[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:older-adults":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,53,0,25,[9,49,78,107,139,165,188,219,246,268,290,323,348,377,402,427,454,478,512,535,563,590,613,641,669],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644607","person-centered-occupational-therapy-in-older-adults-100644607",false,"NCT07672366","Person-Centered Occupational Therapy in Older Adults","Effects of a Person-Centered Occupational Therapy Approach on Life Satisfaction and Occupational Balance in Older Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 65 years or older.\n* Living independently in the community.\n* Scoring 24 or higher on the Mini-Mental State Examination (MMSE).\n* Having sufficient communication abilities to participate in interviews and assessments.\n* Willing to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Having an acute medical or psychiatric condition that may prevent participation in the study.\n* Having communication difficulties that interfere with participation despite the use of assistive devices (e.g., hearing aids, glasses).",true,"ALL","65 Years",{"count":21,"type":22},154,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study was designed to investigate the effects of a person-centered occupational therapy approach on quality of life and occupational balance among community-dwelling older adults. The study is a randomized controlled trial utilizing semi-structured interviews and self-report measures. The target population consists of individuals aged 65 years and older living in Istanbul. The sample size was calculated using G\\*Power software, indicating a minimum of 77 participants per group, for a total of 154 participants. Considering potential attrition, a total sample of 170 participants is planned.\n\nData will be collected using a Sociodemographic Information Form, the Mini-Mental State Examination (MMSE), the Occupational Performance History Interview-II (OPHI-II), Goal Attainment Scaling (GAS), the World Health Organization Quality of Life Instrument-Older Adults Module (WHOQOL-OLD), and the Activity-Role Balance Questionnaire. Cognitive eligibility will be assessed using the MMSE, and individuals scoring 24 or higher will be included in the study. Through the OPHI-II, participants' life histories, roles, habits, and experiences related to daily activities will be explored, and individualized goals will be identified based on the information obtained. These goals will subsequently be structured using the Goal Attainment Scaling method.\n\nParticipants will be randomly allocated to either the intervention group or the control group. Participants in the intervention group will receive person-centered occupational therapy sessions delivered via telerehabilitation, while those in the control group will continue their usual daily routines without additional support. At the end of the study, outcomes related to quality of life and occupational balance will be compared between groups. The findings are expected to provide evidence regarding the role of a person-centered occupational therapy approach in supporting participation in daily life activities among older adults.",[28,29],"Older Adults","Telerehabilitation",[31,32,33,34,35],"older adults","person-centered","occupational therapy","life satisfaction","occupational balance","RECRUITING","2026-06-24",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2026-04-15",{"date":44,"type":22},"2026-08",{"name":46,"class":47},"Atlas University","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100641165","an-ai-based-prediction-of-cognitive-capacity-in-older-adults-and-individuals-with-mild-cognitive-impairment-during-virtual-reality-driving-tasks-100641165","NCT07656389","An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks","From Eye Movements to Visuomotor Coupling: An AI-Based Prediction of Cognitive Capacity in Older Adults and Individuals With Mild Cognitive Impairment During Virtual Reality Driving Tasks","Inclusion Criteria:\n\n* (1) a score of 23 or higher on the Montreal Cognitive Assessment; (2) a Clinical Dementia Rating score of 0 for cognitively healthy participants or 0.5 for participants with mild cognitive impairment (MCI); (3) healthy young adults aged between 30 and 39 years, and cognitively healthy older adults and participants with MCI aged between 65 and 85 years; (4) right-hand dominance; and (5) adequate visual function to complete VR and eye-tracking tasks, defined as corrected binocular visual acuity of at least 0.5 without severe visual field deficits.\n\nExclusion Criteria:\n\n* (1) the presence or history of major psychiatric disorders or central nervous system diseases; (2) significant ocular diseases, such as untreated cataracts, active retinal diseases, moderate-to-severe or poorly controlled glaucoma, or marked visual field deficits beyond a specified level; (3) epilepsy; and (4) severe dizziness or VR-induced motion sickness.","30 Years","85 Years",{"count":59,"type":22},192,"12 Months","OBSERVATIONAL","Driving ability in older adults is essential for independent mobility and social participation, yet declines under high cognitive load or distraction often lead to visual attention failures such as \"look-but-fail-to-see,\" increasing crash risk. Older adults and individuals with mild cognitive impairment (MCI) show impairments in visual attention, executive control, and visuomotor integration, which are not adequately captured by conventional assessments. Virtual reality (VR) integrated with eye-tracking and upper-limb motion analysis enables ecologically valid simulation of driving scenarios and precise quantification of visuomotor behavior. However, current studies are limited by single-scenario designs, unimodal AI models, and insufficient integration of action-related data.\n\nThis study proposes a multi-phase framework: Year 1 develops an eye-movement-based AI model for MCI identification; Year 2 integrates multimodal data in VR driving tasks; and Year 3 establishes an explainable AI system with longitudinal validation. The study aims to advance cognitive assessment and develop a digital tool for early MCI detection and driving risk prediction.",[64,65,66,67,28],"Mild Cognitive Impairment (MCI)","Virtual Reality","Eye Movement Disorder","Multimodal Monitoring","NOT_YET_RECRUITING","2026-06-14",{"date":71,"type":40},"2026-06-18",{"date":73,"type":22},"2026-06-20",{"date":75,"type":22},"2029-12-31",{"name":77,"class":47},"National Cheng-Kung University Hospital",{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":12,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":90,"conditions":91,"keywords":96,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":48},"100642566","phase-4-fascia-iliaca-block-using-liposomal-bupivacaine-for-analgesia-after-hip-fracture-surgery-100642566","NCT07643792","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery: a Randomized Trial","Inclusion Criteria:\n\n* Aged ≥ 55 years.\n* Diagnosed as hip fracture and scheduled to undergo hip replacement surgery.\n* Agree to receive regional nerve block and postoperative patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Inability to communicate due to visual, auditory, language, or other reasons before surgery.\n* Chronic opioid dependence and long-term use of various types of analgesics (for more than 3 months).\n* Severe coagulation abnormalities (International Normalized Ratio \\> 1.7, activated partial thromboplastin time exceeding the normal value by more than 4 seconds, platelet count \\\u003C 80 × 10⁹\u002FL), trauma or infection at the intended puncture site, or severe low back pain.\n* Preoperative severe renal insufficiency (serum creatinine \\> 442 μmol\u002FL or requiring renal replacement therapy), hepatic insufficiency (Child-Pugh class C), or ASA physical status \\> IV.\n* Known allergy to local anesthetics.\n* Any other condition that the investigator or attending physician deems unsuitable for participation in the study.","55 Years",{"count":87,"type":22},148,[89],"PHASE4","Older patients with hip fractures often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (such as plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia, decrease opioid consumption, and improve postoperative recovery quality within 72 hours in older patients after hip fracture surgery.",[28,92,93,94,95],"Hip Fracture Surgery","Fascia Iliaca Block","Liposomal Bupivacaine","Postoperative Pain",[28,97,93,94,95],"Hip fracture surgery","2026-06-11",{"date":100,"type":40},"2026-06-15",{"date":102,"type":22},"2026-07",{"date":104,"type":22},"2028-08",{"name":106,"class":47},"Peking University First Hospital",{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":124,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":138},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933","NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors",{"count":114,"type":22},64,[25],"The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[118,28,119,120,121,122,123],"Older Adults With Cognitive Decline","AI-Based Fitness","Wearables","Cognitive Decline","Physical Activity","Physical Inactivity",[125,126,119,122,123,127,128,129],"Older adults","Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults","2026-06-10",{"date":100,"type":40},{"date":133,"type":40},"2026-06-08",{"date":135,"type":22},"2028-06-08",{"name":137,"class":47},"The University of Tennessee, Knoxville",2,{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":18,"minAge":146,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":156,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":48},"100638812","phase-4-intranasal-dexmedetomidine-esketamine-on-sleep-and-cognition-in-older-adults-with-mild-to-moderate-cognitive-impairment-100638812","NCT07610343","Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment","Impact of Intranasal Dexmedetomidine-esketamine on Sleep Quality and Cognitive Function in Older Adults With Mild-to-moderate Cognitive Impairment: a Randomized, Double-blind, and Placebo-controlled Trial","Inclusion Criteria:\n\n1. Aged ≥ 60 years.\n2. Meeting the clinical diagnostic criteria for Alzheimer's disease, with mild cognitive impairment (MoCA score 18-25) or moderate cognitive impairment (MoCA score 10-17) due to Alzheimer's disease.\n3. Comorbid with sleep disorders (Pittsburgh Sleep Quality Index \\[PSQI\\] score ≥ 7).\n4. Signed informed consent.\n\nExclusion Criteria:\n\n1. Cognitive impairment\u002Fdementia due to other causes (e.g., vascular dementia, frontotemporal dementia, Parkinson's disease dementia).\n2. Unsuitable for intranasal administration due to nasal cavity diseases (e.g., rhinitis, nasal polyps, or nasal congestion of any cause).\n3. Inability to communicate due to visual, auditory, language, or other reasons, or Mini-Mental State Examination (MMSE) score ≤ 9 or MoCA score ≤ 9.\n4. History of schizophrenia, epilepsy, or Parkinson's disease, or confirmed diagnosis of glaucoma, hyperthyroidism, pheochromocytoma, or myasthenia gravis.\n5. Confirmed diagnosis of restless legs syndrome or sleep apnea, or judged to be at high risk of moderate-to-severe sleep apnea according to STOP-Bang score, or Body Mass Index (BMI) \\> 30 kg\u002Fm2.\n6. History of stroke or transient ischemic attack within 12 months prior to enrollment, confirmed intracranial aneurysm, or elevated intracranial pressure from any cause.\n7. Uncontrolled hypertension (e.g., hypertensive crisis or systolic blood pressure \\> 160 mmHg and\u002For diastolic blood pressure \\> 100 mmHg prior to enrollment), myocardial infarction, unstable angina, revascularization surgery within 12 months prior to enrollment, or NYHA class III.\n8. Sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C 50 beats\u002Fmin), atrioventricular block above degree II without a pacemaker, corrected QT interval (Fridericia-corrected QTcF) ≥ 450 ms, or other severe arrhythmias (e.g., frequent premature ventricular contractions).\n9. Uncontrolled diabetes (e.g., HbA1c \\> 9%, diabetic ketosis, hyperglycemic coma, or hypoglycemia).\n10. Severe hepatic dysfunction (Child-Pugh Class C), renal dysfunction (eGFR ≤ 30 ml\u002Fmin\u002F1.73m2), respiratory insufficiency (SpO2 \\\u003C 93% on room air), or other severe diseases (e.g., frailty with inability to walk independently, advanced-stage tumors).\n11. Alcohol or drug dependence (manifested as strong cravings, uncontrolled use, and withdrawal symptoms upon cessation), or use of contraindicated medications.\n12. Major surgery under general anesthesia within 12 weeks prior to enrollment, or planned surgery within 12 weeks.\n13. Allergy to dexmedetomidine and\u002For esketamine.\n14. Participation in other interventional clinical studies.\n15. Any other conditions deemed unsuitable for study inclusion by the investigator.","60 Years",{"count":148,"type":22},60,[89],"Patients with cognitive decline are frequently comorbid with sleep disorders which may in turn aggravate cognitive decline. Sedative dose dexmedetomidine improved sleep quality but incresed bradycardia and hypotension; low dose dexmedetomidine produce less side effects, but the sleep promoting effects are relatively weak. Low dose esketamine also has sleep-promoting effects but may produce neuropsychiatric side effects. Both dexmedetomidine and esketamine are approved for intranasal administration. We suppose that intranasal administration of dexmedetomidine-esketamine combination may improve sleep quality and therefore cognitive function in older ptients with Alzheimer's disease cognitive impairment and sleep disorders.",[28,152,153,154,155],"Cognitive Impairment","Sleep Disorders","Dexmedetomidine","Esketamine",[28,152,153,154,155],"2026-05-28",{"date":159,"type":40},"2026-06-01",{"date":161,"type":22},"2026-06",{"date":163,"type":22},"2027-12",{"name":106,"class":47},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":48},"100523024","motivational-interviewing-to-enhance-advance-care-planning-for-older-adults-and-caregivers-after-emergency-visits-100523024","NCT06090240","Motivational Interviewing to Enhance Advance Care Planning for Older Adults and Caregivers After Emergency Visits","Maximizing Teachable Moments: Motivational Interviewing (MI) to Enhance Advance Care Planning (ACP) for Older Adults and Caregivers After Emergency Visits - A Mixed-Method Randomized Controlled Trial","The target group will be dyads comprising older adults who have had ER visits within the previous six months and their family caregivers. A dyad is defined as one older adult and one primary family caregiver of the older adult.\n\nFor older adults:\n\nInclusion Criteria:\n\n* Aged 65 or older\n* At least one episode of ER visit in the last six months\n* Has a family caregiver to be present during the intervention\n* Able to communicate in Chinese\n\nExclusion Criteria:\n\n* Has completion of an AD\n* Moderate to severe cognitive impairment or diagnosis of dementia, as identified in health records\n* Communication problems (e.g., deafness or aphasia)\n\nFor family caregivers:\n\nInclusion Criteria:\n\n* Aged 18 or above\n* Immediate or extended family member or friend nominated by an eligible older adult participant as primary caregiver\n* Able to communicate in Chinese\n\nExclusion Criteria:\n\n* Moderate to severe cognitive impairment\n* Communication problems (e.g., deafness or aphasia)",{"count":173,"type":22},300,[25],"This study aims to evaluate the effectiveness of a motivational interviewing (MI) intervention in enhancing advance care planning (ACP) among older adults who have visited the Emergency Room (ER) in the past six months and their family caregivers. The main question it aims to answer is: The effectiveness of the MI-based ACP intervention implemented within six months of an ER visit on improving older adults' advance directives (AD) completion rate.\n\nCompared to participants in the control group who will only receive a self-education booklet, participants in the intervention group will receive a motivational interview educational intervention to see the effectiveness of an MI-based ACP intervention implemented within six months following an emergency room visit regarding the completion of AD for older adults.",[28,177,178,179],"Advance Care Planning","Advance Directives","Family Members",{"date":181,"type":40},"2026-06-02",{"date":183,"type":40},"2023-12-14",{"date":185,"type":22},"2027-07-31",{"name":187,"class":47},"The University of Hong Kong",{"id":189,"slug":190,"hasResults":12,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":12,"sex":18,"minAge":146,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":199,"conditions":200,"keywords":203,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":215,"locationsCount":218},"100637138","phase-2-vaccination-response-modulation-with-a-targeted-rapamycin-protocol-study-100637138","NCT07587801","Vaccination Response Modulation With a Targeted Rapamycin Protocol Study","Vaccination Response Modulation With a Targeted Rapamycin Protocol (VON TRAPP) Study","VON TRAPP","Inclusion Criteria:\n\n* End-stage kidney disease requiring in-centre haemodialysis three times per week as kidney replacement therapy\n* Aged \\>60 years\n\nExclusion Criteria:\n\n* Aged \\\u003C60 years\n* Alternative haemodialysis regimens (e.g. twice-weekly haemodialysis, second-daily home haemodialysis)\n* Recent infection (\\\u003C6 months) with proven Influenza A, Influenza B, or RSV\n* Current use of immunosuppressive medications, including:\n\n  * Oral steroid at a dose equivalent of 5 mg\u002Fday prednisolone or greater\n  * Mycophenolate mofetil\n  * Azathioprine\n  * Calcineurin inhibitors\n  * mTOR inhibitors\n* Recent use of intravenous immunosuppressive medications (\\\u003C6 months), including:\n\n  * T-cell depleting agents (e.g. anti-thymocyte globulin)\n  * B-cell depleting agents (e.g. rituximab)\n  * Cyclophosphamide\n* Has a history of problems with side-effects associated with sirolimus use including\n\n  * Angioedema\n  * Active\u002Frecent opportunistic infection\n  * Current or prior interstitial lung disease, non-infectious pneumonitis, organising pneumonia, or pulmonary fibrosis\n  * Clinically significant pleural effusion or pericardial effusion\n  * Active non-healing wounds, chronic skin ulcers, or planned major surgery\u002Fprocedures\n  * Current malignancy or recent malignancy with high recurrence risk\n  * Severe or uncontrolled hyperlipidaemia\n  * History of rhabdomyolysis\n  * Severe hepatic impairment\n* Ongoing use of strong CYP3A4\u002FP-gp inhibitors or inducers including\n\n  * Inhibitors: Ketoconazole, Voriconazole, Itraconazole, Telithromycin, Clarithromycin\n  * Inducers: Rifampicin, Rifabutin\n* Unable or unwilling to provide informed consent to participate in the trial\n* Known allergy to or intolerance of sirolimus (rapamycin) or the contents of the influenza or RSV vaccine",{"count":148,"type":22},[198],"PHASE2","This study will investigate dialysis recipients' responses to important vaccines.\n\nResearch suggests that a medication commonly used by transplant recipients may improve vaccine responses. The investigators will be conducting a clinical trial to see whether a short course of low-dose Sirolimus improves the response to vaccination against respiratory syncytial virus (RSV) and influenza (flu) in patient with kidney disease over 60 years old who receive haemodialysis.",[201,202,28],"Vaccine Immune Response","Haemodialysis Patients",[204,205,206,207,31,208],"influenza","RSV","vaccine","haemodialysis","immunosenescence","2026-05-11",{"date":211,"type":40},"2026-05-14",{"date":213,"type":22},"2026-05",{"date":102,"type":22},{"name":216,"class":217},"Central Adelaide Local Health Network Incorporated","OTHER_GOV",3,{"id":220,"slug":221,"hasResults":12,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":23,"phases":228,"briefSummary":229,"conditions":230,"keywords":234,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":242,"leadSponsor":244,"locationsCount":48},"100640906","feasibility-and-effects-of-inspiratory-muscle-training-combined-with-blood-flow-restriction-for-frail-older-adults-100640906","NCT07573995","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years and older who are classified as at least \"vulnerable\" using the Clinical Frailty Scale (score ≥4).\n* Participants must have no cognitive impairment and be able to follow commands, as assessed by the Mini-Mental State Examination (MMSE).\n\nExclusion Criteria:\n\n* (1) are unable to participate in exercise (e.g., due to severe musculoskeletal disorders)\n* (2) have high-risk factors for exercise, such as uncontrolled hypertension (\\>150 mmHg systolic blood pressure (SBP) \u002F \\>90 mmHg diastolic blood pressure (DBP), coagulation disorders, and deep venous thrombosis\n* (3) have hematological disorders or are using hematology related-medications\n* (4) have significant comorbidities, including a history of stroke, diabetes with severe complications, or cardiovascular diseases\n* (5) chronic lung conditions (e.g., obstructive pulmonary disease, asthma), and\n* (6) have participated in a structured exercise training program within the past 3 months at a frequency exceeding three sessions per week.",{"count":227,"type":22},30,[25],"This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults. Outcomes of interest include feasibility, physical function, respiratory muscle strength, handgrip strength, five-times sit-to-stand performance, body composition, frailty level, fall efficacy, blood pressure, and adverse events.",[231,28,232,233],"Frailty Syndrome","Blood Flow Restriction (BFR) Training Effects","Inspiratory Muscle Training",[235,31,236,237],"frailty","blood flow restriction","inspiratory muscle training","2026-05-01",{"date":240,"type":40},"2026-05-07",{"date":213,"type":22},{"date":243,"type":22},"2026-10",{"name":245,"class":47},"Taipei Medical University",{"id":247,"slug":248,"hasResults":12,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":12,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":23,"phases":255,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":48},"100601077","dance-intervention-to-improve-executive-function-and-physical-performance-in-older-adults-with-cognitive-impairment-100601077","NCT07105800","Dance Intervention to Improve Executive Function and Physical Performance in Older Adults With Cognitive Impairment","A Pilot Study of Dance Intervention for Enhancing Executive Function and Physical Performance in Cognitively Impaired Older Adults","Inclusion Criteria:\n\n* Subjective Cognitive Decline (SCD) with a score ≥5 on the SCD-Q9 questionnaire, or Mild Behavioral Impairment (MBI) with a score ≥7 on the MBI-Checklist, with symptoms persisting for more than three months.\n* Ability to follow instructions.\n* Ability to stand unsupported or with assistive devices for at least 10 minutes.\n* Ability to walk at least 10 meters, either unsupported or with assistive devices.\n\nExclusion Criteria:-Age below 55 years.\n\n* Severe visual or hearing impairment.\n* Score \\\u003C16 on the Montreal Cognitive Assessment (MoCA).\n* Emotional or anxiety symptoms caused by psychiatric medications that significantly impair the ability to perform study-related motor tasks.",{"count":254,"type":22},50,[25],"This pilot study investigates the effects of a music-based dance intervention on executive function and physical performance in middle-aged and older adults with cognitive impairment. Dance, as a form of dual-task training, integrates music, rhythmic movement, and cognitive-motor coordination. When combined with group interaction and partner-guided physical cues, it has the potential to enhance both cognitive and motor functions simultaneously.\n\nThe intervention features a simple, structured dance sequence designed to stimulate rhythm, attention, and coordination through music-based movement. This study aims to evaluate the feasibility and preliminary efficacy of this approach in improving executive function and lower limb physical performance among individuals with cognitive impairment.",[28,258],"Cognitive Impairment, Mild","2026-04-27",{"date":261,"type":40},"2026-04-28",{"date":263,"type":40},"2025-11-01",{"date":265,"type":22},"2026-06-30",{"name":267,"class":47},"Taipei Medical University Shuang Ho Hospital",{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":48},"100540984","tvns-during-motor-training-in-older-adults-100540984","NCT06323954","tVNS During Motor Training in Older Adults","Pairing tVNS With Motor Skill Training in Older Adults","Inclusion Criteria:\n\n* 65-84 years old across all races, genders, and ethnicities.\n* Right-handed\n* Physically and cognitively healthy\n\nExclusion Criteria:\n\n* Younger than 65 years old or older than 84 years old\n* Current or history of cardiac disease\n* Have an implanted device such as a neurostimulator or cochlear implant\n* Current or history of tympanic membrane perforation\n* Have a musculoskeletal issue that prevents hand function (e.g., arthritis)\n* Have a vision problem not corrected by glasses or contact lenses\n* Uncorrected auditory impairments\n* Had a stroke or lesion (including tumor) in the brain\n* Had a head injury or brain surgery\n* Suffer from frequent or severe headaches\n* Had a fainting spell or syncope\n* Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work\n* Have any implanted device such as cardiac pacemakers, medical pumps, or intracardiac lines\n* Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer)\n* Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor)\n* Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion\n* Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia)\n* Suspected of pregnancy\n* Pregnant\n* Cognitive status issues as confirmed with the Mini-Mental State Exam (MMSE \\\u003C26)\n* Musculoskeletal condition or injury that would limit hand range of motion","84 Years",{"count":277,"type":22},32,[25],"The goal of this study is to learn about the effect of applying transcutaneous vagus nerve stimulation (tVNS) during motor training on motor learning in older adults. The main question it aims to answer is whether applying tVNS after successful motor trials (post-success tVNS) will facilitate the rate of motor learning. Participants will be randomly assigned to tVNS or sham group and receive tVNS or sham, respectively, at the outer ear during finger control training sessions. Finger control performance will be tested before and after the training sessions without outer ear stimulation.",[28],"2026-04-16",{"date":283,"type":40},"2026-04-21",{"date":285,"type":40},"2025-05-27",{"date":287,"type":22},"2026-07-31",{"name":289,"class":47},"Georgia Institute of Technology",{"id":291,"slug":292,"hasResults":12,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":17,"sex":18,"minAge":297,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":23,"phases":300,"briefSummary":301,"conditions":302,"keywords":306,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":48},"100632279","a-multi-level-strategy-for-de-implementing-mammography-overuse-among-older-women-100632279","NCT07511621","A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women","De-implementation of Overuse of Mammography Screening in Older Racially and Ethnically Diverse Women","Patient level criteria\n\nInclusion criteria\n\n* English- or Spanish-speaking women based on preferred language in electronic health record\n* Aged 75 and older at the time of their scheduled primary care visit\n* Women who have a primary care visit scheduled within the next 2-4 weeks\n* Women who have not had a screening mammogram 6 months prior to their scheduled primary care visit but have had a screening mammogram 7-18 months prior to their scheduled primary care visit\n\nExclusion Criteria\n\n* Women with a history of atypical ductal hyperplasia (ADH) or non-invasive or invasive breast cancer (assessed via ICD 10 code)\n* Women with dementia (assessed via ICD 10 code)\n* ICD codes to use across exclusion criteria: F01-F03, Z85.3, G30-G31, N60, C50, or D05\n\nProvider level criteria\n\nInclusion Criteria\n\n• Primary care clinicians attributed to the 2 intervention clinics that serve adult patients, including those ≥75 years\n\nExclusion Criteria\n\n* Specialists\n* Primary care clinicians for patients \\\u003C 18 years old\n* Non-clinicians\n* Physician assistants","18 Years",{"count":299,"type":22},500,[25],"This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75 years. Informed by an innovative participatory, stakeholder-driven innovation tournament and a discrete choice experiment, the research team identified, prioritized, and tailored a multilevel de-implementation strategy. The research team will conduct a cluster randomized controlled trial (at the provider level) to test the impact of the provider- and patient-level components of the multilevel strategy on screening mammography use, and secondarily, on provider referrals\u002Forders for screening mammography. The organizational level components of the multilevel strategy will be implemented among all participants, not via random assignment.",[303,304,305,28],"Mammography","Medical Overuse","Evidence-based Practice",[303,307,308,309,310,311,312,313],"Medical overuse","Implementation science","Aging","Women","Randomized controlled trial","Screening cessation","De-implementation","2026-03-30",{"date":316,"type":40},"2026-04-06",{"date":318,"type":40},"2026-03-11",{"date":320,"type":22},"2028-03",{"name":322,"class":47},"Columbia University",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":17,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":23,"phases":332,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":346,"locationsCount":4},"100631106","dyadic-management-intervention-in-older-people-with-co-occurring-cognitive-impairment-and-diabetes-as-a-supplementary-approach-to-chronic-diseases-self-management-program-100631106","NCT07496359","Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program","Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program: A Hybrid Effectiveness-implementation Study","Inclusion Criteria:\n\n* Individuals with DM aged \\>= 55 years old;\n* Recent glycosylated haemoglobin (HbA1c) level of 6.5% or above without change in diabetes medication within the last 3 months based on centre's records;\n* Subjective cognitive decline (using SCDQ21) (separately reported by the patient and\u002For caregiver) and confirmed by MOCA (Chinese version) screened by the research nurses;\n* Subjects with nominated primary caregivers will be recruited in the intervention group;\n* For caregivers: they will be considered in the project if they have been the primary caregiver for the person for at least 1 year and are providing or involved in the patient's care on a daily basis.\n\nExclusion Criteria:\n\n* Medical diagnoses of dementia;\n* Those who have terminal illness;\n* For caregivers: those who are temporary caregivers and have only provided\u002Finvolved in care for less than a year.",{"count":331,"type":22},309,[25],"The goal of this study is to evaluate the effectiveness and implementation of a dyadic management of the Chronic Disease Self-Management Program (CDSMP) for older adults with co-occurring cognitive impairment and diabetes with the involvement of caregivers.\n\nThe main questions it aims to answer are:\n\n* Does the intervention improve diabetes self-management and cognitive function in older adults?\n* How is the implementation of the intervention in real-world settings?\n\nParticipants will:\n\n* Attend weekly CDSMP session over a 6-week period (2.5-hour per session).\n* Provide feedback on their experience with the intervention through interviews and surveys.",[335,336,337,338,339,28],"Choroid Disease","Caregiver","Self-management","Diabetes","Mild Cognitive Impairment","2026-03-23",{"date":342,"type":40},"2026-03-27",{"date":344,"type":22},"2026-03",{"date":163,"type":22},{"name":347,"class":47},"The Hong Kong Polytechnic University",{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":17,"sex":18,"minAge":355,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":23,"phases":358,"briefSummary":359,"conditions":360,"keywords":362,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":138},"100630936","group-based-exercise-intervention-to-prevent-cognitive-and-motor-decline-100630936","NCT07494149","Group-Based Exercise Intervention to Prevent Cognitive and Motor Decline","Effects of the Ideomotor Group Program Exercise on Cognitive Functioning, Motor Functioning and Overall Well-being in Community-Dwelling Older Adults","Inclusion Criteria:\n\n* At least 50 years old;\n* Able to move independently;\n* Live in the community;\n* Demonstrated ability to comprehend complex verbal instructions.\n\nExclusion Criteria:\n\n* Presence of severe neurological and psychological conditions;\n* Less than 9,36 score in the FAB15;\n* Lack of medical clearance to participate in an exercise program;\n* Less than 75% of attendance.","50 Years",{"count":357,"type":22},158,[25],"The goal of this clinical trial is to evaluate the efficacy of the Ideomotor Program in healthy older adults living in the community. The main research questions are:\n\n1\\) Is the Ideomotor Program effective in improving cognitive function? 2) Is the Ideomotor Program effective in improving motor function? 3) Is the Ideomotor Program effective in improving overall well-being?\n\nResearchers will compare the Ideomotor Program to a community group cognitive training program to determine whether the effects are superior. Participants will: undergo assessments at baseline, at the mid-intervention point, and upon program completion; participate in a 16-week group exercise program in a community gym two times per week; keep a diary to monitor the number of falls and any adverse events.",[361,28],"Healthy",[363,364,365,366,367,368],"Exercise","Cognition","Psychological Well-Being","Primary Prevention","Physical Fitness","healthy longevity","2026-03-19",{"date":342,"type":40},{"date":372,"type":40},"2026-02-01",{"date":374,"type":22},"2026-08-01",{"name":376,"class":47},"University of Bergamo",{"id":378,"slug":379,"hasResults":12,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":18,"minAge":146,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":23,"phases":385,"briefSummary":386,"conditions":387,"keywords":390,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":4},"100630567","n-of-1-trial-to-promote-beta-blocker-titration-in-heart-failure-100630567","NCT07489352","N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure","N-of-1 Trials to Promote Patient-Centered Beta-Blocker Titration in Heart Failure With Reduced Ejection Fraction","Inclusion Criteria:\n\n* Adults aged ≥60 years\n* Diagnosed with HFrEF (LVEF \\\u003C40%)\n* Taking below 50% of guideline-based target β-blocker dose (guideline-based target doses: metoprolol 200mg daily; carvedilol 25mg BID; bisoprolol 10mg daily)\n\nExclusion Criteria:\n\n* Contraindication to beta-blocker including allergy\n* Treating physician disapproval of enrollment\n* Clinical instability",{"count":254,"type":22},[25],"In this study we seek to understand whether N-of-1 trials using a crossover withdrawal\u002Freversal design with as many 2-week periods can be used to identify the highest tolerated beta-blocker dose for patients with Heart Failure with Reduced Ejection Fraction (HFrEF). To achieve this objective we will conduct a 2-arm randomized controlled trial of 50 participants, comparing intervention(N-of-1 trials) to enhanced usual care.\n\nFor participants randomized to the intervention, we will use collect data via validated patient-reported outcomes and then display this data on a visualization tool. This tool was iteratively developed for N-of-1 trials with patient input - a comparison of how the patient felt on different beta-blockers. If well-tolerated and the participant agrees to continue with dose escalation based on review of their data, the participant will take a higher dose for the next 2-week period; and the study team will again collect data on how they feel during this time. This approach of sharing end-of-period data with participants and subsequently escalating the dose (based on the participant's decision) for another 2-week period will continue until the guideline-directed target dose is reached or until the participant feels that their symptoms are limiting dose escalation. The N-of-1 intervention is purposefully structured to allow the participant to participate in as many periods (and as many dose combinations) as they wish until they are confident that they have reached their highest tolerated dose. This adaptive design for N-of-1 trials is intended to be patient-centered and patient-driven.\n\nWe will also conduct brief semi-structured interviews with intervention participants.\n\nParticipants randomized to enhanced usual care will not have access to patient-reported outcomes or the data visualization tool. Since attention can affect outcomes, we will \"enhance usual care\" by conducting phone calls at the same frequency as the intervention group.",[388,389,28],"Heart Failure","Beta-blocker",[391,392],"Guideline-directed medical therapy","N-of-1 trials","2026-03-18",{"date":395,"type":40},"2026-03-24",{"date":397,"type":22},"2026-05-05",{"date":399,"type":22},"2027-03-05",{"name":401,"class":47},"Brigham and Women's Hospital",{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":17,"sex":18,"minAge":408,"maxAge":4,"enrollmentInfo":409,"targetDuration":4,"studyType":23,"phases":411,"briefSummary":412,"conditions":413,"keywords":417,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":48},"100224513","influenza-immunization-in-adults-over-age-75-100224513","NCT02200276","Influenza Immunization in Adults Over Age 75","Inclusion Criteria:\n\n* Adults over age 75 years\n\nExclusion Criteria:\n\n* Allergies to egg or vaccine\n* Active malignancies\n* On radiation or chemotherapy\n* Active systemic inflammatory diseases including rheumatoid arthritis, Crohn's disease, and ulcerative colitis\n* Acute exacerbation of chronic cardiopulmonary conditions including decompensated CHF or COPD\n* Taking oral steroids (such as prednisone) or immune modulating drugs (such as methotrexate).\n* Lacking the capacity to consent (individuals who do not understand what Flu shot is or need someone else to decide if s\u002Fhe should get the Flu shot)","75 Years",{"count":410,"type":22},1025,[25],"The immune system is the part of the body that protects against infection. The immune system often doesn't work as effectively as people get older. This research is being done to find out how the immune systems in older people who are over age 75 respond to influenza vaccine (flu shot). We also want to find out if chronic cytomegalovirus (CMV) infection, a common virus infection in older persons affects the immune response in people older than 75 years of age who receive a flu shot. The Flu Shot is a vaccine approved for the prevention of influenza (\"Flu\") infections and is recommended every year for all persons 50 years and older. People who are older than 75 years of age are considered healthy or frail may join. A total of 1025 persons will be participating in this study.\n\nIn order to determine if you are qualified for the study, we would ask you to answer a few questions over the phone that will take approximately 5 minutes. If you qualify and agree to proceed, you will be asked to come to Johns Hopkins Bayview Medical Center or, if you are unable to come to Bayview, one of our staff can visit you at your home. During that visit we obtain consent, review your medical history, and measure your vital signs, walking speed and grip strength. We will also administer a few brief questionnaires and collect urine and blood samples. We will then give you the Influenza vaccine for free. 7 days post receiving your Influenza Vaccine we will collect a small blood sample for further immune system testing. also, you will be asked to complete a 12-question survey which will assess your symptoms over the past 7 days (post receiving the Influenza vaccine). Also 4 weeks post receiving your Influenza vaccine you will be asked to complete a third visit that will include follow up health questionnaires and an influenza symptoms assessment questionnaire and vital signs. A third blood draw will be collected (approximately 10 teaspoons) to measure immune responses to the influenza vaccine. In addition, you will receive your test result (CBC\u002Fw\u002FDiff.) from visit #1. Throughout the influenza study season, we will call you once a week to ask about your general health and any Flu-like symptoms. These calls will be made throughout the Flu season which typically lasts through May. If you begin to have any influenza like symptoms at any time during the study, we ask that you call our office to report these symptoms so that we may perform vital signs, nasal swab to confirm influenza, and a fourth blood draw to look at the immune response and protection of influenza vaccine.",[414,415,28,416],"Influenza","Immunization","Over Age 75",[414],"2026-03-13",{"date":420,"type":40},"2026-03-16",{"date":422,"type":4},"2014-03",{"date":424,"type":22},"2027-11-30",{"name":426,"class":47},"Johns Hopkins University",{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":433,"eligibilityCriteria":434,"healthyVolunteers":12,"sex":18,"minAge":297,"maxAge":4,"enrollmentInfo":435,"targetDuration":4,"studyType":23,"phases":437,"briefSummary":438,"conditions":439,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":453},"100561314","improving-needs-among-older-adults-100561314","NCT06588556","Improving Needs Among Older Adults","Improving Needs Among Older Adults: the ICUconnect 2 Primary Palliative Care RCT","ICUconnect 2","Inclusion Criteria:\n\nPatients (who are not interviewed but whose characteristics prompt enrollment of family members)\n\n1. Adult aged ≥18 years\n2. Managed in an adult medical, cardiac, trauma, surgical, or neurological ICU\n3. Serious acute illness associated with a need for invasive mechanical ventilation\n4. ICU team expect patient to require mechanical ventilation for 2 or more days\n\nFamily members\n\n1. Adult aged ≥18 years\n2. Family member: self-described as the individual (related or unrelated) who provides the most support and with whom the eligible patient has a significant relationship (Society of Critical Care Medicine definition of family; Davidson J, et al. Crit Care Med, 45:103-128; 2017)\n\nICU clinicians\n\n1. Adult aged ≥18 years\n2. ICU clinician: ICU attending caring for the eligible patient on the day of family member informed consent\n\nExclusion Criteria:\n\nPatients\n\n1. Death or full comfort care plan expected within 24 hours by ICU attending or fellow physician Rationale: measurable intervention effect unlikely\n2. Palliative care consultative team and\u002For palliative care specialists are currently involved in the patient's care.\n\n   Rationale: this would dilute the intervention's effect.\n3. ICU length of stay \\>4 days during current ICU admission. Rationale: this would dilute intervention effect by widening the timeframe of family-clinician interactions and limiting standardization.\n\n6\\. Imprisoned person. Rationale: this is a vulnerable population.\n\nFamily members\n\n1. Low palliative care need burden (i.e., NEST scale score \\\u003C15) at baseline. Rationale: if there are very low baseline needs, the intervention cannot impact the primary outcome measure (i.e., NEST).\n2. Lack of English or Spanish fluency, operationalized as need for a translator to understand medical forms or participate in medical discussions.\n\n   Rationale: the app has not been translated into other languages; also, many outcome measures aren't validated in languages other than English and Spanish.\n3. Endorsement of suicidal ideation (i.e., PHQ-9 suicidality item) at the time of baseline data collection.\n\n   Rationale: this indicates a serious level of distress that will require professional assistance beyond that provided by the intervention (or control).\n4. Patient regains decisional capacity after informed consent but before the first family meeting. Rationale: as in our past ICU-based studies, this circumstance (the entry of the patient as a decision maker), would substantially change the nature of the interactions of family members and clinicians.\n5. The ICU clinician changes from a consented clinician to a non-consented clinician before the first family meeting. Rationale: in this circumstance the intervention cannot be fully deployed.\n\nICU clinicians None",{"count":436,"type":22},350,[25],"Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable across hospitals and clinicians, due in part to specialists' limited workforce and geographic inconsistency. To address these gaps, the investigators developed an innovative mobile app-based primary palliative care intervention called ICUconnect. ICUconnect facilitates families' and patients' self-report of actual palliative care needs across all core domains of palliative care quality, provides ICU clinicians with a scalable digital infrastructure for coordinating consistent and personalized needs-targeted care, and provides a variety of informational supports relevant to each user's role. In this RCT, the investigators will test ICUconnect vs. usual care control among 350 patient-family member dyads with elevated baseline levels of unmet palliative care need in a 4-site network serving a diverse population (Duke, Medical University of South Carolina, University of Alabama at Birmingham, Columbia).\n\nThe specific aims are to: (1) Test the efficacy of ICUconnect vs. usual care control in improving palliative care needs and other person-centered outcomes including psychological distress, (2) Determine participant characteristics associated with a greater treatment response using a heterogeneity of treatment effects approach, and (3) Ensure off-the-shelf intervention readiness for implementation using a mixed-methods integration of qualitative analysis of semi-structured trial participant interviews and quantitative RE-AIM implementation framework-informed trial data.",[440,441,28,442,443],"Critical Illness","Palliative Care","Informal Caregivers","Care Delivery Model","2026-03-04",{"date":446,"type":40},"2026-03-06",{"date":448,"type":40},"2025-09-16",{"date":450,"type":22},"2028-12-31",{"name":452,"class":47},"Duke University",4,{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":12,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":461,"targetDuration":4,"studyType":23,"phases":463,"briefSummary":464,"conditions":465,"keywords":467,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":476,"locationsCount":4},"100626822","the-count-me-in-program-in-support-of-social-participation-for-older-people-with-loss-of-autonomy-100626822","NCT07440628","The Count Me In Program in Support of Social Participation for Older People With Loss of Autonomy","The Count Me In Program in Support of Social Participation for Seniors Residing in Long-term Care Facilities and Seniors With Loss of Autonomy in Day Centres","Inclusion Criteria:\n\n* Must be over 55 years old\n* Must be able to understand and speak French fluently\n* Must be able to attend a group meeting lasting about 45 minutes\n* Must currently participate in at least one leisure activity in a day centre\n\nExclusion Criteria:\n\n* None",{"count":462,"type":22},8,[25],"The goal of this observational study is to determine whether the Count Me In Program (Participe-Présent in French), which focuses on the strengths and power to act of older adults, can improve social participation and psychosocial factors among older adults with loss of autonomy, as assessed by the following outcome measures: (1) loneliness; (2) depressive symptoms; (3) cognition; (4) frequency of participation in leisure activities; and (5) type of social participation.\n\nParticipants will attend seven weekly workshops in the Count Me In Program.",[28,466],"Loss of Autonomy",[125,468,469],"Loss of autonomy","Day centre","2026-02-25",{"date":472,"type":40},"2026-02-27",{"date":474,"type":22},"2026-04-01",{"date":159,"type":22},{"name":477,"class":47},"Université du Québec à Trois-Rivières",{"id":479,"slug":480,"hasResults":12,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":484,"eligibilityCriteria":485,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":486,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":488,"conditions":489,"keywords":493,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":506,"completionDateStruct":507,"leadSponsor":509,"locationsCount":511},"100626159","orthopedic-procedures-and-postoperative-delirium-in-older-adults-in-the-czech-republic-100626159","NCT07432009","Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic","Orthopedic Procedures and Postoperative Delirium in the Czech Republic","ORTOPODCZ","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective total hip arthroplasty in general or regional anesthesia\n* ASA physical status I-III\n* Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)\n* Expected postoperative hospitalization in ICU, PACU, or standard ward\n\nExclusion Criteria:\n\n* Glasgow Coma Scale ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)\n* Active oncological disease\n* Chronic use of strong opioids\n* Premedication with anxiolytics or antipsychotics during preanesthetic evaluation\n* Acute reoperation within 3 months of primary surgery\n* Refusal to participate or withdrawal of consent",{"count":487,"type":22},400,"This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.\n\nThe study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.\n\nApproximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.",[490,152,28,491,492],"Frailty","Hip Arthroplasty","Postoperative Delirium",[494,495,496,497,498,499,500,501,502,503],"ALBA test","CAM-ICU","Cognitive Screening","Geriatric Patients","Perioperative Neurocognitive Disorders","Polypharmacy","Clinical Frailty Scale","Total Hip Replacement","Observational Study","Prospective Cohort","2026-02-24",{"date":470,"type":40},{"date":474,"type":22},{"date":508,"type":22},"2030-03-31",{"name":510,"class":47},"Tomas Bata Hospital, Czech Republic",7,{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":17,"sex":18,"minAge":146,"maxAge":4,"enrollmentInfo":518,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":520,"conditions":521,"keywords":522,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":530,"leadSponsor":532,"locationsCount":534},"100620268","frailty-geriatric-syndromes-and-care-pathways-of-older-adults-living-with-hiv-in-west-africa-100620268","NCT07355413","Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa","Inclusion Criteria:\n\n* HIV+ Group\n\n  * Person 60 years of age and older\n  * Infected with HIV-1 and\u002For 2\n  * Able to move around the data collection site\n  * Having given free and informed consent\n* HIV- Group\n\n  * Person 60 years of age and older\n  * HIV-uninfected\n  * Able to move around the data collection site\n  * Having given free and informed consent\n\nExclusion Criteria:\n\nPerson deprived of liberty (guardianship, curatorship, judicial safeguard) Karnofsky Index 50≤50% Hospitalized\n\n\\-",{"count":519,"type":22},600,"With currently available antiretroviral therapy, people living with HIV (PLWHIV) are living longer. This exposure to HIV and combination antiretroviral therapy may accelerate the aging of this population, thus increasing the prevalence of premature frailty.\n\nThere are few data on the prevalence of frailty and geriatric syndromes among older people living with HIV (OpHIV) in sub-Saharan Africa (SSA) and the screening and diagnostic tools to identify them.\n\nThe initiation contract financed by the ANRS-MIE in 2021 whose objective was to 1) carry out an inventory and evaluate the feasibility of a project for monitoring OpHIV in Burkina-Faso in Côte d'Ivoire and Togo and 2) to select the collection tools adapted to the description of geriatric syndromes in these elderly people has allowed to highlight the following (i) The collection of data on geriatric conditions and syndromes is almost non-existent in the daily care and management practice (ii) there is a significant proportion (10,6%) of PLWHIV aged 60 years and over in the active files of the PLWHIV care centers that participated in the survey (iii) Adapted screening tools have been selected and will allow documentation of the above-mentioned syndromes. This research project, which follows on from this initiation contract, will therefore make it possible to obtain data from the geriatric evaluation, to identify the specificities of PLWHIV by comparing them to a population not infected with HIV and to propose geriatric management adapted to PLWHIV. Its innovative nature also lies in its mixed approach combining quantitative and qualitative methods, which will make it possible to document the needs and resources for the care of PLWHIV in a global and holistic manner.\n\n600 participants, aged 60 years and over (300 living with HIV and 300 not living with HIV), in three West African countries (Burkina Faso, Côte d'Ivoire, Togo) will be included in this study whose primary objective is to compare the prevalence of frailty among people aged 60 years and over (PA60) between HIV-infected and non-HIV-infected; the secondary objective is to estimate the prevalence of frailty among PA60 according to HIV status. A population-based matching will be performed on sex and age class (threshold 70 years), during the recruitment of HIV- PA60.\n\nThis will be a mixed study combining:\n\n* A \"clinical\" component comprising a stratified, comparative, international, multicenter cross-sectional study;\n* A \"health systems strengthening\" component combining a quantitative cross-sectional survey and a qualitative survey;\n* A qualitative socio-anthropological component including individual interviews and focus groups with people living with HIV60, their families and caregivers.\n\nThe 3 components will be conducted with a time lag between the different components due to the overlapping constitution of the source populations.\n\nMost research on aging with HIV in the context of SSA has been very clinically focused (e.g., frailty or cognitive impairment). This research will provide a more comprehensive approach that takes into account the different levels of factors influencing health (individual, health system, social environment).",[28],[523,490,524,525],"HIV","Geriatric syndromes","Care pathways","2026-01-14",{"date":528,"type":40},"2026-01-21",{"date":344,"type":22},{"date":531,"type":22},"2029-03",{"name":533,"class":217},"ANRS, Emerging Infectious Diseases",6,{"id":536,"slug":537,"hasResults":12,"nctId":538,"briefTitle":539,"officialTitle":539,"acronym":4,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":18,"minAge":541,"maxAge":542,"enrollmentInfo":543,"targetDuration":4,"studyType":23,"phases":545,"briefSummary":546,"conditions":547,"keywords":549,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":561,"locationsCount":48},"100514426","supa-mobility-supporting-physical-activity-for-mobility-in-mobility-limited-older-adults-100514426","NCT05978336","SuPA Mobility: Supporting Physical Activity for Mobility in Mobility-Limited Older Adults","Inclusion Criteria:\n\n* scored ≤ 9\u002F12 on the SPPB\n* are able to complete the 400-m walk in ≤ 15 minutes without sitting or physical assistance from another person or walker (use of cane is acceptable)\n* scored 22\u002F30 or higher on the Mini-Mental State Examination (MMSE)\n* have no significant functional impairment as indicated by a score of 6\u002F8 or higher on the Lawton and Brody Instrumental Activities of Daily Living Scale\n* are able to safely engage in MVPA as indicated by the PAR-Q+ and by the family or study physician as necessary\n* are community-dwelling\n* are able to provide written informed consent.\n\nExclusion Criteria:\n\n* are diagnosed with dementia or stroke\n* self-report engaging in MVPA ≥ 10 minutes per week in the prior 3 months\n* are unable to understand, speak, and read English proficiently","70 Years","89 Years",{"count":544,"type":22},290,[25],"The goal of this randomized controlled trial is to investigate the effectiveness of a health-coaching intervention to improve physical activity in older adults with limited mobility when compared to a control, health education group.",[548,28],"Limitation, Mobility",[550,551,552,553],"physical activity","health coaching","exercise","limited mobility","2026-01-10",{"date":556,"type":40},"2026-01-13",{"date":558,"type":40},"2023-09-05",{"date":560,"type":22},"2027-12-30",{"name":562,"class":47},"University of British Columbia",{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":23,"phases":571,"briefSummary":572,"conditions":573,"keywords":574,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":583,"lastUpdatePostDateStruct":584,"startDateStruct":586,"completionDateStruct":587,"leadSponsor":588,"locationsCount":48},"100612258","supplement-and-exercise-effects-on-stationary-immunity-and-health-in-older-adults-100612258","NCT07251244","Supplement and Exercise Effects on Stationary Immunity and Health in Older Adults","Effects of a Nutritional Supplement and Functional Exercise Program on Seasonal Immunity, Perceived Health, and Oxidative Stress in Older Adults","Inclusion Criteria:\n\n* Adults aged 65 years or older\n* Functional independence, defined as the ability to perform activities of daily living without assistance\n* Sufficient cognitive capacity to understand instructions and complete questionnaires, assessed through interview or brief cognitive screening if necessary\n* Not immunosuppressed\n* Not regular users of antioxidant or immunomodulatory supplements\n* Ability and availability to attend exercise sessions and scheduled assessments throughout the six-month study period\n* Commitment to maintain stable dietary and physical activity habits during the intervention\n\nExclusion Criteria:\n\n* Active autoimmune diseases or clinically relevant immunosuppression\n* Use of corticosteroids or immunosuppressive drugs in the 4 weeks prior to study initiation\n* Active infection or compatible symptoms (fever, cough, diarrhea) in the 2 weeks prior to any measurement\n* Unstable cardiovascular conditions or medical contraindications for moderate physical exercise\n* Moderate to severe cognitive impairment that prevents proper participation in the scheduled activities\n* Participation in another clinical trial in the last 3 months\n* Known allergy or hypersensitivity to the supplement or any of its excipients",{"count":148,"type":22},[25],"The goal of this clinical trial is to learn whether a natural-origin nutritional supplement, combined with a moderate-intensity functional exercise program, can improve seasonal immunity, perceived health, and oxidative stress in older adults. The study will also assess the safety of this combined intervention.\n\nThe main questions it aims to answer are:\n\n* Does the combination of supplementation and exercise enhance immune function during seasonal changes?\n* Does it reduce oxidative stress and improve perceived health and functional capacity?\n\nResearchers will compare a supplement to a placebo. All participants will follow the same supervised functional exercise program.\n\nParticipants will:\n\n* Take a daily nutritional supplement for 6 months.\n* Attend two weekly functional exercise sessions (60 minutes each), including mobility, explosive strength, and coordination\u002Fagility training.\n* Complete three assessments (before, midway, and after the intervention) including blood tests, physical function evaluations, and quality of life questionnaires.",[309,28],[125,575,576,577,578,579,580,581,582,311],"Nutritional supplement","Functional exercise","Seasonal immunity","Oxidative stress","Multicomponent training","Healthy aging","Quality of life","Non-pharmacological intervention","2025-12-15",{"date":585,"type":40},"2025-12-22",{"date":583,"type":40},{"date":102,"type":22},{"name":589,"class":47},"University of Valencia",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":594,"acronym":4,"eligibilityCriteria":595,"healthyVolunteers":12,"sex":18,"minAge":85,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":23,"phases":599,"briefSummary":600,"conditions":601,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":604,"lastUpdatePostDateStruct":605,"startDateStruct":607,"completionDateStruct":609,"leadSponsor":611,"locationsCount":48},"100597157","pain-and-split-belt-motor-learning-in-older-adults-100597157","NCT07054840","Pain and Split-belt Motor Learning in Older Adults","Inclusion Criteria:\n\n* Age 55-90 years old\n* Self-identifying as generally medically healthy\n* Able to read, write and speak English\n* Able to provide informed consent and attend all testing sessions\n* Willing to undergo the experimental pain paradigm, if selected\n\nExclusion Criteria:\n\n* Resting heart rate \\\u003C 50 or \\> 100 bpm\n* Resting blood pressure \\\u003C 90\u002F60 or \\> 165\u002F95\n* Any history or current mental health condition, learning\u002Fdevelopmental disability or cognitive impairment, including severe untreated ADD\u002FADHD, severe untreated anxiety, severe untreated depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc. (Mild to moderate treated ADD\u002FADHD, anxiety, and\u002For depression are allowed.)\n* Score on the Montreal Cognitive Assessment (MoCA) \\\u003C23\n* Score on the Generalized Anxiety Disorder-7 Scale ≥ 10\n* Score on the Patient Health Questionnaire-2 ≥ 2 and score on the Patient Health Questionnaire-9 ≥ 10\n* Any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, pulmonary, metabolic, psychiatric or neurological diagnosis that affects activities of daily living or would confound testing or place the subject at risk by participating, such as a significant cardiovascular condition or event (e.g., heart attack \\\u003C 3 months ago, uncontrolled atrial fibrillation, uncontrolled angina, congestive heart failure, chronic obstructive pulmonary disorder, or peripheral vascular disease)\n* Any impaired sensation or weakness in either lower extremity\n* History of serious concussion or head injury, defined as a loss of consciousness for \\> 5 minutes and\u002For requiring medical treatment, or \\> 2 concussions over the lifespan\n* Any history of acute or chronic problems with balance, any dizziness, or \\> 1 fall in the last 12 months\n* Currently or regularly using any analgesic medications, over-the-counter remedies, or any other treatment for the purposes of pain relief (i.e., baby aspirin for heart health is allowed)\n* Any current or chronic pain condition during the last year, located anywhere in the body with an intensity of \\> 2\u002F10\n* Allergy to capsaicin or hot peppers\n* Any skin lesion, breakage or irritation in the area targeted for the painful stimulus\n* Significant skin sensitivity to soaps\u002Fcreams\u002Fperfumes or to heat\n* Poor circulation in the area targeted for the painful stimulus\n* Prior participation in a split-belt locomotor learning study in the Neuromotor Behavior Lab in the past 2 years","90 Years",{"count":598,"type":22},34,[25],"The purpose of this research is to investigate the impact of acute pain, induced using an experimental pain paradigm of capsaicin paired with heat, on implicit locomotor learning and its retention in older adults.",[309,28,602,603],"Pain","Motor Learning","2025-12-03",{"date":606,"type":40},"2025-12-04",{"date":608,"type":40},"2025-08-26",{"date":610,"type":22},"2026-05-31",{"name":612,"class":47},"University of Delaware",{"id":614,"slug":615,"hasResults":12,"nctId":616,"briefTitle":617,"officialTitle":618,"acronym":619,"eligibilityCriteria":620,"healthyVolunteers":12,"sex":18,"minAge":408,"maxAge":4,"enrollmentInfo":621,"targetDuration":4,"studyType":23,"phases":623,"briefSummary":624,"conditions":625,"keywords":629,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":639,"locationsCount":48},"100598146","impact-of-physical-exercise-on-hospitalized-older-adults-malnourished-or-at-risk-with-oral-nutritional-support-100598146","NCT07067697","Impact of Physical Exercise on Hospitalized Older Adults Malnourished or at Risk, With Oral Nutritional Support","The Effect of Physical Exercise on the Physical Function of Hospitalized Older Adults Malnourished or at Risk of Malnourishment With Oral Nutritional Supplementation","NUTPHYS","Inclusion Criteria:\n\n* Aged 75 years or above\n* Hospitalized in the Acute Unit of the Geriatrics Service at the University Hospital of Navarra\n* 4 days or more of expected hospitalization\n* Malnourished according to the GLIM criteria or at risk of malnourishment (MUST scale)\n* Barthel Index ≥ 60 points\n* Capable of tolerating oral intake\n* Able to walk (with or without assistance)\n* Able to understand instructions and communicate\n* Consent to participate in the study after being informed of its objectives and who sign the informed consent (the participant or their legal guardian in case of disability).\n\nExclusion Criteria:\n\n* Advanced major neurocognitive disorder (GDS 6 and 7)\n* Uncontrolled cardiac arrhythmia, acute pulmonary thromboembolism, acute myocardial infarction, or bone fractures within the last 3 months\n* Chronic kidney disease stage 4 or 5\n* Safe and effective swallowing only with pudding texture\n* Inability to participate in the physical exercise program due to physical limitations\n* Participate in another study that may interfere with data interpretation or have participated in another study in six months prior to their entry into the study.",{"count":622,"type":22},102,[25],"The aim of this research is to analyze whether nutritional intervention combined with a multicomponent physical training program based on strength, balance, and aerobic exercises can prevent disability caused during hospitalization in individuals aged 75 years or older admitted for medical conditions, thereby improving functional and cognitive capacity.\n\nTo achieve this objective, we will conduct a randomized clinical trial in which patients are randomly assigned to either the control group, which does not perform the physical training, or the intervention group, which participates in the multicomponent physical training program.",[626,28,627,628],"Hospitalized","Physical Exercise","Oral Nutritional Supplementation",[630,31,631,632],"hospital-acquired disability","physical exercise","oral nutritional supplementation","2025-09-23",{"date":635,"type":40},"2025-09-24",{"date":637,"type":40},"2025-07-14",{"date":102,"type":22},{"name":640,"class":47},"Fundacion Miguel Servet",{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":649,"enrollmentInfo":650,"targetDuration":4,"studyType":23,"phases":652,"briefSummary":653,"conditions":654,"keywords":657,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":663,"completionDateStruct":665,"leadSponsor":667,"locationsCount":138},"100550929","transfer-effects-of-stationary-bicycle-perturbation-training-on-older-adults-cycling-skills-100550929","NCT06453473","Transfer Effects of Stationary Bicycle Perturbation Training on Older Adults' Cycling Skills","The Transfer Effects of Stationary Bicycle Perturbation Training on Older Adults' Cycling Skills and Behavior (BiPerAge): a Single Blind Randomized Controlled Trial","BiPerAge","Inclusion Criteria:\n\n* Ability and willingness to provide informed consent and accept randomization to either study arm\n* Ability to come to cycle course testing locations\n* ≥3 errors in pre-test of cycle course\n\nExclusion Criteria:\n\n* Severe diseases e.g. ischemic heart disease which restricts exercise, chronic obstructive pulmonary disease (COPD), uncontrolled blood pressure, manifest osteoporosis or any other disease leading to increased fracture risks\n* A period less than one year after hip or knee replacement surgery or after fractures of the lower extremities\n* Amputation of a lower limb\n* Neurological diseases or 6-month after a stroke\n* Inability to ambulate independently\n* Severe visual impairments (blindness), non-compensable hearing\n* Cognitive impairment, scoring less than 24 on the MMSE (Mini-Mental State Examination), inability to understand and follow instructions\n* Participation in another intervention trial at the same time or within the previous 6 months","100 Years",{"count":651,"type":22},127,[25],"The Israeli research group of this trial has developed the Perturbation Stationary Bicycle Robotics (PerStBiRo) system that can challenge balance while sitting. With this system, unexpected perturbations can be provided under controlled and safe conditions. Within the BiPerAge-project it will be evaluated if 20 training sessions (20 minutes each) on the PerStBiRo system will lead to transfer effects on safe cycling skills of community-dwelling older adults (age 65 years and older). The ability to cycle safely will be tested prior and after the training period using a cycling course, which consists of variant tasks requiring motor and cognitive skills.",[28,655,656],"Exercise Training","Bicycling",[656,658,659,660],"Perturbation","Balance control","Falls","2025-09-09",{"date":448,"type":40},{"date":664,"type":40},"2025-03-12",{"date":666,"type":22},"2027-03-31",{"name":668,"class":47},"University of Erlangen-Nürnberg Medical School",{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":4,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":18,"minAge":146,"maxAge":4,"enrollmentInfo":676,"targetDuration":4,"studyType":23,"phases":678,"briefSummary":679,"conditions":680,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":685,"lastUpdatePostDateStruct":686,"startDateStruct":688,"completionDateStruct":690,"leadSponsor":692,"locationsCount":48},"100583679","mhealth-person-centred-self-care-support-for-homebound-older-adults-a-hybrid-effectiveness-implementation-study-100583679","NCT06879457","mHealth Person-centred Self-care Support for Homebound Older Adults: A Hybrid Effectiveness-implementation Study","Empowering Homebound Older Adults in Self-care Using a Mobile Health-assisted, Person-centred Care Approach: A Hybrid Effectiveness-implementation Design","Inclusion Criteria:\n\n* Aged 60 years or older;\n* Unable to leave home more than twice per week due to physical or functional health problems;\n* Own and have basic proficiency in using a smartphone;\n* Speak Cantonese;\n* Indicate sufficient cognitive ability; and\n* Be moderately frail or below.\n\nExclusion Criteria:\n\n* Unable to hear, see, or communicate effectively;\n* Be completely bed-bound; or\n* Reside in an area without stable internet coverage.",{"count":677,"type":22},130,[25],"The aim of the study is to evaluate the effectiveness and implementation of the mobile health (mHealth)-assisted, person-centred care (PCC) self-care support programme for homebound older adults. The researcher will compare PCC approach to a conventional care provider-led model. Participants (n = 130) will receive the intervention of six bi-weekly WhatsApp video call sessions over three months with nurse case managers (NCMs).",[681,682,683,684,28],"Mobile Health","Person-Centred Care","Self-Care","Homebound","2025-09-08",{"date":687,"type":40},"2025-09-15",{"date":689,"type":40},"2025-03-10",{"date":691,"type":22},"2027-12-31",{"name":347,"class":47}]