[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstructive-apnea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstructive-apnea":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100635625","night-to-night-variability-of-novel-physiological-parameters-in-home-sleep-apnea-testing-100635625",false,"NCT07555119","Night-to-Night Variability of Novel Physiological Parameters in Home Sleep Apnea Testing","N2N-OSA","Inclusion Criteria:\n\n* Patients with suspected or diagnosed sleep-disordered breathing, irrespective of disease severity, as defined by the indications for home sleep apnea testing in the German guidelines \\[15\\]\n* No active treatment during sleep recordings or within preceding two weeks (e.g., mandibular advancement devices, positive airway pressure therapy)\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Known or suspected neurological sleep disorder (e.g., narcolepsy, parasomnia)\n* Known or suspected psychiatric sleep disorder\n* Known or suspected central and complex sleep apnea\n* Participants who are unable to perform sleep measurements reliably\n* Insufficient knowledge of the project language (German)\n* Inability to give consent\n* Shift workers (with shift work \\\u003C2 weeks before testing)","ALL","18 Years",{"count":19,"type":20},192,"ESTIMATED","OBSERVATIONAL","Obstructive sleep apnea (OSA) is usually diagnosed from a single night of home sleep apnea testing using the apnea-hypopnea index (AHI). However, the AHI varies substantially from night to night, undermining diagnostic accuracy, and shows only modest correlation with symptoms. This variability further limits its usefulness for predicting cardiovascular and other complications. Besides the traditional AHI, more robust physiological markers are needed.\n\nSeveral emerging physiological metrics - hypoxic burden, ventilatory burden, heart rate variability, autonomic arousals, and the pulse wave amplitude drop index - capture the physiological impact of OSA more comprehensively and demonstrate stronger associations with cardiovascular risk. Despite this promise, their night-to-night variability has not been studied.\n\nA systematic evaluation of both established and novel OSA metrics across nights is essential to identify reliable, stable parameters suitable for clinical routine. This improves diagnostic precision beyond what traditional metrics can provide, enhances patient selection, reduces costs and patient harm, and may improve treatment outcomes.",[24,25,26],"Obstructive Apnea","Diagnostic","Sleep Apnea Syndrome (OSAS)",[28],"Home Sleep Apnea Testing","NOT_YET_RECRUITING","2026-04-28",{"date":32,"type":33},"2026-05-05","ACTUAL",{"date":35,"type":20},"2026-05-01",{"date":37,"type":20},"2027-06-30",{"name":39,"class":40},"Insel Gruppe AG, University Hospital Bern","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":41},"100562940","comparison-of-a-demand-oxygen-delivery-100562940","NCT06609694","Comparison of a Demand Oxygen Delivery","Comparison of a Demand Oxygen Delivery to Continuous Flow for Administration of Oxygen During Sleep","DOSA","Inclusion Criteria:\n\n1. Age 5-17 years with or without Down Syndrome (DS).\n2. Children with obstructive sleep apnea (OSA) and obstructive apnea hypopnea index (OAHI) 5-40 \u002F hour: The rationale for selecting this range of OAHI is that a large number of children with DS with this range of OSA severity are untreated for months to years. It is important to understand the response to oxygen across the spectrum of disease severity. Notably, children with severe disease are left with few options (e.g., tracheostomy).\n3. Absence of clinically significant hypoxia defined as oxygen saturation \\\u003C 88% for 5 minutes or episodic desaturation to 60% as these levels would otherwise identify children eligible to routinely receive oxygen.\n\nExclusion Criteria:\n\n1. Current CPAP use with documented compliance (\\> 4 hrs\u002F night; \\> 70% of nights).\n2. Oxygen saturation \\\u003C 90% at rest during wakefulness\n3. Chronic daytime or nighttime use of supplemental oxygen.\n4. Unable to participate in a Polysomnogram (PSG).\n5. Enrolled or planning to enroll in another study that may conflict with protocol requirements or confound results in this trial.",true,"5 Years","17 Years",{"count":54,"type":20},10,"INTERVENTIONAL",[57],"NA","Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea.\n\nThe aim of the study is to conduct a comparison between the 2 methods of oxygen delivery during sleep in 15 children from Cincinnati Children's Hospital and Children's Hospital of Los Angeles. 2 polysomnographies will be performed, one with continuous flow and the second with pulse flow.",[24],[61,62,63],"Sleep Apnea","Down Syndrome","Continuous Positive Airway Pressure (CPAP)","RECRUITING","2026-01-05",{"date":67,"type":33},"2026-01-07",{"date":69,"type":33},"2023-01-09",{"date":71,"type":20},"2028-12-01",{"name":73,"class":40},"Children's Hospital Medical Center, Cincinnati",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":50,"sex":16,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":55,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100616127","pilot-study-of-negative-pressure-neck-therapy-npnt-100616127","NCT07301567","Pilot Study of Negative Pressure Neck Therapy (NPNT)","A Proof-of-concept Pilot Study to Determine the Safety and Effectiveness of the Negative Pressure Neck Therapy (NPNT) in Healthy Participants.","Inclusion Criteria:\n\n* Body mass index ≤42 kg\u002Fm2\n* Able to speak, read, and write English\n\nExclusion Criteria:\n\n* Known sleep disorder such as Obstructive Sleep Apnea (OSA), narcolepsy, restless leg syndrome, idiopathic hypersomnolence or chronic insomnia\n* No previous surgery, injury, or radiation to the neck\n* Excessive hair or beard in the area of the neck, and\u002For unwillingness to shave that area for the duration of this study\n* Inflammatory skin condition, such as acne or eczema in the neck area\n* Known silicone allergy\n* Night shift work because of irregular sleep-wake cycles\n* Excessive alcohol intake, defined as that leading to interference with work, home life, or the ability to optimally perform normal everyday duties and tasks\n* Use of illicit drugs currently or within the past 5 years\n* Serious pulmonary disease\n* Use of home oxygen or oxygen saturation \\\u003C94%\n* Cancer that has been in remission for less than one year\n* Previous surgery for peripheral arterial disease","19 Years",{"count":54,"type":20},[57],"Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation. This pilot study will evaluate the Safety and Efficacy of Negative Pressure Neck Therapy (NPNT) in up to 10 healthy participants. Participants will undergo 2 separate home sleep apnea tests (HSAT) approximately 1 week apart and will be randomly assigned to wear the NPNT device at either night 1 or night 2 of HSAT. Participation will include 5 on-site visits and 1 phone call over approximately 1 month.",[24,86,87],"Sleep Apnea Syndrome, Obstructive","Sleep Disorder (Disorder)",[89,90,91],"sleep apnea","Obstructive sleep apnea","sleep disordered breathing","2025-12-10",{"date":94,"type":33},"2025-12-24",{"date":96,"type":20},"2026-01",{"date":98,"type":20},"2026-12",{"name":100,"class":40},"University of British Columbia",2]