[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstructive-pulmonary-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstructive-pulmonary-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,70,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100054163","lung-health-and-the-microbiome-among-adults-in-botswana-the-go-hema-cohort-100054163",false,"NCT07699614","Lung Health and the Microbiome Among Adults in Botswana: the Go-hema Cohort","Determinants of Lung Health Among Batswana Adults With and Without HIV: the Go-Hema Study","Inclusion Criteria:\n\n* Adults 35 years of age or older\n* In case at a clinic in Botswana\n* Documented HIV status\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Respiratory infection in the prior 4 weeks\n* Active pulmonary tuberculosis\n* Inability to perform spirometry including eye, abdominal, or\n* Thoracic surgery or myocardial infarction in the prior 6 weeks\n* Pregnancy",true,"ALL","35 Years",{"count":20,"type":21},900,"ESTIMATED","4 Months","OBSERVATIONAL","Chronic respiratory diseases like chronic obstructive pulmonary disease (COPD) are responsible for millions of deaths each year, the majority of which occur in low- and middle-income countries (LMICs). LMICs also have high rates of abnormal lung function, including restrictive spirometric pattern (RSP), which can precede the development of chronic respiratory diseases and is associated with all-cause mortality. Additionally, LMICs in sub-Saharan Africa are home to the majority of the world's population of people with HIV (PWH). HIV increases the risk of COPD and COPD associated mortality, but the mechanisms underlying this risk are incompletely understood.",[26,27],"Obstructive Pulmonary Disease","Restrictive Pulmonary Disease","RECRUITING","2026-07-08",{"date":31,"type":32},"2026-07-13","ACTUAL",{"date":34,"type":32},"2024-12-01",{"date":36,"type":21},"2030-12-20",{"name":38,"class":39},"Duke University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":16,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100590173","using-community-health-workers-to-support-rural-care-partners-of-seriously-ill-older-veterans-100590173","NCT06963970","Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans","PATH","Inclusion Criteria:\n\nCare Partner Inclusion Criteria\n\n* A relative, friend, or partner (18 years of age) with whom Veteran patient has a personal relationship who assists Veteran regularly with care and\u002For care coordination as defined under \"Veterans\" below\n* Residing in a rural area based on RUCC or Rural-Urban Continuum Codes83\n* Must be enrolled in CSP Program of General Caregiver Support Services\n* Can live with or separately from the Veteran; able to communicate in English by phone\n\nVeteran Inclusion Criteria\n\n* Receiving care at Durham, Asheville, and Richmond VA Health Systems (e.g., at least 2 outpatient visits in past year; has a primary provider) and residing in a rural area.\n* Diagnosed with congestive heart failure, chronic obstructive pulmonary disease, cancer, dementia, or end-stage renal disease.\n* Requires assistance with at least one ADL (i.e., walking, feeding, toileting, transferring, bathing, or dressing) or IADL (i.e., transport, medication, financial management, shopping, or meal preparation)\n* 50 years old or older and able to communicate in English by phone (for assessments)\n\nExclusion Criteria:\n\nVeteran Exclusion Criteria\n\n* Flag or social work note indicating suspected Caregiver abuse.\n* Unable to communicate in English by phone for assessments.","18 Years",{"count":50,"type":21},480,"INTERVENTIONAL",[53],"NA","The investigators aim to support care partner's well-being and satisfaction with VA care and decrease their work burden by offering extra support from a trained Community Health Worker who will help connect the care partner to helpful resources in their communities and in the VA. The investigators also hope to help Veterans well-being and satisfaction with VA care by supporting their care partner more sufficiently allowing the care partner to focus on caregiving tasks.",[56,57,58,26],"Dementia","Cancer","Renal Disease","NOT_YET_RECRUITING","2026-06-16",{"date":62,"type":32},"2026-06-17",{"date":64,"type":21},"2026-09-01",{"date":66,"type":21},"2028-09-30",{"name":68,"class":69},"VA Office of Research and Development","FED",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":16,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":51,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":40},"100353931","measurement-of-viscoelastic-properties-of-bronchopulmonary-secretions-100353931","NCT03888300","Measurement of Viscoelastic Properties of Bronchopulmonary Secretions.","VLM-2: Measurement of Viscoelastic Properties of Bronchopulmonary Secretions.","VLM-2","Inclusion Criteria:\n\n* obstructive pulmonary disease\n\nExclusion Criteria:\n\n* none",{"count":79,"type":21},500,[53],"The study is experimental and aims to (a) compare the viscoelastic properties of bronchial secretions obtained in patients suffering from obstructive respiratory disease, and (b) to compare the viscoelastic properties of bronchial secretions obtained in patients before and after application of a respiratory physiotherapy or exercise as usually prescribed.\n\nAfter agreement, the sputum of the participants will be collected according to the method used in clinical routine.Experiments (collection and analysis of sputum) will be conducted at the Saint-Luc University Clinic.",[26],"2026-04-24",{"date":85,"type":32},"2026-04-29",{"date":87,"type":32},"2019-08-01",{"date":89,"type":21},"2027-08-01",{"name":91,"class":39},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":51,"phases":102,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100559393","fcv-vs-vcv-in-obstructive-and-asthmatic-patients-100559393","NCT06563544","FCV Vs VCV in Obstructive and Asthmatic Patients","Flow Versus Volume-Controlled Ventilation in Intubated Obstructive and Asthmatic Patients","Inclusion Criteria:\n\n* 18 years or older;\n* Provided written informed consent;\n* Undergoing controlled mechanical ventilation via an endotracheal tube;\n* Reason for intubation being exacerbation of asthma or COPD;\n* Intubated ≤72 hours\n\nExclusion Criteria:\n\n* Severe sputum stasis or production requiring frequent bronchial suctioning (more than 5 times per nurse shift)\n* Untreated pneumothorax (i.e. no pleural drainage)\n* Hemodynamic instability defined as a mean arterial pressure below 60mmHg not responding to fluids and\u002For vasopressors or a noradrenalin dose \\>0.5mcrg\u002Fkg\u002Fmin\n* High (\\>15 mmHg) or instable (an increase in sedation or osmotherapy is required) intracranial pressure\n* An inner tube diameter of 6mm or less\n* Anticipating withdrawal of life support and\u002For shift to palliation as the goal of care\n* Inability to perform adequate electrical impedance tomography (EIT) measurements with, e.g.:\n\n  * Have a thorax circumference inappropriate for EIT-belt\n  * Thoracic wounds, bandages or deformities preventing adequate fit of EIT-belt\n  * Recent (\\\u003C7 days) pulmonary surgery including pneumonectomy, lobectomy or lung transplantation\n  * ICD device present (potential interference with proper functioning of the EIT device and ICD device)\n  * Excessive subcutaneous emphysema\n* Contra-indications for nasogastric tube or inability to perform adequate transpulmonary pressure measurements with, e.g.:\n\n  * Recent esophageal surgery\n  * Prior esophagectomy\n  * Known presence of esophageal varices\n  * Severe bleeding disorders","100 Years",{"count":101,"type":21},10,[53],"The goal of this physiological pilot study with a randomized crossover design is to study the effect of Flow-controlled ventilation (FCV) on the minute volume compared to Volume-controlled ventilation (VCV) in intubated patients with an exacerbation of their asthma or COPD.\n\nOur hypothesis is that FCV will results in a lower minute volume compared to VCV in this patient category.\n\nPatients will be randomized between two ventilation sequences, namely 90 minutes of FCV followed by 90 minutes of VCV or vice versa.",[26,105,106],"Mechanical Ventilation Pressure High","Asthma COPD","2024-10-16",{"date":109,"type":32},"2024-10-18",{"date":111,"type":21},"2024-10",{"date":113,"type":21},"2027-10",{"name":115,"class":39},"Erasmus Medical Center",2]