[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstructive-jaundice\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstructive-jaundice":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,73,105,131,151,172,199],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642549","supraglottic-oxygenation-via-oral-transtracheal-catheter-for-reducing-the-incidence-of-hypoxemia-during-ercp-under-sedation-100642549",false,"NCT07637721","Supraglottic Oxygenation Via Oral Transtracheal Catheter for Reducing the Incidence of Hypoxemia During ERCP Under Sedation","Supraglottic Oxygenation Via Oral Transtracheal Catheter for Reducing the Incidence of Hypoxemia During ERCP Under Sedation：a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age≥18years\n* The ASA classification ranges from I to III\n* Patients have signed the informed consent form\n* Patients scheduled to undergo sedated ERCP examination procedure\n\nExclusion Criteria:\n\n* Severe cardiac dysfunction (\\\u003C4 METs);\n* Diagnosed chronic obstructive pulmonary disease (COPD) or other acute\u002Fchronic pulmonary diseases requiring long-term\u002Fintermittent oxygen therapy;\n* Upper respiratory tract infections including oral, nasal or pharyngeal infections;\n* Fever (core temperature \\>37.5°C);\n* Confirmed pregnancy or current breastfeeding;\n* Hypersensitivity to sedative drugs such as propofol;\n* Current participation in other clinical trials;","ALL","18 Years",{"count":19,"type":20},410,"ESTIMATED","INTERVENTIONAL",[23],"NA","Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used for the diagnosis and treatment of pancreatobiliary diseases. While Monitored Anesthesia Care (MAC) enhances the efficiency of ERCP, deep sedation introduces significant airway risks, particularly hypoxemia resulting from sedative-induced upper airway collapse. With reported hypoxemia rates ranging from 10% to 69%, and the potential for severe complications such as myocardial ischemia and neurological damage, effective airway management is paramount. Supraglottic oxygenation via oral transtracheal catheter provides a viable method for relieving obstruction and enabling positive pressure ventilation, serving as a less invasive alternative to tracheal intubation. Despite its proven utility in other settings, this technique has not yet been evaluated in the context of deeply sedated ERCP.",[26,27,28,29],"Choledocholithiasis With Cholecystitis With Obstruction","Obstructive Jaundice","Pancreatitis","Cholelithiasis",[31,32,33,34,35],"ERCP","Monitored Anesthesia Care","deep sedation","hypoxemia","The Supraglottic Oxygenation Via Oral Transtracheal Catheter","NOT_YET_RECRUITING","2026-06-09",{"date":39,"type":40},"2026-06-10","ACTUAL",{"date":42,"type":20},"2026-06-12",{"date":44,"type":20},"2027-12-31",{"name":46,"class":47},"Zhejiang University","OTHER",3,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":31,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100636275","determinants-of-technical-success-and-safety-in-therapeutic-ercp-for-obstructive-jaundice-100636275","NCT07563569","Determinants of Technical Success and Safety in Therapeutic ERCP for Obstructive Jaundice","Determinants of Technical Success and Safety in Therapeutic ERCP for Obstructive Jaundice: A Prospective Comparative Study.","Inclusion Criteria:\n\n* Adult patients above 18 years old.\n* Patient with obstructive jaundice as an indication for therapeutic ERCP.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Patients below 18 years old.\n* Indications for ERCP other than obstructive jaundice.\n* with coagulopathy not corrected prior to procedure.\n* severe active cardiopulmonary comorbidities.\n* Previous altered upper GIT anatomy (e.g gastric by-pass).\n* Pregnancy",{"count":57,"type":20},100,[23],"compare the impact of type of anesthesia on ERCP including technical success, rate of complications, peri procedural safety, patient and endoscopist satisfaction in adult patients with obstructive jaundice",[27,31,61,62],"Anesthesia Complication","Anesthesia Effectiveness",[31],"2026-04-25",{"date":66,"type":40},"2026-05-04",{"date":68,"type":20},"2026-05-20",{"date":70,"type":20},"2027-05-20",{"name":72,"class":47},"Sohag University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100633905","impact-of-intraoperative-ptcd-catheter-retention-versus-removal-on-postoperative-short-term-outcomes-after-pancreaticoduodenectomy-in-obstructive-jaundice-100633905","NCT07532759","Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice","Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice: An Exploratory Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 85 years\n* Patients with pancreatic head or periampullary tumors scheduled for pancreaticoduodenectomy\n* Presence of obstructive jaundice and completion of preoperative\n* percutaneous transhepatic cholangial drainage (PTCD)\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Able to understand the study and provide written informed consent\n\nExclusion Criteria:\n\n* Presence of distant metastasis or locally unresectable disease\n* Severe cardiac, renal, or pulmonary dysfunction that contraindicates surgery\n* Uncontrolled infection\n* Pregnancy or breastfeeding\n* History of major surgery within 4 weeks prior to enrollment\n* Poor compliance or inability to complete follow-up","85 Years",{"count":57,"type":20},[23],"Pancreaticoduodenectomy (PD) is a complex surgical procedure commonly performed for tumors of the pancreatic head and periampullary region. Many patients present with obstructive jaundice and undergo preoperative percutaneous transhepatic cholangial drainage (PTCD) to relieve biliary obstruction. However, there is currently no consensus on whether the PTCD catheter should be removed or retained during surgery.\n\nThis multicenter, prospective randomized controlled trial aims to compare two intraoperative strategies: removal versus retention of the PTCD catheter during PD. Participants will be randomly assigned to either group. The study will evaluate whether these different approaches influence postoperative outcomes, particularly major complications such as bile leak and severe postoperative morbidity within 90 days after surgery.\n\nIn addition to complications, the study will assess recovery after surgery, including return of gastrointestinal function, length of hospital stay, and quality of recovery, as well as laboratory indicators of liver function and inflammation.\n\nThe results of this study are expected to provide evidence to guide surgical decision-making regarding PTCD management during PD and to improve patient outcomes.",[27,85,86,87],"Pancreatic Head Cancer","Periampullary Neoplasms","Biliary Tract Neoplasms",[89,90,91,92,93,94,95],"Pancreaticoduodenectomy","PTCD","Biliary drainage","Biliary complications","Bile leak","Enhanced recovery","Randomized controlled trial","2026-04-09",{"date":98,"type":40},"2026-04-16",{"date":100,"type":20},"2026-05-01",{"date":102,"type":20},"2028-04-30",{"name":104,"class":47},"Xu'an Wang",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},"100596938","phase-2-feasibility-and-safety-of-supraglottic-oxygen-delivery-via-an-endotracheal-tube-for-non-intubated-ercp-anesthesia-a-two-stage-phase-ii-clinical-study-100596938","NCT07051980","Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study","Inclusion Criteria:\n\n* Age ≥18 years；\n* The ASA classification ranges from I to III.\n* Patients have signed the informed consent form.\n* Patients scheduled to undergo sedated ERCP examination;\n* The estimated duration of the procedure does not exceed 45 minutes.\n\nExclusion Criteria:\n\n* Severe cardiac dysfunction (\\\u003C4 METs);\n* Severe renal insufficiency (requiring preoperative dialysis);\n* Diagnosed chronic obstructive pulmonary disease (COPD) or other acute\u002Fchronic pulmonary diseases requiring long-term\u002Fintermittent oxygen therapy;\n* Increased intracranial pressure;\n* Upper respiratory tract infections (oral\u002Fnasal\u002Fpharyngeal);\n* Fever (core temperature \\>37.5°C);\n* Confirmed pregnancy or current breastfeeding;\n* Allergy to sedatives (e.g., propofol) or medical adhesives;\n* BMI \\>30 kg\u002Fm²;\n* Current participation in other clinical trials;",{"count":112,"type":20},50,[114],"PHASE2","Endoscopic retrograde cholangiopancreatography (ERCP) is a technique for evaluating the bile duct, pancreatic duct, and ampulla. Hypoxia is the most common cardiopulmonary complication during ERCP, with a reported rate of 16.2 to 39.2%. The key to preventing hypoxia is to ensure the sufficient oxygenation and ventilation of patients during these procedures. The commonly used approaches to treat hypoxia with a non-instrumented airway are increasing the oxygen flow and lifting the jaw, applying with both hands, displacing the jaw upwards and anteriorly, which allowed the upper airway to remain open. We hypothesized that the supraglottic oxygen delivery via an endotracheal tube can reduce the incidence of hypoxia in patients under deep sedation during ERCP.",[26,27,28,29],[31,118,119,120],"respiratory depression","Hypoxia","Sedation","RECRUITING","2025-07-14",{"date":124,"type":40},"2025-07-17",{"date":126,"type":40},"2025-06-12",{"date":128,"type":20},"2026-12-31",{"name":46,"class":47},1,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},"100593925","phase-2-combo-endoscopy-oropharyngeal-airway-in-sedated-endoscopic-retrograde-cholangiopancreatography-for-patients-100593925","NCT07012772","COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients","Inclusion Criteria:\n\n* Age ≥18 years；\n* The ASA classification ranges from I to III.\n* Patients have signed the informed consent form.\n* Patients scheduled to undergo sedated ERCP examination;\n* The estimated duration of the procedure does not exceed 45 minutes.\n\nExclusion Criteria:\n\n1. Patients with coagulation disorders, tendency for oral\u002Fnasal bleeding, mucosal injury\u002Foccupying lesions, or difficult oropharyngeal airway insertion making airway management unfeasible;\n2. Severe cardiac dysfunction (\\\u003C4 METs);\n3. Severe renal insufficiency (requiring preoperative dialysis);\n4. Child-Pugh class C;\n5. Diagnosed chronic obstructive pulmonary disease (COPD) or other acute\u002Fchronic pulmonary diseases requiring long-term\u002Fintermittent oxygen therapy;\n6. Increased intracranial pressure;\n7. Upper respiratory tract infections (oral\u002Fnasal\u002Fpharyngeal);\n8. Fever (core temperature \\>37.5°C);\n9. Confirmed pregnancy or current breastfeeding;\n10. Allergy to sedatives (e.g., propofol) or medical adhesives;\n11. Emergency procedures;\n12. Multiple trauma injuries;\n13. Peripheral oxygen saturation (SpO2) levels below 95% while breathing room air preoperatively;\n14. BMI \\\u003C18.5 or \\>30 kg\u002Fm²;\n15. Current participation in other clinical trials;\n16. Other conditions deemed ineligible by investigators.",{"count":112,"type":20},[114],"Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) with propofol. A recent innovation in this domain is the COMBO Endoscopy Oropharyngeal Airway-a multifaceted device that encompasses capnography monitoring, bite block , oxygenation support, and oropharyngeal airway management. This device has been purposefully designed to cater to the unique requirements of endoscopic procedures. The principal objective of this study is to assess the efficacy of the COMBO Endoscopy Oropharyngeal Airway in reducing the incidence of hypoxia in patients undergoing ERCP under sedation.",[26,27,28,29],[118,142,119,120,31],"The COMBO Endoscopy Oropharyngeal Airway","2025-06-23",{"date":145,"type":40},"2025-06-24",{"date":126,"type":40},{"date":148,"type":20},"2025-12-31",{"name":46,"class":47},2,{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":161,"phases":4,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":4},"100574062","diagnostic-accuracy-of-magnetic-resonance-cholangiopancreatography-in-patients-with-obstructive-jaundice-100574062","NCT06754397","Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients With Obstructive Jaundice","Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography as Compared to Ultrasound and Computed Tomography in Patients With Obstructive Jaundice","Inclusion Criteria:\n\nAdult male and female patients clinically diagnosed obstructive jaundice are included in the study with positive laboratory tests.\n\nExclusion Criteria:\n\nPatients with non-obstructive (prehepatic\u002Fhepatic) cause of jaundice. Patients having contraindications to perform MRI (Patients with any electrically, magnetically or mechanically activated implants, pacemaker, cochlear implants or any metallic orthopedic implants and claustrophobic patients).","15 Years","89 Years",{"count":112,"type":20},"OBSERVATIONAL","Evaluate the diagnostic accuracy of Magnetic Resonance Cholangiopancreatography (MRCP) compared with Ultrasound and Computed Tomography (CT) in patients with obstructive jaundice taking findings of ERCP\u002F PTC and histopathology as gold standard.",[27],"2024-12-22",{"date":166,"type":40},"2024-12-31",{"date":168,"type":20},"2025-01",{"date":170,"type":20},"2025-12",{"name":72,"class":47},{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":21,"phases":182,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":130},"100360795","evaluation-of-the-use-of-a-biodegradable-endoprothesis-in-the-prevention-of-post-endoscopic-retrograde-choloangiopancreatography-pancreatitis-100360795","NCT03977779","Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis","Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis","ARCHIMEDE","Inclusion Criteria:\n\n* Age\\>18 years\n* Patients at risk of developing a Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis (procedure and\u002For patient-related risk factors\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Recent diagnosis (\\\u003C1 month) of acute pancreatitis\n* contraindication to endoscopy\n* Hypersensitivity to indomethacine",{"count":181,"type":20},46,[23],"The use of an endoprothesis in a pancreatic duct is a measure to minimize the incidence and severity of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis. In this study we will evaluate the use of a Biodegradable Endoprothesis: Archimede Fast Biodegradable Pancreatic Stent in patients with high risk of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis.The ARCHIMEDES Fast biodegradable pancreatic stent will be placed during the Endoscopic Retrograde CholoangioPancreatography. The efficacy and the security of the device will be evaluated.",[27,185,186],"Biliary Stricture","Sphincter of Oddi Dysfunction",[188,189],"biodegradable stent","Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis","2024-10-23",{"date":192,"type":40},"2024-10-24",{"date":194,"type":40},"2022-01-20",{"date":196,"type":20},"2024-12-15",{"name":198,"class":47},"Institut Paoli-Calmettes",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":21,"phases":210,"briefSummary":211,"conditions":212,"keywords":214,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":225,"locationsCount":130},"100557686","a-new-strategy-for-preoperative-drainage-of-resectable-pancreatic-head-cancer-combined-severe-obstructive-jaundice-100557686","NCT06541340","A New Strategy for Preoperative Drainage of Resectable Pancreatic Head Cancer Combined Severe Obstructive Jaundice","A New Strategy for Preoperative Drainage of Resectable Pancreatic Head Cancer Combined Severe Obstructive Jaundice, a Multicenter, Open-label, Randomized Controlled Clinical Study","PROB","Inclusion Criteria:\n\n1. Pathological diagnosis of pancreatic head cancer, or clinical diagnosis of pancreatic head cancer after multidisciplinary discussion, clear presence of obstructive jaundice caused by pancreatic head tumor, and planned to undergo radical pancreaticoduodenectomy\n2. Preoperative imaging stage is resectable\n3. Baseline serum total bilirubin ≥ 250μmol\u002FL, and no history of preoperative biliary drainage\n4. Age \\>18 and ≤75 years old\n5. ECOG(Eastern Cooperative Oncology Group) physical score ≤ 2\n6. Signed informed consent, received preoperative endoscopic biliary drainage (ERCP) and radical surgery timing evaluation\n\nExclusion Criteria:\n\n1. Combined with other malignant tumors\n2. Combined with uncontrolled medical diseases or organ dysfunction and other absolute counterindications for surgery\n3. Pregnant and lactating women\n4. Patients who cannot tolerate preoperative biliary drainage or radical surgery\n5. Other situations that are not suitable for inclusion in clinical trials","75 Years",{"count":209,"type":20},360,[23],"Severe obstructive jaundice caused by pancreatic head cancer usually requires preoperative biliary drainage, but its necessity and effectiveness are controversial, and specific strategies lack clear standards. This study proposed a new strategy for preoperative biliary drainage using serum prealbumin as the main evaluation index, and compared it with the traditional strategy using serum total bilirubin as the main evaluation index. Through a randomized, controlled, multicenter prospective study, we explored the effects of different drainage strategies on the incidence of in-hospital complications and long-term prognosis of patients with resectable pancreatic head cancer, guided clinical decisions on preoperative drainage time and surgical timing, and provided high-quality evidence-based medicine for preoperative biliary drainage of pancreatic head cancer.",[213,27],"Pancreatic Cancer",[215,216,217,218],"pancreatic head cancer","obstructive Jaundice","preoperative biliary drainage","prealbumin","2024-08-06",{"date":221,"type":40},"2024-08-07",{"date":223,"type":40},"2024-08-01",{"date":128,"type":20},{"name":226,"class":47},"Ruijin Hospital"]