[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"onabotulinumtoxina\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:onabotulinumtoxina":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100634133","botulinum-toxin-andor-greater-occipital-nerve-block-for-patients-with-chronic-migraine-100634133",false,"NCT07535723","Botulinum Toxin and\u002For Greater Occipital Nerve Block for Patients With Chronic Migraine","Inclusion Criteria:\n\n* Diagnosis of chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3): headache occurring on ≥15 days per month for more than three months, with at least 8 days per month exhibiting migraine features. (International Headache Society, 2013)\n* Age \\> 18 years\n* Stable preventive migraine regimen for at least two months prior to recruitment\n\nExclusion Criteria:\n\n* Co-morbid other\n* Prior treatment with BoNT-A or GONB for headache within the previous 3 months.\n* Known hypersensitivity to BoNT-A or local anesthetics.\n* Cervical anatomical abnormalities that hinder proper localization of injection sites or compromise the safety of the procedure\n* Neuromuscular junction disorders (e.g., myasthenia gravis).\n* Coagulation disorders or anticoagulant therapy that contraindicates nerve block.\n* Significant psychiatric comorbidity that would impair proper pre and post treatment assessment.\n* Pregnancy.","ALL","18 Years",{"count":18,"type":19},90,"ESTIMATED","INTERVENTIONAL",[22],"NA","Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy.",[25,26,27,28],"Chronic Migraine Headache","OnabotulinumtoxinA","Greater Occipital Nerve Block","Combination Therapy","NOT_YET_RECRUITING","2026-04-15",{"date":32,"type":33},"2026-04-17","ACTUAL",{"date":35,"type":19},"2026-04",{"date":37,"type":19},"2026-12",{"name":39,"class":40},"Beni-Suef University","OTHER"]