[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"older-people\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:older-people":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,25,0,[8,39,70,100,131,163,192,219,243,275,306,330,350,372,391,421,442,466,492,519,543,564,601,621,649],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100053638","groningen-meander-walking-test-in-older-adults-with-balance-problems-100053638",false,"NCT07692373","Groningen Meander Walking Test in Older Adults With Balance Problems","Test-Retest Reliability and Construct Validity of the Groningen Meander Walking Test in Older Adults With Self-Reported Balance Problems and\u002For a History of Falls","Inclusion Criteria:\n\nAged 65 years or older Self-reported balance problems during activities of daily living and\u002For a history of at least one fall within the previous 12 months Able to walk independently with or without a single walking aid Able to understand and follow verbal instructions Willing to provide written informed consent\n\nExclusion Criteria:\n\nPresence of neurological, vestibular, visual, orthopedic, systemic, or medical conditions that may substantially affect gait or balance Acute lower-extremity injury or recent lower-extremity surgery Severe pain preventing completion of the walking or balance tests Cognitive impairment that may limit the ability to understand or follow test instructions Inability to walk independently without personal assistance Use of a rollator","ALL","65 Years",{"count":19,"type":20},70,"ESTIMATED","OBSERVATIONAL","This observational cross-sectional psychometric study aims to examine the test-retest reliability and construct validity of the Groningen Meander Walking Test in older adults with self-reported balance problems and\u002For a history of falls. Participants aged 65 years or older will be recruited from the Orthopedics and Traumatology outpatient clinic of Ordu University Training and Research Hospital. The Groningen Meander Walking Test will be performed twice during the first session and repeated in a second session to assess within-day and between-day reliability. Construct validity will be evaluated using the Timed Up and Go Test, Figure-of-Eight Walking Test, Berg Balance Scale, and Falls Efficacy Scale-International. The study will also explore the ability of the Groningen Meander Walking Test to discriminate between participants with low and increased fall risk according to the Berg Balance Scale.",[24,25,26],"Fall","Gait Disorders in Old Age","Older People","NOT_YET_RECRUITING","2026-07-09",{"date":30,"type":31},"2026-07-13","ACTUAL",{"date":33,"type":20},"2026-07-15",{"date":35,"type":20},"2026-09-01",{"name":37,"class":38},"Ordu University","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":53,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100641473","the-finger-model---preventing-cognitive-decline-and-promoting-health-of-older-people-100641473","NCT07661472","The FINGER Model - Preventing Cognitive Decline and Promoting Health of Older People.","The FINGER Model for Preventing Cognitive Decline and Promoting Health - Older Peoples' Perspectives on Participating in the Projects \"Hjärngänget\" and \"Hjärncellskapet\" - a Pathway to Better Health.","Inclusion Criteria:\n\n* older person is 65 years or older, registered as a resident in Bollnäs Municipality, and responds to questions about lifestyle habits, well-being, memory, and cardiovascular diseases. Participants must also be able to take responsibility for their own transport to and from physical meetings, have access to their own digital device, such as a smartphone, computer, or iPad, and have the time and opportunity to attend weekly sessions over a period of nine months. For participation in the research study, participants must also be able to take part in an interview in Swedish, complete a questionnaire, and provide informed consent. For participants who are only included in the questionnaire-based part of the study, the criteria are the ability to complete a questionnaire and provide informed consent.\n\nExclusion Criteria:\n\n* if the person has cognitive impairment or dementia to such an extent that an interview is not considered possible or ethically appropriate, has pronounced communication difficulties that make an interview impossible, and\u002For requires an interpreter.",{"count":47,"type":20},180,"INTERVENTIONAL",[50],"NA","Cognitive impairment and dementia can cause considerable suffering, both for the person affected and for next of kin. They also pose major challenges for health and social care. At the same time, research shows that many risk factors for cognitive decline can, in fact, be influenced. This is particularly the case when several areas are addressed simultaneously, such as physical activity, healthy eating habits, mental stimulation, social connectedness, and good cardiovascular health. A well-known model for such a multidomain preventive intervention is the FINGER model: the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. In the randomized controlled FINGER study, the results showed that a two-year programme comprising diet, exercise, cognitive training, social activity, and structured monitoring of vascular risk factors could improve and maintain cognitive function among older people at increased risk of cognitive decline. However, the research evidence is not unequivocal. Other randomized studies found no effect on cognitive outcomes over three years in the studied population, and in a cluster-randomized study reported no clear effects on the incidence of dementia in the older population. In addition, studies are needed that follow changes when the model is implemented in clinical practice. In recent years, the FINGER model has also been adapted and tested in several countries through the FINGER network, with the aim of developing and evaluating interventions that work in different contexts, while also strengthening knowledge and enabling comparisons of results between countries. A recently published qualitative study showed that participants were often motivated by an expectation of personal benefit, both for brain health and physical health, but also by concerns about cognitive decline. Social aspects also played an important role, as did the need for the interventions to feel understandable and for lifestyle changes to be perceived as realistic and feasible in everyday life.\n\nThe overall aim of the project is to evaluate a municipality-initiated, health-promoting multicomponent programme, based on the FINGER model, for older people, with a focus on health, health-related quality of life, well-being, and lifestyle habits (group A), and to compare it with a programme with fewer components (group B) implemented in the municipality. Furthermore, the aim is to explore older people's experiences of participating in the project, as well as how older people in the study rate their health and well-being before, during, and after completing their participation in the project.\n\nThe main research questions are:\n\n* How do older people rate their health, health-related quality of life, well-being, and lifestyle habits before, during, and after participation in the municipality's project (groups A and B)?\n* What cognitive and physical functional ability do older people have before, during, and after participation in the municipality's project (group A)?\n* Are there any differences over time within each group (A and B), and are there any differences over time between the groups in the project?\n* Do self-rated health and health-related quality of life in this study population differ from the values reported in a previously published study?\n* How do older people experience participating in the project (group A)?",[26],[54,55,56,57,58,59],"Physical activity","Health","health-related quality of life","well-being","lifestyle habits","cognitive and physical functional ability","2026-06-16",{"date":62,"type":31},"2026-06-22",{"date":64,"type":20},"2026-06-01",{"date":66,"type":20},"2028-03-31",{"name":68,"class":38},"University of Gavle",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":48,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":69},"100584251","exploring-the-acute-and-dynamic-relationships-between-movement-and-pain-in-older-adults-with-musculoskeletal-pain-100584251","NCT06886906","Exploring the Acute and Dynamic Relationships Between Movement and Pain in Older Adults With Musculoskeletal Pain","Inclusion Criteria:\n\n* Community-dwelling men and women\n* Answer yes to the following question: Have you experienced any musculoskeletal pain (pain affecting joints, bones, ligaments, tendons or muscles) in the past month?\n\nExclusion Criteria:\n\n* Cardiovascular issues such as uncontrolled blood pressure over 150\u002F99 mmHg, heart failure, or history of acute myocardial infarction;\n* Angina in the last month (squeezing, pressure, heaviness, tightness, or pain in chest)\n* Serious systemic disease or condition (e.g., severe osteoarthritis, injury) that restricts normal daily activities\n* Neurological disease (e.g., Parkinson's Disease, multiple sclerosis, epilepsy)\n* Serious psychiatric conditions (schizophrenia, bipolar disorder) or hospitalization within the preceding year for psychiatric illness\n* Known peripheral neuropathy\n* Chronic opioid use (defined as ≥ 90 days)\n* Unable to walk for 6 minutes without assistive devices\n\nSession exclusion criteria:\n\n• Participants will be asked to not participate in vigorous or unaccustomed exercise 48 hours prior to each study session.","55 Years","85 Years",{"count":79,"type":20},40,[50],"The purpose of this research study is to evaluate the effect of brief bouts of intermittent walking on bodily pain, pain during movement, and how the body adapts to musculoskeletal pain in older adults.",[26,83],"Pain",[85,86,87,88,89],"physical activity","movement evoked pain","sitting","quantitative sensory testing","musculoskeletal pain","RECRUITING","2026-04-14",{"date":93,"type":31},"2026-04-17",{"date":95,"type":31},"2024-11-13",{"date":97,"type":20},"2026-08-01",{"name":99,"class":38},"Indiana University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":109,"conditions":110,"keywords":118,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100632068","elderly-care-in-transition---perspectives-of-the-elderly-and-the-staff-100632068","NCT07508878","Elderly Care in Transition - Perspectives of the Elderly and the Staff","Elderly Care in Transition - The Elderlys' and the Staffs' Perspective on Person-centered Care, Environment, Health and Well-being","Inclusion Criteria - Older people:\n\n* Living in nursing homes - academic or standard\n* Able to complete a questionnaire independently or with reading assistance\n\nInclusion Criteria - Staff:\n\n* Employed at an Academic nursing home or a regular nursing home (comparison unit)\n* Belonging to care, nursing, or rehabilitation staff, including registered nurses, occupational therapists, and physiotherapists\n* Able to complete a questionnaire\n\nExclusion Criteria - Older people:\n\n* Individuals receiving only safety alarm services and\u002For meal delivery (no ongoing care contact)\n* Individuals unable to provide informed consent\n* Individuals unable to complete a questionnaire, even with reading assistance\n* Individuals with acute medical conditions that make participation inappropriate (as judged by care staff)\n* Individuals with severe cognitive impairment preventing meaningful participation in surveys.",{"count":108,"type":20},600,"Elderly care in Sweden faces several significant challenges. The number of older people is increasing at the same time as there are fewer of working age. Elderly care staff, such as nurses, care assistants and nurses, have on average more sick days than many other professional groups and often experience high work-related stress. In some municipalities, there are also problems with high staff turnover and a lack of formal competence. At the same time, research shows that many employees experience work in elderly care as meaningful and valuable. Taking advantage of and strengthening these positive aspects is central to creating good conditions for the health and well-being of staff and for the quality of care and care for older people. An important area of development in elderly care is person-centred care, which means that care is based on the individual person's needs, wishes, life history and resources. Person-centred practice emphasises the relationship between the older person, the staff and, if the person so wishes, relatives. Although person-centered care is often seen as an obvious part of good care, research shows that it is not fully implemented in practice and that the introduction of person-centered working methods can be complex and demanding.\n\nThis study is being carried out in collaboration between municipalities and the University of Gävle and is linked to the establishment of nursing homes for the elderly that will function as academic nursing homes. In these nursing homes, person-centered care will be a pronounced focus area. Through recurring measurements, the activities will be monitored and developed in close collaboration between practice and research. The overall aim of the study is to investigate older people's experience of academic nursing homes with a focus on person-centered care and nursing, outdoor environment, health and well-being, and to investigate the staff's experience of person-centered working methods, learning, structural conditions and work-related well-being. The study also aims to analyze the relationship between older people's experiences of person-centered care, outdoor environment, health and well-being, both among older people living in academic nursing homes and among older people living in their own homes. The study has a longitudinal design and data will be collected at several points in time using questionnaires and interviews, which enables both statistical analyses and an in-depth understanding of the participants' experiences over time. By highlighting the perspectives of both older people and staff, the study can contribute new knowledge about how person-centered care can be developed and maintained in practice. In the long term, the results can contribute to a more health-promoting, sustainable and attractive elderly care for both older people and staff.",[111,112,55,113,114,115,116,26,117],"Person-Centred Care","Well Being","Environment","Work-related Well-being","Structural Conditions","Learning Development","Staff Working in Nursing Homes",[119,120,121,122],"person-centered care","elderly care","work-related well-being","health","2026-03-30",{"date":125,"type":31},"2026-04-02",{"date":127,"type":20},"2026-04-01",{"date":129,"type":20},"2028-12-31",{"name":68,"class":38},{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":48,"phases":141,"briefSummary":142,"conditions":143,"keywords":148,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100614390","hemodiafiltration-versus-hemodialysis-in-older-people-100614390","NCT07278973","Hemodiafiltration Versus Hemodialysis in Older People","HemoDiafiltration Versus HemoDialysis in OLDER People: a Randomized, Multicenter, Crossover, Pragmatic Clinical Trial","HD-OLDER","Inclusion Criteria:\n\n* Signed and dated informed consent\n* Age \\>84 years\n* Diagnosed with kidney failure\n* On maintenance hemodialysis \\>3months\n* Willing to have a dialysis session of 3.5 to 4-hour duration, three times a week\n* Has a reliable vascular access\n* Is covered by the health insurance\n\nExclusion Criteria:\n\n* Patients with cognitive impairment (assessed with a mini-test if needed)\n* Hospitalized at inclusion\n* Have difficulties with French speaking\n* Terminally ill with life expectancy\\\u003C3 months\n* With active cancer",{"count":140,"type":20},62,[50],"This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF).\n\nPatients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his\u002Fher own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis.\n\nThese two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this question.",[144,145,146,147,26],"Hemodialysis","Hemodiafiltration","Fatigue Symptom","Quality of Life of Patients",[144,145,149,150,151,152],"Older people","Fatigue","Patient reported outcome","Dialysis recovery time","2026-02-20",{"date":155,"type":31},"2026-02-23",{"date":157,"type":20},"2026-02-19",{"date":159,"type":20},"2026-12-19",{"name":161,"class":38},"AUB Santé",4,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":48,"phases":172,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":69},"100591642","phase-2-efficacy-of-trazodone-to-treat-insomnia-in-older-adults-tradition-study-100591642","NCT06983080","Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study)","The Efficacy of Trazodone for the Treatment of Insomnia in Older Adults: A Randomized Controlled Trial (The TRADITION Study)","TRADITION","Inclusion Criteria:\n\n* Individuals aged 65 or older in an outpatient setting\n* Insomnia according to the criteria of the ICSD-3R\n\nExclusion Criteria:\n\n* Contraindication to trazodone (hypersensitivity)\n* Presence of a ventricular cardiac arrhythmia (e.g., torsades de pointes)\n* Recent myocardial infarction (\\\u003C 6 months)\n* Substances that may alter sleep (hypnotics or any other medication intended to induce sleep, such as mirtazapine or quetiapine, corticosteroids, melatonin, psychostimulant drugs)\n* Active, unstable psychiatric disorder\n* Initiation or titration of an antidepressant within the past 6 months\n* Cognitive-behavioral therapy ongoing or planned during the study period\n* Major neurocognitive disorder (NCD) moderate or severe, or other cognitive disorders that may prevent the participant from being able to participate in the study, according to the judgment of the evaluating physician\n* Parkinson's disease\n* Priapism\n* Known angle-closure glaucoma\n* Symptomatic restless leg syndrome \\> 3 times per week\n* QTc interval \\> 500 ms\n* Parasomnias, dyssomnias other than insomnia\n* Severe sleep apnea with AHI \\> 30 without CPAP treatment\n* Use of a monoamine oxidase inhibitor\n* Use of a strong CYP 3A4 inducer or inhibitor\n* Hospitalized individuals\n* Seizure within the past 6 months\n* History of orthostatic hypotension\n* History of delirium within the last 6 months\n* Consumption of \\> 14 alcoholic drinks per day or use of alcohol to induce sleep.",{"count":79,"type":20},[173],"PHASE2","This study aims to evaluate how effective trazodone is in treating insomnia in adults aged 65 years and older. The main question it aims to answer is :\n\n\\- Is trazodone more effective than a placebo in reducing the severity of insomnia symptoms in older adults?\n\nParticipants will :\n\n* Take 25 to 50 mg of trazodone or a matching placebo before bed for 28 days. After a 2-week break, they will then take the other medication for another 28 days.\n* Visit the clinic three times for checkup and test\n* Complete a sleep diary and wear an actimeter during the night.",[176,26,177],"Insomnia Chronic","Drug Therapy",[179,180,181,182],"insomia","Trazodone","Older adults","randomized controlled trial","2025-12-02",{"date":185,"type":31},"2025-12-08",{"date":187,"type":31},"2025-11-10",{"date":189,"type":20},"2027-12",{"name":191,"class":38},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":200,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":48,"phases":203,"briefSummary":204,"conditions":205,"keywords":207,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":218},"100520112","efficacy-and-safety-of-conventional-neoadjuvant-therapy-versus-total-neoadjuvant-therapy-in-older-patients-with-locally-advanced-rectal-cancer-100520112","NCT06052332","Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer","Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer: a Multicentre, Open-label, Randomised Pragmatic Clinical Trial","SHAPERS","Inclusion Criteria:\n\n1. Age ≥ 70 years old\n2. ECOG performance status (PS):\n\n   * ≤1 if age \\> 75 years old\n   * ≤2 if age ≤ 75 years old\n3. Histologically or cytologically confirmed adenocarcinoma of the rectum\n4. Distal border of the tumour below the peritoneal reflection and within 15 cm of the anal verge\n5. Operable stage III or high-risk stage II rectal cancer (high-risk tumours defined as those having ≥1 of the following features: T4, mesorectal fascia (MRF) involvement\u002Fthreatening \\[i.e.,tumour within 1 mm of the MRF\\], extramural venous invasion). Patient with involvement of lateral pelvic lymph nodes are also eligible.\n6. Adequate bone marrow function as defined below:\n\n   * Absolute neutrophil count ≥1,500\u002FµL\n   * Haemoglobin ≥9 g\u002FdL\n   * Platelets ≥100,000\u002FµL\n7. Adequate liver function as defined below:\n\n   * Serum total bilirubin ≤1.5 x ULN. In case of known Gilbert's syndrome \\\u003C3xUNL is allowed\n   * AST (SGOT) and ALT (SGPT) ≤2.5 x ULN\n   * Alkaline phosphatase ≤2.5 x ULN\n8. Adequate renal function as defined by estimated glomerular filtration rate (GFR) ≥30 mL\u002Fmin\u002F1.73m² (according to the CKD-EPI 2021 equation).\n9. Absence of clinical conditions that in the opinion of the investigator, would contraindicate neoadjuvant therapy and\u002For surgery.\n10. Signed Informed Consent form (ICF) obtained prior to any study related procedure.\n11. Male subjects with partners of childbearing potential must agree to use condom during the course of this study and for at least 6 months after the last administration of study drugs.\n\nExclusion Criteria:\n\n1. Extensive growth into cranial part of the sacrum (above S2\u002F3 junction) or the lumbosacral nerve roots indicating that surgery will never be possible even if substantial tumour down-sizing is achieved.\n2. Presence of metastatic disease or recurrent rectal tumour.\n3. Presence of grade ≥2 peripheral neuropathy according to the Common Toxicity Criteria for Adverse Events (CTCAE) v.5.0.\n4. Significant medical, neuro-psychiatric, or surgical condition, currently uncontrolled by treatment, which, in the principal investigator's opinion, may interfere with completion of the study.\n5. Any contraindication to pelvic irradiation as evaluated by the investigator.\n6. Known hypersensitivity reactions to the study drugs or to any excipients, premedications or non-investigational medicinal products or concomitant medications.\n7. Any investigational anti-cancer therapy other than the protocol specified therapies (participation in other prospective studies which do not imply any specific intervention may be allowed after discussion with the Study Chair).\n8. Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment.\n9. Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident\u002Fstroke, myocardial infarction, unstable angina, congestive heart failure (grade III or IV as classified by the New York Heart Association), or serious cardiac arrhythmia requiring medication within the past 6 months.\n10. Complete dihydropyrimidine dehydrogenase (DPD) deficiency.\n11. Any previous treatment for rectal cancer.\n12. Use of brivudine, sorivudine or their chemically related analogues.","70 Years",{"count":202,"type":20},230,[50],"The SHAPERS study is a multicentre, open-label, randomised, pragmatic clinical trial, comparing standard-of-care neoadjuvant treatment options for older (i.e., ≥70 years) subjects with high-risk stage II and stage III rectal cancer.",[206,26],"Locally Advanced Rectal Cancer",[208],"rectal cancer","2025-11-28",{"date":211,"type":31},"2025-12-05",{"date":213,"type":31},"2024-02-07",{"date":215,"type":20},"2033-12",{"name":217,"class":38},"Jules Bordet Institute",19,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":226,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":48,"phases":229,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":4},"100571493","aquarebal---aquatic-reactive-balance-training-for-older-adults-100571493","NCT06720974","AquaReBal - Aquatic Reactive Balance Training for Older Adults","AquaReBal","Inclusion Criteria:\n\n* 65 years and older\n* able to stand ≥1 min\n* able to independently walk ≥10 m without assistance\n* a history of ≥2 falls in the past 12 months, history of an injurious fall in the past 12 months, and\u002For self-reported balance difficulties\n\nExclusion Criteria:\n\n* Current diagnosis of neurological or sensory disorders\n* uncorrected vision problems\n* recurrent dizziness\n* cognitive deficits\n* medical conditions that could increase injury risk during balance tests (e.g. presence of a prior fragility fracture)\n* conditions that would not allow the participant to get into the therapy pool (e.g. wounds, fear of water)\n* currently attending physiotherapy or supervised exercise.",true,{"count":228,"type":20},15,[50],"Falls are the second leading cause of accidental injury deaths worldwide, mostly in older adults. Injuries resulting from a fall are a leading cause of hospitalizations among older adults in Canada with a higher total injury cost than any other cause of injury. People must often perform rapid and complex movements to keep from falling. Reactive balance training (RBT) is a type of training that focuses on improving an individual's ability to perform those types of movements and respond to unexpected or sudden changes. RBT and aquatic therapy were identified as a research priority for fall prevention. There is evidence that RBT reduces the rate of falls by a half in daily life and improvements in reactive balance are maintained up to a year after the end of the program. When RBT is conducted on land, some adverse events such as fear of falling and joint pain may occur. The water environment could minimize the limitations and barriers associated with land-based RBT. To date, there are no studies showing the effects of water-based RBT on reactive balance control in older adults.The study aims to explore if water-based RBT is a practical intervention to reduce the number of falls in older adults. Older adults will be recruited from the Greater Toronto Area. They will receive training 2 times per week for 6 weeks. The main practical factors around the intervention, such as how participants adhere to the treatment and how they accept the intervention will be measured. It will be assessed how the water-based and land-based RBT affects falls, balance, mobility and quality of life. With this study, the aim is to inform the way for a larger study targeting falls - one of the biggest problems among older adults.",[232,26,233],"Older Adults, Balance","Aquatic Physical Exercise","2025-09-10",{"date":236,"type":31},"2025-09-16",{"date":238,"type":20},"2025-12",{"date":240,"type":20},"2027-04",{"name":242,"class":38},"Józef Piłsudski University of Physical Education",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":226,"sex":16,"minAge":251,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":48,"phases":254,"briefSummary":255,"conditions":256,"keywords":263,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":4},"100595529","probiotics-and-active-aging-enhancing-gut-health-100595529","NCT07033637","Probiotics and Active Aging: Enhancing Gut Health","Promoting Health Through Symbiosis: Exploring the Relationship Between Gut Microbiota, Probiotics, and Physical Activity in Older Adults","PAAEGH","Inclusion Criteria:\n\n* Adults aged 60 years or older.\n* Residents of Castilla-La Mancha or Madrid.\n* Able to provide informed consent.\n* For the intervention group: enrolled in a municipal physical activity program with a minimum frequency of 2 sessions per week.\n* Willing to participate in all assessments and follow study instructions.\n* Consent: Participants must provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Recent serious musculoskeletal injuries (e.g., muscle tears, ligament ruptures, fractures).\n* Current symptoms during exercise such as chest pain, dizziness, or joint pain.\n* Uncontrolled hypertension (≥160\u002F100 mmHg).\n* Recent cardiac failure or infectious disease (e.g., meningitis, hepatitis, flu).\n* Chronic gastrointestinal diseases (e.g., Crohn's disease, ulcerative colitis, IBS).\n* Regular use of medications affecting gut motility or microbiota (e.g., laxatives \\>3 times\u002Fweek).\n* Immunodeficiency (e.g., HIV, active cancer).\n* Use of antibiotics (oral or parenteral) within 4 weeks prior to the study.\n* Regular intake of probiotic supplements or foods (e.g., Actimel) within 2 weeks prior to the study.","60 Years",{"count":253,"type":20},90,[50],"The general objective of this clinical trial is to assess the physical fitness and gut microbiota of older adults, thereby highlighting the importance of focusing on health maintenance. By making use of available resources and fostering collaboration among the elements involved in the study, more specific objectives can be defined:\n\n1. To determine the state of the gut flora in older adults through the analysis of the intestinal microbiota.\n2. To identify changes in the intestinal microbiota resulting from the intake of probiotics in older adults.\n3. To evaluate the effects of the intestinal microbiota in older adults participating in a training programme.\n4. To assess the physical fitness and perceived quality of life in older adults who engage in sport activities supported by technology.\n\nParticipants will:\n\n* Perform physical tests such as the 6-Minute Walk Test (6MWT), the Timed Up and Go (TUG), and the Sit-to-Stand test.\n* Complete wellbeing questionnaires to assess their perceived quality of life and health status.\n* Complete dietary habit questionnaires.\n* Provide stool samples for microbiota analysis.\n* Take part in exercise interventions or placebo exercise sessions, depending on their assigned group.",[257,26,258,259,260,261,262],"Gut -Microbiota","Physical Activity","Physical Fitness","Mental Health","Probiotic","Healthy",[264,265,85],"older people","gut microbiota","2025-06-13",{"date":268,"type":31},"2025-06-24",{"date":270,"type":20},"2025-09-01",{"date":272,"type":20},"2026-06-30",{"name":274,"class":38},"Jose Luis Felipe",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":48,"phases":284,"briefSummary":285,"conditions":286,"keywords":293,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":69},"100562918","the-effect-of-nature-and-game-based-activities-on-older-people-100562918","NCT06609408","The Effect of Nature and Game Based Activities on Older People","The Effect of Nature and Game Based Activities on Happiness, Spiritual Well-Being, Frailty and Cognitive Status of Older People in Nursing Home","Inclusion Criteria:\n\n* Older people who have been in a nursing home for at least 6 months,\n* Older people aged 65 years and over,\n* Older people with a Mini Mental State score of 24 and above,\n* Older people who are open to communication and co-operation will be included in the study.\n\nExclusion Criteria:\n\n* Older people with physical problems that may prevent them from participating in nature and game based activities (such as stroke, Parkinson\\'s),\n* Older people with visual and hearing loss that may pose an obstacle to nature and game based activities,\n* Older people with mental problems (such as dementia) that would prevent participation in nature and game based activities were excluded from the study.",{"count":283,"type":20},52,[50],"The purpose of this study is determine the effect of nature and game based activities on happiness, spiritual well-being, frailty and cognitive status of older people in nursing home.\n\nHypotheses of the Research H0: Nature and game-based activities don't affect the happiness, spiritual well-being, cognitive function and frailty of older people in nursing home.\n\nH1a: Happiness levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1b: Spiritual well-being levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1c: Cognitive function levels of older people in nursing home will be an increase after nature and game-based activities.\n\nH1d: Frailty status of older people in nursing home will be a decrease after nature and game-based activities.",[287,26,288,289,290,291,292],"Nature, Human","Nursing Home","Happiness","Spiritual Well-being","Frailty","Cognitive Ability, General",[294,26,288,289,295,291,296],"Nature","Spiritual Well-Being","Cognition","2025-06-11",{"date":299,"type":31},"2025-06-12",{"date":301,"type":20},"2025-07-01",{"date":303,"type":20},"2026-05-01",{"name":305,"class":38},"Ondokuz Mayıs University",{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":11,"sex":16,"minAge":313,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":48,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":69},"100540064","phase-2-carbon-ion-radiotherapy-for-locally-advanced-lung-cancer-in-elderly-patients-100540064","NCT06311981","Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients","A Prospective Phase II Clinical Study of Carbon Ion Radiotherapy for Locally Advanced Non-small Cell Lung Cancer in the Older Adult","Inclusion Criteria:\n\n* Older than 75 years old.\n* ECOG general status score of 0-2.\n* Primary non-small cell lung cancer (NSCLC) confirmed by histology or cytological pathology, T1-4N1-3M0, stage IIb-IIIc (AJCC\u002FUICC 8th edition).\n* Medically inoperable, or patient refuses surgery.\n* Adequate organ function: 1). Blood function: absolute neutrophil count (ANC) ≥1.5 x 109\u002FL, platelet count ≥80 x 109\u002FL, hemoglobin ≥9 g\u002FdL 2). Lung function: FEV1\\>25%, DLCO\\>25% 3). Cardiac function: no serious pulmonary hypertension, cardiovascular and cerebrovascular diseases, peripheral vascular diseases, serious chronic heart disease and other complications that may affect radiotherapy.4). Adequate liver function: total bilirubin \\\u003C1.5 times the upper limit of normal value, and AST, ALT\\\u003C2 times the upper limit of normal value. 5). Adequate renal function: serum creatinine ≤1.5 times the upper limit of normal or calculated creatinine clearance ≥50 ml \u002Fmin, and urinary protein \\\u003C2+. Patients with a baseline urinary protein level of 2+ or more should have a 24-hour urine collection and evidence of a 24-hour urinary protein level of 1g or less.\n* Sign informed consent.\n\nExclusion Criteria:\n\n* Patient with squamous cell carcinoma was treated with bevacizumab before carbon ion radiotherapy.\n* Complicated with other malignant tumors that have not been controlled.\n* Patient whose particle radiotherapy plan cannot meet the minimum target dose coverage and dose volume limitation requirements, or cannot meet the dose constrains of normal tissue or organs.\n* Chest radiation therapy or radioactive particle implantation history.\n* Cardiac pacemakers or other internal metal prosthesis implants that may be affected by high-energy radiation or may affect the dose distribution to the radiation target area.\n* HIV positive. Hepatitis virus replication phase, need to receive antiviral therapy, but because of concomitant disease cannot receive antiviral therapy. Active stage of syphilis.\n* A history of mental illness may hinder the completion of treatment.\n* With serious comorbidity that may interfere with radiotherapy, including: (a) Acute infectious diseases or acute active phase of chronic infection. b) Unstable angina pectoris, congestive heart failure, myocardial infarction that has been hospitalized in the past 6 months. c) Exacerbations of chronic obstructive pulmonary disease or other respiratory conditions requiring hospitalization. d) Severely impaired immune function. e) Diseases with excessive sensitivity to radiation such as ataxia telangiectasia. f) Other diseases that may affect particle radiotherapy.\n* Other circumstances that the physician considers inappropriate to participate in clinical study.","75 Years",{"count":315,"type":20},29,[173],"To observe the effect and toxicity of carbon ion radiotherapy on local advanced non-small cell lung cancer over 75 years old patients. Systemic therapy could be targeted therapy, chemotherapy or immunotherapy.",[319,26,320,321],"Non-small Cell Lung Cancer","Carbon Ion Radiotherapy","Radiotherapy Side Effect","2025-06-10",{"date":266,"type":31},{"date":325,"type":31},"2024-08-08",{"date":327,"type":20},"2026-06-17",{"name":329,"class":38},"Jian Chen",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":48,"phases":338,"briefSummary":339,"conditions":340,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":346,"leadSponsor":348,"locationsCount":69},"100591742","tele-rehabilitation-intervention-in-community-based-healthcare-for-patients-with-osteoporosis-dheal-com-op-100591742","NCT06984380","Tele-Rehabilitation Intervention in Community-Based Healthcare for Patients With Osteoporosis (DHEAL-COM-OP)","DHEAL-COM-OP","Inclusion Criteria:\n\n* Patients with a positive MOC for osteoporosis without a history of major fractures (femur and vertebrae);\n* Functional Ambulation Category (FAC) score ≥ 3;\n* Stability of drug treatment for at least 1 month;\n* Maintaining an upright position independently \\> 30\";\n* Mini-Mental State Examination (MMSE) ≥ 24;\n* Geriatric depression scale (GDS) \\\u003C 2;\n\nExclusion Criteria:\n\n* Myocardial infarction or stroke within 6 months;\n* Painful arthritis, spinal stenosis, amputation, painful foot lesions, or neuropathy that limits balance and mobility;\n* Uncontrolled hypertension\n* Metastatic cancer or immunosuppressive therapy;\n* Significant visual or hearing impairment",{"count":79,"type":20},[50],"The DHEAL-COM-OP study is characterized as a feasibility study. The general objective is to evaluate the improvement in the physical performance of patients with osteoporosis detected through the Performance-Oriented Mobility Assessment (POMA) scale, following a rehabilitation intervention integrated with the BTS TELEREHAB technology.",[341,26],"Osteoporosis","2025-05-23",{"date":344,"type":31},"2025-05-30",{"date":270,"type":20},{"date":347,"type":20},"2026-05-30",{"name":349,"class":38},"Istituto Nazionale di Ricovero e Cura per Anziani",{"id":351,"slug":352,"hasResults":11,"nctId":353,"briefTitle":354,"officialTitle":354,"acronym":355,"eligibilityCriteria":356,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":48,"phases":359,"briefSummary":360,"conditions":361,"keywords":363,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":366,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":69},"100591741","a-socio-technological-intervention-in-community-based-healthcare-for-individuals-with-mild-cognitive-impairment-dheal-com-mci-100591741","NCT06984367","A Socio-Technological Intervention in Community-Based Healthcare for Individuals With Mild Cognitive Impairment (DHEAL-COM-MCI)","DHEAL-COM-MCI","Inclusion Criteria:\n\n* diagnosis of Mild Cognitive Impairment;\n* MoCA ranged 21 - 27;\n* Geriatric Depression Scale 5 items (GDS-5items) ≤ 1\n\nExclusion Criteria:\n\n* Use of active implantable or non-implantable medical devices;\n* Nickel allergy;\n* Myocardial infarction or stroke within 6 months;\n* Painful arthritis, spinal stenosis, amputation, painful foot lesions, or neuropathy that limits balance and mobility;\n* Uncontrolled hypertension;\n* Pacemaker or implantable cardioverter defibrillator;\n* Metastatic cancer or immunosuppressive therapy;\n* Significant vision or hearing disturbances.",{"count":358,"type":20},60,[50],"The objectives of the intervention are to counteract the progression of cognitive decline, enhance the intrinsic abilities of users and support the well-being of elderly people with mild cognitive impairment (MCI) through a socio-technical intervention that includes cognitive stimulation, technology and robotics.",[362,26],"Mild Cognitive Impairment",[364,365],"social assistive robotics","technology acceptance",{"date":344,"type":31},{"date":368,"type":31},"2025-04-08",{"date":370,"type":20},"2025-12-31",{"name":349,"class":38},{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":48,"phases":380,"briefSummary":381,"conditions":382,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":390,"locationsCount":69},"100591743","tele-rehabilitation-intervention-in-community-based-healthcare-for-patients-with-parkinsons-disease-dheal-com-pd-100591743","NCT06984393","Tele-Rehabilitation Intervention in Community-Based Healthcare for Patients With Parkinson's Disease (DHEAL-COM-PD)","DHEAL-COM-PD","Inclusion Criteria:\n\n* Suffering from Parkinson's disease: Hoehn \\& Yahr stage I-III;\n* Functional Ambulation Category (FAC) score ≥ 3;\n* Stability of drug treatment for at least 1 month;\n* Maintaining an upright position independently \\> 30\";\n* No acute or untreated health problems;\n* Mini Mental State Examination (MMSE) ≥ 24;\n* Geriatric Depression Score (GDS) \\\u003C 2;\n\nExclusion Criteria:\n\n* Myocardial infarction or stroke within 6 months;\n* Painful arthritis, spinal stenosis, amputation, painful foot lesions, or neuropathy that limits balance and mobility;\n* Uncontrolled hypertension\n* Metastatic cancer or immunosuppressive therapy;\n* Significant visual or hearing impairment.",{"count":79,"type":20},[50],"The study aims to measure the improvement in functional capacity in a group of elderly people suffering from early-stage Parkinson's disease (Hoehn \\& Yahr scale 1-3), following a telerehabilitation intervention integrated with BTS TELEREHAB technology.",[383,26],"Parkinson Disease","2025-05-14",{"date":386,"type":31},"2025-05-22",{"date":388,"type":20},"2025-09-02",{"date":347,"type":20},{"name":349,"class":38},{"id":392,"slug":393,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":397,"eligibilityCriteria":398,"healthyVolunteers":226,"sex":16,"minAge":251,"maxAge":399,"enrollmentInfo":400,"targetDuration":4,"studyType":48,"phases":402,"briefSummary":403,"conditions":404,"keywords":405,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":69},"100589535","the-effects-of-moderate-intensity-cycle-ergometer-vs-treadmill-training-on-physiological-resilience-in-older-adults-100589535","NCT06955676","The Effects of Moderate Intensity Cycle Ergometer vs. Treadmill Training on Physiological Resilience in Older Adults","The Effects of Moderate Intensity, Time-matched Cycle Ergometer vs. Treadmill Exercise Training on Parameters Associated With Physiological Resilience in Older Adults: A Pilot Study","MICeT","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study\n* Participants who are able to perform exercises safely and freely\n* Participants who are 60-80 years old\n\nExclusion Criteria:\n\n* Cardiopulmonary diseases except for well-controlled hypertension and asthma\n* Severe cognitive impairment\n* Joint disorders avoiding exercise participation\n* A recent heart attack, unstable angina, or severe heart failure\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance\n* Participants who are currently engaging in more than 150 min of moderate-intensity exercise per week or 75 min of vigorous-intensity exercise per week (WHO physical activity recommendations)","80 Years",{"count":401,"type":20},36,[50],"Government guidelines suggest that we should all take part in approximately two and a half hours each week of moderate-intensity aerobic exercise. Older adults are particularly important as their overall health may decline as they get older. Therefore, exercising is important especially for older adults to improve heart and muscle health and functioning in carrying out tasks of daily living. The overall effects of aging on the body can make people less likely to withstand challenges to the body - this is termed 'resilience'. Although aerobic exercise is not super easy and requires continuity, it is not extremely difficult to get used to. However, we still do not know if some types of aerobic exercise are better for you than others at improving resilience. Therefore, this study will look at cycling vs walking to see if one is better at improving resilience in older adults who are 60-80 years old. You will be trained on either a treadmill or cycle ergometer and these exercise sessions will be done over 5 weeks, 3 days a week. Each session will last 40 minutes, start with warm-up and end with cool-down sessions. Assessments will include heart, lung, muscle, and memory and thinking measurements, all of which will be taken before and after the intervention period. This work will help us to better understand how we can improve exercise prescriptions for older adults to sustain their health and functioning in their daily life.",[26],[406,407,408,409,410,411],"aerobic exercise","older adults","elderly","resilience","treadmill","cycle ergometer","2025-04-24",{"date":414,"type":31},"2025-05-02",{"date":416,"type":31},"2024-06-01",{"date":418,"type":20},"2026-02-01",{"name":420,"class":38},"University of Nottingham",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":425,"acronym":426,"eligibilityCriteria":427,"healthyVolunteers":11,"sex":16,"minAge":313,"maxAge":4,"enrollmentInfo":428,"targetDuration":4,"studyType":48,"phases":429,"briefSummary":430,"conditions":431,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":69},"100555518","geriatric-assessment-at-discharge-from-the-intensive-care-unit-in-patients-aged-75-years-and-older-a-feasibility-study-100555518","NCT06513130","Geriatric Assessment at Discharge From the Intensive Care Unit in Patients Aged 75 Years and Older: a Feasibility Study","PreGEDI","Inclusion Criteria:\n\n* Patients over 75 years of age\n* Admitted to the intensive care unit, for whatever reason, and having survived their stay, considered as leaving the intensive care unit.\n* Subjects affiliated to a health insurance scheme\n* Able to understand the aims and risks of the research and to give dated, signed informed consent,\n* In the event of confusion on leaving the intensive care unit, a close relative available to give dated, signed informed consent, with the patient's consent collected as soon as his or her condition permits.\n\nExclusion Criteria:\n\n* Protected subject as defined by law: safeguard of justice, guardianship or curatorship procedures\n* Subject moribund, or whose life expectancy as estimated by the clinician in charge is less than 1 month\n* Patient not living in Bas-Rhin (visit to M6)",{"count":19,"type":20},[50],"The number of patients aged over 75 continues to grow, and, according to INSEE, will represent almost 10% of the French population in 2021, an increase of 2.4 points since 2000. This demographic change is also observed in the intensive care units, where admitted patients aged over 80 represent now up to 10-20% of critical care admissions, depending on the facility.\n\nThe admission of these patients remains controversial, with questions about the benefit to elderly patients, both in terms of in-hospital and distant survival, as well as induced morbidity or subsequent quality of life: functional status is impaired in up to two-thirds of survivors.\n\nThe challenge of identifying the patients most able to withstand a stay is a major one. Indeed, a stay in intensive care represents a major stress for the organism, due to the acute condition associated with one or more organ failure(s). Bed rest, immobilization and the use of drugs are responsible for formidable complications in the elderly: muscle-wasting, loss of adaptation to physical effort, loss of autonomy, delirium and agitation, all of which have their own long-term impact.\n\nWhile many studies have looked at the prognostic factors on admission of these patients, and the selection of the patient with the greatest probability of surviving the intensive care unit (ICU), improving the outcome of patients who survive to the ICU stay remains a little-investigated subject. However, the impact of physical and psychological disturbances induced by these patients' stay in intensive care is major, and their detection and management could be elements of interest in improving the care of this population. However, the feasibility of carrying out such an assessment immediately after an ICU stay has yet to be evaluated. The aim of this study would be to evaluate the feasibility of a geriatric assessment at the end of the ICU stay (or within 7 days of discharge) and at 6 months. This study is a prospective, randomized, single-center, open-label interventional study.",[432,433,26,291],"Critical Illness","Geriatric Assessment",{"date":435,"type":31},"2025-04-29",{"date":437,"type":31},"2024-11-01",{"date":439,"type":20},"2027-01-02",{"name":441,"class":38},"University Hospital, Strasbourg, France",{"id":443,"slug":444,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":451,"conditions":452,"keywords":453,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":465},"100585613","underprescribing-in-geriatric-patients-a-prevalence-study-and-analysis-of-factors-contributing-to-potential-prescription-omissions-under-pres-100585613","NCT06904638","Underprescribing in Geriatric Patients: a Prevalence Study and Analysis of Factors Contributing to Potential Prescription Omissions (Under-PRES)","Under-PRES","Inclusion Criteria:\n\n* Geriatric ward admission or outpatient geriatric appointment\n* Capacity to provide informed consent by the patient or legal guardian\n\nExclusion Criteria:\n\n* Limited life expectancy as measured by the Clinical Frailty Scale (CFS) \\>8",{"count":450,"type":20},374,"This observational study will determine the prevalence of underprescription in a cohort of elderly patients, recruited at the time of an outpatient geriatric visit, or hospitalized, upon admission to a geriatric ward.",[26],[454,455,456],"underprescription","START criteria","potential prescriptive omissions","2025-03-25",{"date":459,"type":31},"2025-04-01",{"date":461,"type":31},"2024-06-20",{"date":463,"type":20},"2026-12-31",{"name":349,"class":38},2,{"id":467,"slug":468,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":226,"sex":16,"minAge":251,"maxAge":4,"enrollmentInfo":473,"targetDuration":4,"studyType":48,"phases":475,"briefSummary":476,"conditions":477,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":69},"100584514","a-service-learning-program-for-comprehensive-geriatric-assessment-and-health-promotion-in-older-adults-100584514","NCT06890325","A Service-Learning Program for Comprehensive Geriatric Assessment and Health Promotion in Older Adults","GEROS","Inclusion Criteria:\n\nA) For users:\n\n* Any person aged 60 or older who can move to the facility (Faculty of Health Sciences and Welfare) independently or accompanied by a caregiver.\n\nB) For students:\n\n* Students from Nursing, Physiotherapy, Nutrition and Dietetics, Occupational Therapy and Psychology degrees of UVic-UCC.\n\nExclusion Criteria:\n\n* For users: Individuals institutionalized in a long-term care institution.",{"count":474,"type":20},100,[50],"The GEROS Project aims to develop and implement a Service-Learning (S-L) program that integrates Comprehensive Geriatric Assessment (CGA) and health promotion, for students at the Faculty of Health Sciences and Welfare at the University of Vic - Central University of Catalonia (UVic-UCC). This initiative engages university students, healthcare professionals, and older adults (60+) in a participatory, intergenerational approach that fosters mutual learning and community engagement.\n\nThe study follows a non-experimental mixed-method design, involving students from Nursing, Physiotherapy, Human Nutrition and Dietetics, Occupational Therapy, and Psychology. Participants include older adults (60+) who can independently travel to the university.\n\nThe project is integrated into different subjects, in groups of 4-5 students, participants conduct a Comprehensive Geriatric Assessment (CGA), evaluating frailty using VIG-Frail, intrinsic capacity with ICOPE, quality of life with EUROQOL 5D-5L, and specific health indicators with Nursing Outcomes Classification (NOC).\n\nTo assess the program's effectiveness, several outcome measures will be analyzed including students' perceived knowledge, competencies, and skills, as well as older adults' awareness of their health status, lifestyle, and risk factors. Additionally, the satisfaction levels of both will be evaluated. The items will be evaluated using a 1-5 Likert Scale, and the analysis will be conducted with SPSS. Data recording will be carried out through REDCap.\n\nThe GEROS Project aligns with the United Nations' Sustainable Development Goals (SDGs), specifically SDG 3 (Good Health and Well-being) and SDG 10 (Reduced Inequalities). By offering care to the aging population and providing them with personalized health recommendations, the project promotes preventive strategies, active aging, and intergenerational learning.\n\nFurthermore, GEROS integrates innovative educational methodologies, encouraging experiential learning, collaboration with healthcare professionals, and the development of practical skills in real-world contexts. The program's scalability and adaptability could serve as a model for other universities and healthcare institutions aiming to enhance geriatric care through service-learning initiatives.",[291,26,478,479,480,481,482],"Comprehensive Geriatric Assessment","Health Promotion","SERVICE LEARNING","Students","Student Education","2025-03-19",{"date":485,"type":31},"2025-03-24",{"date":487,"type":31},"2024-11-11",{"date":489,"type":20},"2025-12-20",{"name":491,"class":38},"University of Vic - Central University of Catalonia",{"id":493,"slug":494,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":498,"eligibilityCriteria":499,"healthyVolunteers":11,"sex":16,"minAge":313,"maxAge":500,"enrollmentInfo":501,"targetDuration":4,"studyType":48,"phases":502,"briefSummary":503,"conditions":504,"keywords":506,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":465},"100580834","comprehensive-approach-to-reduce-elderly-functional-decline-in-diabetes-the-cared-study-100580834","NCT06842459","Comprehensive Approach to Reduce Elderly Functional Decline in Diabetes: the CARED Study","Prevention of Functional Decline by Multimodal Intervention in Older Patients With Diabetes","CARED","Inclusion criteria:\n\n* Age ≥75 years;\n* Diagnosis of diabetes mellitus;\n* Functional limitation defined as a Short Physical Performance Battery (SPPB) score between 4 (included) and 9 (included), and\n* Willingness to participate in the study.\n\nExclusion criteria:\n\n* Severe disability in basic activity of daily living (dependency in 3 or more activities),\n* Not being resident in the hospital catchment area; residence in long-term care;\n* Diagnosis of schizophrenia, other psychotic or bipolar disorder, or severe cognitive impairment (MMSE score \\\u003C 21\u002F30);\n* Alcohol abuse (\\> 14 drinks per week);\n* Cancer requiring treatment in the past 3 years, except for non-melanoma skin cancers or cancers that have an excellent prognosis (e.g., the early stage breast or prostate cancer);\n* Respiratory insufficiency requiring regular use of supplemental oxygen;\n* Recent (\\\u003C 6 months) myocardial infarction;\n* Class IV NYHA heart failure;\n* Severe chronic kidney disease (stage V, dialysis);\n* Decompensated liver cirrhosis;\n* Inability or unwillingness to provide informed consent.","110 Years",{"count":47,"type":20},[50],"Importance. Conventionally, treatment goals for diabetic patients primarily target glycemic levels and traditional cardiovascular risk factors (blood pressure, lipids) control to reduce macro- and micro-vascular complications. More recently, the relevance of assessing functional status in older diabetic patients has emerged. A knowledge gap exists regarding the risk of functional dependency in older diabetic patients and on the impact of Comprehensive Geriatric Assessment (CGA) on the achievement of easily calculated and objective patient-centered outcomes.\n\nObjective To investigate if a personalized plan of care base on CGA would reduce the risk of functional decline over time in older patients with diabetes as compared to usual care Design. Individual patient randomized controlled trial comparing intervention with usual care.\n\nSetting. Three hospitals in Cagliari, Ferrara, and Milano, Italy. Participants. One-hundred and eighty diabetic patients aged ≥75 years. Intervention. Usual care for both the Control and Intervention groups will be assured by a diabetologist according to in-use guidelines. After randomization, a geriatrician will administer a thorough CGA to all participants allocated to the intervention groups. CGA will be used to identify specific treatment goals according to the functional status of the patient and to incorporate Patient-preferred outcome in the management of diabetes and comorbidities. Using the results of the CGA the geriatricians along with the attending diabetologist and additional healthcare professionals, if needed, will implement a personalized diagnostic and therapeutic plan of care. Participants in the Control group will receive no additional intervention over and above usual care.\n\nFollow-up. Follow-up visit will be scheduled at 6 and 12 months after randomization.\n\nMain outcome measures. The primary outcome will be represented by the change in physical performance, assessed by change in the Short Physical Performance Battery (SPPB) score over time.\n\nSecondary outcomes will be represented by change in cognitive function, sarcopenia, dependency, glycated hemoglobin levels, and rate of hospitalization as well as Time-at-home.\n\nExpected Results. The CGA-driven intervention applied to older diabetic patients will have significant benefits on functional outcomes as compared to usual care.\n\nImplications. Multimodal intervention in older diabetic patients will significantly impact on the ageing population and allow a novel process to be developed for interventions that produce the maximum disability-free life years lived combined with the highest quality of life for this vulnerable and often neglected group of adults.",[505,26],"Diabetes",[507,264,508,509],"diabetes","geriatric assessment","functional outcomes","2025-02-18",{"date":512,"type":31},"2025-02-24",{"date":514,"type":31},"2025-02-03",{"date":516,"type":20},"2026-10",{"name":518,"class":38},"University of Cagliari",{"id":520,"slug":521,"hasResults":11,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":525,"eligibilityCriteria":526,"healthyVolunteers":226,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":527,"targetDuration":4,"studyType":48,"phases":528,"briefSummary":529,"conditions":530,"keywords":531,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":539,"leadSponsor":541,"locationsCount":69},"100576632","impact-of-a-musical-intervention-in-older-adults-ara-project---armona-recreativa-para-el-adulto-mayor-100576632","NCT06787820","Impact of a Musical Intervention in Older Adults (ARA Project - Armonía Recreativa Para El Adulto Mayor)","Evaluation of the Cognitive and Socioemotional Impact of a Musical Intervention in Older Adults","ARA","Inclusion Criteria:\n\n* Older adults residing in a protected residence.\n* Consent to participate in the study.\n\nExclusion Criteria:\n\n* Physical or cognitive impairments that prevent participation in musical intervention activities.\n* Mild cognitive impairment determined by the GDS-3 scale, reported by the residence therapists.",{"count":79,"type":20},[50],"Currently, the world is facing the challenge of population aging. At this stage of life, various deteriorations, such as cognitive decline, begin to appear, significantly impairing the quality of life. Therefore, it is imperative to seek interventions that can positively impact the life trajectory of older adults. While the cognitive benefits of musical interventions for children and young people are well-documented, there is a lack of evidence regarding their effects on the cognitive and socioemotional well-being of institutionalized older adults.\n\nTo address this, the investigators will conduct a non-randomized clinical trial at Fundación Las Rosas, which operates various homes for the elderly. The trial will involve two groups: a control group and an experimental group. The control group will attend concerts held within the care facility, while the experimental group will participate in a music workshop once a week for three months.\n\nTo evaluate the outcomes, cognitive and socioemotional assessments will be conducted at three points: prior to the musical intervention (baseline), at the end of the intervention period, and one month after the interventions conclude (follow-up). The results will provide valuable insights to support the development and implementation of cost-effective non-pharmacological interventions, specifically musical interventions, to promote well-being in older adults by demonstrating their applicability and effectiveness within the national context. By assessing the intervention's impact on both cognitive and socioemotional dimensions, this study will also contribute to a deeper understanding of how these skills can be developed and promoted among older adults.",[26],[532,533,534],"Music","Elderly persons","Institutionalized","2025-01-20",{"date":537,"type":31},"2025-01-22",{"date":416,"type":31},{"date":540,"type":20},"2025-05-01",{"name":542,"class":38},"University Diego Portales",{"id":544,"slug":545,"hasResults":11,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":551,"targetDuration":4,"studyType":48,"phases":553,"briefSummary":554,"conditions":555,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":69},"100577069","reablement-in-residential-aged-care---a-randomized-controlled-trail-100577069","NCT06793501","Reablement in Residential Aged Care - a Randomized Controlled Trail","A Reablement Intervention in Residential Aged Care (Re-RAC): Study Protocol for a Multi-center, Pragmatic Randomized Controlled, Open-label Trial","Re-RAC","Inclusion Criteria: Older adults aged 65 years and above, residing in a somatic ward at one of the RAC facilities where the study will be conducted, and meeting the inclusion criteria, are eligible to participate in the study. The inclusion criteria require that the older adult must be able to engage in conversations in Swedish and be able to participate in both the assessments and the intervention.\n\nExclusion Criteria: Persons having severe cognitive impairment (≤17) according to Mini Mental State Examination-Swedish version (MMSE-SR; screening for cognitive function) or being very severely frail or terminally ill according to Clinical Frailty Scale (≥8) (CFS-9) will be excluded.",{"count":552,"type":20},84,[50],"Background: The global increase in older adults presents challenges for maintaining health and autonomy in residential aged care (RAC) facilities, where passivity has been shown to often diminish quality of life. However, the reablement approach, which enhances independence through personalized, multidisciplinary strategies, shows promise for addressing these issues and requires further evaluation, particularly in Swedish contexts.\n\nThe research project Reablement in RAC (Re-RAC) aims to evaluate the impact of the Re-RAC intervention on activity performance and satisfaction, participation, quality of life and well-being, and health economic outcomes for older adults in RAC facilities, while also describe participant and staff experiences.\n\nMethods: This study is a multi-center prospective pragmatic randomized controlled trial with two parallel groups that will evaluate the Re-RAC intervention compared to treatment as usual, using quantitative, qualitative and health economic methods.\n\nThe Re-RAC intervention begins with an interview according to Canadian Occupational Performance Measure (COPM) to identify a meaningful goal, followed by a personalized support plan with training activities, supported by nursing staff. The intervention lasts 8 weeks, with adjustments made based on progress, and ends with a COPM reassessment of the participant's performance and satisfaction. Eighty-six participants will be included, assessed for performance (COPM-performance), satisfaction (COPM-satisfaction), health-related quality of life (EQ-5D-5L), psychological well-being (WHO-5), and physical activity levels (measured by an accelerometer), before and after the intervention. Pain will also be assessed for potential associations with other outcomes. Participants' and staff's experiences will be described through interviews, and cost-effectiveness will be evaluated by calculating the cost per quality adjusted life-years gained.\n\nDiscussion: The Re-RAC project evaluates the impact of a reablement intervention on activity performance, satisfaction, quality of life, well-being, and health outcomes for older adults in RAC facilities through a pragmatic randomized controlled trial, with assessments before and after the 8-week intervention. The study also explores participant and staff experiences and evaluates cost-effectiveness. The results of this study will offer valuable insights to inform the future implementation and assessment of reablement interventions in RAC settings.",[26],{"date":557,"type":31},"2025-01-27",{"date":559,"type":31},"2024-10-10",{"date":561,"type":20},"2026-08-31",{"name":563,"class":38},"Region Örebro County",{"id":565,"slug":566,"hasResults":11,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":572,"targetDuration":4,"studyType":48,"phases":574,"briefSummary":575,"conditions":576,"keywords":583,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":591,"lastUpdatePostDateStruct":592,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":598,"locationsCount":600},"100572291","improved-prescribing-for-older-nursing-home-patients-100572291","NCT06731361","Improved Prescribing for Older Nursing Home Patients","Improving Medication Prescription in the contExt of Advance Care Planning for paTients Receiving Long Term nUrSing Home Care","IMPETUS","Inclusion Criteria:\n\nNursing home patients:\n\n* Age 65years and above\n* Living at long term care wards in nursing homes\n* Living at a long term care ward for at least 4 weeks before start of the study\n\nExclusion Criteria:\n\n* Temporary nursing home patients (i.e. geriatric rehabilitation or end-of-life\u002Fhospice care)\n* Life expectancy \\\u003C 4 weeks\n* Life expectancy clearly \\> 1.5 - 2 years (i.e. patients with Huntingtons disease)",{"count":573,"type":20},450,[50],"Research aim:\n\nTo investigate the effect of training health care professionals in medication assessments on the medication use of nursing home residents with a limited life expectancy (\\\u003C 1.5-2 years).\n\nThe core of the training is to tailor medication use to (palliative) treatment goals of nursing home residents.\n\nDesign:\n\nA cluster randomized controlled trial on long term care wards in nursing homes, with the nursing home care organisations as unit of randomisation. The investigators intent to include 6 organisations and 450 nursing home patients. The research starts in september and lasts 1 year and 3 months. Eligible patients are nursing home patients of 65 years and older with a limited life expectancy (\\\u003C 1.5-2 year) of long term care wards.\n\nIntervention:\n\nThe intervention includes a method in which healthcare professionals (medical practitioner, pharmacist and care worker) are trained to tailor medication to the (palliative) treatment goals of nursing home patients with a limited life expectancy. The training consists of 2 components: 1) medication assessment, and 2) advance care planning (ACP). In the intervention group, healthcare professionals receive the training in combination with supporting tools and educational materials, in the control group care continues as normal. The allocation ratio for control and intervention groups is 1:1. A process evaluation will take place simultaneously with the intervention study. Data collection takes place before the start of the intervention (T0), after 6 months (T1) and after 12 months (T2).\n\nOutcome measures:\n\nThe primary outcome measure is potential under- and over-treatment with medication. The secondary outcome measure is experienced involvement in decision-making (measured with a short questionnaire based on the revised PATD (patients' attitude towards deprescribing)). Tertiary outcome measures are: quality of life, deaths, falls, hospital admissions\u002Facute first aid referrals and pain.\n\nDiscussion:\n\nThe intervention is expected to result in a decrease in chronic and preventive medication prescriptions, an increase in medication for symptom treatment and more involvement (and satisfaction) of the nursing home resident in decision-making, without adverse effects.",[577,26,578,579,580,581,582],"Nursing Home Residents","Prescribing","Advance Care Planning","Medication Reviews","Decision Making","Prescribing Practices",[584,585,586,587,588,589,590],"limited life expectancy","ReNeWAL criteria (adjusted STOPP\u002FSTART criteria)","decision making involvement","appropriate prescribing","Cluster randomised trial","Educational intervention","Prescribing practices","2024-12-09",{"date":593,"type":31},"2024-12-12",{"date":595,"type":31},"2024-09-10",{"date":597,"type":20},"2025-12-01",{"name":599,"class":38},"Amsterdam UMC, location VUmc",7,{"id":602,"slug":603,"hasResults":11,"nctId":604,"briefTitle":605,"officialTitle":605,"acronym":4,"eligibilityCriteria":606,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":399,"enrollmentInfo":607,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":609,"conditions":610,"keywords":611,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":69},"100568884","cross-cultural-adaptation-and-psychometric-properties-of-urdu-version-of-fall-risk-questionnaire-100568884","NCT06687031","Cross Cultural Adaptation and Psychometric Properties of Urdu Version of Fall Risk Questionnaire","Inclusion Criteria:\n\n\\-\n\nInclusion Criteria:\n\n* Both male and female gender will be included.\n* Age of the individuals will be 65 to 80 year.\n* Individuals can ambulate without using assistive devices.\n* Individuals can speak Urdu.\n* Individuals can understand the command.\n* Individuals who don't have communication problem.\n* Individuals having mini mental score equal and greater than 24.\n\nExclusion Criteria:\n\nIndividuals with neurological and orthopedic problem that disturb their balance and walking.\n\n* Individuals with cardiovascular problem or uncontrolled hypertension.\n* Individual who are alcoholic or any drug addict.\n* Individuals who undergo chemotherapy or radiotherapy .",{"count":608,"type":20},120,"Fall is an event that result a person coming to rest inadvertently on the ground or floor or other lower level. Fall and fall related injuries are very common in older population. Fall can cause potentially life threatening events that can lead to hospitalization and increase cost and burden on society and even lead to the death. Several tools are use for fall risk assessment but in current study we will use fall risk questionnaire that is translated in many languages that is Arabic, Persian, Brazil Turkish and Chinese but no study has translated the fall risk questionnaire into Urdu language. The objective of current study is to translate the fall risk questionnaire into Urdu to determine its reliability and validity in Urdu speaking older population of Pakistan. .\n\nThe study will be cross sectional in which original English version of questionnaire will be translated into Urdu language using five steps as described by beaten. The study will be conducted at Service hospital Lahore and Mian Munshi District Head Quarter hospital Lahore. In this study sample size of 120 participants is calculated based on previously published guidelines and according to previously described inclusion and exclusion criteria individuals with age 65 or above 65 who can speak and understand urdu will be included and individuals with any neurological or orthopedic problem that disturb their walking and balance will be excluded. For data collection two physiotherapist (assessor A and assessor B) will examine the enrolled individual separately using fall risk questionnaire, time up and go test, berg balance scale, 5 times sit to stand test and the assessor B will conduct examination 2 hours later to check the inter rater reliability .To determine the intra rater reliability assessor A will again conduct the examination after 7 to 10 days. After collection of data the statistical data analysis will be performed of the collected data using SPSS version 21 with p value will be set to be statistically significant at 0.05 to check the reliability and validity of the Urdu version of fall risk questionnaire. Pearson r will show the co relation of fall risk questionnaire with Berg balance scale, time up and Go test and five times sit to stand test and cronbach's value will show the internal consistency and interclass correlation coefficient ICC will assess the test retest reliability of fall risk questionnaire.",[26],[612],"Fall risk questionnaire, Psychometric, Reliability, Translation, Validity,","2024-11-12",{"date":95,"type":31},{"date":616,"type":20},"2024-11-10",{"date":618,"type":20},"2025-07-30",{"name":620,"class":38},"Riphah International University",{"id":622,"slug":623,"hasResults":11,"nctId":624,"briefTitle":625,"officialTitle":626,"acronym":627,"eligibilityCriteria":628,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":629,"targetDuration":4,"studyType":48,"phases":631,"briefSummary":632,"conditions":633,"keywords":635,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":640,"lastUpdatePostDateStruct":641,"startDateStruct":643,"completionDateStruct":645,"leadSponsor":647,"locationsCount":162},"100533341","a-personalized-prevention-program-ppp-based-on-the-comprehensive-geriatric-assessment-cga-for-the-prevention-of-multidimensional-frailty-related-to-non-communicable-chronic-diseases-ncds-in-older-people-100533341","NCT06224556","A Personalized Prevention Program (PPP) Based on the Comprehensive Geriatric Assessment (CGA) for the Prevention of Multidimensional Frailty Related to Non-communicable Chronic Diseases (NCDs) in Older People","A Personalized Prevention Program (PPP) Based on the Comprehensive Geriatric Assessment (CGA) for the Prevention of Multidimensional Frailty Related to Non-communicable Chronic Diseases (NCDs) in Older People: a Practical Approach in Primary Care Setting","PrimaCare_P3","Inclusion Criteria:\n\n* 65 years old and over\n* At least 1 non-communicable chronic disease\n* Signed informed consent\n\nExclusion Criteria:\n\n* not willing in partecipating in the study and no signed informed consent\n* \\\u003C65 years old\n* without non-communicable chronic diseases",{"count":630,"type":20},1216,[50],"* Non-Communicable Diseases (NCDs) can accelerated the aging process and increase the frailty condition\n* The Comprehensive Geriatric Assessment (CGA) is the gold standard in the geriatric clinical context\n* Recently, in Italy the first Guidelines about the CGA in different settings for older people has been pubblicated\n* The CGA can identify older people at high risk of frailty who can benefit from a personalized prevention program\n* No studies has been investigated the effects of a personalized prevention program (PPP) based on the CGA in a primary care setting\n* The main hypothesis is that the CGA assessment can result in personalized prevention programs for older subjects in primary care settings with an effect in reducing the hospitalization rate and can be related to the biological paramters in NCDs",[26,634],"Non-Communicable Chronic Diseases",[636,478,149,637,638,639],"Primary care setting","Non-communicable chronic diseases","Personalized Prevention Program","Saliva collection","2024-08-27",{"date":642,"type":31},"2024-08-28",{"date":644,"type":31},"2024-06-04",{"date":646,"type":20},"2025-05",{"name":648,"class":38},"Alberto Pilotto",{"id":650,"slug":651,"hasResults":11,"nctId":652,"briefTitle":653,"officialTitle":654,"acronym":4,"eligibilityCriteria":655,"healthyVolunteers":226,"sex":16,"minAge":251,"maxAge":4,"enrollmentInfo":656,"targetDuration":4,"studyType":48,"phases":658,"briefSummary":659,"conditions":660,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":672,"locationsCount":69},"100557060","psycho-educational-intervention-programme-for-comprehensive-preparation-for-retirement-study-protocol-100557060","NCT06533202","Psycho-educational Intervention Programme for Comprehensive Preparation for Retirement: Study Protocol","Study Protocol for a Randomised Controlled Trial: Effect of a Psycho-educational Intervention Programme for Comprehensive Preparation for Retirement and the New Phase of Life","Inclusion Criteria:\n\n* Be retired or nearing retirement (within 5 years)\n* Be 60 years of age or older\n* Voluntarily sign the consent form to participate\n* Complete the initial assessment\n\nExclusion Criteria:\n\n* No evidence of literacy difficulties or a significant deficit in language comprehension\n* Not meet any of the inclusion criteria.",{"count":657,"type":20},26,[50],"Background: The transition to retirement can be a challenging event, necessitating the adjustment of new routines, roles and expectations. Such modifications have the potential to impact the individual's quality of life and psychosocial well-being. t is of the utmost importance to develop intervention programmes that prepare people for retirement, with the objective of facilitating a positive and healthy transition.\n\nMethods: A parallel randomised controlled clinical trial with two arms will be conducted. The study will be conducted at the Faculty of Psychology of the University of Salamanca (USAL) in Spain. The study will recruit individuals aged 60 years or older who are already retired or who will retire within the next five years. The participants will be divided into two groups: the intervention group (IG), which will undergo a comprehensive psychoeducational intervention programme, and the control group (CG), which will engage in a controlled follow-up. The programme will comprise 12 sessions over a period of three months. All participants will be assessed at the outset and conclusion of the study, as well as after three months, during which time data regarding their socio-demographic characteristics and responses to the following scales will be collected: The World Health Organization Quality of Life Measure - Brief Version (WHOQOL-BREF), the Retirement Attitudes Scale (EAJ), the Satisfaction With Life Scale (SWLS), the Questionnaire of Stereotypes towards Old Age (CENVE), the Acceptance and Action Questionnaire-II (AAQ-II), the MOS Questionnaire of Perceived Social Support (MOS), the General Health Questionnaire (GHQ), the Generalised Self-Efficacy Scale (EAG) and the Self-Regulation Scale (EAR).\n\nDiscussion: The objective of this study is to enhance the comprehension and implementation of intervention programmes in anticipation of retirement and the subsequent phase of life. To this end, a comprehensive psychoeducational intervention is proposed, with the aim of improving quality of life and attitudes towards retirement, increasing life satisfaction, psychological flexibility, perceived social support and general health, self-efficacy and self-regulation, and reducing stereotypes about ageing. The programme is designed to equip individuals with the skills and knowledge to navigate the challenges and opportunities associated with the transition to retirement.",[661,662,663,664,26,665],"Aging","Adaptation","Psychosocial Factors","Psychology","Retirement","2024-07-29",{"date":668,"type":31},"2024-08-01",{"date":670,"type":20},"2024-09-09",{"date":370,"type":20},{"name":673,"class":38},"University of Salamanca"]