[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"older-adults-65-years-and-older\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:older-adults-65-years-and-older":31},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,68,107,138,173,197,226,252,278,305,331,366,392,425,444,467,490,520,549,572,596,625,653,686,713],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":67},"100615555","phase-2-targeting-muscle-strength-loss-due-to-hospitalization-in-older-adults-by-blood-flow-restriction-combined-with-an-electromyography-driven-serious-game-100615555",false,"NCT07294131","Targeting Muscle Strength Loss Due to Hospitalization in Older Adults by Blood-flow Restriction Combined With an Electromyography-driven Serious Game.","Targeting Muscle Strength Loss Due to Hospitalization in Older Adults by Blood-flow Restriction Combined With an EMG-driven Serious Game","GHOSTLY+","PATIENTS\n\nInclusion Criteria:\n\n* Hospitalized, and expected to remain hospitalized for approximately 14 days\n* 65+ yrs\n* Unable to bear weight or transfer independently and at high risk of muscle strength loss due to prolonged immobility\n\nExclusion Criteria:\n\n* Contraindications for physical exercise as assessed by the treating physician using the risk assessment tool proposed by Kacin et al. (2015) (can be overruled by the physician)\n* Contraindications for blood flow restriction as assessed by the treating physician (can be overruled by the physician)\n* Cognitive impairment (MMSE score \\\u003C 19)\n* Any condition that renders the patient unable to understand instructions or safely interact with the GHOSTLY+ system\n\nTHERAPISTS\n\nInclusion Criteria:\n\nTherapists will be included if\n\n* They are licensed physiotherapists employed at one of the three participating clinical sites\n* They are involved in the daily rehabilitation of hospitalized older adults.\n\nExclusion Criteria:\n\nTherapists will be excluded from participation if\n\n* They are unable or unwilling to complete the GHOSTLY+ training\n* They are not directly involved in the care of eligible patients during the study period\n* They express any conflict of interest or ethical concern that may compromise the integrity of the study",true,"ALL","65 Years",{"count":22,"type":23},120,"ESTIMATED","INTERVENTIONAL",[26],"PHASE2","This study investigates a new training method designed to help older adults preserve their muscle strength during hospitalization. When older adults are admitted to the hospital and spend long periods in bed, their muscles can weaken very quickly. This condition is known as hospital-associated disability (HAD), and it can lead to longer hospital stays, reduced independence, and an increased risk of complications or even death. Conventional strength training with heavy weights is often too demanding or unsafe for frail patients, especially just after surgery or illness. As a safer alternative, this study combines light muscle exercises with a medically validated technique called blood flow restriction (BFR), which gently reduces blood flow to the leg to boost the effects of light exercises.\n\nTo make training more engaging and personalized, the GHOSTLY+ system was developed. This system consists of a game played on a tablet that responds to muscle activity through sensors placed on the skin. While playing, patients perform isometric muscle contractions (exercises where the muscles tighten without moving the joint) that help to maintain and rebuild strength. The system was carefully designed in collaboration with patients and therapists, and it has already been tested in a smaller pilot study at UZ Brussel.\n\nThe current study is a multicenter randomized controlled trial, taking place at UZ Brussel, UZ Antwerpen, and UZ Leuven. A total of 120 patients aged 65 or older will be recruited, all of whom are hospitalized and are unable to bear weight or transfer (e.g., from lying to seated position). Participants will be randomly assigned to one of two groups. One group receives standard physiotherapy. The other group receives standard therapy plus the GHOSTLY+ training program.\n\nThose in the GHOSTLY+ group will train at least five times per week for two weeks, or until discharge from the hospital. Each training session lasts approximately 30 minutes and involves three sets of 12 muscle contractions, guided by the game. The difficulty is adapted to the individual's muscle strength, which is measured at the beginning of the training using a built-in calibration protocol. During the session, a smart cuff is applied to the upper leg to partially restrict blood flow - a technique shown to safely enhance muscle adaptation. The cuff is inflated to 50% of the individual's arterial occlusion pressure and deflated after the session ends. Before beginning, participants receive a short training session with a physiotherapist. Our pilot study (Debeuf et al., 2025) shows that most patients can use the system independently after about one hour of instruction.\n\nMeasurements and evaluations take place at three timepoints: before starting the training, after one week, and again at discharge. The main goal is to assess leg muscle strength, which will be measured using a handheld device called a dynamometer. In addition, researchers will collect information on:\n\n* Muscle mass, via ultrasound of the thigh muscle\n* Functional capacity, using a 30-second sit-to-stand test and a walking scale (Functional Ambulation Category)\n* An index of independence in activities of daily living (Katz scale)\n* Cognitive functioning, using the Mini-Mental State Examination (MMSE)\n* Time spent bedridden and total length of hospital stay\n* Therapy adherence and user experience, via usage data and questionnaires\n* Muscle activity signals, such as fatigue, recorded during gameplay\n* Implementation outcomes (collected via surveys, interview, site logbooks)\n\nThe study will also assess how easily the GHOSTLY+ system can be implemented in real hospital environments. This includes evaluations of user satisfaction, therapist feedback, and how consistently the system is used across hospital settings. Information will be gathered through structured interviews, surveys, and data logs from the app. These insights are crucial to understanding whether GHOSTLY+ can be broadly adopted in other hospitals in the future.\n\nBlood flow restriction training is considered very safe when applied correctly and is already used in rehabilitation clinics and sports medicine worldwide. Over 300,000 sessions have been conducted internationally, with a very low rate of complications. Minor discomfort, such as temporary tightness or muscle fatigue, may occur, but the risk of serious side effects is extremely small.\n\nBy participating in this study, patients may benefit from improved muscle strength, reduced time spent in bed, and greater physical independence at discharge. The study also contributes to the development of more effective and enjoyable rehabilitation methods for older adults in hospitals.",[29,30,31],"Hospital Associated Disability","Immobility","Older Adults (65 Years and Older)",[33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,16],"hospital-associated disability","HAD","muscle strength loss","blood flow restriction","BFR","serious games","EMG-driven rehabilitation","geriatric rehabilitation","older adults","lower-limb strength","non-weight-bearing","randomized controlled trial","RCT","physical deconditioning","hospitalization","electromyography","digital rehabilitation","implementation science","rehabilitation technology","exergaming","inpatient rehabilitation","strength training","RECRUITING","2026-06-23",{"date":58,"type":59},"2026-06-26","ACTUAL",{"date":61,"type":59},"2026-06-05",{"date":63,"type":23},"2029-01-01",{"name":65,"class":66},"Vrije Universiteit Brussel","OTHER",3,{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":12,"sex":19,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":24,"phases":79,"briefSummary":81,"conditions":82,"keywords":95,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100638424","ecardiacrehab---a-hybrid-patient-centered-ehealth-programme-100638424","NCT07590635","eCardiacRehab - a Hybrid Patient-Centered eHealth Programme","eCardiacRehab - a Randomized Controlled Trial on a Hybrid Home-Based Patient-Centered eHealth Programme With Tailored Solutions","eCardiacRehab","Inclusion Criteria:\n\n* Adult Norwegian (or Scandinavian) speaking patients (≥ 18 years) who have a Norwegian national identification number\n* With coronary artery disease after percutaneous coronary intervention\n* Living at home\n* Have internet available\n* Provide signed informed consent\n\nExclusion Criteria:\n\n* Patients with cognitive impairment that may interfere with the ability to comply with the study protocol\n* Severe aortic stenosis\n* Severe arrhythmias\n* Expected lifetime less than one year as determined by study personnel\n* Otherwise clinically unstable\n* Not fully revascularized\n* Awaits percutaneous coronary intervention or coronary artery bypass graft surgery\n* Inability to comply with the study protocol due to any physical disability, somatic disease, or mental problems as determined by study personnel","18 Years",{"count":78,"type":23},1000,[80],"NA","The overall aim of eCardiacRehab trial is to meet rehabilitation needs of patients with coronary artery disease (CAD) regardless of their access to traditional place-based rehabilitation by developing and evaluating the efficacy and cost effectiveness of an interdisciplinary and comprehensive home-based hybrid programme. eCardiacRehab address patient- and system level challenges to increase access to cardiac rehabilitation (CR). We give particular attention to older patients, women, and those with comorbidities or mental health challenges. The vision of the hybrid home-based eCardiacRehab programme is to make CR available to all.\n\neCardiacRehab is a prospective, multicentre randomized open-label blinded end point evaluation (PROBE) trial. The primary endpoint is a hierarchical composite endpoint using a win-ratio framework combining cardiovascular (CV) death, unplanned contacts to the Emergency Department (ED) for observation or admission (\\>24 hours) for CV disease, and quality of life. Inclusion criteria are adult Scandinavian speaking patients (≥ 18 years) who have a Norwegian national identification number, with CAD treated with Percutaneous Coronary Intervention (PCI), are living at home, and have internet available to them and providing signed informed consent. Exclusion criteria are patients with severe aortic stenosis, severe arrhythmias, expected lifetime less than one year as determined by study personnel, otherwise clinically unstable, not fully revascularized, awaits PCI or coronary artery bypass graft operation (CABG) or inability to comply with the study protocol due to any physical disability, somatic disease, cognitive impairment or mental health challenges as determined by study personnel.",[83,84,85,31,86,87,88,89,90,91,92,93,94],"Comorbidities and Coexisting Conditions","Ethics","Continuity of Patient Care","Cost-Benefit Analysis","Adherence, Medication","Secondary Prevention of Coronary Heart Disease","Health Literacy","eHealth Literacy","Mental Health","Cardiac Rehabilitation","Womens's Health","Coronary Artery Disease (CAD)",[92,96,97],"Coronary Artery Disease","Percutaneous Coronary Intervention","2026-06-18",{"date":56,"type":59},{"date":101,"type":59},"2026-05-21",{"date":103,"type":23},"2037-12-31",{"name":105,"class":66},"Haukeland University Hospital",1,{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":24,"phases":117,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100641983","home-based-monitoring--enabled-medication-independence-with-new-digital-tools-100641983","NCT07659548","Home-based Monitoring & Enabled Medication Independence With New Digital Tools","Technological Innovation to Support Medication Safety and Optimization in Older Adults Living Alone With Cognitive Decline","HOME-MIND","Inclusion Criteria:\n\n* Older adults (≥ 65 years old)\n* Living alone (in a non-institutional setting without others)\n* With subjective or mild cognitive decline (a screening test to confirm)\n* Taking at least five prescribed medications concurrently\n* With suboptimal self-reported medication adherence (a screening test to confirm)\n* Having access to a computer or mobile device and internet service\n* Able to read and speak English\n\nExclusion Criteria:\n\n* Having severe cognitive, vision, hearing, or other impairment\n* Unable to use computers or mobile devices\n* Relying on someone else to manage medications",{"count":116,"type":23},60,[80],"This clinical trial is studying an online tool that may help older adults safely manage their medications at home. The study focuses on older adults who live alone and have memory concerns or mild changes in thinking. Many people in this group take several medications, which can make it hard to keep track of when and how to take them, notice side effects, or know when to ask for help.\n\nIn this study, participants use an online self-monitoring platform to record any problems, symptoms, or concerns they have while taking their medications. The platform also provides helpful education and suggestions for managing medications and symptoms. Participants can share summaries from the platform with their health care team, which may help improve communication and support.\n\nThe goal of the study is to see whether this tool can help older adults feel more confident, informed, and prepared to manage their medications safely while living at home.",[31,120,121,122],"Living Alone","Mild Cognitive Decline","Polypharmacy (People Under Treatment With 5 or More Drugs)",[41,124,125,126,127],"mild cognitive decline","medication self-management","symptom self-tracking","online digital tool","NOT_YET_RECRUITING","2026-06-15",{"date":131,"type":59},"2026-06-22",{"date":133,"type":23},"2026-08-01",{"date":135,"type":23},"2028-05-31",{"name":137,"class":66},"University of Michigan",{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":24,"phases":148,"briefSummary":149,"conditions":150,"keywords":156,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":106},"100636793","promoting-walking-among-older-adults-through-affective-communication-and-step-monitoring-100636793","NCT07570303","Promoting Walking Among Older Adults Through Affective Communication and Step-Monitoring","Self-Continuity Messages and Step-Monitoring to Promote Walking Among Older Adults: Protocol of a 4-Arm Randomised Controlled Trial","NOSTEP","Inclusion Criteria:\n\n* Age between 65 and 74 years\n* Willingness and ability to install and use the mobile applications required for study participation\n* Sufficient proficiency in the Italian language to understand study materials and complete the questionnaires.\n\nExclusion Criteria:\n\n\\- Physical disabilities or medical conditions that preclude engagement in light to moderate physical activity, specifically:\n\n1. medical advice or prescription prohibiting engagement in light to moderate physical activity, assessed via a close-ended screening question;\n2. positive screening on a study specific close-ended question assessing ability to perform physical activity;\n3. positive screening on the adapted revised Physical Activity Readiness Questionnaire (rPAR-Q), indicating that participant may be unsafe.","74 Years",{"count":78,"type":23},[80],"Physical inactivity increases substantially after age 60 and represents a major public health challenge in older adults, as it is linked to increased risk of functional and cognitive decline and aging problems. Walking is one of the most accessible and recommended forms of light-to-moderate physical activity for this population. However, promoting sustained engagement in walking remains difficult, as traditional informational approaches often fail to activate personally meaningful motivations.\n\nThis study tests whether persuasive affective messages can promote walking by leveraging self-continuity, meaning the use of autobiographical memory to maintain the sense of being the same person across time and contexts, connecting the past, present, and future self. Self-continuity is associated with psychological resources such as self-esteem, self-efficacy, and a sense of meaning in life. The affective mechanism that sustains self-continuity is nostalgia: both promote emotional and behavioral regulation and support goal achievement. Building on this framework, the present trial examines whether activating feelings of self-continuity and positive nostalgic memories can strengthen older adults' motivation to engage in walking behavior.\n\nIn addition, the study investigates whether combining self-continuity messaging with a self-regulation strategy (daily step monitoring) enhances intervention effectiveness. Self-monitoring is a well-established behavioral technique that supports goal pursuit by increasing awareness and feedback.\n\nUsing a 4-arm randomised controlled factorial design, the study compares the effects of self-continuity messages, step-monitoring reminders, their combination, and an active control condition on walking behaviour and its psychological determinants.\n\nA national sample of 1,000 Italian adults aged 65-74, recruited through a certified panel provider (Ipsos) and balanced for age, gender, and geographic region, will be randomly assigned to one of the four conditions. All participants will receive one message per day through a mobile application over a 14-day period. Participants in the step-monitoring conditions will also be asked to track and report their daily step count using a pedometer application. Behavioral, psychological, and process measures will be collected at baseline, post-intervention, and follow-up.\n\nThe study therefore aims to provide experimental evidence on the role of self-continuity as a motivational driver of health behaviour change, and to clarify whether combining affective and self-regulatory strategies enhances intervention effectiveness in older adults.",[151,31,152,153,154,155],"Walking","Messaging","Mobile Applications","Psychosocial Factors","Health Behaviour",[157,158,159,41,160,161,162,163],"health behaviour change","physical activity","walking","persuasive communication","messages","self-monitoring","self-continuity","2026-06-10",{"date":166,"type":59},"2026-06-12",{"date":168,"type":23},"2026-06",{"date":170,"type":23},"2026-08",{"name":172,"class":66},"Catholic University, Italy",{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":24,"phases":183,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":67},"100642586","using-virtual-reality-travel-to-reduce-loneliness-in-older-adults-100642586","NCT07644416","Using Virtual Reality Travel to Reduce Loneliness in Older Adults","Virtual Reality Travel (VRT) as a Loneliness Intervention for Older Adults: A Pilot Randomized Controlled Trial","VRT","Inclusion Criteria:\n\n* Adults aged 65 years or older\n* Express willingness to engage with VR technology\n\nExclusion Criteria:\n\n\\- No self-reported physical, sensory, neurological, or cognitive conditions that would make VR use unsafe or impractical (e.g., uncontrolled seizures, severe vertigo, or significant uncorrected vision\u002Fhearing impairments).",{"count":182,"type":23},40,[80],"This study aims to investigate whether and how virtual reality travel (VRT) can reduce loneliness among older adults. It will utilize a mixed-methods research design that combines an randomly assigned experiment with follow-up semi-structured interviews.\n\nThis is a pilot study and it is essential to establish the feasibility and acceptability of the protocol, assess the tolerability of VR technology in this population prior to conducting a full-scale RCT, and generate preliminary effect size estimates to inform future sample size calculations.",[186,31,187,188],"Loneliness","Virtual Reality","Leisure Activities","2026-06-08",{"date":166,"type":59},{"date":192,"type":23},"2026-06-01",{"date":194,"type":23},"2027-05-30",{"name":196,"class":66},"Indiana University",{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":204,"targetDuration":206,"studyType":207,"phases":4,"briefSummary":208,"conditions":209,"keywords":213,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":222,"leadSponsor":224,"locationsCount":106},"100642921","role-of-dual-task-cost-in-predicting-fall-risk-among-older-adults-receiving-institutional-care-100642921","NCT07631975","ROLE OF DUAL-TASK COST IN PREDICTING FALL RISK AMONG OLDER ADULTS RECEIVING INSTITUTIONAL CARE","ROLE OF DUAL-TASK COST IN PREDICTING FALL RISK IN OLDER ADULTS RECEIVING INSTITUTIONAL CARE: A CROSS-SECTIONAL CLASSIFICATION MODEL","Inclusion Criteria:\n\n* Being 65 years of age or older\n* Residing in a nursing home or care institution for at least 1 month\n* Ability to walk a distance of at least 10 meters\n* Ability to ambulate independently with an assistive device (e.g., cane, walker), if needed\n* Having a Montreal Cognitive Assessment (MoCA) score of 18 or above\n* Ability to understand and execute single- and two-step verbal commands\n* Voluntary agreement to participate in the study and providing informed consent\n\nExclusion Criteria:\n\n* History of stroke or major orthopedic surgery within the past 6 monthsPresence of Parkinson's disease Stage ≥3 (Hoehn \\& Yahr) or any other neurological condition significantly affecting gait\n* Having a MoCA score below 18\n* History of fracture within the past 3 months\n* Presence of severe pain affecting gait during test administration (Visual Analog Scale \\[VAS\\] ≥ 7)\n* Uncontrolled hypertension (≥ 180\u002F100 mmHg) or unstable cardiovascular status\n* Active vestibular disease or a history of syncope within the past 3 months\n* Visual or hearing impairment severe enough to impede test execution\n* Inability to walk\u002Fambulate without the physical assistance of another person",{"count":205,"type":23},52,"12 Months","OBSERVATIONAL","There is a need for studies that examine the role of dual-task cost in predicting fall risk among older adults receiving institutional care and that develop classification models that can be used in clinical practice. The planned study aims to determine the discriminative ability of dual-task cost in identifying fall risk and to establish clinically meaningful cutoff values. In this respect, the study will both contribute to a more sensitive assessment of fall risk and provide a scientific basis for a low-cost, practical, and applicable screening approach.",[31,210,211,212],"INSTITUTIONAL CARE","Dual Task Cost","Falls in Old Age",[214,215,216,217,218],"Dual Task","Dual-task cost","Fall risk","Functional mobility","Institutionalized older adults","2026-06-03",{"date":189,"type":59},{"date":192,"type":23},{"date":223,"type":23},"2026-11-01",{"name":225,"class":66},"Ondokuz Mayıs University",{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":18,"sex":19,"minAge":234,"maxAge":235,"enrollmentInfo":236,"targetDuration":206,"studyType":207,"phases":4,"briefSummary":238,"conditions":239,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":106},"100571927","physical-and-cognitive-aging-study-in-older-adults-100571927","NCT06726616","Physical and Cognitive Aging Study in Older Adults","PASOS: Physical and Cognitive Aging Study in Older Adults","PASOS","Inclusion Criteria:\n\n• Hispanic and non-Hispanic adults age 55-85 years, at least 8th grade education, community dwelling.\n\nAdditional Inclusion for Hispanic Americans\n\n* Self-identify as Hispanic American\n* Report Spanish as primary language • No evidence of dementia or mild cognitive impairment based on cognitive screening \\[i.e., Montreal Cognitive Assessment (MoCA) administered during Visit 1; ≥26 among non-Hispanic White, ≥25 among Hispanics, ≥24 among non-Hispanic Blacks (Milani et al., 2018)\\]\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Artificial joint or severe disability that would make it impossible or contraindicated performing the isokinetic test\n* Sensory loss (vision, hearing) or motor deficits that would preclude participation in the experimental tasks or neuropsychological assessment\n* Previous major strokes or other known significant brain abnormalities or diseases affecting the brain and\u002For cognition (e.g., Parkinson disease, multiple sclerosis, seizure disorder, brain surgery, moderate TBI, REM Behavior Sleep Disorder, untreated sleep apnea, etc.)\n* Unstable and uncontrolled medical conditions (metastatic cancer, HIV, moderate-severe kidney disease, uncontrolled diabetes, uncontrolled hypertension, severe cardiac disease, etc.). No current cancer diagnosis.\n* Current or past history of major psychiatric disturbance including schizophrenia, or active psychosis, bipolar disorder, current major depressive episode, current alcohol or substance abuse or history thereof within the past six months\n* Use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)\n* Use of prescribed 'memory enhancing' medications, such as Aricept or Namenda\n* Previous participation in a cognitive or physical activity training study within the last 6 months or current involvement in another study involving cognitive, physical or other intervention at the time of enrollment","55 Years","85 Years",{"count":237,"type":23},100,"Hispanic Americans are the fastest growing older adult group in the United States, disproportionally increasing the risk of an Alzheimer's disease and related dementias diagnosis. Efforts to reduce this risk and mitigate the related cognitive\u002Fphysical declines are critical. The aim of this study is to assess the feasibility of enrolling older adults into an aging trajectory cohort, while generating preliminary data on associations of physical and cognitive aging trajectories. Our secondary objective is to generate preliminary data on the association of standard measures of physical activity and physical function with cognitive status. This study fits within our longitudinal research goal to reduce dementia incidence by understanding the mechanisms that drive the cognitive-physical aging trajectory.",[31,240,241,242,243],"Hispanic Americans","Cognitive Aging","Aging, Healthy","Exercise",{"date":245,"type":59},"2026-06-04",{"date":247,"type":59},"2025-03-19",{"date":249,"type":23},"2027-09-20",{"name":251,"class":66},"University of Florida",{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":24,"phases":260,"briefSummary":261,"conditions":262,"keywords":264,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":106},"100638943","how-video-game-therapy-affects-thinking-and-emotions-in-older-adults-with-cognitive-impairment-100638943","NCT07615647","How Video Game Therapy Affects Thinking and Emotions in Older Adults With Cognitive Impairment","COGNITIVE AND AFFECTIVE-MOTIVATIONAL EFFECTS OF A THERAPEUTIC INTERVENTION USING THE GOLDEN GAMERS METHODOLOGY IN OLDER ADULTS WITH COGNITIVE IMPAIRMENT","Inclusion Criteria:\n\n* Older adults with mild to moderate cognitive impairment, able to connect with their environment and participate in group or individual activities, and who agree to take part in the study.\n\nExclusion Criteria:\n\n* Severe cognitive impairment with lack of environmental awareness, serious visual limitations that prevent interaction, or any condition causing distress or making participation unsafe.",{"count":116,"type":23},[80],"Golden Gamers Go is running a study together with Rey Juan Carlos University to better understand how videogames can help older adults, especially those with memory problems or cognitive decline.\n\nThe study takes place in real care settings, such as day centers, and involves around 45 older participants. Over two months (with a possible follow-up period), participants take part in two to three sessions per week using video games on PlayStation.\n\nThese are not special \"health games,\" but popular, commercial video games that have been carefully selected and adapted to be easy to use, enjoyable, and meaningful for older adults.\n\nThe goal is to see whether playing these games can help improve thinking abilities and also how participants feel during the activity - for example, if they are more engaged, motivated, or emotionally positive.\n\nThis study builds on previous experience where this approach has already shown promising results in increasing participation, motivation, and overall wellbeing.\n\nBy carrying out this research, Golden Gamers Go aim to better understand how meaningful and enjoyable activities like videogames can support healthier and more active aging.",[31,263],"Cognitive Impairment, Mild",[265,266,267,268],"Alzheimer","Senior","Videogames","Therapy","2026-05-28",{"date":271,"type":59},"2026-05-29",{"date":273,"type":59},"2026-04-13",{"date":275,"type":23},"2026-07-06",{"name":277,"class":66},"Golden Gamers Go SL",{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":24,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":297,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":304},"100621191","zinc-supplementation-and-infections-in-older-medical-patients-100621191","NCT07367412","Zinc Supplementation and Infections in Older Medical Patients","Effect of Zinc Supplementation on Occurrence of Infections in Older Medical Patients (ZOOM) - a Cluster Randomized Controlled Trial (ZOOM OUT).","ZOOM OUT","Inclusion Criteria:\n\n* All medical patients aged ≥ 65 years assessed at the Medical Emergency Department, Herlev Hospital\n\nExclusion Criteria:\n\n* Self-supplementing with zinc at time of assessment (\\> 10 mg zinc\u002Fday)\n* Terminal illness (life expectancy \\\u003C 6 months, estimated by Clinical Frailty Scale ≥8)\n* Patients receiving parenteral nutrition (partial or complete)\n* Patients treated with hemodialysis or peritoneal dialysis\n* Patients know with known severe dementia\n* Patients who do not understand Danish and patients with temporary civil person registration numbers (CPR)",{"count":287,"type":23},8000,[80],"The goal of this clinical trial is to learn about the effect of zinc supplementation once daily for 12 months in older acute medical patients. The main question it aims to answer is:\n\n• Can daily zinc supplementation for 12 months increase Days Alive and Out of Hospital (DAOH)? Researchers will compare zinc supplementation to a control group, a group who do not receive zinc supplementation, to see if zinc supplementation can increase Days Alive and Out of Hospital, reduce antibiotic use, readmissions and mortality.\n\nParticipants will take 22 mg zinc supplementation once daily for 12 months or not.\n\nThe researchers will draw data on readmissions, antibiotic use and mortality during the 12 months follow-up period.",[31,291],"Medical Patients in the Emergency Department",[293,294,295,296],"Older adults","Infections","Days alive and out of hospital","Zinc supplementation",{"date":271,"type":59},{"date":299,"type":59},"2026-02-01",{"date":301,"type":23},"2028-03-15",{"name":303,"class":66},"Herlev Hospital",2,{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":24,"phases":314,"briefSummary":315,"conditions":316,"keywords":319,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":106},"100573880","optimizing-care-transition-process-for-older-colorectal-surgery-patients-100573880","NCT06752031","Optimizing Care Transition Process for Older Colorectal Surgery Patients","Optimization of Care and Recovery in Older Colorectal Surgery Patients: A Hybrid Effectiveness-Implementation Pilot Study Protocol","Inclusion Criteria:\n\n* Adult patients (\\>65 years old)\n* Scheduled to undergo an elective colorectal surgery procedure\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Emergent, non-elective colorectal procedures\n* Non-English Speaking",{"count":313,"type":23},30,[80],"The goal of this study to test if a care transition intervention designed for older colorectal surgery patients would improve outcomes after discharge. It will assess the feasibility of the intervention.",[317,318,31],"Colorectal Surgery","Care Transition",[320,321,293],"Colorectal surgery","Care transition","2026-05-08",{"date":324,"type":59},"2026-05-13",{"date":326,"type":59},"2025-10-30",{"date":328,"type":23},"2027-12",{"name":330,"class":66},"Massachusetts General Hospital",{"id":332,"slug":333,"hasResults":12,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":19,"minAge":339,"maxAge":146,"enrollmentInfo":340,"targetDuration":4,"studyType":24,"phases":342,"briefSummary":343,"conditions":344,"keywords":348,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":106},"100638369","effects-of-short-and-long-courses-of-intermittent-hypoxic-hyperoxic-training-in-patients-with-type-2-diabetes-including-elderly-100638369","NCT07574333","Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly","A Single-Center Randomized Clinical Trial With Prospective Follow-up of the Efficacy and Safety of Short and Long Duration Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Mellitus Including Elderly Patients","EFIR","Inclusion Criteria:\n\n* Age 50-74 years inclusive\n* Type 2 diabetes mellitus confirmed by medical documentation\n* Stable therapy for diabetes and other chronic diseases for at least 4 weeks prior to enrollment\n* Ability to comply with study protocol requirements\n* Signed informed consent\n\nExclusion Criteria:\n\n* Type 1 diabetes mellitus\n* Acute diabetes complications within 6 months (diabetic ketoacidosis, hyperosmolar hyperglycemic state, lactic acidosis, hypoglycemic coma)\n* Acute or active chronic infections\n* Angina pectoris functional class III-IV\n* Uncontrolled grade 3 arterial hypertension (SBP ≥180 and\u002For DBP ≥110 mmHg)\n* Acute cerebrovascular accident, myocardial infarction, surgical interventions, clinically significant injuries within 6 months\n* Internal carotid artery stenosis \\>60% and\u002For symptomatic stenosis 50-99%\n* Chronic obstructive pulmonary disease and bronchial asthma\n* Exacerbation and decompensation of chronic diseases within 1 month ALT and\u002For AST levels \\>2-3 times upper limit of normal\n* Congenital heart and major vessel abnormalities\n* Implanted cardiac pacemaker\n* Cancer with remission \\\u003C5 years\n* Mental illness, drug addiction, alcohol dependence\n* Pregnancy\n* Inability to participate throughout the study period","50 Years",{"count":341,"type":23},250,[80],"This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus aged 50-74 years. Participants will be randomized into three groups: 3-day IHHT course (n≥100), 10-day IHHT course (n≥100), or control group receiving gas mixture with constant O2 21% for 10 days (n≥50). The primary outcomes are fasting glucose levels and HbA1c. Secondary outcomes include cardiovascular parameters, quality of life, cognitive function, and biological age.",[345,346,347,31],"Type 2 Diabetes Mellitus (T2DM)","Hyperglycemia","Metabolic Syndrome",[349,350,351,352,353,354,355],"Intermittent hypoxic-hyperoxic training","T2DM","Type 2 Diabetes Mellitus","Glycemic control","Elderly patients","Non-pharmacological intervention","Hypoxia conditioning","2026-05-04",{"date":358,"type":59},"2026-05-07",{"date":360,"type":59},"2025-10-15",{"date":362,"type":23},"2027-12-15",{"name":364,"class":365},"National Medical Research Center for Therapy and Preventive Medicine","OTHER_GOV",{"id":367,"slug":368,"hasResults":12,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":24,"phases":376,"briefSummary":377,"conditions":378,"keywords":381,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":388,"leadSponsor":390,"locationsCount":106},"100623199","a-pilot-randomized-controlled-trial-of-a-social-network-intervention-100623199","NCT07393529","A Pilot Randomized Controlled Trial of a Social Network Intervention","A Pilot Randomized Controlled Trial of a Social Network Intervention for Older Patients With Cancer","SONATA 2","Patients\n\nInclusion criteria:\n\n* Age ≥65 years\n* A diagnosis of advanced or likely incurable cancer, as determined by the primary oncologist\n* Able to speak English\n* Able to provide informed consent\n\nExclusion criteria:\n\n* Any psychiatric or cognitive impairments interfering with participation as determined by the oncology team\n* Unwilling to complete study procedures\n\nSocial Network Members (if available, for intervention arm only)\n\nInclusion criteria:\n\n* Age ≥18 years\n* Identified as an SN member by the patient in the intervention arm\n* Able to speak English\n* Able to provide informed consent\n\nExclusion criteria:\n\n• Unwilling to complete study procedures",{"count":375,"type":23},70,[80],"This is a pilot randomized controlled trial to assess the feasibility, acceptability, appropriateness, and structure of the SONATA intervention. In addition, it will assess the preliminary efficacy of SONATA compared to enhanced usual care among 70 older adults with advanced cancer.",[379,31,380],"Advanced Cancer","Social Networks",[382,383],"geriatric oncology","social networks","2026-04-10",{"date":386,"type":59},"2026-04-15",{"date":384,"type":59},{"date":389,"type":23},"2029-03-31",{"name":391,"class":66},"University of Rochester",{"id":393,"slug":394,"hasResults":12,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":398,"eligibilityCriteria":399,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":235,"enrollmentInfo":400,"targetDuration":4,"studyType":24,"phases":402,"briefSummary":403,"conditions":404,"keywords":410,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":106},"100633108","acute-power-training-effects-in-older-adults-100633108","NCT07522398","Acute Power Training Effects in Older Adults","Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults","APTE-OA","Inclusion criteria:\n\nParticipants must:\n\n* Be 65 to 85 years old.\n* Be able to live independently and perform everyday activities without help.\n* Not have regularly done resistance or strength training in the past year.\n* Be able to understand study instructions and communicate in the study language.\n* Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.\n\nExclusion criteria\n\nParticipants will not be eligible if they have any of the following:\n\n* Unstable heart disease, neurological disease, acute infection, or fever.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.\n* Use of whey protein, casein, or amino acid supplements in the month before the study.\n* Acute or chronic injuries to the legs or lower body muscles.\n* Any injury or condition that prevents safe leg extension exercises.\n* Recent lower-limb joint replacement (less than 6 months ago).\n* Dependence on walking aids.\n* Current participation in another interventional trial.",{"count":401,"type":23},42,[80],"The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.\n\nThe main questions the study aims to answer are:\n\n* How does the level of fatigue during power training acutely affect strength, movement, and muscle function?\n* How does it affect recovery, muscle soreness, and how hard the exercise feels?\n\nResearchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.\n\nParticipants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.\n\nDuring the study, participants will:\n\n* Perform power training on a pneumatic leg press machine\n* Complete strength and mobility tests before and after exercise\n* Provide small blood samples to measure body responses to exercise\n* Rate how hard the exercise feels\n* Report muscle soreness for up to two days after exercise\n\nThe results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.",[405,406,31,407,408,409],"Muscle Power","Functional Performance","Neuromuscular Function","Physiological Responses","Healthy Older Adults",[411,412,413,405,414,415,407,406,408,416],"Power Training","Older Adults","Aging","Velocity Loss","Resistance Training","Exercise Fatigue","2026-04-03",{"date":273,"type":59},{"date":420,"type":23},"2026-04-20",{"date":422,"type":23},"2027-01",{"name":424,"class":66},"Hasselt University",{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":433,"conditions":434,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":106},"100632930","predictors-of-climate-change-health-literacy-in-older-individuals-100632930","NCT07520084","Predictors of Climate Change Health Literacy in Older Individuals","Inclusion Criteria:- Being 65 years of age or older\n\n* Volunteering to participate in the study\n* Inclusion of elderly individuals who score 6 or higher on the Hodkinson Mental Test.\n\nExclusion Criteria:- older adults who cannot be contacted due to reasons such as Alzheimer's disease, dementia, or psychosis\n\n* Having another chronic illness that may cause pain (rheumatic diseases, hemiplegia, multiple sclerosis, diabetes, etc.)\n* Having a neurological disease (hemiplegia, Parkinson's, multiple sclerosis, vertigo, epilepsy, etc.)\n* Being blind\n* Having an orthopedic, neurological, or intellectual disability",{"count":432,"type":23},159,"The aim of this study is to identify predictors of climate change health literacy in older adults.",[31],"2026-04-02",{"date":437,"type":59},"2026-04-09",{"date":439,"type":59},"2026-03-25",{"date":441,"type":23},"2026-09-15",{"name":443,"class":66},"Pamukkale University",{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":24,"phases":452,"briefSummary":453,"conditions":454,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":106},"100631840","effects-of-breathing-exercises-on-cognition-in-older-adults-100631840","NCT07505914","Effects of Breathing Exercises on Cognition in Older Adults","Comparing Different Breathing Exercises Added to Balance Training on Cognitive and Functional Outcomes in Elderly Population","Inclusion Criteria:\n\n* Adults aged 65 years and older\n* Able to walk independently\n* Suitable for light to moderate physical activity\n* Willing and able to attend 2 sessions per week for 8 weeks\n\nExclusion Criteria:\n\n* Underwent surgery within the last 6 months\n* Currently participating in another structured rehabilitation program\n* Neurological disorders that significantly restrict mobility (e.g., Parkinson's disease, stroke)",{"count":182,"type":23},[80],"The goal of this interventional clinical trial is to investigate the effects of breathing exercises added to balance training on cognitive function in individuals aged 65 years and older.\n\nThe main questions it aims to answer are:\n\nDo breathing exercises affect cognition? Do different breathing exercises affect cognition in different ways?\n\nResearchers will administer two different breathing protocols and evaluate cognition before and after each protocol.\n\nParticipants will take part in an 8-week program consisting of sessions that include 30 minutes of balance-based exercises and 15 minutes of breathing exercises. Sessions will be held twice weekly under the supervision of a physical therapist.",[31,455,456,457],"Cognition","Balance Control in Elderly","Fall Prevention in Healthy Aging","2026-03-29",{"date":460,"type":59},"2026-04-01",{"date":462,"type":23},"2026-03-20",{"date":464,"type":23},"2026-12",{"name":466,"class":66},"Istanbul University - Cerrahpasa",{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":24,"phases":476,"briefSummary":477,"conditions":478,"keywords":479,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":485,"completionDateStruct":486,"leadSponsor":488,"locationsCount":106},"100631945","technology-based-hand-rehabilitation-in-older-people-100631945","NCT07507279","Technology-based Hand Rehabilitation in Older People","The Effects of Technology-based Hand Rehabilitation and Dual Task on Upper Extremity Functions in Older People","Inclusion Criteria:\n\n* 65 years of age and older\n* Not receiving hand-related physiotherapy and rehabilitation\n* Ability to follow instructions,\n* Scoring 24 points or more on the Mini Mental Test\n\nExclusion Criteria:\n\n* Having a neuropsychiatric diagnosis\n* Acute hand and arm injury\n* Having a diagnosis of rheumatological and orthopedic diseases affecting the hand",{"count":475,"type":23},66,[80],"Because hand and cognitive functions decline in the elderly, intervention programs addressing these problems are necessary. In recent years, creating rehabilitation programs using technology has gained popularity. The aim of this study is to examine the effects of technology-based rehabilitation using LMC (Light Mood Enhancer) and dual upper extremity tasks on joint position sense, grip strength, functionality, and executive functions in elderly individuals; and to compare these effects with those of an exercise program performed solely with an LMC device and a control group consisting of a hand rehabilitation program performed with a physiotherapist. The research is a randomized controlled trial and will consist of 3 groups. After randomization, individuals' joint position sense, gross and fine grip strength, functionality, and executive functions will be evaluated. Evaluations will be performed twice, at the beginning and end of the 8-week program.",[31],[41,480,481,482],"hand rehabilitation","technology","dual task","2026-03-27",{"date":435,"type":59},{"date":439,"type":23},{"date":487,"type":23},"2026-09-25",{"name":489,"class":66},"Akdeniz University",{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":4,"eligibilityCriteria":496,"healthyVolunteers":18,"sex":19,"minAge":497,"maxAge":4,"enrollmentInfo":498,"targetDuration":4,"studyType":24,"phases":499,"briefSummary":500,"conditions":501,"keywords":503,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":516,"leadSponsor":518,"locationsCount":106},"100625160","improv-music-therapy-for-older-adults-100625160","NCT07419022","Improv Music Therapy for Older Adults","Impact of Improvisation Music Therapy for Persons Living With Dementia and Their Care Partners","Inclusion Criteria\n\nInclusion criteria for the Person Living with Dementia (PLWD) are:\n\n* Age 60 and over, living independently in the community\n* Medical diagnosis of Alzheimer's Disease\n* Mild dementia defined as MoCA score between 16-20, or MMSE score between 19-24\n* Sufficient visual and hearing acuity (age-related to normal hearing loss with assistive devices)\n* English fluency rated fairly well to well (self-rated English fluency)\n\nInclusion Criteria for Caregiver are:\n\n* Age 18 or Older\n* Moderate to good English fluency (self-rated English fluency)\n* Willing to participate in intervention with PLWD\n\nExclusion Criteria\n\nExclusion criteria for PLWD are:\n\n* Medical diagnosis of severe dementia (any etiology)\n* Non-AD dementia diagnosis (e.g., frontotemporal dementia)\n* Serious medical condition (e.g., an end-stage disease requiring hospice, aphasia from stroke, paralysis, brain injury) requiring active medical management that would interfere with participation in the study\n* Significant difficulty moving the hands or arms (severe arthritis, neuropathy)\n* Plans to move out of the area within six months\n\nExclusion criteria for Caregiver are:\n\n* Current but not prior severe psychiatric disorder (e.g., schizophrenia, bipolar disorder)\n* Serious medical condition (e.g., an end-stage disease requiring hospice, aphasia from stroke, paralysis, brain injury) requiring active medical management that would interfere with participation in the study\n* Plans to move out of the area","60 Years",{"count":182,"type":23},[80],"Older adults and their care partners will participate in music therapy sessions for approximately 8 weeks. Before and after the 8 week study period, participants will fill out questionnaires about their mood, stress levels, and emotions. During the music therapy sessions, they may be observed or asked questions about the music therapy sessions.",[502,31],"Alzheimer's Disease (AD)",[504,505,506,507,508,509,510,511],"music","improvisation","person living with dementia","caregiver","Alzheimer's Disease and related diseases","mechanism of behavior change","stress reduction","behavior change","2026-02-20",{"date":514,"type":59},"2026-02-23",{"date":464,"type":23},{"date":517,"type":23},"2028-12",{"name":519,"class":66},"University of California, San Francisco",{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":4,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":527,"targetDuration":4,"studyType":24,"phases":528,"briefSummary":529,"conditions":530,"keywords":534,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":547,"locationsCount":106},"100607443","virtual-reality-enhanced-behavioral-activation-for-older-adults-with-depression-100607443","NCT07188623","Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression","VR-Enhanced BA for Older Adults With Major Depressive Disorder","Inclusion Criteria:\n\n* Patient must meet DSM V criteria for MDD\n* Patient must be at least 65 years of age\n* Patient must be English speaking\n* Without cognitive impairment\n\nExclusion Criteria:\n\n* Substance Use Disorders in past year\n* Any psychosis or bipolar I disorder\n* Any seizure in the last 6 months or untreated epilepsy\n* Current nonsuicidal self-injury or parasuicidal behavior\n* Current suicidal urges and intent\n* Changing psychotherapy treatment within three months of study entry\n* Changing psychotropic medication(s) within two months of study entry",{"count":313,"type":23},[80],"The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive virtual reality (VR) headset to engage in behavioral activation (BA) for older adults diagnosed with major depressive disorder (MDD). The secondary aim of this study is to explore the efficacy of using VR to enhance BA therapy in a clinical MDD older adult population.",[531,31,532,533],"Depression - Major Depressive Disorder","Behavioral Activation Treatment","Virtual Reality Therapy",[535,536,537,538,539,540,541,41],"Depression","Older adult","major depressive disorder","MDD","behavioral activation","VR","virtual reality","2026-02-18",{"date":512,"type":59},{"date":545,"type":59},"2025-09-30",{"date":170,"type":23},{"name":548,"class":66},"Stanford University",{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":554,"acronym":4,"eligibilityCriteria":555,"healthyVolunteers":12,"sex":19,"minAge":497,"maxAge":4,"enrollmentInfo":556,"targetDuration":4,"studyType":24,"phases":558,"briefSummary":559,"conditions":560,"keywords":561,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":565,"startDateStruct":566,"completionDateStruct":568,"leadSponsor":570,"locationsCount":106},"100576904","cbt-i-in-older-african-american-adults-100576904","NCT06791356","CBT-I in Older African American Adults","Cognitive Behavioral Therapy for Insomnia in Older African American Adults","Inclusion Criteria:\n\n* Reading level 6th grade or better and can speak and understand English well.\n* Self-identify as African American or Black.\n* Ages 60 and over.\n* Score of \\>2 in PSQI sleep duration, sleep disturbance, or overall sleep quality calculated components.\n* Participating in the \"Pathways to Healthy Aging in African Americans\" study.\n* Has established chronic insomnia issues for at least three months.\n* Subjects must be willing to participate in 8 sessions of CBT-I via Zoom for the CBT-I group.\n* Subjects must be willing to come for pre\u002Fpost assessment visits.\n* MoCA score of between 20-26.\n\nExclusion Criteria:\n\n* Currently taking any of the following medications consistently: Benzodiazepines (ProSom, Restoril, Ativan and Xanax); Z Drugs (eszopiclone (Lunesta), zaleplon (Sonata) and zolpidem (Ambien, Ambien CR, Edluar, and Zolpimist); antidepressants that affect sleep (doxepin, mirtazapine, trazodone); antihistamines (diphenhydramine and doxylamine succinate); barbiturates (methohexital, pentobarbital, primidone, secobarbital).\n* Diagnosed with any sleep disorder other than insomnia (i.e. obstructive sleep apnea using STOP-BANG, restless leg syndrome, REM sleep behavior disorder, etc.).\n* Classified as high fall risk.\n* Primary causes for frequent awakenings are due to a medical condition that is not related to insomnia, such as chronic pain, urinary frequency, upper respiratory infection.\n* Previous experience with CBT-I.",{"count":557,"type":23},20,[80],"Sleep problems, like insomnia, are common in older African Americans. About 25% of older adults in the US have at least 2 symptoms of insomnia, such as having trouble falling asleep, staying asleep, or getting good sleep for a month or more. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a recommended non-pharmacological treatment for insomnia. Unlike medicines that might only help for a short time or have many side effects, CBT-I deals with the root causes of insomnia. It helps people change how they think and act about sleep, leading to better habits and attitudes. This can make sleep better for a long time, even after the treatment is over. While CBT-I is commonly used among adults with insomnia, its benefits among older adults and specifically older African American adults are not well understood. Thus, the current pilot study will investigate the feasibility of CBT-I in older African American adults and establish preliminary evidence for the potential benefit of CBT-I on sleep as well as cognition in this population.\n\nFor this study, participants will be asked to complete pencil-and-paper questionnaires, psychological tests of cognition, 7-day actigraphy, 2 nights of at home sleep monitoring, which collects specific sleep measures such as brain waves and sleep stage timing, and computer-based neuropsychological tests before and after intervention. Study interventions will consist of 8 weekly sleep training sessions via Zoom or a single session of education on strategies to improve sleep quality. Sleep training sessions will include education about strategies to improve sleep quality, changing thought process that contribute to insomnia, training the brain on the optimal sleep environment, and reducing sleep initially to establish a consistent sleep schedule before increasing sleep time. Three months after the post-intervention visit, participants will be asked to come back in for a follow-up evaluation which consists of complete pencil-and-paper questionnaires, psychological tests of cognition, 7-day actigraphy, 2 nights of at home sleep monitoring, and computer-based neuropsychological tests.",[31],[562,563,564],"insomnia","cognitive-behavioral therapy for insomnia","African Americans",{"date":512,"type":59},{"date":567,"type":59},"2025-06-02",{"date":569,"type":23},"2027-06",{"name":571,"class":66},"Rutgers, The State University of New Jersey",{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":578,"eligibilityCriteria":579,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":580,"targetDuration":4,"studyType":24,"phases":581,"briefSummary":582,"conditions":583,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":587,"lastUpdatePostDateStruct":588,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":594,"locationsCount":106},"100595579","modifying-the-geriatric-acute--post-acute-care-coordination-program-for-fall-prevention-in-the-emergency-department-for-telehealth-100595579","NCT07034287","Modifying the Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department for Telehealth","eGAPcare: Modifying the Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department for Telehealth","eGAPcare","Inclusion Criteria:\n\n* Community-dwelling adult (non-institutionalized) 65 years-old or older presenting to ED after a fall\n* Fall not due to syncope or external force (i.e., struck by car or assault)\n* Fall not due to serious illness (i.e., stroke, acute myocardial infarction)\n* Will be discharged to home\u002Fassisted living\u002Frehabilitation at completion of ED visit (i.e., not admitted)\n* Proxy available to give informed consent if patient lacks capacity\n\nExclusion Criteria:\n\n* Unable to give informed consent due to intoxication or acute change in mental status\n* Presence of injuries that prevent mobilization (i.e., pelvic or lower extremity fractures)",{"count":182,"type":23},[80],"The goal of this clinical trial is to determine the feasibility of eGAPcare, a telehealth modification of the GAPcare fall prevention intervention, in older adults in a community emergency department. The main questions it aims to answer are:\n\n* Can telehealth physical therapy and pharmacy consultations be conducted in a community emergency department?\n* Does the telehealth modification of GAPcare decrease recurrent falls at 6 months? Participants will\n* Receive telehealth physical therapy and pharmacy consultation while in the emergency department\n* Participate in follow-up visits over the phone for 6 months following the initial emergency department visit\n* Complete study questionnaires delivered by study staff.",[31,584,585,586],"Fall Prevention","Telehealth","Emergency Department","2026-02-09",{"date":589,"type":59},"2026-02-11",{"date":591,"type":59},"2026-01-13",{"date":593,"type":23},"2027-01-01",{"name":595,"class":66},"University of Colorado, Denver",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":4,"eligibilityCriteria":602,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":603,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":605,"conditions":606,"keywords":611,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":623,"locationsCount":106},"100621397","self-compassion-self-efficacy-and-health-outcomes-in-older-adults-100621397","NCT07370090","Self-Compassion, Self-Efficacy, and Health Outcomes in Older Adults","The Effect of Self-Compassion and Self-Efficacy on Postural Awareness, Pain, and Health-Promoting Lifestyle Behaviors in Older Adults","Inclusion Criteria:\n\n* Aged 65 years and older\n* Able to read and understand Turkish\n* Able to complete online questionnaires independently\n* Provided informed consent\n\nExclusion Criteria:\n\n* Diagnosis of severe cognitive impairment (e.g., dementia or Alzheimer's disease)\n* Severe psychiatric disorders (e.g., schizophrenia or bipolar disorder)\n* Inability to complete questionnaires independently\n* Incomplete or inconsistent questionnaire responses",{"count":604,"type":23},150,"This cross-sectional observational study aims to examine the relationship between self-compassion, self-efficacy, postural awareness, pain, quality of life, and health-promoting lifestyle behaviors in adults aged 65 years and older. Data will be collected using validated self-report questionnaires administered online. The findings are expected to contribute to a better understanding of psychological factors associated with physical and behavioral health outcomes in older adults.",[31,607,608,609,610],"Health Behavior","Self-Compassion","Self-Efficacy","Pain",[612,613,293,614,615,610],"Self-compassion","Self-efficacy","Postural awareness","Health-promoting lifestyle","2026-01-19",{"date":618,"type":59},"2026-01-27",{"date":620,"type":23},"2026-01-15",{"date":622,"type":23},"2026-03-01",{"name":624,"class":66},"Acibadem University",{"id":626,"slug":627,"hasResults":12,"nctId":628,"briefTitle":629,"officialTitle":630,"acronym":631,"eligibilityCriteria":632,"healthyVolunteers":18,"sex":19,"minAge":76,"maxAge":4,"enrollmentInfo":633,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":634,"conditions":635,"keywords":638,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":644,"lastUpdatePostDateStruct":645,"startDateStruct":647,"completionDateStruct":649,"leadSponsor":651,"locationsCount":106},"100601544","healthcare-services-for-older-people-who-have-fallen-with-potential-head-injury-100601544","NCT07111871","Healthcare Services for Older People Who Have Fallen With Potential Head Injury","Understanding Care Pathways for Older People on Anticoagulant or Antiplatelet Medications With Falls and Head Injury","Anti-HI-Falls","Inclusion Criteria:\n\n* • Aged 18 years or above\n\n  * Healthcare professional whose primary employment is within HIOW\n  * Have experience reviewing older adults on anticoagulant or antiplatelet medications who have had a fall as part of their job role\n  * Confirmed consent to participate on the completed survey\n\nExclusion Criteria:\n\n* • Did not consent to participate on the completed survey",{"count":78,"type":23},"Every year, one in three older people (\\>65 years old) experience a fall. Older people may have long-term health conditions and take medications that can increase their risk of bleeding (blood thinners). The UK national guidelines recommend that older people who are on blood thinning medications should have a CT head scan considered due to concerns of a brain bleed if they have hit their head after a fall. Many older people are therefore brought into hospital for assessment. However, the risk of bleeding in the brain is very low especially if older people do not have any symptoms such as loss of consciousness, weakness, headaches or vomiting. Some people could experience long waits in the emergency department or end up being admitted to hospital unnecessarily. This could worsen mobility, cause confusion, pressure sores or infections in older people.\n\nMore importantly, older people should have a comprehensive falls assessment to reduce their risk of future falls and have their medications reviewed after experiencing a fall. These assessments could potentially take place in their own homes if they prefer, rather than in hospital. Yet, current healthcare services outside the hospital setting may not be set up to manage an older person after fall.\n\nUsing an online survey, the investigators want to understand how current healthcare services in the Hampshire and Isle of Wight (HIOW) region work to look after older people who have had a fall. The study will focus particularly on older people taking blood thinning medications who may have a head injury but do not have any symptoms. The investigators will ask NHS workers what their role is, where they work and what they do when assessing an older person who has fallen if there is a concern about head injury. The survey will also ask participants to describe what challenges they may face, and if they have any suggestions to improve the care for older people.\n\nThis study will help the investigators understand what services are available in our current healthcare system for older people on blood thinning medications who have fallen and may have a head injury. The investigators hope that the results will help improve how healthcare services can work together with older people and their closed ones to provide care based on what matters most to them in their preferred place of care. This could reduce unnecessary use of emergency services and hospital admissions for older people.",[31,636,637],"Falls","Head Injury",[639,640,641,636,642,643],"Older People","Anticoagulants","Antiplatelets","Head injury","Care pathways","2025-12-16",{"date":646,"type":59},"2025-12-23",{"date":648,"type":59},"2025-09-11",{"date":650,"type":23},"2026-05-31",{"name":652,"class":365},"Portsmouth Hospitals NHS Trust",{"id":654,"slug":655,"hasResults":12,"nctId":656,"briefTitle":657,"officialTitle":657,"acronym":658,"eligibilityCriteria":659,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":660,"targetDuration":4,"studyType":24,"phases":662,"briefSummary":663,"conditions":664,"keywords":669,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":680,"completionDateStruct":682,"leadSponsor":684,"locationsCount":106},"100609222","integrated-care-for-older-adults-with-major-depression-and-physical-multimorbidity---the-i-connect-100609222","NCT07211750","Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT","I-CONNECT","Inclusion Criteria:\n\n* Age 65 years or older\n* Clinical diagnosis of a mood disorder (depression or bipolar disorder)\n* Currently receiving care from a psychiatrist\n* At least two chronic physical health conditions\n* Living independently at home in the Leuven region\n* Ongoing care from both a general practitioner and a psychiatrist\n\nExclusion Criteria:\n\n* Severe cognitive impairment (e.g., advanced dementia) that prevents participation in assessments or shared decision-making\n* Inability to provide informed consent",{"count":661,"type":23},82,[80],"The goal of this clinical trial is to learn if I-CONNECT (Integrated Care for Older Adults with Major Depression and Physical Multimorbidity) can improve the health and well-being of older adults with depression or bipolar disorder and at least two chronic physical conditions, such as diabetes or high blood pressure. It will also study if the care model improves how people experience their care, lowers treatment burden, and how well the program is delivered.\n\nResearchers will compare two groups:\n\nI-CONNECT group: participants receive care coordination, a personalized care plan, medication review, shared decision-making support, and regular follow-up from a care coordinator working with their GP, psychiatrist, pharmacist, and specialists.\n\nUsual care group: participants continue with their normal healthcare from their GP and psychiatrist.\n\nParticipants will:\n\nReceive either I-CONNECT or usual care, depending on their group\n\nComplete questionnaires about their mood, quality of life, and care experience\n\nHave their healthcare use (emergency visits and hospitalizations) tracked during the study",[665,31,666,531,667,668],"Multimorbidity","Mood Disorders","Bipolar","Integrated Care",[670,671,672,673,674,665,535,675,293,676],"Integrated care","Care coordination","Person-centered care","Shared decision-making","Self-management support","Bipolar disorder","Quality of life","2025-12-11",{"date":679,"type":59},"2025-12-12",{"date":681,"type":59},"2025-10-01",{"date":683,"type":23},"2027-10-30",{"name":685,"class":66},"KU Leuven",{"id":687,"slug":688,"hasResults":12,"nctId":689,"briefTitle":690,"officialTitle":691,"acronym":4,"eligibilityCriteria":692,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":693,"targetDuration":4,"studyType":24,"phases":695,"briefSummary":696,"conditions":697,"keywords":699,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":705,"lastUpdatePostDateStruct":706,"startDateStruct":708,"completionDateStruct":710,"leadSponsor":712,"locationsCount":106},"100613018","effect-of-health-promotion-model-based-oculomotor-exercise-program-on-sleep-quality-in-older-adults-100613018","NCT07261124","Effect of Health Promotion Model-Based Oculomotor Exercise Program on Sleep Quality in Older Adults","Investigation of the Effect of Health Promotion Model Based Oculomotor Exercise Program on Sleep Quality in Elderly Living in a Nursing Home: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 65 years or older\n* Residing in the nursing home for at least 6 months\n* Scoring 4 or above on the Mini-Cog test\n* Pittsburgh Sleep Quality Index (PSQI) score ≥ 5 (indicating poor sleep quality)\n* No diagnosis of psychiatric disorders such as depression, bipolar disorder, or schizophrenia\n* No diagnosis of serious sleep disorders such as sleep apnea or narcolepsy\n* No medical condition causing frequent nocturnal awakenings, such as nocturia\n* Not using antipsychotic or other medications that may affect sleep quality\n* Having chronic diseases (e.g., diabetes mellitus, hypertension, coronary artery disease) that are controlled with pharmacological treatment\n* No communication problems\n\nExclusion Criteria:\n\n* Older adults unable to perform self-care independently\n* Older adults with dizziness or balance problems\n* Participants who are hospitalized for any reason during the follow-up or exercise sessions will be excluded from the study",{"count":694,"type":23},68,[80],"The goal of this clinical trial is to investigate the effect of a Health Promotion Model-based oculomotor exercise program on sleep quality among older adults living in a nursing home.\n\nThe main questions it aims to answer are:\n\nDoes the Health Promotion Model-based oculomotor exercise program improve sleep quality in older adults living in a nursing home? Does participation in the program enhance self-efficacy and promote better health behaviors related to sleep?",[698,31],"Sleep Quality",[700,701,702,703,704],"sleep quality","health promotion","Eye Movements","nursing","aged","2025-11-23",{"date":707,"type":59},"2025-12-03",{"date":709,"type":23},"2026-01-05",{"date":711,"type":23},"2026-12-30",{"name":466,"class":66},{"id":714,"slug":715,"hasResults":12,"nctId":716,"briefTitle":717,"officialTitle":718,"acronym":719,"eligibilityCriteria":720,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":721,"targetDuration":4,"studyType":207,"phases":4,"briefSummary":723,"conditions":724,"keywords":728,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":732,"lastUpdatePostDateStruct":733,"startDateStruct":735,"completionDateStruct":737,"leadSponsor":739,"locationsCount":4},"100605530","incidence-and-factors-of-functional-decline-after-emergency-department-discharge-in-older-adults-with-falls-100605530","NCT07163715","Incidence and Factors of Functional Decline After Emergency Department Discharge in Older Adults With Falls","Prospective Cohort Study on the Incidence and Associated Factors of Decline in Activities of Daily Living Among Older Adults Discharged From the Emergency Department After a Fall","FALL-ADL","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Presentation to the emergency department with a simple (non-injurious) fall\n* Discharged from the ED without hospitalization\n* Cognitively able to answer online or telephone follow-up interviews\n\nExclusion Criteria:\n\n* Falls due to traumatic events other than simple falls\n* Hospital admission required after the fall\n* Presence of acute confusion, dementia, or other severe cognitive impairment\n* Inability to access online or telephone follow-up during the 30-day study period",{"count":722,"type":23},280,"The goal of this observational study is to learn about changes in activities of daily living (ADL) in older adults after being discharged from the emergency department (ED) following a fall.\n\nThe main questions this study aims to answer are:\n\nHow often do older adults experience a decline in their ability to perform daily activities after being discharged from the ED for a fall? What health or lifestyle factors (such as frailty, medications, physical activity, or fear of falling) are related to this decline? Participants will be 65 years or older, admitted to the ED for a simple fall, and discharged without hospitalization. At the time of their ED visit, participants will be asked questions about their health, medications, activity level, and daily functioning. They will then be contacted online or by phone at 7 days and 30 days after discharge to answer follow-up questions.\n\nThis study will help identify how common functional decline is after falls in older adults discharged from the ED, and which factors may predict higher risk. These findings could help improve follow-up care and prevention strategies for older patients.",[725,726,727,31],"Fall","Daily Activities","Functional Decline",[636,729,730,731],"Decline fictional status","Decline daily activities","Emergency medicine","2025-09-02",{"date":734,"type":59},"2025-09-09",{"date":736,"type":23},"2025-09-05",{"date":738,"type":23},"2025-12-05",{"name":740,"class":66},"Ege University"]