[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oncology-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oncology-pain":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,57,88],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100613134","developing-a-multimodal-cancer-pain-database-to-support-ai-based-automatic-pain-assessment-100613134",false,"NCT07262632","Developing a Multimodal Cancer Pain Database to Support AI-Based Automatic Pain Assessment","SENSAI: Seeing, hEaring, seNsing: Smart, Effortless and Objective Pain Assessment With Mobile AI Technology - DataBase Development","SENSAI-DBD","Inclusion Criteria:\n\n* Adult patients (≥18 years)\n* Diagnosed with cancer, active\n* Able to communicate verbally in Dutch or English\n* Able to provide written informed consent.\n* Pain group specific:\n* Experiencing pain related to cancer\n* Admitted to the hospital due to pain\n* Control group specific:\n* Not experiencing pain (NRS = 0)\n* Admitted to the hospital for chemotherapy\n\nExclusion Criteria:\n\n* Cognitive, physical, or medical limitations that prevent participation in the audiovisual recording sessions or affect facial expressions or voice (e.g. facial paralysis, tracheostomy, severe speech impairment).\n* Critical illness or end-of-life care where participation would impose an additional burden.\n* Experiencing pain not associated with cancer\n* Infectious isolation precautions that prevent safe data collection","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","3 Weeks","OBSERVATIONAL","The goal of this observational study is to collect short video and sound recordings of people with cancer to create a secure database that can be used in future research to develop an artificial intelligence (AI) tool for pain assessment. The main aim is to build a large, high-quality collection of audiovisual data showing how people with cancer express themselves when they do and do not have pain.\n\nParticipants will include adults with cancer who are admitted to the oncology ward for pain treatment and a control group admitted for chemotherapy who have no pain. After giving consent, participants will:\n\n* Be recorded on video (from the shoulders up) for up to 60 seconds while reading a short sentence and describing their pain or daily experience.\n* Complete a short questionnaire about their mood and pain expression.\n* Allow researchers to collect some information from their medical record, such as their pain score, medications, and cancer type.\n\nThese recordings will be securely stored and used to create a database for future AI research. No medical tests, new treatments, or extra hospital visits are involved. This study will provide the foundation for developing future AI-based tools that could support doctors and patients in monitoring and managing pain more accurately and easily.",[26,27,28,29,30,31,32,33,34],"Cancer-related Pain","Pain Assessment","Artificial Intelligence (AI)","Oncology","Oncology Pain","Database","Facial Expression","Voice","Cancer",[26,36,28,29,30,31,37,38,39,40,41,42,43],"Pain assessment","Facial Action Unit","Vocalizations","Acoustic","Automatic assessment","Machine learning","Audiovisual data","Paralinguistics","RECRUITING","2026-03-10",{"date":47,"type":48},"2026-03-11","ACTUAL",{"date":50,"type":48},"2025-12-01",{"date":52,"type":21},"2027-12-31",{"name":54,"class":55},"Dr. Mark Mulder","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100584053","spinal-palliation-in-irradiation-for-neoplastic-analgesia-and-life-quality-100584053","NCT06884332","Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality","Étude de Non infériorité Sur l'Impact de la Diminution Des Volumes d'Irradiations vertébraux en Cas d'Irradiation Palliative Rachidienne métastatique Osseuse Sur l'efficacité Antalgique","SPINAL","Inclusion Criteria:\n\n* Patient with bone pain related to at least 1 or more bone metastases of spinal location, contiguous or not, cervical (excluding C1), thoracic, lumbar or sacral up to and including S2; a patient can be included even if he or she is irradiated concomitantly or not for analgesic purposes on another non-spinal bone metastatic site. Bone lesions are objective on an imaging examination less than 3 months old: CT and\u002For MRI and\u002For PET and\u002For bone scintigraphy;\n* Patient with at least moderate pain with EN ≥ 5;\n* Patient on analgesic drug treatment for at least 7 days or poor tolerance of analgesics;\n* Patient irradiated for palliative analgesic purposes. Post-cementoplasty irradiation is possible; an extension to the soft tissues is not a contraindication to inclusion;\n* Patient with a validated palliative bone irradiation plan: 8 Gy \u002F 1 fr or 20 Gy \u002F 5 fr;\n* Patient with planning only in static IMRT, arc therapy or helical tomotherapy;\n* Patient with a primary cancer or a haemopathy;\n* Patient currently undergoing or not a specific oncological systemic treatment, left to the discretion of the investigating physician;\n* Patient currently undergoing or not a treatment with bisphosphonates and denosumab, left to the discretion of the investigating physician;\n* WHO ≤ 2;\n* Patient with a life expectancy ≥ 3 months;\n* Patient able and agreeing to follow all study procedures in accordance with the protocol;\n* Patient having understood, signed and dated the consent form;\n* Patient affiliated to the social security system.\n\nExclusion Criteria:\n\n* Pediatric patient;\n* Patient undergoing stereotaxic irradiation;\n* Patient undergoing oligometastatic disease;\n* Patient undergoing re-irradiation unless the dose is not limiting to OARs;\n* Patient treated with RT2D (conventional 2-dimensional radiotherapy) or RT3D (conventional 3-dimensional radiotherapy);\n* Patient with MESCC (metastatic epidural spinal cord compression) except for a Bilsky grade \\\u003C 1b;\n* Patient who does not have a means of responding to online questionnaires;\n* Patient and their entourage who cannot read or express themselves in French;\n* Visually impaired patient;\n* Patient already included in another therapeutic trial with an experimental molecule;\n* Persons deprived of liberty or under guardianship (including curatorship).\n* Pregnant woman, likely to be pregnant, or breastfeeding",{"count":66,"type":21},598,"INTERVENTIONAL",[69],"NA","The goal of this clinical trial is to assess the impact of reducing the volume of palliative metastatic bone irradiation on analgesic effectiveness at day 30 and to evaluate the efficiency of telemonitoring in identifying patients who could benefit from Patient-Reported Outcomes (PROs) and require care.\n\nThese objectives will be addressed in a multicenter, randomized, prospective study with two arms:\n\nA standard arm with spinal irradiation without sparing the adjacent vertebrae. An experimental arm with spinal irradiation sparing the adjacent vertebrae. The results will determine whether reducing the irradiated volume can maintain effective pain relief while minimizing side effects.",[72,30],"Bone Metastasis",[74,75,76,77],"Bone metastasis","Irradiation","Palliative","Analgesic","2025-09-22",{"date":80,"type":48},"2025-09-23",{"date":82,"type":48},"2025-07-02",{"date":84,"type":21},"2029-01-02",{"name":86,"class":55},"Institut de Cancérologie de Lorraine",4,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":17,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100576855","paediatric-breakthrough-pain-assessment-100576855","NCT06790719","Paediatric Breakthrough Pain Assessment","Development and Validation of a Paediatric Breakthrough Pain Assessment Tool","BEACON","Inclusion Criteria:\n\n* Children and young people aged 8-25 years who have experienced 1) background pain related to a life limiting or life threatening condition and 2) around-the-clock analgesia prescribed for the previous week, as confirmed by their healthcare team (Studies 1, 2, and 3).\n* Children and young people must be able to communicate and read in English at a level close to, or in line with their chronological age.\n* For study 1, non-verbal children and young people, or those with limited verbal ability, will be recruited if they are happy to participate using the Microsoft Teams chat function.\n* Parents and caregivers of children and young people aged 3-month-25-years who have experienced 1) background pain related to a life limiting or life threatening condition and 2) around-the-clock analgesia prescribed for the previous week, as confirmed by their healthcare team. (Studies 1, 2, and 3).\n* Caregivers can be caring for verbal, non-verbal, or pre-verbal children with or without cognitive or developmental difficulties of any level.\n* Parents and caregivers must have self-reported full or partial responsibility for assessing the child or young person's pain.\n* Healthcare professionals in primary, secondary and tertiary care who are involved in the care of children and young people with life limiting or life threatening conditions (Studies 2 and 3).\n\nExclusion Criteria:\n\n* • Children, young people, parents and caregivers with limited ability to communicate and read in English.\n\n  * Children and young people judged by caregivers or healthcare professionals to lack capacity to take part, who are too unwell, or might find it too distressing.\n  * Parents and caregivers judged by healthcare professionals to lack capacity to consent, or to be 'struggling' too much. However, if they wish to take part, they can send an email or text message to the study email account or mobile phone.",true,"8 Years","99 Years",{"count":100,"type":21},210,"Many children and young people with life-limiting and life-threatening illnesses get sudden bursts of pain called breakthrough pain. At the moment, there aren't any good ways to measure this pain in children and young people. The investigators are developing two questionnaires to help: one for patients to fill out themselves and another for parents or healthcare professionals to complete for younger children and young people who cannot explain their pain for themselves.\n\nThe investigators plan to work with 210 people across hospitals and hospices in England and Wales. This includes children and young people with life-limiting and life-threatening illnesses, their caregivers, and healthcare professionals. The investigators have already made a first version of the questionnaires.\n\nThe project has three main Studies:\n\nIn Study 1, the investigators will talk to 5-10 young patients and 5-10 caregivers about their experiences with breakthrough pain. The investigators will use their feedback to improve the questionnaires.\n\nIn Study 2, the investigators will ask 5-10 patients, 5-10 caregivers, and 5-10 healthcare professionals to fill out the questionnaires while speaking their thoughts out loud. This will help the investigators find any parts that are confusing or difficult to understand.\n\nIn Study 3, the investigators will test how well the questionnaires works. 80 patients, 40 caregivers, and 40 healthcare professionals will complete the questionnaires three different times to make sure they measure breakthrough pain as accurately as possible.\n\nThese questionnaire will be useful for hospitals and hospices across England and Wales to help them better manage pain, including breakthrough pain, in patients aged 3 months to 25 years who have life-limiting and life-threatening illnesses.",[103,104,30,105,106],"Breakthrough Pain","Palliative Medicine","Pediatric ALL","Young People",[108,109,110,111,112],"Breakthrough pain","paediatrics","paediatric pain","palliative care","pain assessment","NOT_YET_RECRUITING","2025-01-17",{"date":116,"type":48},"2025-01-24",{"date":118,"type":21},"2025-01-20",{"date":120,"type":21},"2025-12",{"name":122,"class":55},"University of Southampton"]