[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstructive-sleep-apnea-hypopnea-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstructive-sleep-apnea-hypopnea-syndrome":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100602223","egr2-and-nlrp3-pathways-in-obstructive-sleep-apnea-related-cognitive-and-mood-disorders-100602223",false,"NCT07120711","EGR2 and NLRP3 Pathways in Obstructive Sleep Apnea-Related Cognitive and Mood Disorders","Regulatory Mechanisms of EGR2 and NLRP3 Inflammatory Pathways in Cognitive Impairment and Depressive-Anxiety-Like Behaviors Associated With Obstructive Sleep Apnea-Hypopnea Syndrome","Inclusion Criteria:\n\nChildren aged 2-18 years with obstructive snoring or sleep apnea features on initial ENT outpatient screening.\n\nAdults (\\>18 years) with suspected OSAS in a sleep or respiratory clinic, presenting with chronic snoring, witnessed apneas, or daytime sleepiness, and without severe chronic heart, liver, kidney failure, psychiatric disorders, or pregnancy.\n\nSigned written informed consent by the participant or their legal guardian. Not currently enrolled in any other registered clinical trial.\n\nExclusion Criteria:\n\nPresence of congenital craniofacial malformations. Severe heart, lung, liver, or kidney failure, or major neurological disease. Recent use of anti-inflammatory or other immunomodulatory medications. Current psychiatric disorder or pregnancy",true,"ALL","5 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","Obstructive sleep apnea-hypopnea syndrome (OSAS) is a common disorder in which repeated airway blockages during sleep lead to low oxygen levels, inflammation, and disrupted sleep. Many OSAS patients-both children and adults-experience problems with memory, attention, and mood, such as anxiety or depression. However, the exact molecular drivers of these brain changes are not fully understood.\n\nThis observational study will enroll:\n\nChildren (ages 2-18) and adults (\\>18 years) with OSAS, as well as age- and sex-matched healthy volunteers.\n\nClinical assessments: Children will undergo routine ENT examinations (including nasal endoscopy and X-rays); adults will have an overnight sleep study (polysomnography). All participants will complete questionnaires on sleepiness (e.g., ESS), mood (PHQ-9, GAD-7), and cognitive screening (MoCA for adults, age-appropriate scales for children).\n\nSample collection: A small blood draw (3 mL) and, when applicable (e.g., adults undergoing surgery), a tiny subcutaneous fat biopsy. Saliva samples will also be collected.\n\nLaboratory tests:\n\nMeasure expression levels of two key inflammatory pathway genes-EGR2 and NLRP3-in blood cells, saliva, and fat tissue using RNA sequencing, RT-qPCR, and Western Blot.\n\nCorrelate these molecular markers with sleep parameters (AHI, oximetry), cognitive scores, and mood scores.\n\nData analysis: Develop and validate machine-learning models that integrate data from multiple tissues to predict who is at highest risk for cognitive or mood disturbances.",[25,26,27],"Obstructive Sleep Apnea-Hypopnea Syndrome","Anxiety Disorders","Depressive Disorders","RECRUITING","2025-08-07",{"date":31,"type":32},"2025-08-13","ACTUAL",{"date":34,"type":32},"2025-07-01",{"date":36,"type":21},"2026-09-30",{"name":38,"class":39},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","OTHER","Obstructive Sleep Apnea-hypopnea Syndrome"]