[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oncologic-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oncologic-disease":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,64,91,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100644007","outpatient-cancer-patients-the-relationship-between-information-overload-symptom-severity-and-empowerment-level-100644007",false,"NCT07667881","OUTPATIENT CANCER PATIENTS: THE RELATIONSHIP BETWEEN INFORMATION OVERLOAD, SYMPTOM SEVERITY, AND EMPOWERMENT LEVEL","CANCER PATIENT","Inclusion Criteria: Eligibility criteria include having a clinical diagnosis of cancer, having received at least one course of outpatient chemotherapy, and being 18 years of age or older.\n\n\\-\n\nExclusion Criteria: The criteria for eligibility include having a severe mental disorder that could affect the patient's perception and responses, it being the first day of treatment, and the patient being under 18 years of age.\n\n\\-","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","3 Months","OBSERVATIONAL","Examining the relationship between information load, symptom severity, and empowerment level in outpatient cancer patients is of great importance for developing holistic care plans tailored to the individual needs of patients and for planning supportive interventions in oncology nursing.",[25],"Oncologic Disease",[27],"cancer, information overload, symptom management, patient empowerment, nursing","NOT_YET_RECRUITING","2026-06-18",{"date":31,"type":32},"2026-06-25","ACTUAL",{"date":34,"type":20},"2026-07",{"date":36,"type":20},"2026-09",{"name":38,"class":39},"University of Yalova","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":4},"100637608","adapted-physical-activity-apa-following-hospitalization-in-frail-older-adults-100637608","NCT07617714","Adapted Physical Activity (APA) Following Hospitalization in Frail Older Adults","Inclusion Criteria:\n\n* The study is open to individuals aged 65 and older.\n* Current diagnosis or recent history of cancer.\n* Patients currently undergoing treatment (chemotherapy, immunotherapy, targeted therapy) or in follow-up after recent treatment (≤12 months since completion).\n* Functional capacity compatible with participation in an adapted physical activity program, as determined by clinical assessment.\n* Recent hospitalization: Patients must have been discharged following a hospital stay.\n* Frailty: Presence of a significant level of frailty at hospital discharge.\n\nExclusion Criteria:\n\n* Short Physical Performance Battery\\> 10: Patients considered \"robust\" are excluded to maximize the relevance of the intervention.\n* Acute unstable medical condition or contraindication to exercise: Any unstabilized acute condition that makes physical activity dangerous (e.g., acute cardiac complication, ongoing severe infection). Recent major medical events (myocardial infarction, major surgery, bone fracture, or major amputation in the past few weeks) will also be excluded.\n* Severe chronic conditions incompatible with exercise: Severe progressive diseases that prevent safe exercise, such as severe neuromuscular diseases or advanced organ failure (e.g., end-stage renal failure).\n* Short-term life-threatening prognosis: Patients in the terminal phase or with a very limited life expectancy (less than 6 months).\n* Total functional dependence or severe motor impairment: Patients who are completely dependent for basic activities (very low Barthel Index, e.g., \\\u003C20\u002F100) or who are unable to move even minimally (e.g., unable to walk a few steps or stand, even with assistance).\n* Severe cognitive impairment: Severe cognitive impairment (e.g., advanced dementia without the ability to follow simple instructions) that prevents active participation in the program.\n* Severe sensory or communication disorders: Significant sensory impairments-such as profound uncompensated blindness or deafness-or any communication barrier (severe aphasia, language barrier) that prevents participation in the program, unless a caregiver (family member or professional) can be present to ensure safety during the exercises.\n* Institutionalization of the patient: Individuals who do not live in their usual residence are excluded. The study focuses on older adults returning home, as the institutional setting involves different care.\n* Lack of valid informed consent: Any patient who refuses to participate or who cannot provide valid consent (due to lack of legal capacity or understanding) will be excluded.\n* Participation in another concurrent program or trial: Simultaneous participation in another physical exercise program or trial.","65 Years",{"count":48,"type":20},100,"INTERVENTIONAL",[51],"NA","To evaluate the effectiveness of an Adapted Physical Activity (APA) program in improving functional capacity and reducing frailty in older adults following hospital discharge.\n\nThe aim is to determine whether a structured program of personalized exercises improves mobility, strength, and quality of life compared to standard care.",[25],"2026-06-01",{"date":56,"type":32},"2026-06-02",{"date":58,"type":20},"2026-06",{"date":60,"type":20},"2027-12-31",{"name":62,"class":63},"Biobizkaia Health Research Institute","OTHER_GOV",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100632132","dynamic-postoperative-trends-for-early-detection-of-complications-after-gastrointestinal-surgery-100632132","NCT07509710","Dynamic Postoperative Trends for Early Detection of Complications After Gastrointestinal Surgery","CARES III - Dynamic Postoperative Trends for Early Detection of Complications After Gastrointestinal Surgery (DYNAMIC-GI Study): A Snapshot Study","DYNAMIC-GI","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Elective or urgent major GI surgery\n* Availability of postoperative clinical data and at least three postoperative measurements of inflammatory markers to allow identification of trajectory patterns\n\nExclusion Criteria\n\n* Procedures without postoperative monitoring\n* Death within 24 hours of surgery\n* Absence of key postoperative clinical or laboratory data",{"count":73,"type":20},1500,"Postoperative complications after gastrointestinal (GI) surgery remain a major source of morbidity, mortality, prolonged hospitalisation, and healthcare costs. Early identification of complications is essential to reduce the burden of this issue on individual patients and the healthcare system.\n\nIn the immediate postoperative period, clinical parameters and laboratory biomarkers, particularly inflammatory markers such as white blood cell count, C-reactive protein (CRP), and procalcitonin (PCT), may be altered as a result of an evolving surgical complication, but may also reflect the physiological inflammatory response to surgical trauma. In daily clinical practice, clinicians are frequently required to determine when such deviations justify escalation to second-level diagnostic investigations, including computed tomography or invasive procedures, and when continued observation is appropriate. Acting too early may lead to unnecessary investigations, whereas delayed recognition of pathological trends may result in missed opportunities for timely intervention. The vast majority of these decisions are based on clinical experience and on studies focusing on static assessments of biomarkers at specific time points. However, there is a lack of studies evaluating the dynamic trends of these markers over the postoperative period and providing objective measures to guide clinical decision-making.\n\nThe DYNAMIC-GI study is a snapshot study designed to evaluate how the temporal trends of routinely collected clinical and laboratory markers are associated with the development of postoperative complications after elective or urgent GI surgery. It aims to provide solid, objective evidence on the timing, magnitude, and comprehensive evaluation of postoperative markers to improve early risk stratification and inform clinical decision-making in the postoperative setting. Additionally, the study will explore whether specific postoperative inflammatory trajectories may facilitate more rational antimicrobial management, including the safe de-escalation of antibiotic therapy in patients without evidence of evolving postoperative complications.",[25,76],"Urgent Surgery",[78,79,80,81,82],"Postoperative complications","Clinical outcomes","Surgery","Elective surgery","Urgent surgery","2026-03-31",{"date":85,"type":32},"2026-04-03",{"date":36,"type":20},{"date":88,"type":20},"2027-06",{"name":90,"class":39},"Azienda Ospedaliero Universitaria Maggiore della Carita",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":100,"conditions":101,"keywords":106,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100615548","incidence-and-risk-factors-of-post-induction-hypotension-in-geriatric-cancer-patients-100615548","NCT07294040","Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Cancer Patients","A Prospective Observational Study to Determine the Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Oncologic Patients Undergoing General Anesthesia at a Tertiary Oncology Center","Inclusion Criteria:\n\n* Adults ≥65 years of age\n\nPatients with a diagnosis of cancer and scheduled for surgery\n\nAbility and willingness to provide written informed consent\n\nASA physical status class II-IV\n\nExclusion Criteria:\n\nPatients under 65 years of age\n\nPatients without a confirmed oncologic diagnosis\n\nRefusal to provide written informed consent\n\nPatients undergoing regional anesthesia\n\nPatients with tracheostomy or requiring multiple intubation attempts\n\nHistory of peripheral arterial disease\n\nUse of vasopressors before the start of surgery\n\nUncontrolled hypertension (blood pressure \\>180\u002F110 mmHg)\n\nAdvanced heart failure (Ejection Fraction \\\u003C40%)\n\nSevere arrhythmias such as atrial fibrillation or significant ventricular arrhythmias that preclude reliable hemodynamic monitoring",{"count":99,"type":20},140,"This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia. PIH is defined as a drop in mean arterial pressure of ≥30% from baseline or below 65 mmHg within the first 20 minutes after anesthesia induction, prior to surgical stimulation.\n\nThe primary objective is to determine the frequency of PIH in elderly oncology patients. Secondary objectives include evaluating the association of PIH with age, ASA score, cancer type, oncological treatments (chemotherapy\u002Fradiotherapy), comorbidities, medication use, anemia, biochemical parameters, and preoperative perfusion index (PI) and pleth variability index (PVI).\n\nFindings from this study are expected to contribute to improved perioperative management and to the development of tailored anesthesia protocols for geriatric oncology patients.",[102,103,25,104,105],"Post-induction Hypotension (PIH)","Geriatric Patient","Hemodynamic Effects of General Anesthesia","Risk Factors Associated With Anesthesia-Induced Hypotension",[107,108,109,110,111,112,113],"Post-induction Hypotension","Perfusion Index (PI)","Pleth Variability Index (PVI)","geriatric patient","Oncologic Patients","General Anesthesia","Hemodynamics","RECRUITING","2025-12-07",{"date":117,"type":32},"2025-12-19",{"date":119,"type":32},"2025-05-25",{"date":121,"type":20},"2026-05-25",{"name":123,"class":39},"Dolunay ARIK",1,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":49,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100539465","molecular-characterizazion-and-biological-samples-centralisation-of-patients-affected-by-oncoematolofic-pathology-100539465","NCT06304194","Molecular Characterizazion and Biological Samples Centralisation of Patients Affected by Oncoematolofic Pathology","Pilot Study to Assess the Feasibility of Centralizing Biological Samples at Onset and Relapse of Patients Referred to CROP Centers for Molecular Characterization of Oncohematologic Pathology","Inclusion Criteria:\n\n* Diagnostic suspicion of oncologic, hematologic or onco-immunologic disease\n* Suspected recurrence of oncological, onco-hematological, hematological or onco -immunological disease\n* Availability of biological material\n* Signature of informed consent\n* Age between 0 and 30 years\n\nExclusion Criteria:\n\n* Failure to sign the consent\n* Insufficiency of biological material for analysis\n* Patients with HIV, HCV and HBV seropositivity (HBSAg) due to biohazard and bias related to patients' immunological status that could influence gene expression and tumor behavior.","0 Years","30 Years",{"count":135,"type":20},340,[51],"Currently, the molecular characterization of onco-hematological, onco-immunological and hematological diseases, at onset or in relapse, of patients with suspected diagnosis afferent to the CROP centers, is done through centralization of biological samples at reference laboratories outside the Tuscany Region.\n\nIn order to preserve the wealth of clinical and biological data and use it for the benefit of present and future patients treated at the CROP centers, it is useful to evaluate the feasibility of centralization and molecular typing of mutations present in tumor tissue at the IRCCS AOU Meyer Oncohematology Laboratories and subsequently the analysis of clinical data from patients with diseases not under study to lay the foundations of a translational database that can then be associated with a biobank in the future.\n\nThis will enable a targeted contribution to pediatric oncohematology research, investing in possible targeted therapies with those patient subgroups that benefit from personalized disease assessment in mind. The goal of the project is to improve the regional infrastructure dedicated to organized data collection and management of biological samples in adequate time resulting in better and more comprehensive data collection.",[25,139],"Hematologic Diseases","2024-03-04",{"date":142,"type":32},"2024-03-12",{"date":144,"type":32},"2023-07-05",{"date":146,"type":20},"2028-07-05",{"name":148,"class":39},"Meyer Children's Hospital IRCCS",3]