[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"occipital-lobe-infarct\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:occipital-lobe-infarct":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,56,96,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100583352","visual-restoration-using-focused-ultrasound-stimulation-and-immersive-virtual-reality-after-stroke-100583352",false,"NCT06875206","Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke","LIFU-IVR","Inclusion Criteria:\n\n* ≥ 18 years old of any gender and race\n* Clinical ischemic stroke or hemorrhagic (confirmed by CT or MRI) that occurred \\>= 6-24 months ago\n* Partial or complete homonymous hemianopsia on clinical exam\n\nExclusion Criteria:\n\n* Documented history of severe dementia with or without medication before stroke that affect subject's ability to participate in and be compliant to study protocol\n* Significant upper motor deficits and the subject cannot do IVR sessions at the baseline\n* History of seizures\n* Inability to get a new MRI\n* Presence of any ultrasonic stimulation risk factors: an electrically, magnetically, or mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, or any other electrically sensitive support system; non-fixed metal in any part of the body; pregnancy (the effect of ultrasonic stimulation on the fetus is unknown); preexisting scalp lesion or wound or bone defect or hemicraniectomy.\n* Patients will be excluded if they have a previous diagnosis of hemianopsia, a new diagnosis of central retinal ischemic injury, or visual blindness or a history of any other ocular disease.\n* Concerns about the inability to complete study visits\u002Fprocedures by the PI.","ALL","18 Years",{"count":19,"type":20},28,"ESTIMATED","INTERVENTIONAL",[23],"NA","This research will explore if brain stimulation combined with virtual reality therapy improves visual impairment. The stimulation technique is called low-intensity focused ultrasound stimulation (LIFUS). The treatment uses ultrasound to stimulate vision specific parts of the brain. Before this therapy, the participants will get structural brain imaging. Functional brain imaging will be performed before and after the study's completion to measure brain activity response to therapy.\n\nThe purpose of this research study is to evaluate patients who have had a stroke between 6 and 24 months ago with a visual field impairment. The duration of active participation in the study is 1.5 months.",[26,27,28,29,30,31,32],"Stroke","Visual Field Defect","Visual Field Defect Following Cerebrovascular Accident","Hemianopia","Quadrantanopia","Occipital Lobe Infarct","Visual Fields Hemianopsia",[34,35,36,37,38,39,40,41,42],"virtual reality","stroke","visual deficit","chronic stroke","ultrasound stimulation","neuromodulation","stroke recovery","visual field defect","funcational imaging","NOT_YET_RECRUITING","2026-05-19",{"date":46,"type":47},"2026-05-22","ACTUAL",{"date":49,"type":20},"2026-12-01",{"date":51,"type":20},"2027-04",{"name":53,"class":54},"Duke University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":21,"phases":66,"briefSummary":67,"conditions":68,"keywords":74,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":55},"100445805","improving-visual-field-deficits-with-noninvasive-brain-stimulation-100445805","NCT05085210","Improving Visual Field Deficits With Noninvasive Brain Stimulation","Visual Restoration of Losses Caused by Cortical Damage: a New Protocol to Promote Fast Recovery","Inclusion Criteria:\n\n1. 18 years of age or older.\n2. Presence of some intact visual cortical areas (other than primary visual cortex) in the damaged brain hemisphere. This assessment will be made from MRI or CT scans of the subject's head, which will be obtained via standard release from their neurologist.\n3. First ever ischemic or hemorrhagic stroke with damage to primary visual cortex, and rendered blind over a portion of their visual field.\n\n   * Ischemic stroke patients will be either subacute (within 6 months of their stroke) or chronic (more than 6 months)\n   * Hemorrhagic stroke patients will be chronic only (greater than 6 months)\n4. Must demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field as measured by visual perimetry.\n5. Imaging evidence that the stroke is primarily affecting the visual cortex.\n6. Willing and able to participate in the study protocol and to comply with study procedures.\n\nExclusion Criteria:\n\n1. No evidence of damage to the primary visual cortex.\n2. Visual cortex damage as a result of a subsequent stroke (not primary).\n3. Total cortical blindness, covering both left and right visual fields.\n4. Unable to fixate visual targets precisely or unable to perform the visual training exercises as directed.\n5. Complete loss of reading abilities.\n6. Current or prior history of any neurological disorder other than stroke, such as epilepsy, a progressive neurologic disease (e.g. multiple sclerosis) or intracranial brain lesions other than the qualifying stroke lesion.\n7. Current history of poorly controlled migraines including chronic medication for migraine prevention.\n8. History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or immediate (1st degree relative) family history of epilepsy; with the exception of a single seizure of benign etiology (e.g. febrile seizure) in the judgment of the investigator.\n9. History of fainting spells of unknown or undetermined etiology that might constitute seizures.\n10. Past or current history of major depression, bipolar disorder or psychotic disorders, or any other major psychiatric condition.\n11. Participants who are suffering from one-sided attentional neglect as determined by standard neuropsychological tests: figure cancellation and line bisection tasks.\n12. Contraindication for receiving tRNS.\n13. Chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.).\n14. Any complex, uncontrolled\u002Funstable or terminal medical illness.\n15. Substance abuse or dependence within the past six months.\n16. Medications will be reviewed by the responsible MD (Drs. Sandeep Kumar or Dan Press) and a decision about inclusion will be made based on the following: The patient's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination of CNS active drugs.\n17. All female participants that are pre-menopausal will be required to have a pregnancy test; any participant who is pregnant or breastfeeding will not be enrolled in the study.\n18. Subjects who, in the investigator's opinion, might not be suitable for the study.\n19. A hair style or head dress that prevents electrode contact with the scalp or would interfere with the stimulation (for example: thick braids, hair weave, afro, wig).\n20. Additional criteria for Group 1b only: Contraindication for using VR technology, specifically an implanted medical device such as a pacemaker, implanted defibrillator, deep brain or vagal nerve stimulator. Participants with a history of seizures are already excluded per the above criteria.","80 Years",{"count":65,"type":20},24,[23],"This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimulation on the visual cortex will promote and speed up recovery of visual abilities within the blind field in VFD participants. Moreover, it is expected that visual recovery positively correlates with reduction of the blind field, as measured with traditional visual perimetry: the Humphrey visual field test or an eye-tracker based visual perimetry implemented in a virtual reality (VR) headset. Finally, although results will vary among participants depending on the extent and severity of the cortical lesion, it is expected that a bigger increase in neural response to moving stimuli in the blind visual field in cortical motion area, for those participants who will show the largest behavioral improvement after training. The overarching goals for the study are as follows: Group 1a will test the basic effects of transcranial random noise stimulation (tRNS) coupled with visual training in stroke cohorts, including (i) both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants, and (ii) longitudinal testing up to 6 months post-treatment. Group 1b will test the effects of transcranial tRNS coupled with visual training on a Virtual Reality (VR) device in stroke cohorts, including both chronic\u002Fsubacute ischemic and chronic hemorrhagic VFD stroke participants. Group 2 will examine the effects of tRNS alone, without visual training, also including chronic and subacute VFD stroke participants and longitudinal testing.",[69,26,70,71,30,72,73,31,32],"Visual Field Defect, Peripheral","Visual Impairment","Hemianopsia","Cortical Blindness","Visual Field Defect Homonymous Bilateral",[75,76,77,78,79,80,81,82,83,84,85],"Visual Field defects","Occipital Stroke","Ischemic Stroke","visual cortex","noninvasive brain stimulation","transcranial direct current stimulation","visual training","visual recovery","vision loss","quadrantanopia","Hemorrhagic stroke","RECRUITING","2026-03-03",{"date":89,"type":47},"2026-03-04",{"date":91,"type":47},"2022-01-25",{"date":93,"type":20},"2026-06",{"name":95,"class":54},"Beth Israel Deaconess Medical Center",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":103,"sex":16,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":117,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":55},"100519758","vision-loss-impact-on-navigation-in-virtual-reality-100519758","NCT06047717","Vision Loss Impact on Navigation in Virtual Reality","The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality","Cortically Blind Group:\n\nInclusion Criteria:\n\n* Residents of the United States or Canada\n* Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and\u002For CT scans)\n* Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.\n* Willing, able, and competent to provide their own informed consent\n* Cognitively able, responsible to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Those who have never driven or earned a drivers' license\n* Past or present ocular disease interfering with visual acuity\n* Best corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Sustained damage to the dorsal lateral geniculate nucleus\n* Presence of diffuse, whole-brain degenerative processes\n* Presence of brain damage deemed by study staff to potentially interfere with outcome measures\n* History of traumatic brain injury\n* Documented history of drug\u002Falcohol abuse\n* Diagnosis of cognitive or seizure disorders\n* Diagnosis of one-sided attentional neglect\n\nControl Group:\n\nInclusion Criteria:\n\n* Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above\n* Competent and responsible, as determined by the Principal Investigator\n* Willing, able, and competent to provide their own informed consent\n* Normal cognitive abilities, be able to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Subjects who have never driven or earned a drivers' license\n* BCVA worse than 20\u002F40 in either eye\n* Presence of vision loss from ocular diseases or disorders\n* Presence of a visual field defect\n* Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly\n* Subjects with a history of neurological disorders\n* Subjects with a history of TBI\n* Persons who lack the competence or are otherwise unable to perform the visual testing as directed.",true,"21 Years","75 Years",{"count":107,"type":20},40,[23],"The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).",[111,30,112,113,29,71,31,69,114,115,116],"Stroke, Ischemic","Hemianopsia, Homonymous","Hemianopia, Homonymous","Vision Loss Partial","Quadrantanopsia","Stroke Hemorrhagic",[118,119,120,121,122,123,124,35],"Occipital stroke","Vision loss after stroke","Vision recovery","Vision restoration","Partial vision loss","Homonymous quadrantanopsia","Homonymous quadrantanopia","2026-01-07",{"date":127,"type":47},"2026-01-09",{"date":129,"type":47},"2023-11-28",{"date":131,"type":20},"2028-10",{"name":133,"class":54},"University of Rochester",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":103,"sex":16,"minAge":104,"maxAge":63,"enrollmentInfo":142,"targetDuration":4,"studyType":144,"phases":4,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":55},"100603304","mechanisms-of-visual-restoration-after-occipital-stroke-100603304","NCT07134777","Mechanisms of Visual Restoration After Occipital Stroke","Mechanisms of Visual Restoration After Occipital Stroke (MOVROS)","MOVROS","Cortically Blind Subjects (n=50)\n\nInclusion:\n\n* Subjects between 21 and 80 years of age\n* Subjects must be residents of the United States or Canada\n* Subjects must exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 80 years (verified by MRI and\u002For CT scans)\n* Subjects with reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey, MAIA, Goldmann, and\u002For equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.\n* Subjects must be able to fixate on visual targets reliably for 1000ms, with jitter over less than 1-deg of visual angle.\n\n  o Note: This will be initially assessed by review of visual field reports as supplied by subjects during the screening process. However, we will be unable to fully assess their fixation ability until they start the psychophysics testing in our lab. If at that time we discover that they are unable to maintain adequate fixation, they will be withdrawn from the study.\n* Subjects must be willing, able, and competent to provide their own informed consent\n* Subjects must have their own home computer (desktop or laptop) and reliable internet access\n* All subjects must have normal cognitive abilities and memory, sufficient to be able to understand and follow written and oral instructions in English, as well as to remember how to complete visual training at home, on their own, as instructed, for several months.\n* Justification: We can only accept English-speaking subjects due to a lack of resources for supporting those who would require interpreter services. As all of our subjects are required to spend 3-5 days in lab with rigorous testing and training requirements, we must be able to communicate clearly and with minimal misunderstandings. This would require for up to 5-full days of in person interpreter services, for which we do not have funding. Additionally, ongoing communications take place by phone, email, and\u002For text as a part of home training (for routine check-ins and technical support for example) in the intervals between laboratory visits. This would require us to essentially have \"on demand\" access to interpreter services, which is simply not feasible.\n* Subjects must be safe and willing to undergo magnetic resonance imaging (MRI) scans\n\nExclusion:\n\n* Subjects who have past or present ocular disease interfering with visual acuity\n* Subjects with best-corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Subjects who have documented or suspected damage to the dorsal Lateral Geniculate Nucleus\n* Subjects who have diffuse whole-brain degenerative processes\n* Subjects who have experienced traumatic brain injury\n* Subjects who have any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures\n* Subjects who have oculomotor defects deemed by study staff to potentially interfere with training ability or outcome measures (i.e., by impairing stable fixation during testing or training)\n* Subjects who have documented history of drug\u002Falcohol abuse\n* Subjects who are currently taking neuroactive medications which would impact training, as determined by PI\n* Subjects who have cognitive, memory or seizure disorders\n* Subjects with one-sided attentional neglect\n* Subjects who lack the competence or are otherwise unable to perform the visual training exercises as directed.\n* Subjects who have contradictions to MRI scanning will be excluded. These contraindications include: a) central nervous system aneurysm clips; b) implanted neural stimulator; c) implanted cardiac pacemaker or defibrillator; d) cochlear implant; e) ocular foreign body (e.g., metal shavings); f) insulin pump; g) metal shrapnel or bullet; h) any implanted device that is incompatible with MRI.\n* Subjects who have conditions that preclude MRI scanning, e.g., morbid obesity, claustrophobia.",{"count":143,"type":20},100,"OBSERVATIONAL","This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system. Our goal is to improve understanding of the consequences of permanent visual cortex damage in humans, and to understand how visual training impacts the function of the residual visual system to restore perception.",[72,147,114,32,29,148,31],"Stroke Ischemic","Hemianopia Homonymous",[150,83,151],"occipital stroke","Homonymous quadranopsia","2025-11-26",{"date":154,"type":47},"2025-12-04",{"date":156,"type":47},"2025-10-17",{"date":158,"type":20},"2029-08-01",{"name":133,"class":54}]