[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstructive-sleep-apnea-of-child\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstructive-sleep-apnea-of-child":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,65,87,113,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100622184","diaphragm-ultrasound-n-children-with-osas-100622184",false,"NCT07380321","Diaphragm Ultrasound İn Children With OSAS","Perioperative Ultrasonographic Assessment Of Diaphragmatic Function İn Pediatric Obstructive Sleep Apnea","Inclusion Criteria:\n\n* ASA physical status I-II\n* Children aged 1 to 12 years\n* Scheduled to undergo elective surgery under general anesthesia\n* Written informed consent obtained from parents or legal guardians\n* Availability of a completed pediatric sleep questionnaire (PSQ)\n\nExclusion Criteria:\n\n* Patients younger than 1 year or older than 12 years\n* Presence of a neuromuscular disease\n* Use of medications that may affect neuromuscular function\n* Diaphragmatic paralysis\n* ASA physical status III-IV\n* Refusal to participate in the study or failure to provide informed consent\n* Body mass index (BMI) \\> 35 kg\u002Fm²",true,"ALL","1 Year","12 Years",{"count":21,"type":22},60,"ESTIMATED","OBSERVATIONAL","This is a prospective observational study evaluating perioperative diaphragmatic function by ultrasonography in children aged 1-12 years undergoing elective surgery under general anesthesia.\n\nParticipants will be classified preoperatively based on the parent-completed Pediatric Sleep Questionnaire (PSQ). Children with suspected obstructive sleep apnea syndrome who are scheduled for adenotonsillectomy will form the study group, while children without clinical findings suggestive of obstructive sleep apnea who are scheduled for elective non-airway-related otolaryngologic surgeries will serve as controls.\n\nDiaphragm ultrasound assessments will be performed before and after surgery in the supine position during spontaneous breathing. Measurements will include diaphragmatic thickness at end-inspiration and end-expiration, diaphragmatic thickening fraction, and diaphragmatic excursion during quiet and deep breathing.\n\nThe primary objective is to compare diaphragmatic excursion and thickening fraction between groups. Secondary objectives include evaluating the association between perioperative respiratory parameters, postoperative recovery, and diaphragm ultrasound measures.",[26],"Obstructive Sleep Apnea of Child",[28,29,30],"Pediatric Sleep Questionnaire","diaphragm ultrasound","adenotonsillectomy","RECRUITING","2026-01-27",{"date":34,"type":35},"2026-02-02","ACTUAL",{"date":37,"type":35},"2025-09-01",{"date":39,"type":22},"2026-08-30",{"name":41,"class":42},"Istanbul University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":63,"locationsCount":43},"100619491","bodysleep-algorithm-for-osa-diagnosis-in-children-100619491","NCT07345312","BodySleep Algorithm for OSA Diagnosis in Children","The Use of the BodySleep Algorithm (ResMed) for the Diagnosis of Obstructive Sleep Apnea Syndrome in Children","Inclusion Criteria:\n\n* Children suspected of OSA who are addressed for a PSG by the ear nose throat physician, pediatric pulmonologist, neurologist, psychiatrist, sleep specialist, genetics, and nutritionist physician.\n* Age between 2 and 18 years\n\nExclusion Criteria:\n\n* Age under 2 years and over 18 years","2 Years","18 Years",{"count":54,"type":22},90,"Diagnosing obstructive sleep apnea-hypopnea syndrome in children (OSA) requires the performance of polysomnography (PSG) in the hospital which is sometimes challenging to perform in children, and time-consuming for installation and analysis. Simplified recording and analysis methods are preferable in children but require validation in this population.\n\nThe BodySleep automatic algorithm of the polysomnograph used in our lab (A1-Nox, ResMed) associated only with respiratory signals could be used to identify respiratory events. Thus the child would have fewer sensors installed on him.",[26],"2026-01-09",{"date":59,"type":35},"2026-01-15",{"date":61,"type":22},"2026-01-10",{"date":59,"type":22},{"name":64,"class":42},"Central Hospital, Nancy, France",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":43},"100448170","single-cell-sequencing-of-tonsillar-tissue-in-children-with-osa-100448170","NCT05115968","Single Cell Sequencing of Tonsillar Tissue in Children With OSA","Single Cell Sequencing to Examine the Pathogenesis of Adenotonsillar Hypertrophy in Children With Obstructive Sleep Apnoea","Inclusion Criteria:\n\nCase: Chinese children aged 6-11 years old with habitual snoring (≥3 nights per week) and polysomnography (PSG) confirmed OSA (obstructive apnoea hypopnoea index (OAHI) of ≥1\u002Fhour), with adenotonsillar hypertrophy and clinical indications for adenotonsillectomy will be recruited as cases.\n\nControl: Non-OSA subjects (with PSG OAHI \\\u003C1\u002Fhour) who undergo adenotonsillectomy for other reasons such as recurrent tonsillitis.\n\nExclusion Criteria:\n\nPrevious upper airway surgery, genetic or syndromal disease, congenital or acquired neuromuscular disease, congenital or acquired immunodeficiency, known metabolic syndrome, craniofacial abnormalities.","6 Years","11 Years",{"count":75,"type":22},15,"Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep. It is an important disease as it is associated with a large spectrum of end-organ morbidities.\n\nAdenotonsillar hypertrophy is the commonest cause of OSA in children, however, the cause of the lymphoid tissue hypertrophy in some individuals but not the others remains unknown. To address the cellular heterogeneity and immune cell involvement in adenotonsillar hypertrophy, here, we propose to employ single-cell sequencing analysis to identify the cell-specific expression patterns associated with the disease, which will enhance our understanding of the pathogenesis of tonsillar hypertrophy in children with OSA and may provide directions for development of novel therapy.",[26],"2025-02-12",{"date":80,"type":35},"2025-02-13",{"date":82,"type":35},"2023-01-01",{"date":84,"type":22},"2025-12-31",{"name":86,"class":42},"Chinese University of Hong Kong",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":43},"100564829","comparison-of-two-reeducation-methods-in-children-with-persistent-sleep-apnea-a-randomized-controlled-trial-100564829","NCT06634264","Comparison of Two Reeducation Methods in Children With Persistent Sleep Apnea, a Randomized Controlled Trial","PERSIST-B-RCT","Inclusion Criteria:\n\nparticipants must:\n\n* present signs of obstructive sleep apnea: snoring, apnea \u002F respiratory pauses audible by the entourage (objectivized by a score, to the Pediatric Sleep Questionnaire (PSQ) , greater than or equal to 0.33- This questionnaire comprises twenty-two Questions and has a good sensitivity (83%) and specificity (87%) in screening for pediatric sleep apnea.\n* be programmed for adenoidectomy, tonsillectomy or adeno-tonsillectomy within 3 months (or more).\n\nExclusion Criteria:\n\nparticipants should not:\n\n* present with a craniofacial syndrome nor a severe medical condition with complex medical management,\n* present with an abnormality of the neuromuscular tone (such as Duchenne myopathy or cerebral palsy)\n* receive orthodontic therapy during the study\n* have a class III malocclusion (mandibular prognathy type), for which a propulsion oral appliance is contraindicated because it may aggravate mandibular prominence. Maxillary deficiency is not a exclusion criterion.\n* A non-nutritive oral habit such as digital sucking (or pacifier) that persists because it interferes with oral reeducation and is a contraindication to orthodontic treatments. Children who have recently stopped such a habit may be included in the study.","4 Years","14 Years",{"count":21,"type":22},"INTERVENTIONAL",[99],"NA","Myofunctional therapy has been shown to be effectively reduce symptoms of paediatric obstructive sleep apnea, usually performed after adenotonsillectomy.\n\nThis study aims to evaluate the effectiveness of Passive Oral Myofunctional Reeducation (using a flexible oral appliance) compared to nasal hygiene alone (control group), in a population of children scheduled for adenotonsillectomy.",[26,102,103],"Sleep-Disordered Breathing","Adenotonsillar Hypertrophy","2024-10-07",{"date":106,"type":35},"2024-10-09",{"date":108,"type":35},"2024-03-20",{"date":110,"type":22},"2027-03-31",{"name":112,"class":42},"Université de Montréal",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":120,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":43},"100544324","validation-of-pediatric-sleep-questionnaire-on-a-swedish-cohort-100544324","NCT06367400","Validation of Pediatric Sleep Questionnaire on a Swedish Cohort","Validation of Pediatric Sleep Questionnaire, a Multi-center Study in Sweden","Inclusion Criteria:\n\n* Children with OSDB-symptoms referred to ENT-clinics\n* Age between 18 months and 15 years old.\n* Good knowledge of the Swedish language\n\nExclusion Criteria:\n\n* Craniofacial abnormalities\n* Mb Down\n* neuromuscular disorders\n* do not understand swedish","18 Months","15 Years",{"count":123,"type":22},520,"This study is aimed to validate the questionnaire called Pediatric Sleep Questionnaire on a Swedish cohort of children from 18 months to 15 years old with obstructive sleep disordered breathing.",[126,127,128,26],"Obstructive Sleep Apnea","Sleep Disorder","Sleep Disorders in Children",[130,131,132],"OSDB","PSQ","Pediatrics","2024-04-11",{"date":135,"type":35},"2024-04-16",{"date":137,"type":35},"2024-03-01",{"date":139,"type":22},"2034-12-31",{"name":141,"class":42},"Uppsala University",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":19,"enrollmentInfo":150,"targetDuration":4,"studyType":97,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":157,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":43},"100523293","endoscopic-classification-and-dise-guided-surgery-in-pediatric-obstructive-sleep-disordered-breathing-100523293","NCT06093802","Endoscopic Classification and DISE-Guided Surgery in Pediatric Obstructive Sleep-Disordered Breathing.","Endoscopic Classification of Airway Obstruction and Drug Induced Sleep Endoscopy-Guided Surgery in Children With Obstructive Sleep-Disordered Breathing.","DISE","Inclusion Criteria:\n\n* Surgically naïve, otherwise healthy, non-syndromic children aged 2-12 years with suspected oSDB of any severity\n* One completed Pediatric Sleep Questionnaire - Sleep Related Breathing Disorder (PSQ)\n* Home Respiratory Polygraphy (HRP) and\u002For in-house Polysomnography (PSG) showing OSA according to the definition of AAO-HNSF\n\nExclusion Criteria:\n\n* Syndromes and congenital\u002Facquired craniofacial abnormalities\u002Fmalformations of the upper airways\n* Neurological conditions affecting upper airway muscle tone\n* Lower airway disease (tracheomalacia, asthma)\n* Previous surgery of the nose\u002Fpharynx\u002Flarynx",{"count":151,"type":22},250,[99],"Pediatric obstructive sleep apnea (OSA) can lead to severe health issues if untreated. While polysomnography is the gold standard for diagnosis, current surgical treatment in Denmark relies on caregiver reports and clinical exams. Approximately 25% of patients have persistent symptoms post-surgery, indicating the need for better diagnostic and treatment options. Drug-Induced Sleep Endoscopy (DISE) allows dynamic upper airway visualization during mild sedation, aiding in treatment decisions. This research project aims to evaluate the impact of DISE-guided interventions on pediatric OSA outcomes and compare its effectiveness and cost\u002Fbenefit with traditional diagnostic approaches.",[26],[156],"Drug-induced Sleep Endoscopy","NOT_YET_RECRUITING","2023-10-17",{"date":160,"type":35},"2023-10-23",{"date":162,"type":22},"2025-01-01",{"date":164,"type":22},"2029-07-01",{"name":166,"class":42},"Regional Hospital West Jutland"]