[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obstructive-sleep-apnea-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obstructive-sleep-apnea-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100450604","functional-magnetic-resonance-imaging-in-patients-with-obstructive-sleep-apnea-syndrome-100450604",false,"NCT05147649","Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome","Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions","IRM SAOS","Inclusion criteria :\n\n1. OSAS patients\n\n   * severe OSAS with an Apnea-Hypopnea Index (AHI) \\> 30\u002Fh\n   * without CPAP treatment\n2. Non-OSAS patients\n\n   * absence of OSAS (AHI \\\u003C 15\u002Fh and absence of excessive daytime sleepiness with Epworth score \\\u003C11)\n\nNon-inclusion criteria :\n\n* \\\u003C 18 years old\n* \\>75 years old\n* left-handed\n* BMI\\> 40 kg\u002Fm²\n* another sleep disorder\n* central component of sleep apnea syndrome (central apnea index\\> 5 \u002F h)\n* current or past neurological pathology\n* respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)\n* MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)\n* taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.),\n* uncorrected sensory impairment (vision or hearing)\n* protected by law.\n\nExclusion criteria :\n\n* pregnant woman according to the positive beta-hCG test result\n* left-handed following the laterality questionnaire\n* MINI results showing:\n\n  * a current mood episode\n  * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)\n  * an eating disorder\n  * a diagnosis of bipolar disorder, current or past schizophrenia",true,"ALL","18 Years","75 Years",{"count":22,"type":23},70,"ESTIMATED","INTERVENTIONAL",[26],"NA","The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.",[29],"Obstructive Sleep Apnea Syndrome","RECRUITING","2025-11-28",{"date":33,"type":34},"2025-12-02","ACTUAL",{"date":36,"type":34},"2023-03-02",{"date":38,"type":23},"2027-07-02",{"name":40,"class":41},"CHU de Reims","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":24,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":68,"locationsCount":4},"100403818","trained-patient-involvement-to-promote-the-resumption-of-cpap-in-patients-who-have-discontinued-its-use-100403818","NCT04538274","Trained Patient Involvement to Promote the Resumption of CPAP in Patients Who Have Discontinued Its Use","A Peer-driven Intervention to Help Patients Resume CPAP Therapy Following Discontinuation: a Multicenter, Randomized Clinical Trial with Patient Involvement","Inclusion Criteria:\n\n* Over 18 years old\n* Diagnosed with of severe OSA (AHI ≥ 30 events\u002Fhour)\n* Discontinuation of CPAP 4 to 12 months after initiation Followed by the home health care provider Agiradom\n* Access to a computer and\u002For tablet and an internet connection\n* Oral and written French\n* Able to provide written informed consent\n* Affiliated to social security or beneficiary of such a scheme\n\nExclusion Criteria:\n\n* CPAP cessation due to a resolution of the OSAS (e.g. weight loss after bariatric surgery) or another pathology that prevents the continuation of treatment (e.g. ENT surgery, etc.).\n* Severe and\u002For unstable comorbidity that required hospitalisation for decompensation in the previous year (heart, kidney, respiratory, liver, psychiatric or other insufficiency).\n* Patient being treated with a mandibular advancement orthosis\n* Lack of availability (e.g. night worker or patient who travels frequently, etc.).\n* Current participation in, participation in the month prior to inclusion in another clinical intervention research study that may impact the study: this impact is left to the investigator's discretion.\n* Referred to in Articles L1121-5 to L1121-8 of the CSP (corresponds to all protected persons: pregnant woman, breastfeeding mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure)","120 Years",{"count":52,"type":23},208,[26],"The primary objective of this randomized clinical trial is to evaluate the role of patient researchers in promoting the resumption of CPAP therapy in apneic patients who had previously stopped CPAP",[29],[57,58,59,60,61],"Sleep Apnea","CPAP adherence","Patient and Public Involvement (PPI)","cognitive-behavioural and motivation enhancement therapies","Patient Involvement (PI)","NOT_YET_RECRUITING","2025-02-18",{"date":65,"type":34},"2025-02-20",{"date":63,"type":23},{"date":63,"type":23},{"name":69,"class":41},"AGIR à Dom",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100560374","predictive-factors-for-occlusal-changes-in-obstructive-sleep-apnea-treatment-with-mandibular-advancement-appliance-100560374","NCT06576310","Predictive Factors for Occlusal Changes in Obstructive Sleep Apnea Treatment With Mandibular Advancement Appliance","Evaluation of Predictive Factors for Dental Occlusal Changes in the Treatment of Obstructive Sleep Apnea With Mandibular Advancement Appliance","APNEAMOUVE","Inclusion Criteria:\n\n* Patient with complete dentition (up to second molars)\n* Polysomnography or polygraphy\n* Diagnosis of OSA\n* Patient receiving OAM treatment at the Odontology Department of Toulouse University Hospital\n* Patient with contemporary panoramic and lateral cephalometric X-rays (common practice) taken at the time of orthotic treatment\n* Individual affiliated with or covered by a social security scheme\n* Voluntary, informed, written consent, signed by both participant and investigator (prior to inclusion and any necessary research-related examinations).\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Pregnant or breastfeeding patient\n* Patient with curators, guardians, or legal protection",{"count":79,"type":23},118,"OBSERVATIONAL","This research addresses obstructive sleep apnea syndrome (OSAS), affecting 6-12% of French adults, often treated with mandibular advancement devices (MADs). MADs may lead to occlusal modifications, causing a 50% treatment abandonment rate. The study employs surface electromyography to assess masticatory muscle activity before and during MAD use, correlating it with occlusal changes after 6 months. The primary goal is to determine dental displacement profiles post-6-month MAD treatment, providing insights for personalized care and minimizing treatment failures.",[29],[84,85,86,87],"MAD therapy","side effect","Dental occlusion","electromyography","2024-08-26",{"date":90,"type":34},"2024-08-28",{"date":92,"type":23},"2024-11-01",{"date":94,"type":23},"2026-12-01",{"name":96,"class":41},"University Hospital, Toulouse"]