[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"off-pump-coronary-artery-bypass\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:off-pump-coronary-artery-bypass":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100617093","multivessel-minimally-invasive-coronary-bypass-grafting-as-hybrid-revascularization-versus-conventional-off-pump-coronary-artery-bypass-grafting-100617093",false,"NCT07314138","Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting","MICRA-HYBRID Trial: A Randomized Controlled Trial of 'Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-Pump Coronary Artery Bypass Grafting'","MICRA-HYBRID","Inclusion Criteria:\n\n* Patients with three-vessel disease (either angiographic stenoses \\>70% or a fractional flow reserve value ≤0.80)\n* Left main diameter stenosis ≥50% or a left main intravascular ultrasound minimal luminal area of ≤4.5 mm2 or fractional flow reserve value ≤0.80 combined with significant CAD of the right coronary artery\n\nExclusion Criteria:\n\nA potential participant who meets any of the following criteria will be excluded from participation in this study:\n\n* Age \\\u003C 18 or \\> 85 years\n* Chronic total occlusion of the RCA\n* In-stent RCA restenosis\n* RCA stenosis with high-risk clinical features requiring urgent PCI or surgical revasculari-zation.\n* Reverse hybrid coronary revascularization, defined as PCI-RCA followed by surgical re-vascularization.\n* Acute cardiac ischemia necessitating immediate intervention.\n* EF \\\u003C 30 %\n* eGFR \\\u003C 30 ml\u002Fmin\n* Indication for concomitant cardiac surgery (e.g. valve or arrhythmia surgery) or non-cardiac surgery\n* Previous thoracic or cardiac surgery, mediastinal irradiation, significant trauma to the chest\n* Preoperative severe end-organ dysfunction (dialysis, liver failure, respiratory failure) or cancer.\n* Hemodynamically significant left subclavian stenosis\n* Severe chest wall deformities\n* History of pericarditis\n* Body mass index \\> 40 Kg\u002Fm2.",true,"ALL","18 Years","85 Years",{"count":22,"type":23},250,"ESTIMATED","INTERVENTIONAL",[26],"NA","The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD and LCx) plus PCI of the RCA versus conventional off-pump coronary artery bypass grafting (OPCAB) via median sternotomy in patients with three-vessel coronary artery disease. The primary goal is to evaluate whether multivessel-HCR provides superior 30-day \"textbook\" clinical outcomes (mortality, MI, stroke, re-exploration for bleeding, and other complications) while improving perioperative recovery and long-term cardiovascular outcomes.",[29,30,31,32],"Coronary Artery Disease (CAD)","Bypass, Cardiopulmonary","Minimally Invasive Coronary Revascularization Surgery","Off-pump Coronary Artery Bypass",[34,35,36,37,38],"minimally invasive coronary surgery","percutaneous coronary intervention","off-pump coronary artery bypass grafting","hybrid coronary revascularization","heart surgery","NOT_YET_RECRUITING","2025-12-23",{"date":42,"type":43},"2026-01-02","ACTUAL",{"date":45,"type":23},"2026-04-01",{"date":47,"type":23},"2034-05-01",{"name":49,"class":50},"Catharina Ziekenhuis Eindhoven","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100606212","safety-and-effectiveness-of-no-touch-technique-for-ascending-aorta-in-mics-cabg-100606212","NCT07172620","Safety and Effectiveness of No-touch Technique for Ascending Aorta in MICS-CABG","Safety and Effectiveness of No-touch Technique for Ascending Aorta in Minimally Invasive Cardiac Surgery Coronary Artery Bypass Grafting(MICS-CABG)","Inclusion Criteria:\n\n* Patients with angina pectoris who experience functional limitations in daily life and work despite conservative medical treatment and who require coronary artery bypass grafting surgery, as confirmed by coronary angiography, are eligible for enrollment.\n* Patients with calcification of the ascending aorta, as confirmed by CT, who are not suitable for sidewall clamping are also eligible for enrollment.\n\nExclusion Criteria:\n\n* The patient presents with an old, large myocardial infarction with no surviving myocardium, as evidenced by both isotope and echocardiographic imaging. This is a group of patients who are prone to complications, including significant cardiac enlargement, a cardiothoracic ratio greater than 0.75, an ejection fraction (EF) less than 30%, a left ventricular diameter (LVDd) greater than 70mm, the presence of a left ventricular ventricular wall tumor, or severe arrhythmia. Intraoperative hemodynamic instability;\n* Valve surgery or other intracardiac surgery at the same time;\n* Patients expected to undergo extracorporeal circulation surgery;\n* Poor myocardial infarction conditions, extensive lesions, distal or full diffuse stenosis, or lumen diameter less than or severe calcification that cannot be anastomosed.\n* Previous open heart surgery.\n* Patients with preoperative hemodynamic instability requiring emergency surgery.\n* Other conditions include terminal malignant tumors, uncontrollable infections, bleeding, persistent progressive degenerative systemic diseases, severe brain injuries, and multiple organ failure. Additionally, other significant organ function serious impairments, such as severe liver function impairment, severe heart failure, or cardiogenic shock, may also be considered contraindications. Inability to tolerate surgery may also be considered a contraindication.\n* The participant declines to take part in this study.",{"count":59,"type":23},260,"5 Years","OBSERVATIONAL","The goal of this single-center prospective cohort study is to compare perioperative safety metrics and follow-up survival analyses in patients receiving Minimally Invasive Cardiac Surgery Coronary Artery Bypass Grafting(MICS-CABG) and Off-Pump Coronary Artery Bypass(OPCAB). The main question it aims to answer is:\n\nIs the bridge vessel patency rate of patients in the MICS-Notouch group noninferior to that of a saphenous vein bridge with conventional open-chest bypass?\n\nParticipants will be divided into two groups:\n\nExposure group (MICS-Notouch group): non-extracorporeal circulation multiple coronary artery bypass grafting surgery performed under direct visualization of a small incision in the left chest, including the application of LIMA (left internal mammary artery) + SVG (saphenous vein) multiple bypass grafting.\n\nControl group (OPCAB group): conventional median chest opening, non-extracorporeal circulation multi-branch coronary artery bypass graft surgery.",[64,32,65,66],"Coronary Artery Bypass Grafting","Minimally Invasive Cardiac Surgery","Coronary Arterial Disease (CAD)","RECRUITING","2025-09-11",{"date":70,"type":43},"2025-09-15",{"date":72,"type":43},"2025-06-01",{"date":74,"type":23},"2030-12-31",{"name":76,"class":50},"Peking University Third Hospital",1]