[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstetric-labor-premature\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstetric-labor-premature":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,83,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100459604","the-periviable-goals-decision-support-tool-100459604",false,"NCT05264779","The Periviable GOALS Decision Support Tool","Promoting Shared Decision Making in Periviable Care: A Randomized Controlled Trial of the Periviable GOALS Decision Support Tool","Inclusion Criteria for Pregnant Persons:\n\n* Adults (18 years or older)\n* Pregnant between 22 0\u002F7 to 25 6\u002F7 weeks gestation (this window may be slightly different for each recruitment site, as the gestational window that defines periviable delivery varies by institution).\n* Presenting to Labor \\& Delivery at an approved study site with a pregnancy complication that poses the potential threat of or need for periviable delivery (e.g., rupture of membranes, preterm labor, shortened cervix, pre-eclampsia, and growth restriction).\n* Must have been counseled on their neonatal treatment options (e.g. resuscitation, comfort care) by their healthcare team prior to being approached by the study team.\n\nInclusion Criteria for Important Others:\n\n* Adults (18 years or older)\n* 1 per pregnant person\n* Is identified by the pregnant person as someone who will be involved in making decisions for the baby\n* Must be present at the time of randomization to participate\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Incarcerated\n* Medically unstable (i.e. in active labor and dilated 6cm or more)\n* Emotionally unstable\n* Have not been counseled by their healthcare team regarding neonatal treatment options\n* Are not admitted to Labor \\& Delivery for reasons indicative of a threatened early delivery\n* If they are experiencing a known fatal fetal anomaly\n* Are not present at the time of randomization (only for important others)","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","INTERVENTIONAL",[23],"NA","The Periviable GOALS (Getting Optimal Alignment around Life Support) decision support tool (DST) is meant to facilitate informed shared decision-making regarding neonatal resuscitation for families facing the threat of a periviable delivery (deliveries occurring between 22 0\u002F7 - 25 6\u002F7 weeks gestational age). It is designed for parents to review independent of their clinician, and is intended to supplement, not replace, clinician counseling. The focus of the DST is the provision of patient-centered outcomes information and assistance with values clarification regarding neonatal outcomes. This is a multisite, randomized controlled trial to test the effect of the Periviable GOALS DST on shared decision making and decision satisfaction. The investigators hypothesize that participants who utilize the GOALS DST will have improved shared decision making and higher decision satisfaction.",[26,27,28,29,30],"Pregnancy Preterm","Premature Birth","Pregnancy Complications","Obstetric Labor, Premature","Obstetric Labor Complications",[32,33,34,35,36],"Decision making","Periviable delivery","Preterm birth","Risk Communication","Neonatal Resuscitation","RECRUITING","2026-05-06",{"date":40,"type":41},"2026-05-11","ACTUAL",{"date":43,"type":41},"2022-06-06",{"date":45,"type":20},"2027-02",{"name":47,"class":48},"Indiana University","OTHER",12,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100640472","bed-rest-with-a-short-cervix-on-preterm-birth-100640472","NCT07577388","Bed Rest With a Short Cervix on Preterm Birth","BEWISE - Bed Rest With a Short Cervix on Preterm Birth","BEWISE","Pregnant women with gestational age 20+0 to 33+6\n\n* Cervical length \\\u003C 25 mm in singleton pregnancies and \\\u003C 30 mm in multiple pregnancies\n* Above 18 years of age\n* Reads and understands Danish or English","FEMALE",{"count":60,"type":20},6000,[23],"Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.\n\nThe use of maternal AR to prevent preterm birth is largely based on observational evidence linking strenuous physical activity to an increased risk of preterm birth, and the assumption that reduced activity may decrease myometrial activity. However, the existing evidence on the clinical effects of AR remains limited and has not demonstrated a reduction in preterm birth or a delay in deliv-ery. In contrast, some studies suggest a potential increase in preterm birth following AR and instead significant adverse maternal and fetal effects.\n\nThe overall aim of this study is to compare gestational age at birth in women with a short cervix who are prescribed AR compared with women with a short cervix who are not prescribed AR (NAR).\n\nThe primary hypothesis is that NAR is non-inferior to AR in prolonging pregnancy in women with a short cervix.\n\nSecondary hypotheses are that, compared with AR, NAR is associated with higher level of physical activity, lower risk of maternal depression, and reduced risk of loss of maternal bone mineral density.\n\nThrough the BEWISE study, we wish to implement a change in the Danish national clinical practice regarding AR from recommending AR in risk groups (current practice) to no longer recommending AR as part as routine care (new practice). We will evaluate this change in clinical practice by prospectively collecting data from women both before and after implementation of the new recommendation. The transition from AR to NAR will be implemented sequentially in each Danish region using a randomised stepped-wedge (SW) cluster design, with each region constituting a cluster. The order in which regions transition is determined by randomisation. Each region will adopt the new recommendation at 3-month intervals, resulting in full national transition from AR to NAR within 12 months Eligible participants are pregnant women in gestational age 20+0 to 33+6 and cervical length \\\u003C 25 mm in singleton pregnancies and \\\u003C 30 mm in multiple pregnancies. Participants must be above 18 years of age and be able to read and understand Danish or English. There are no exclusion criteria.\n\nThe primary outcome is gestational age in days (continuous).",[64,65,66,28,67,68,69,70,71,27,29,72,73],"Preterm Birth","Cervical Insufficiency","Bed Rest","Immobilization","Depression, Postpartum","Pregnancy Outcome","Infant, Premature","Uterine Cervical Incompetence","Physical Activity","Bone Density","NOT_YET_RECRUITING","2026-05-03",{"date":40,"type":41},{"date":78,"type":20},"2026-05-01",{"date":80,"type":20},"2029-05-01",{"name":82,"class":48},"Julie Glavind",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":90,"studyType":93,"phases":4,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100491946","multisite-inventory-of-neonatal-perinatal-interventions-mini-minimum-dataset-100491946","NCT05685745","Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset","Inclusion Criteria:\n\n* All local births with gestational ages of 22 weeks 0 days - 23 weeks 6 days, regardless of pregnancy outcome or neonatal intensive care (NICU) admission; AND\n* All outborn NICU admissions with gestational age at birth of 22 weeks 0 days - 23 weeks 6 days\n* Optional: Centers who desire to include data for NICU admissions of infants born \\\u003C22 weeks' gestation may also submit these data.","0 Years","1 Year",{"count":92,"type":20},5000,"OBSERVATIONAL","The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and practices for all deliveries and infants admitted to intensive care at 22-23 weeks' gestation at participating hospitals.",[96,29,27,97,98],"Infant, Extremely Premature","Intensive Care, Neonatal","Intensive Care Units, Neonatal","2026-04-28",{"date":101,"type":41},"2026-05-04",{"date":103,"type":41},"2019-01-01",{"date":105,"type":20},"2030-01-01",{"name":107,"class":48},"The University of Texas Health Science Center, Houston",51,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":58,"minAge":17,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100448026","phase-4-single-dose-of-antenatal-corticosteroids-for-pregnancies-at-risk-of-preterm-delivery-snacs-100448026","NCT05114096","Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)","Single Dose of Antenatal Corticosteroids (SNACS) Randomized Controlled Trial for Pregnancies at Risk of Preterm Delivery: To Keep Babies and Children Safe","SNACS","Inclusion Criteria:\n\n1. Pregnant people, aged 18 to 55 years old, at risk of preterm birth with a singleton or twins between 22 weeks and 0 days and \\\u003C34 weeks and 6 days gestation who have received only a single dose of Celestone within 24 hours\n2. Capable of giving informed, written consent.\n\nExclusion Criteria:\n\n1. Contraindication to corticosteroids\n2. Systemic corticosteroids for medical conditions during the pregnancy (e.g. lupus, severe asthma, Covid, etc).\n3. Previous participation in this trial (in a previous pregnancy)\n4. Known severe\u002Flife-threatening fetal or pregnant patient condition (e.g. fetal congenital\u002Fchromosomal abnormality)\n5. Demise of one or more fetuses after 14 weeks and 0 days","55 Years",{"count":119,"type":20},3254,[121],"PHASE4","Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome.\n\nThe standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity.\n\nThe investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.",[64,27,124,29,28],"Complication of Prematurity",[126,34,127,128,129,130,131,132,133,134,135,136,137,138,139],"Premature birth","Obstetric labour","Betamethasone","Betamethasone Valerate","Betamethasone-17,21-dipropionate","Betamethasone benzoate","Betamethasone sodium phosphate","Anti-Inflammatory Agents","Glucocorticoids","Hormones","Hormones, Hormone Substitutes and Hormone Antagonists","Physiological Effect of Drugs","Anti-Asthmatic Agents","Respiratory System Agents","2026-01-05",{"date":142,"type":41},"2026-01-07",{"date":144,"type":41},"2023-07-20",{"date":146,"type":20},"2029-12-31",{"name":148,"class":48},"McMaster University",25]