[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"olfaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:olfaction":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100641404","olfactory-transcranial-focused-ultrasound-100641404",false,"NCT07658365","Olfactory Transcranial Focused Ultrasound","Modulation of Olfactory Valence by Transcranial Focused Ultrasound (tFUS)","O-tFUS","Inclusion Criteria:\n\n* Age 18-65 years\n* Healthy adult volunteers\n* Normal olfactory function (Sniffin' Sticks total TDI ≥ 30.75)\n* Ability to provide informed consent\n* English fluency sufficient for task completion\n\nExclusion Criteria:\n\n* MRI or tFUS contraindications (e.g., metal implants, claustrophobia, pregnancy)\n* Sinonasal conditions affecting airflow or smell\n* Current use of medications that alter olfaction\n* Positive urine drug screen",true,"ALL","18 Years","65 Years",{"count":22,"type":23},28,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults. Participants undergo sham and active tFUS targeting the amygdala (AMYG) and ventral striatal olfactory tubercle (VSOT) in a within-subject, randomized, sham-controlled crossover design. Outcomes include subjective odor ratings and objective neurophysiological and behavioral indices of odor valence processing. This research is exploratory and mechanistic in nature and is not intended to evaluate clinical safety or therapeutic efficacy.",[29,30],"Healthy","Olfaction",[32,33,34,35],"healthy volunteer","electroencephalography (EEG)","magnetic resonance imaging (MRI)","odors","NOT_YET_RECRUITING","2026-06-15",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":23},"2026-09-01",{"date":44,"type":23},"2028-04-30",{"name":46,"class":47},"Medical University of South Carolina","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100622614","a-clinical-trial-to-study-the-effects-on-the-olfaction-capacity-of-an-individual-undergoing-skull-base-surgeries-using-cautery-vs-scalpel--100622614","NCT07385911","A Clinical Trial to Study the Effects on the Olfaction Capacity of an Individual Undergoing Skull Base Surgeries Using Cautery vs Scalpel .","Olfactory Outcomes of Cautery Vs Scalpel in Endoscopic Endonasal Skull Base Surgery- A Prospective Randomised Controlled Study.","Inclusion Criteria:\n\n-Patients undergoing endoscopic endonasal skull base surgeries that require the raising of a nasoseptal flap\n\nExclusion Criteria:\n\n* Patients with preoperative anosmia due to any cause.\n* Patients with a previous history of sino-nasal, pituitary, or skull base surgery.\n* Patients with a medical history of neurodegenerative diseases (for example, Alzheimer's disease or Parkinson's disease), chronic rhinosinusitis",{"count":56,"type":23},80,[26],"Olfaction is a prominent entity that determines a person's quality of life. During human evolution, olfaction has played an essential role in determining safe food, assessing threats, and developing social relationships. Endoscopic endonasal surgeries are widely used today for the removal of brain tumors involving the pituitary and skull base. The minimal invasiveness, rapid recovery, better visualization, and lower occurrence of complication make endonasal endoscopic surgery an ideal approach for tumors involving the pituitary and midline skull base. However, the olfactory epithelium is at risk of injury during endoscopic skull base surgeries due to the orientation of the olfactory epithelium fibers.It has been found that the olfactory neuroepithelium extends from the cribriform plate superiorly to the septum for the superior-most 1 to 2 cm medially and onto the upper half of the superior turbinates laterally.It also extends from the face of the sphenoid posteriorly to the attachment of the middle turbinate anteriorly.This makes the olfactory fibers susceptible to injury during endonasal surgery that requires superior or upper limb septal incisions, such as the pedicled nasoseptal flap (the Hadad-Bassagasteguy flap) and modified nasoseptal rescue flap.It has been debated whether using a scalpel instead of cautery could have a differential effect on the olfaction of an individual, as some surgeons believe that the heat generated by a cautery injures the nearby olfactory mucosa.This study aims at determining the method which is better at preserving the olfactory capacity of an individual undergoing endoscopic endonasal skull base surgery.",[30],"RECRUITING","2026-01-27",{"date":63,"type":40},"2026-02-04",{"date":65,"type":40},"2025-05-18",{"date":67,"type":23},"2026-08-31",{"name":69,"class":70},"All India Institute of Medical Sciences, Jodhpur","OTHER_GOV",1]