[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"occlusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:occlusion":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,41,71,95,117,138,165,193],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100499235","diagnostic-performance-of-the-resistance-index-ri-for-the-assessment-of-cerebral-vasoreactivity-in-transcranial-doppler-100499235",false,"NCT05780619","Diagnostic Performance of the Resistance Index (RI) for the Assessment of Cerebral Vasoreactivity in Transcranial Doppler","REVACEIR","Inclusion Criteria:\n\n* The patient must have given their free and informed consent and signed the consent form\n* The patient must be a member or beneficiary of a health insurance plan\n* Stenosis ≥ 70% in diameter reduction in NASCET equivalent or occlusion of atheromatous origin of the cervical internal carotid artery, asymptomatic or symptomatic.\n* Presence of a temporal window sufficient to record the homolateral and contralateral middle cerebral artery.\n* Patient of legal age with free and informed consent.\n* Patient who has signed the consent form.\n* Patient affiliated or beneficiary of a health insurance plan.\n\nExclusion Criteria:\n\n* The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study\n* The subject refuses to sign the consent\n* It is impossible to give the subject informed information\n* The patient is under safeguard of justice or state guardianship\n* Contraindication to Acetazolamide Diamox® injection.\n* Absence of temporal acoustic window (non visualization of the cerebral parenchyma, no recordable intracranial vessel).\n* Insufficient temporal window (visualizable brain parenchyma, no recordable MCA)\n* Internal or common carotid artery stenosis ≥70% or occlusion, contralateral to the primary lesion.\n* Stenosis ≥50% of the middle cerebral artery homolateral or contralateral to the cervical lesion.\n* Patient in exclusion period determined by another study.\n* Patient under court protection, guardianship, or conservatorship.\n* Patient refusing to sign the consent form.\n* Patient unable to express his or her will (dementia, disturbed consciousness, etc.)\n* Patient for whom it is impossible to give informed information for health reasons or because of a language barrier.\n* Pregnant, parturient, or breastfeeding patient.","ALL","18 Years",{"count":19,"type":20},77,"ESTIMATED","OBSERVATIONAL","Routine revascularization of asymptomatic carotid stenosis is questionable as optimal medical therapy has significantly reduced the risk of stroke. Therefore, it is crucial to identify high-risk patients who may still benefit from carotid revascularization. In 2017, the ESC guidelines clarified the criteria associated with a high risk of stroke despite optimal treatment to consider a revascularization procedure, including altered cerebral vasoreactivity. However, cerebral vasoreactivity using transcranial Doppler ultrasound is reserved for qualified centers. It requires a technical platform and trained personnel, is time-consuming and generally not readily available.\n\nA simpler test is therefore necessary. The goal is to quickly and easily detect patients with normal vasoreactivity who do not benefit from the cerebral vasoreactivity test (reference standard) and to reserve the time-consuming cerebral vasoreactivity test for patients likely to have altered vasoreactivity.\n\nThe hypothesis of the study is that on a routine measure in transcranial echo-Doppler, the resistance index (RI), can predict the response to the cerebral vasoreactivity test. With this new test, it will be possible to select patients who do not benefit from pharmacological cerebral vasoreactivity testing (\"true negatives\"). Thus, the time-consuming cerebral vasoreactivity test will be reserved only for patients with a possibility of impaired vasoreactivity.",[24,25],"Stenosis","Occlusion",[27],"Acetazolamide","RECRUITING","2026-05-28",{"date":31,"type":32},"2026-06-01","ACTUAL",{"date":34,"type":32},"2023-06-09",{"date":36,"type":20},"2029-06",{"name":38,"class":39},"Centre Hospitalier Universitaire de Nīmes","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100632870","effectiveness-of-a-needle-free-connector-with-anti-reflux-technology-in-reducing-complications-from-long-peripheral-venous-catheters-in-hospitalised-adult-patients-randomised-clinical-trial-100632870","NCT07519304","Effectiveness of a Needle-free Connector With Anti-reflux Technology in Reducing Complications From Long Peripheral Venous Catheters in Hospitalised Adult Patients: Randomised Clinical Trial","FLUSH-ETI","Inclusion Criteria:\n\n* Patients requiring placement of a long peripheral venous catheter.\n* Patients who have provided written informed consent.\n* Patients with an expected hospital stay of ≥7 days.\n\nExclusion Criteria:\n\n\\- Inability to place a long peripheral venous catheter in the upper limbs.",{"count":49,"type":20},62,"INTERVENTIONAL",[52],"NA","A study to evaluate a needle-free connector (a stopper) featuring anti-reflux technology (to prevent blood from flowing back) for catheters (polyurethane tubes inserted into a vein), with the aim of reducing complications associated with these devices: blockages, infections, pain, etc.",[55,56,25,57,58],"Vascular Access Devices","Catheters","Thrombosis","Randomised Controlled Trial",[60],"Needleless connector","NOT_YET_RECRUITING","2026-04-15",{"date":64,"type":32},"2026-04-16",{"date":66,"type":20},"2026-04-20",{"date":68,"type":20},"2026-12-31",{"name":70,"class":39},"Hospital Arnau de Vilanova",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":50,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":40},"100478222","phase-2-characterization-of-the-temporo-masseteric-nerve-block-tmnb-in-healthy-subjects-100478222","NCT05507164","Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects","Non-randomized Pilot Study to Characterize Temporo-masseteric Nerve Block (TMNB) in","Inclusion Criteria:\n\n* 18-64 years of age\n* All ethnicity\n* Male and female sex\n* Fluent in written\u002Fspoken English\n* Never been diagnosed with TMD\n* No significant history of orofacial pain\n* \\\u003C5 headaches\u002Fmonth in the 3 months before enrollment\n* No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening:\n* Pain in jaw or temple on either side of the face in the last 30 days\n* Stiffness or pain in jaw upon awakening in the last 30 days\n* Any pain increase\u002Freduction in the jaw\u002Ftemple region during the last 30 days with\n\n  * Chewing hard or tough food\n  * Opening mouth or moving jaw forward or to the side\n  * Hold teeth together\u002Fclenching\u002Fgrinding\u002Fchewing gum\n  * Using the jaw during activities such as talking, kissing or yawning\n\nExclusion Criteria:\n\n* Traumatic injury\u002F surgery on face or jaw \\\u003C 6 months\n* current orthodontic treatment\n* pregnant or nursing,\n* kidney failure or renal dialysis,\n* heart disease or heart failure,\n* uncontrolled chronic respiratory disease\u002F hypertension\u002F diabetes\n* history of\n* seizures\n* hyperthyroidism\n* drug or alcohol abuse\n* psychiatric disorder\u002Fconditions requiring hospitalization\n* chemotherapy\u002Fradiation",true,"64 Years",{"count":81,"type":20},20,[83],"PHASE2","The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).",[25],"2025-12-04",{"date":88,"type":32},"2025-12-05",{"date":90,"type":32},"2022-10-10",{"date":92,"type":20},"2026-12",{"name":94,"class":39},"Rutgers, The State University of New Jersey",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":78,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":50,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100609486","abutment-analysis-of-metallic-denture-frameworks-in-mandibular-kenedy-class-iii-cases-100609486","NCT07215208","Abutment Analysis of Metallic Denture Frameworks in Mandibular Kenedy Class III Cases","Abutment Health and Occlusal Analysis of CAD-CAM and Conventional Metallic Partial Denture Framework in Mandibular Kenedy Class III Cases: A Randomized Cross Over Clinical Trial","Inclusion Criteria:\n\n* Patients with unilateral bounded saddles in the mandible (Kennedy class III).\n* Opposing dentition is fully intact or restored.\n* Sufficient inter-arch space.\n* Angle's class I maxilla-mandibular relationship.\n\nExclusion Criteria:\n\n* Periodontal affection of the abutment teeth.\n* Skeletal mal-relation.\n* Unmotivated patients to maintain adequate oral hygiene to follow up.\n* Patients with neuromuscular and Psychiatric disorders.\n* Systematic disease affecting bone and periodontal health.\n* Insufficient inter-arch space.\n* Patients with physical disabilities that could affect follow up.",{"count":103,"type":20},22,[52],"This study is aimed to compare CAD\u002FCAM (digitally fabricated) metallic partial denture frameworks to conventionally fabricated metallic partial denture frameworks in mandibular Kennedy class-III arches in terms of abutment health and occlusal analysis",[25,107],"Prosthesis Durability","2025-10-02",{"date":110,"type":32},"2025-10-10",{"date":112,"type":20},"2025-10",{"date":114,"type":20},"2026-01",{"name":116,"class":39},"Cairo University",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":78,"sex":16,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100546982","assessment-of-the-occlusal-characteristics-and-orthodontic-treatment-needs-for-egyptian-children-6-12years-old-100546982","NCT06402045","Assessment of the Occlusal Characteristics and Orthodontic Treatment Needs for Egyptian Children( 6-12)Years Old","Inclusion Criteria:\n\n* Egyptian children of both genders born to Egyptian parents .\n* Children having an age range from 6-12 years old.\n* Cooperative children .\n\nExclusion Criteria:\n\n* Craniofacial anomalies that affect jaw relation and dentition except for cleft lip and palate.\n* History of facial trauma or surgery.\n* Systemic disease that affects craniofacial growth\n* Previously orthodontically treated child Those whom did not sign the consent","6 Years","12 Years",{"count":126,"type":20},70,"The objective of this study is to assess the occlusal characteristics of Egyptian children 6-12 years old and their need for orthodontic treatment.",[25],"2025-02-14",{"date":131,"type":32},"2025-02-18",{"date":133,"type":20},"2025-03-01",{"date":135,"type":20},"2025-09-01",{"name":137,"class":39},"Salma Hassan Widatalla Omar",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":78,"sex":145,"minAge":17,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":40},"100575549","evaluation-of-the-impact-of-integrating-dynamic-patient-specific-motion-and-implementing-a-jaw-tracking-system-in-the-attribution-of-the-occlusion-in-full-arch-restorations-through-a-digital-workflow-a-clinical-study-100575549","NCT06773728","Evaluation of the Impact of Integrating Dynamic Patient-Specific Motion and Implementing a Jaw Tracking System in the Attribution of the Occlusion in Full-Arch Restorations Through a Digital Workflow: A Clinical Study","Evaluation of the Impact of Integrating Dynamic Patient-Specific Motion by Implementing Jaw Tracking Systems and Artificial-intelligence Tools in the Attribution of the Occlusion in Full Arch Restorations Through a Digital Workflow: A Clinical Study","Inclusion Criteria:\n\nPatient age ≥ 18 years Patients with ≥ 10 teeth in each dental arch\n\nExclusion Criteria:\n\n\\- Patients with a local or systemic conditions contra-indicating dental treatment (hypertension, a heart attack \\\u003C 1 year, a stroke \\\u003C 1 year, uncontrolled cardiovascular diseases, uncontrolled diabetes , immunodeficiency, active oral infection as active herpetic lesions etc.) Pregnancy Fully edentulous patients Presence of craniofacial syndromes Patients age \\\u003C18 Association with an active orofacial trauma","MALE",{"count":147,"type":20},40,"The maxillomandibular relationship of diagnostic and definitive casts is a fundamental procedure in prosthodontics. Depending on the prosthodontic treatment involvement, different maxillomandibular relationship records can be selected, including maximal intercuspal position (MIP), centric relation (CR) or most comfortable position. Intraoral scanners (IOSs) provide a digital alternative to obtain diagnostic and definitive casts, as well as the maxillomandibular relationship, by acquiring virtual occlusal records.4 Various techniques are available for tracking and recording the mandibular motion of the patient, including mechanical, photographic, radiographic, electromagnetic, ultrasonic-based devices, and optical motion capturing systems. By implementing a digital jaw tracker, patient's individualized mandibular movement can be recorded and combined with intraoral patient's scan, in order to be simulated through the cad software. However, the accuracy of the maxillomandibular relationship has been evaluated only by one study and for one patient. Also, the accuracy to record and replicate of occlusal contacts, acquired by using optical jaw tracking systems has not been evaluated clinically yet. The purpose of the present study was to clinically evaluate the impact of integrating dynamic patient specific-motion and registration, utilizing a digital jaw analyzer (ModJaw), in the attribution of the occlusion.",[150,25],"Jaw Tracking",[152,153,154,155],"jaw tracking","dental occlusion","artificial intelligence","maxillomandibular position","2025-01-08",{"date":158,"type":32},"2025-01-14",{"date":160,"type":20},"2025-01-15",{"date":162,"type":20},"2025-03-25",{"name":164,"class":39},"National and Kapodistrian University of Athens",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":78,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":171,"targetDuration":172,"studyType":21,"phases":4,"briefSummary":173,"conditions":174,"keywords":179,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":40},"100520125","3d-evaluation-of-the-lip-support-in-a-full-arch-implant-supported-rehabilitations-100520125","NCT06052501","3D Evaluation of the Lip Support in a Full-arch Implant-supported Rehabilitations","Inclusion Criteria:\n\n* Individuals with at least a full-arch implant supported rehabilitation in the upper arch\n* Individuals with a provisional or a definitive implant-supported prosthesis\n* Individuals with a stable occlusion function\n* Individuals with compliance to collaborate with the research protocol\n\nExclusion Criteria:\n\n* Individuals with history of hypersensitivity to external light or any similar condition\n* Individuals in an active surgical treatment period\n* Individuals in an active orthodontic treatment in the opposite arch\n* Individuals in an active facial treatment\n* Individuals who did not attend the maintenance visits",{"count":81,"type":20},"1 Year","The goal of this observational study is to evaluate the impact of a full arch implant-supported prostheses in the lip support. In a complex rehabilitation cases, the process between the diagnosis and the delivery of a prostheses may lead with many clinical and laboratorial choices which influence the final design of the prosthetic work and consequently the facial profile of the patient.\n\nThe use of 3D facial scanners and advanced superimposition methodology allows the investigators to objectively measure several relevant parameters such as vertical occlusion of dimension and lip support.",[175,176,177,178,25],"Digital Technology","Prosthesis User","Lip","Oral Soft Tissue Conditions",[180,181,182,183],"three-dimensional imaging","prosthodontics","full-arch","facial scanner","2024-06-24",{"date":186,"type":32},"2024-06-26",{"date":188,"type":32},"2024-03-30",{"date":190,"type":20},"2024-12-15",{"name":192,"class":39},"Implantology Institute",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":50,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":40},"100544180","tunneled-peripherally-inserted-central-catheter-picc-in-adult-patients-and-associated-outcomes-100544180","NCT06365528","Tunneled Peripherally Inserted Central Catheter (PICC) in Adult Patients and Associated Outcomes","Tunneled Versus Non-Tunneled Peripherally Inserted Central Catheter and Their Effects on Reducing Combined or Isolated Outcomes (Obstruction, Infection, Thrombosis, and Dislodgement): Multicenter Randomized Clinical Trial","Inclusion Criteria:\n\n* adult patients (\\>= 18 years old) admitted to medical clinics, surgical clinics, or ICU, who have an indication for PICC insertion;\n\nExclusion Criteria:\n\n* patients with Chronic Kidney Disease, whether dialytic or not;\n* patients in critical or unstable condition characterized by the need for intubation, respiratory rate \\\u003C8 or \\>35 breaths per minute, oxygen saturation \\\u003C90%, heart rate \\\u003C40 or \\>140 beats per minute, systolic blood pressure \\\u003C90mmHg, decreased Glasgow Coma Scale \\>2 points, or prolonged (\\>5 minutes) or repeated seizures;\n* patients with cognitive deficits that impair their understanding of the study and do not have a responsible party to assist in this stage.",{"count":201,"type":20},840,[52],"The aim of this multicenter randomized clinical trial is to compare the tunneling technique of PICC insertion with the non-tunneled insertion technique in the incidence of the combined or isolated outcome of catheter-related bloodstream primary infection, thrombosis, obstruction, and accidental dislodgement in the adult population within a period of up to 30 days.",[205,206,207,25,208,209],"CLABSI - Central Line Associated Bloodstream Infection","Deep Vein Thrombosis","Dislodged Catheter","Catheter Rupture","Catheter (Other); Complications","2024-05-16",{"date":212,"type":32},"2024-05-20",{"date":214,"type":32},"2024-05-06",{"date":216,"type":20},"2026-07-31",{"name":218,"class":39},"Hospital de Clinicas de Porto Alegre"]