or functional disorder of the stomach, including gastroparesis, gastric ulcer, chronic gastritis, gastric varices, hiatal hernia (\\>3 cm), cancer, or any other disorder of the stomach.\n20. Known history of chronic symptoms suggestive of a structural or functional disorder of the stomach, including any symptoms of chronic upper abdominal pain, chronic nausea, chronic vomiting, chronic dyspepsia, or symptoms suggestive of gastroparesis, including post-prandial fullness or pain, post-prandial nausea or vomiting, or early satiety.\n21. Currently have ongoing symptoms suggestive of intermittent small bowel obstruction, such as recurrent bouts of post-prandial abdominal pain, nausea, or vomiting.\n22. Active H. pylori infection (Subjects with active H. pylori may continue with the screening process if they are treated with an appropriate antibiotic regimen, and eradication has been confirmed).\n23. History of coagulopathy, upper gastrointestinal bleeding conditions such as ulcers, gastric varices, strictures, congenital or acquired intestinal telangiectasia.\n24. Current use of anticoagulation therapy.\n25. Obligate use of anti-inflammatory drugs that cannot be suspended for a minimum of 4 weeks post procedure.\n26. Use of systemic glucocorticoids (excluding topical or ophthalmic application or inhaled forms) for more than 10 consecutive days within 90 days prior to the Screening Visit.\n27. Use of drugs known to affect GI motility (e.g., Metoclopramide).\n28. Receiving any weight loss medications such as Meridia, Xenical, Saxenda, Januvia, Duromine, GLP-1 agonists, GIP\u002FGLP-1 dual agonists, or over-the-counter weight loss medications at screening.\n29. Untreated\u002Finadequately treated hypothyroidism, defined as an elevated Thyroid-Stimulating Hormone (TSH) level at Screening; if on thyroid hormone replacement therapy, must be on a stable dose for at least 6 weeks prior to Screening.\n30. Persistent Anemia, defined as Hemoglobin \\\u003C10 g\u002FdL.\n31. Significant cardiovascular disease including a known history of valvular disease, or myocardial infarction, heart failure, transient ischemic attack, or stroke within the last 6 months.\n32. Known moderate or severe chronic kidney disease (CKD), with estimated glomerular filtration rate (eGFR) \\\u003C45 ml\u002Fmin\u002F1.73m2 (estimated by MDRD).\n33. Known immunocompromised status, including but not limited to individuals who have undergone organ transplantation, chemotherapy, or radiotherapy within the past 12 months, who have clinically significant leukopenia, who are positive for the human immunodeficiency virus (HIV) or whose immune status makes the subject a poor candidate for clinical trial participation in the opinion of the Investigator.\n34. Active systemic infection.\n35. Known active malignancy within the last 5 years (with the exception of treated basal cell or treated squamous cell carcinoma).\n36. Subjects with an established diagnosis of Multiple Endocrine Neoplasia syndrome type 1.\n37. Not a candidate for surgery or general anesthesia.\n38. Active illicit substance abuse or alcoholism.\n39. Current smoker or smoking history in the last six months.\n40. Participating in another ongoing clinical trial of an investigational drug or device.\n41. Any other mental or physical condition which, in the opinion of the Investigator, makes the subject a poor candidate for clinical trial participation.\n42. Other medical conditions that do not allow for an endoscopic procedure.","22 Years",{"count":608,"type":20},5,[23],"The purpose of this study is to evaluate the feasibility, safety, and tolerability of endoscopic selective gastric mucosal ablation (GMA) using argon plasma coagulation after sleeve gastrectomy. In this study, GMA will be performed on patients who have experienced weight regain following an initial successful response to sleeve gastrectomy.",[62,63,27,552],[441,555,556,557,558,559],"2024-11-01",{"date":615,"type":38},"2024-11-05",{"date":617,"type":20},"2024-12",{"date":619,"type":20},"2026-05",{"name":575,"class":45},{"id":622,"slug":623,"hasResults":11,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":4,"eligibilityCriteria":627,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":4,"enrollmentInfo":628,"targetDuration":4,"studyType":21,"phases":630,"briefSummary":631,"conditions":632,"keywords":633,"overallStatus":171,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":639,"startDateStruct":641,"completionDateStruct":642,"leadSponsor":643,"locationsCount":46},"100563658","external-body-weight-effects-on-body-weight-in-adults-with-grade-ii-and-iii-obesity-100563658","NCT06619028","External Body Weight Effects on Body Weight in Adults With Grade II and III Obesity","Effectiveness of the Use of External Body Weight in the Regulation of Body Weight, Body Composition and Analytical Parameters in Adults With Grade II and III Obesity","Inclusion Criteria:\n\n* Age\\>18 years\n* BMI (≥35)\n* Compliance at intervention delivery.\n\nExclusion Criteria:\n\n* Chronic pathology that may hinder the performance of the intervention\n* Chronic pain\n* Regular consumption of pharmacology or supplementation that affects body weight\n* Inability to perform any physical activity or high risk of suffering adverse effects from the interventibariatric-metabolic surgery\n* Reduced mobility\n* Changes of 5kg or more in the last 3 months\n* Drastic changes in lifestyle habits in the last 3 months (physical activity, eating habits, nicotine or alcohol consumption)\n* Apparent risk of not being able to complete the study intervention (at the principal investigator\\'s discretion)\n* Pregnancy",{"count":629,"type":20},24,[23],"Obesity is a growing problem in industrialized societies. This condition is associated with an increase in metabolic and cardiovascular diseases. Its cause is multifactorial, influenced by the environment, excessive calorie consumption, insufficient physical activity, sedentary lifestyle and alterations in energy metabolism.\n\nIn this context, the hormone leptin, responsible for regulating appetite and body weight, presents resistance in people with obesity, altering the metabolic balance. Recent research has explored the concept of the \"gravitostat\", a system that responds to the mechanical stimulus of standing upright, as a promising approach in the regulation of body weight. Animal and human studies have shown positive results in weight loss and body recomposition using this system. However, more research is needed to evaluate the clinical applicability and effectiveness of the gravitostat in the management of obesity.\n\nFor this reason, the present study is proposed, with a prospective longitudinal controlled design in the use of external body weight (where the patients are their own control: intrasubject controlled study) during 4 weeks, with a previous control period of 4 weeks and a follow-up of 4 weeks. The proposed objectives are to analyze the effectiveness of the use of external weight in the regulation of body weight, body composition and analytical parameters in people with grade II and III obesity. In this way, to analyze the clinical applicability of the gravitostat in the management of patients with this metabolic pathology.",[27,64],[64,634,201,635,636,637],"Body Weight","Treatment","Leptin","Gravitostat","2024-09-25",{"date":640,"type":38},"2024-10-01",{"date":640,"type":20},{"date":479,"type":20},{"name":644,"class":45},"Escoles Universitaries Gimbernat"]