[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"one-lung-ventilation-olv\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:one-lung-ventilation-olv":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,82,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100622761","individualized-open-lung-ventilation-and-postoperative-pulmonary-complications-in-thoracic-surgery-100622761",false,"NCT07387822","Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery","Effect of Individualized Versus Standardized Open-Lung Ventilation on Postoperative Pulmonary Complications in Thoracic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Body mass index between 18 and 30 kg\u002Fm².\n* Scheduled for elective video-assisted thoracoscopic surgery (VATS).\n* Expected duration of one-lung ventilation longer than 1 hour.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Emergency surgery or reoperation.\n* History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma.\n* History of heart failure or coronary artery disease.\n* Previous thoracic surgery or mechanical ventilation within 1 month before surgery.\n* Planned postoperative mechanical ventilation.\n* Bilateral thoracic surgery.\n* Participation in another interventional clinical trial.\n* Conversion to open thoracotomy during surgery.","ALL","18 Years","75 Years",{"count":20,"type":21},352,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative \"Individualized Open Lung Ventilation\" strategy compared to a standard lung-protective ventilation strategy in patients undergoing thoracic surgery.\n\nOne-lung ventilation (OLV) is essential for thoracic surgery but can cause lung injury. While standard care often uses fixed ventilation parameters, this study investigates whether personalizing Positive End-Expiratory Pressure (PEEP) to achieve the lowest driving pressure can reduce the incidence of postoperative pulmonary complications (PPCs) within 7 days after surgery.",[27,28,29],"Postoperative Pulmonary Complications (PPCs)","One-lung Ventilation (OLV)","Thoracic Surgery, Video Assisted",[31,32,33,34,35,36],"Individualized Open Lung Ventilation","Driving Pressure","PEEP Titration","Lung Recruitment Maneuver","Lung Protective Ventilation","Video-Assisted Thoracic Surgery","NOT_YET_RECRUITING","2026-01-30",{"date":40,"type":41},"2026-02-04","ACTUAL",{"date":43,"type":21},"2026-02-10",{"date":45,"type":21},"2026-05-10",{"name":47,"class":48},"Aerospace Center Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":49},"100623088","comparison-of-fcv-and-vcv-in-one-lung-ventilation-100623088","NCT07392086","Comparison of FCV and VCV in One-Lung Ventilation","Comparison of the Effects of Flow-Controlled Ventilation (FCV) and Volume-Controlled Ventilation (VCV) on Respiratory Mechanics and Gas Exchange During One-Lung Ventilation: A Multicenter Prospective Observational Study (FCVOLVent)","FCVOLVent","Inclusion Criteria Adult patients aged 18 years and older Patients undergoing thoracic surgery requiring one-lung ventilation (OLV) Requirement for one-lung ventilation for at least 30 minutes American Society of Anesthesiologists (ASA) physical status I-III Provision of written informed consent Patients ventilated with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine clinical practice\n\nExclusion Criteria Requirement for emergency surgery History of untreated asthma High pulmonary risk, defined as predicted postoperative FEV₁ \\\u003C 20 mL\u002Fkg in males and \\\u003C 18 mL\u002Fkg in females High cardiac risk, including advanced cardiomyopathy with left ventricular ejection fraction \\\u003C 30% Body mass index (BMI) \\> 35 kg\u002Fm² Contraindication to total intravenous anesthesia (TIVA) Evidence of pulmonary infection prior to surgery Presence of other significant pulmonary pathologies (e.g., tuberculosis, bullous lung disease, bronchiectasis) Severe COPD (GOLD stage III-IV) or significant restrictive lung disease Age \\\u003C 18 years or \\> 80 years, or pregnancy ASA physical status IV or higher Uncontrolled arrhythmia or history of myocardial infarction within the past 3 months Inability to provide informed consent","80 Years",{"count":60,"type":21},60,"1 Year","OBSERVATIONAL","One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters remain an important clinical concern.\n\nFlow-controlled ventilation (FCV) is a newer ventilation mode that allows precise control of inspiratory and expiratory flow, potentially improving lung mechanics and gas exchange. Volume-controlled ventilation (VCV) is a widely used conventional ventilation strategy during thoracic anesthesia.\n\nThe FCVOLVent study is a multicenter, prospective observational study designed to compare the effects of FCV and VCV during one-lung ventilation in adult patients undergoing thoracic surgery. Patients will be ventilated with either FCV or VCV as part of routine clinical practice.\n\nThe study aims to evaluate respiratory mechanics and oxygenation parameters, including the PaO₂\u002FFiO₂ ratio, airway pressures, lung compliance, and mechanical power during surgery. Data will be collected at predefined time points during one-lung ventilation.\n\nThe results of this study are expected to provide real-world clinical evidence on the potential advantages and limitations of flow-controlled ventilation compared with volume-controlled ventilation during one-lung ventilation.",[28,65,66],"Thoracic Surgery","Respiratory Mechanics",[68,69,70,71],"Flow-Controlled Ventilation","Thoracic Anesthesia","Volume-Controlled Ventilation","One-Lung Ventilation","RECRUITING","2026-01-29",{"date":75,"type":41},"2026-02-06",{"date":77,"type":41},"2026-01-01",{"date":79,"type":21},"2026-12-01",{"name":81,"class":48},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":49},"100622276","correlation-of-oxygenation-and-saturation-indices-in-one-lung-ventilation-100622276","NCT07381517","Correlation of Oxygenation and Saturation Indices in One-Lung Ventilation","Correlation Between Oxygenation Indices (OI and Their Derivatives) and Oxygen Saturation Indices (OSI and Their Derivatives) During One-Lung Ventilation in Thoracic Surgery","OLV-INDICES","Inclusion Criteria:\n\n* Patients aged 18 years and older\n* Patients classified as ASA physical status I-III\n* Patients scheduled for elective thoracic surgery requiring one-lung ventilation for at least 1 hour intraoperatively\n* Patients in whom simultaneous arterial blood gas analysis and continuous SpO₂ monitoring can be performed\n* Patients who have provided written informed consent\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* Patients younger than 18 years of age\n* Patients classified as ASA physical status IV or higher\n* Patients with a history of previous thoracic surgery\n* Patients with a body mass index (BMI) \\>40 kg\u002Fm² or \\\u003C18 kg\u002Fm²\n* Patients with advanced chronic lung disease (COPD stage III-IV)\n* Patients with New York Heart Association (NYHA) class III-IV heart failure\n* Patients undergoing surgery due to pleural effusion",{"count":91,"type":21},51,"One-lung ventilation is commonly used during thoracic surgery but is frequently associated with impaired oxygenation and altered respiratory mechanics. Traditional oxygenation indices require arterial blood gas analysis and do not fully reflect the mechanical stress applied to the lungs.\n\nThis prospective observational study aims to evaluate the correlation between oxygenation indices and oxygen saturation indices during one-lung ventilation in adult patients undergoing elective thoracic surgery. Modified indices incorporating driving pressure and mechanical power will also be assessed.\n\nNo intervention beyond standard clinical care will be applied. The findings of this study may help clarify the clinical utility of non-invasive oxygenation indices for intraoperative monitoring during one-lung ventilation.",[28],[71,95,96,32,97,65],"Oxygenation","Oxygen Saturation Index","Mechanic Power","2026-01-25",{"date":100,"type":41},"2026-02-02",{"date":102,"type":21},"2026-02-09",{"date":104,"type":21},"2026-08-09",{"name":106,"class":107},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":115,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":129,"leadSponsor":131,"locationsCount":49},"100607626","the-role-of-existing-formulas-in-the-double-lumen-tube-in-thoracic-surgery-anesthesia-100607626","NCT07191002","The Role of Existing Formulas in the Double-lumen Tube in Thoracic Surgery Anesthesia","The Role of Existing Formulas and Airway Measurements in Determining the Appropriate Placement Depth of the Double-lumen Tube in Thoracic Surgery Anesthesia: a Prospective Observational Study","Inclusion Criteria:\n\n* Patients older than 18 and younger than 80 years\n* Patients who will undergo surgery under general anesthesia and be intubated with a left DLT\n* Patients with an American Society of Anesthesiologists (ASA) score of I-II-III\n* Patients with a body mass index (BMI) between 18-40 kg\u002Fm²\n* Patients who provide informed consent\n\nExclusion Criteria:\n\n* Patients requiring right DLT placement\n* Patients with ASA score IV and above\n* Patients intubated with a single-lumen tube\n* Patients in whom lung isolation will be achieved with a method other than DLT\n* Emergency cases\n* Patients younger than 18 or older than 80 years",{"count":116,"type":21},30,"In most clinical scenarios, left DLT is preferred for one-lung ventilation because of its anatomical ease of placement; these tubes allow separate ventilation of both lungs. If the DLT is not placed in the proper size and depth, it may result in repeated intubation attempts, airway and dental trauma, failed lung isolation, tube dislodgement, and various unwanted events such as hypoxemia.\n\nThe first and most common method for correct placement of a DLT is the conventional technique, blindly advanced into the left main bronchus, and then confirmed with fiberoptic bronchoscopy (FOB). In this method, the depth at which the tube should be left before performing FOB is left to the clinician's experience. Generally, the DLT is advanced in the trachea until a slight resistance is felt. This may lead to excessive advancement of the DLT into the left main bronchus or premature resistance due to the tube tip touching the carina, causing the clinician to stop before entering the left main bronchus. Therefore, just as selecting the correct size of the DLT is crucial, correctly estimating the appropriate depth is also of great importance. For this reason, different formulas have been proposed in the literature, and new formulas are still being investigated.\n\nThe patient's gender and height are determinant in selecting the appropriate size of the DLT. However, studies in the literature indicate that the accuracy of these formulas may be limited in Asian populations. Therefore, it is important to evaluate the applicability of these formulas in different populations and, if necessary, develop new formulas. In the Turkish population as well, verifying the accuracy of these formulas for determining the proper size and depth of DLT-and if needed, developing new recommendations and formulas-holds clinical importance.\n\nIn this study, conducted at Ankara Atatürk Sanatorium Training and Research Hospital, the aim is to evaluate the accuracy of six different formulas available in the literature for predicting DLT depth in patients undergoing thoracic surgery. Additionally, the correlations between DLT depth and demographic parameters as well as external airway measurements (mouth opening, sternomental distance, thyromental distance, distance between the mentum and manubrio-sternal angle, distance between tragus and manubrio-sternal angle, distance between sternal angle and xiphoid process) will be analyzed. Furthermore, challenges during DLT application, malposition rates and types, and complications will be assessed.\n\nThe primary objective of this study is to evaluate, in patients undergoing thoracic surgery at Ankara Atatürk Sanatorium Training and Research Hospital, how accurate and applicable six different formulas defined in the literature are for predicting the placement depth of the DLT. If the existing formulas are insufficient, the aim is to develop a new formula.",[119,28,69],"Double-lumen Tube",[121,122,123,71,124,69],"Double-Lumen Tube","Fiberoptic Bronchoscopy","Airway Measurements","Tube Placement Depth","2025-09-29",{"date":127,"type":41},"2025-10-02",{"date":125,"type":41},{"date":130,"type":21},"2026-03-30",{"name":106,"class":107}]