[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"one-lung-ventillation-olv\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:one-lung-ventillation-olv":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,81,112,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100638234","hyperangulated-vs-standard-videolaryngoscopy-vs-direct-laryngoscopy-for-double-lumen-endobronchial-tube-intubation-100638234",false,"NCT07614529","Hyperangulated vs Standard Videolaryngoscopy vs Direct Laryngoscopy for Double-Lumen Endobronchial Tube Intubation","Evaluation of Efficacy and Safety of Hyperangulated and Standard Curvature Blade Video Laryngoscopy Versus Direct Laryngoscopy for Double-Lumen Endobronchial Tube Intubation","Inclusion Criteria:\n\n* Age 18 years or older\n* Written informed consent obtained prior to surgery\n* ASA physical status class I, II, or III\n* Scheduled for elective thoracic surgery requiring one-lung ventilation and double-lumen endobronchial intubation\n\nExclusion Criteria:\n\n* Age under 18 years\n* Refusal or inability to provide informed consent\n* ASA physical status class IV or above\n* Emergency surgery\n* Anticipated difficult airway, defined by any of the following: Mallampati score 4, thyromental distance less than 6.5 cm, restricted mouth opening, or BMI greater than 30 kg\u002Fm²\n* History of upper airway surgery\n* Significant upper airway obstruction or stridor\n* Pregnancy","ALL","18 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, randomized, single-center, three-arm, open-label, low-risk medical device clinical study conducted at the Department of Anesthesiology and Reanimation, Trakya University Medical Faculty.\n\nThe study aims to compare the efficacy, safety, and clinical usability of three laryngoscopy methods for double-lumen endotracheal tube (DLT) intubation in patients undergoing elective thoracic surgery requiring one-lung ventilation: (i) C-MAC hyperangulated (D-blade) videolaryngoscopy, (ii) C-MAC Macintosh blade videolaryngoscopy, and (iii) direct Macintosh laryngoscopy.\n\nThe primary outcome is the total time to successful DLT placement (in seconds), defined as the interval from the end of mask ventilation to fiberoptic bronchoscopic confirmation of correct tube position. Secondary outcomes include glottic visualization quality (POGO score and Cormack-Lehane grade), intubation difficulty (Intubation Difficulty Scale), number of intubation attempts, need for auxiliary maneuvers, intubation-related complications, malposition rate, and postoperative airway symptoms (sore throat, dysphonia) assessed at 1, 6, and 24 hours postoperatively.\n\nEligible patients are adults (≥18 years), ASA class I-III, scheduled for elective thoracic surgery requiring one-lung ventilation. Patients with anticipated difficult airway, emergency surgery, pregnancy, or prior upper airway surgery are excluded. A total of 180 patients will be enrolled and randomized 1:1:1 into three groups (60 per group) using computer-generated block randomization.",[26,27,28,29],"Endobronchial Intubation","Double Lumen Tube Intubation","Thoracic Surgery","One Lung Ventillation (OLV)",[31,32,33,34,35,36],"double-lumen endotracheal tube","videolaryngoscopy","direct laryngoscopy","C-MAC","thoracic anesthesia","one-lung ventilation","NOT_YET_RECRUITING","2026-05-28",{"date":40,"type":41},"2026-05-29","ACTUAL",{"date":43,"type":20},"2026-05-15",{"date":45,"type":20},"2029-01-15",{"name":47,"class":48},"Trakya University","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":59,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100621573","association-of-different-tidal-volumes-and-postoperative-pulmonary-complications-100621573","NCT07372378","Association of Different Tidal Volumes and Postoperative Pulmonary Complications","Association of Various Introperative Tidal Volumes and Postoperative Pulmonary Complications After Video-assisted Thoracic Surgery","Inclusion Criteria:\n\n* Age \\> 50 years.\n* ASA physical status I-II.\n* The cardiopulmonary and other vital organ functions are basically normal, and the patient is able to tolerate surgery.\n* Ariscat score \\> 26.\n* Informed consent has been obtained.\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the clinical trial, or have cognitive impairment or impaired ability to understand and express themselves.\n* ASA physical status ≥ III.\n* Patients with congestive heart failure, severe aortic stenosis, or extensive pleural adhesions.\n* Patients with severe psychiatric disorders or allergy to anesthesia-related medications.\n* Patients with severe organ dysfunction such as the liver or kidney dysfunction.","51 Years",{"count":58,"type":20},650,"7 Days","OBSERVATIONAL","The incidence of lung cancer in China is increasing year by year. Currently, the treatment primarily based on video-assisted thoracoscopic surgery (VATS) is still considered the optimal approach for early-stage non-small cell lung cancer. The widespread application of traditional one-lung ventilation (OLV) technology not only achieves effective lung isolation, but also facilitates exposure of the surgical field during thoracoscopic surgery, making it more convenient for surgeons to operate. However, the occurrence of hypoxemia during one-lung ventilation may pose a risk to patient safety.\n\nOne-lung ventilation can lead to increased intrapulmonary shunt, ventilation\u002Fperfusion (V\u002FQ) mismatch, and ischemic-hypoxic lung injury. Hypoxemia is the major problem during one-lung ventilation. Postoperative pulmonary complications (PPCs) are among the major complications following thoracic and general anesthesia surgeries, including atelectasis, pneumonia, and respiratory failure, which significantly prolong hospital stay and increase mortality.\n\nLow tidal volume lung-protective ventilation strategies have been widely implemented. Additionally, permissive hypercapnia, reducing peak airway pressure to minimize barotrauma, and decreasing FiO₂ all help reduce pulmonary complications.Recently, researchers have focused on optimizing ventilation strategies during OLV, such as using PEEP or low VT ventilation alone or in combination, or exploring different combinations of tidal volume and respiratory frequency under consistent minute ventilation (VE), aiming to balance lung protection and oxygenation, reduce complications, and improve patient outcomes.\n\nHowever, to date, there is still no gold standard tidal volume ventilation strategy for reducing pulmonary complications in patients undergoing lung resection.",[63,64,65,29,66],"Pulmonary Complications","Hypoxemia During Surgery","Thoracic Surgery, Video Assisted","Lung Cancer (Non-Small Cell)",[68,69,70,71],"pulmonary complications","hypoxemia","video-assisted thoracic surgery","one lung ventilation","2026-01-19",{"date":74,"type":41},"2026-01-28",{"date":76,"type":20},"2026-01-20",{"date":78,"type":20},"2029-02-01",{"name":80,"class":48},"First Affiliated Hospital of Zhejiang University",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":106,"leadSponsor":108,"locationsCount":111},"100619015","the-effect-of-single-lung-ventilation-duration-and-intraoperative-brain-oxygenation-on-cognitive-function-and-postoperative-pain-in-geriatric-patients-100619015","NCT07339124","The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients","The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients Undergoing Single Lung Ventilation; Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 65 and over with a high school diploma or higher education\n* Patients undergoing lung resection via thoracotomy (wedge resection, lingulectomy, segmentectomy, lobectomy, pneumonectomy)\n* American Society of Anesthesiologists (ASA) score I-II-III,\n* Body mass index (BMI) between 18-40 kg\u002Fm2,\n* Patients undergoing surgery under general anesthesia will be included in the study.\n\nExclusion Criteria:\n\n* Patients under 65 years of age, patients over 65 who are illiterate,\n* Who have completed primary or secondary school,\n* Patients with pre-existing cognitive impairment confirmed by preoperative Mini Mental State Examination (MMSE),\n* Patients with a history of previously diagnosed mental illness, cerebrovascular disease, senile dementia, stroke,\n* Patients using continuous anti-inflammatory\u002Fanalgesic medications,\n* Patients with preoperative chronic pain,\n* Severe cardiovascular disease,\n* Diagnosed neurological and psychiatric diseases,\n* Patients allergic to the anesthetic and analgesic drugs to be administered,\n* Patients with severe renal failure, gastrointestinal ulceration or severe asthma that prevents the administration of standard analgesia protocols,\n* Patients undergoing surgery other than lung resection,\n* Patients undergoing surgery with TIVA (total intravenous anesthesia) will be excluded from the study.","65 Years",{"count":90,"type":20},30,"One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt development is inevitable, and consequently, hypoxia is a frequently encountered condition. Therefore, one of the most important aspects that clinicians pay attention to during OLV is cerebral oxygen saturation in addition to peripheral oxygenation monitoring.\n\nStudies have shown a correlation between decreased cerebral oxygen saturation and postoperative cognitive dysfunction (POCD). Patients undergoing OLV are also at risk of cerebral desaturation due to this non-physiological ventilation.\n\nPatients undergoing OLV are at risk of cerebral oxygen desaturation. Therefore, in these patients, both cognitive dysfunction and changes in brain oxygenation can negatively affect pain-related centers, altering pain perception. Geriatric patients are particularly more affected by these negative effects. It is generally accepted by healthcare professionals specializing in pain management that the application of pain management should differ for elderly patients compared to younger patients. Analgesic dose adjustment should be done more carefully in geriatric patients. Increased sensitivity to opioids due to hypoxia can cause respiratory depression and increased analgesic effects. To avoid these, opioid dose adjustment is necessary in these patients. In conclusion, cerebral oxygen saturation measurement can be an effective method to detect cerebral oxygen desaturation, especially in the geriatric patient group. In this way, the effect of hypoxia caused by OLV on cerebral oxygen saturation can be detected early, and POCD can be limited. We believe that this situation can also contribute to effective postoperative pain management. This study aimed to investigate the effect of intraoperative brain oxygenation on cognitive function and postoperative pain in geriatric patients who underwent OLV.\n\nMATERİAL AND METHODS This study will be conducted in accordance with the Helsinki Declaration and will take place at Health Sciences University Ankara Atatürk Sanatorium Training and Research Hospital . The study will be planned for geriatric patients over 65 years of age with a high school diploma or higher education level who have given informed consent and are scheduled for OLV with standard anesthesia monitoring. These patients, undergoing thoracic surgery via thoracotomy and who agree to participate in this study and sign an informed consent form, will be prospectively enrolled. A total of 30 patients will be included in our study. Preoperatively, patients will undergo standard monitoring including non-invasive arterial blood pressure, electrocardiography, and peripheral oxygen saturation (SpO2). Cerebral oxygenation of patients who have signed an informed consent form the day before will be recorded throughout the surgical procedure using probes placed on the forehead before the induction of anesthetic drugs.\n\nThe standard anesthesia and analgesia protocol that we routinely apply to patients will be applied throughout the surgery. Routine preoperative blood tests, age, height, weight, Body Mass Index (BMI), gender, diagnosis, preoperative comorbidities (hypertension, diabetes, coronary artery disease, chronic obstructive pulmonary disease, etc.), previous surgeries (any surgical procedure performed under general anesthesia before this study), American Society of Anesthesiologists ( ASA) score, and duration of surgery will be recorded for each patient. Hemodynamic data (systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), pulse, SpO2, and cerebral oxygen saturation will be recorded before anesthesia induction, after induction, and at 5, 10, 20, 30, and 60 minutes after the start of OLV. These hemodynamic data will also be recorded at the end OLV and at the end of the operation. OLV duration, anesthesia duration, surgery duration, amount of fluid administered, urine output, and whether blood replacement was performed will be recorded. Visual Analog Scale (VAS) scores will be recorded at 1, 2, 4, 8, 16, and 24 hours postoperatively. Analgesic medications administered during the 24-hour postoperative period will also be recorded. VAS evaluation will be performed on a 100 mm scale, where 0: no pain and 100: maximum pain, indicating the patient's pain level. During this process, any possible side effects that may develop due to analgesic treatment will be recorded.\n\nThe Mini Mental Test (MMT) form will be completed by patients one day before surgery, 48 hours postoperatively, on the 7th day postoperatively. MMT consists of eleven items grouped under five main headings: Orientation, recording memory, attention and calculation, recall, and language, and is evaluated out of a total score of 30.",[93,94,29,95,96],"Thoracic Anesthesia","Geriatric Anesthesia","POCD - Postoperative Cognitive Dysfunction","Postoperative Pain Management",[35,98,99,71,100,101],"geriatric patients","cognitive function","cerebral oxygenation","postoperative pain","2026-01-14",{"date":104,"type":41},"2026-01-15",{"date":104,"type":20},{"date":107,"type":20},"2026-10-30",{"name":109,"class":110},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV",1,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":133,"leadSponsor":135,"locationsCount":111},"100600628","frequency-and-severity-of-respiratory-acidosis-during-one-lung-ventilation-a-retrospective-pilot-study-to-compare-clinician-settings-and-those-proposed-by-the-ventilo-application-100600628","NCT07099963","Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application","Inclusion Criteria:\n\n* Adults (≥ 18 years old)\n* Patients intubated and undergoing one-lung ventilation during thoracic surgery\n* Volume-controlled ventilation mode used intraoperatively\n\nExclusion Criteria:\n\n* Arterial blood gas data unavailable during one-lung ventilation\n* Missing demographic data (sex, height, actual weight)",{"count":119,"type":20},100,"One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml\u002Fkg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.",[122,123,124,125,126,29,127],"Thoracic","Surgery","Mechanical Ventilation","Hypercapnia","Acidosis","Smartphone Application","RECRUITING","2025-08-01",{"date":131,"type":41},"2025-08-06",{"date":129,"type":41},{"date":134,"type":20},"2026-06",{"name":136,"class":48},"Laval University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":144,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":111},"100585064","postoperative-vocal-cord-palsy-between-double-lumen-endobronchial-tube-and-bronchial-blocker-for-robot-assisted-esophagectomy-100585064","NCT06897501","Postoperative Vocal Cord Palsy Between Double-lumen Endobronchial Tube and Bronchial Blocker for Robot-assisted Esophagectomy","Incidence of Postoperative Vocal Cord Palsy Between Double-lumen Endobronchial Tube and Bronchial Blocker for Robot-assisted Esophagectomy: a Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 19 or older\n* American Society of Anesthesiologists physical status I - III\n* Elective robot-assisted esophagectomy\n* Any clinical stage of esophageal cancer\n* Patients who need recurrent laryngeal nerve lymph nodes resection\n\nExclusion Criteria:\n\n* Patients who diagnosed vocal cord palsy or damage before surgery\n* Patients who need specific airway device due to airway problem\n* History of thoracic surgery\n* Emergency surgery\n* Combined surgery with other department\n* Pregnant or nursing women","19 Years",{"count":146,"type":20},202,[23],"The goal of this clinical trial is to investigate whether the use of bronchial blocker could reduce the incidence of postoperative vocal cord palsy than the use of double-lumen endobronchial tube in robot-assisted esophagectomy.",[29],[151,152,153,154],"robot-assisted esophagectomy","double-lumen endobronchial tube","bronchial blocker","vocal cord palsy","2025-05-14",{"date":157,"type":41},"2025-05-18",{"date":159,"type":41},"2025-04-14",{"date":161,"type":20},"2026-12",{"name":163,"class":48},"Samsung Medical Center"]