[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oligomenorrhea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oligomenorrhea":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100577582","treatment-of-menstrual-cycle-alterations-in-adolescents-100577582",false,"NCT06800170","Treatment of Menstrual Cycle Alterations in Adolescents","HP-phD_Adolesc","Inclusion Criteria:\n\n* adolescent women aged 14-19 years old, with at least 3 years passed after menarche, and oligomenorrhea or amenorrhea\n\nExclusion Criteria:\n\n* Primary amenorrhea.\n* Hyperandrogenism due to other factors (i.e. adrenal hyperplasia or Cushing syndrome).\n* Hyperprolactinemia or overt hypothyroidism (TSH ≥4).\n* Other hormonal alterations.\n* Ongoing hormonal therapies, including OCPs, six months before enrollment.\n* Ongoing pharmacological therapies.\n* Ongoing use of myo-Inositol supplement or other source of myo-Inositol, or Dioscorea villosa, six months before enrollment.","FEMALE","14 Years","19 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","the aim of the present study is intended to evaluate how treatment with Myo-Inositol and Dioscorea Villosa can help improve menstrual cycle irregularities in adolescents, both with and without PCOS.",[27,28,29],"Amenorrhea","Oligomenorrhea","PCOS (Polycystic Ovary Syndrome)",[31,32,33],"myo-Inositol","Dioscorea Villosa","adolescents","RECRUITING","2026-01-05",{"date":37,"type":38},"2026-01-06","ACTUAL",{"date":40,"type":38},"2025-06-01",{"date":42,"type":21},"2026-12",{"name":44,"class":45},"Lo.Li.Pharma s.r.l","INDUSTRY",3,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100395092","ovarian-morphology-in-girls-100395092","NCT04424576","Ovarian Morphology in Girls","Trajectory of Ovarian Morphology During the Adolescent Reproductive Transition","OMG","Inclusion Criteria:\n\n* Female adolescents aged 9 to 17 years\n* Menarche within 11 months of the enrollment visit\n* University of Rochester site only: Family history of PCOS (i.e., mother or aunt)\n\nExclusion Criteria:\n\n* Current or recent use of medications or supplements known or suspected to interfere with reproductive or metabolic function in the past 2 months (e.g., contraceptives, metformin, steroids, anti-seizure medications)\n* Untreated and\u002For unstable medical or mental health condition known or suspected to interfere with reproductive or metabolic function\n* Currently pregnant or breast feeding\n* History of ovarian surgery\n* Presence of significant acute or chronic illness which may interfere with study participation",true,"9 Years","17 Years",{"count":59,"type":21},60,"OBSERVATIONAL","Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predictor of normal or abnormal development by following the trajectory of ovarian morphology in conjunction with menstrual cyclicity using 3D transabdominal ultrasound imaging in a prospective cohort study of adolescents. A secondary objective is to identify potential environmental factors such as diet and the gut microbiome which influence the trajectory towards normal or abnormal reproductive development.",[27,28,63],"Puberty",[65,66,67,68,69],"Ovary","Transabdominal Ultrasound","Menarche","Periods","Microbiome","2024-08-08",{"date":72,"type":38},"2024-08-12",{"date":74,"type":38},"2020-01-31",{"date":76,"type":21},"2025-03-31",{"name":78,"class":79},"Cornell University","OTHER"]