[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oocyte-retrieval-for-ivf\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oocyte-retrieval-for-ivf":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100618699","the-role-of-follicular-flushing-at-oocyte-retrieval-100618699",false,"NCT07335016","The Role of Follicular Flushing at Oocyte Retrieval","FOFLOR","Inclusion Criteria:\n\n* Ovarian stimulation with recFSH and GnRH antagonist or PPOS protocol\n* Triggering final oocyte maturation with hCG or GnRH agonist\n* The day of oocyte retrieval at least one follicle of mean diameter of 11mm in each ovary\n* ICSI method of fertilisation.\n\nExclusion Criteria:\n\n* Presence of ovarian cyst of endometriosis\n* History of ovarian surgery\n* Monofollicular growth\n* Presence of only one ovary\n* Ovary not accessible at oocyte retrieval","FEMALE","18 Years","46 Years",{"count":20,"type":21},75,"ESTIMATED","INTERVENTIONAL",[24],"NA","In vitro fertilization (IVF) is the most common method of medically assisted reproduction, involving fertilization of the egg by sperm in a lab. The process includes ovarian stimulation, oocyte retrieval, fertilization and culture, and embryo transfer. The success of IVF depends mainly on female age-as age increases, ovarian reserve and oocyte quality decrease-and the number of oocytes retrieved.\n\nThis study investigates whether follicular flushing during oocyte retrieval can increase the number of mature oocytes retrieved. This randomized study will be conducted in women undergoing ovarian stimulation with recombinant Folicullar Stimulating Hormone (FSH) and Gonadotropin-Releasing Hormone (GnRH) antagonist or Progestin Primed Ovarian Stimulation (PPOS) to suppress premature Luteinizing hormone (LH) rise. Final oocyte maturation will be triggered with recombinant Human chorionic gonadotropin (hCG) or GnRH agonist.\n\nEligible participants will have at least one follicle ≥11 mm in each ovary. On the day of oocyte retrieval, one ovary will be randomized to undergo follicular flushing using a single-lumen needle and the other simple aspiration, using the same needle. All fertilized oocytes from both ovaries will be cultured, seperately, to the blastocyst stage.\n\nStudy outcomes are the number of oocytes and mature oocytes retrieved, the oocyte retrieval rate, the mature oocyte retrieval rate, the maturation rate, the number of fertilized oocytes, the fertilisation rate, the number of blastocytes and the blastulation rate.\n\nSample size of 75 patients (25 per response category: poor, normal, high) provides 82-98% power to detect clinically meaningful interaction effects (Cohen's f=0.19-0.34) between response category and technique (follicular flushing vs. simple aspiration) under conservative assumptions of 50-70% of pilot study effects, lower correlations (ρ=0.35), and increased variability (α=0.05, two-sided, 5% attrition buffer.",[27,28],"Infertility (IVF Patients)","Oocyte Retrieval for IVF",[30,31,32],"ivf","follicular flushing","oocyte retrieval","NOT_YET_RECRUITING","2026-01-11",{"date":36,"type":37},"2026-01-13","ACTUAL",{"date":39,"type":21},"2026-01-14",{"date":41,"type":21},"2029-01-20",{"name":43,"class":44},"Aristotle University Of Thessaloniki","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100609250","analgesic-effect-of-tens-waa-combined-with-tramadol-hydrochloride-during-oocyte-retrieval-surgery-100609250","NCT07212127","Analgesic Effect of TENS-WAA Combined With Tramadol Hydrochloride During Oocyte Retrieval Surgery","Analgesic Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-Ankle Acupuncture Theory Combined With Tramadol Hydrochloride During Oocyte Retrieval Surgery","Inclusion Criteria:\n\n* Females aged between 21 and 42 years.\n* Patients diagnosed with infertility requiring oocyte retrieval for in vitro fertilisation-embryo transfer.\n* Body Mass Index (BMI) 18.5 ≤ BMI ≤ 29.9 kg\u002Fm².\n* Regular menstrual cycles with ultrasound monitoring demonstrating dominant follicle development and ovulation during the natural cycle; good ovarian reserve: follicle-stimulating hormone (FSH) \\\u003C 10 IU\u002FL, antral follicle count (AFC) \\> 6, anti-Müllerian hormone (AMH) \\> 1.5 ng\u002Fml.\n* Undergoing ovarian stimulation therapy using follicle-stimulating hormone (FSH) or gonadotropin protocols.\n* Electing tramadol hydrochloride injection for analgesia during oocyte retrieval.\n* Voluntary participation with signed written informed consent.\n\nExclusion Criteria:\n\n* History of other chronic pain conditions, or prolonged use of opioid medications, history of anaesthetic drug addiction, or chronic alcohol abuse.\n* Severe pelvic adhesions.\n* Presence of pacemakers or other implanted medical electronic devices.\n* Concurrent use of high-frequency surgical equipment, artificial heart-lung machines, medical shortwave therapy, or microwave therapy devices.\n* Presence of scarring or skin lesions at electrode application sites.\n* Severe anxiety, depression, or other psychiatric conditions impairing accurate description of sensations, or any other disorders potentially affecting pain perception.\n* Conditions contraindicating or affecting oocyte retrieval, such as coagulation disorders, acute pelvic inflammation, vaginitis, trichomoniasis, endometriomas, ovarian cysts.\n* Individuals with laparoscopically and\u002For ultrasonographically confirmed endometriosis.\n* Patients with ovarian hyporesponsiveness following conventional ovarian stimulation medication.","21 Years","42 Years",{"count":56,"type":21},60,[24],"This study is a single-centre randomised controlled trial. It aimed to evaluate the efficacy and safety of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory(TENS-WAA) combined with tramadol hydrochloride for analgesia during transvaginal ultrasound-guided oocyte retrieval, by comparing the analgesic effects and the prevention of postoperative nausea and vomiting between the TENS-WAA combined with tramadol hydrochloride group (experimental group) and the sham TENS-WAA combined with tramadol hydrochloride group (control group). Participants were randomly assigned to the experimental or control group. The experimental group received percutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory 30 minutes prior to the procedure, at a frequency of 2Hz with current intensity adjusted to the maximum tolerable level.Tramadol hydrochloride 100mg was administered intramuscularly 20 minutes before surgery. The control group received sham stimulation at the lowest intensity under identical conditions. The primary outcome measure was the Visual Analogue Scale (VAS). Secondary outcome measures included skin conductance response, postoperative nausea scale, and vomiting scale.",[28,60],"Pain","2025-09-30",{"date":63,"type":37},"2025-10-08",{"date":65,"type":21},"2025-11-08",{"date":67,"type":21},"2026-12-31",{"name":69,"class":44},"First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University",1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100600970","virtual-reality-hypnosis-as-sedation-during-oocyte-retrieval-effect-on-propofol-consumption-100600970","NCT07104409","Virtual Reality Hypnosis as Sedation During Oocyte Retrieval: Effect on Propofol Consumption","Virtual Reality Hypnosis as Sedation During Oocyte Retrieval: Effect on Propofol Consumption: a Randomized Study (VRH-IVF)","VRH-IVF","Inclusion Criteria:\n\n* egg retrieval as part of their IVF at the Cliniques universitaires Saint-Luc,\n* to be French-speaking,\n* simple IVF or ICSI IVF\n* 18-42 yrs\n\nExclusion Criteria:\n\n* morbid obesity\n* blindness and\u002For deafness\n* history contraindicating the use of anti-inflammatory drugs\n* long-term psychotherapeutic treatment or taking psychotropic medications.",{"count":80,"type":21},72,[24],"An egg retrieval is performed during an IVF course. This painful procedure is performed using sedation to ensure patient comfort. A combination of sedative and analgesic medications combined with local anesthesia (paracervical block) is used. Propofol, the intravenous anesthetic of choice (rapid-acting and short-acting), and remifentanil (an ultra-short-acting opioid analgesic) are generally combined. The potential impact of these agents used for egg retrieval on egg fertilization and embryo quality is of interest. Indeed, certain drugs such as propofol could accumulate in the follicular fluid. The few studies conducted to date show contradictory results. While a harmful effect appears to be reported in experimental studies on mice, this effect is uncertain in clinical studies. Given this uncertainty, any method aimed at reducing propofol consumption in this context may be of interest. Virtual reality hypnosis (VRH) is a digital tool that has already been shown to be effective in reducing preoperative anxiety during oocyte retrieval. Furthermore, VRH has also demonstrated analgesic effects.\n\nThe primary objective of this study is to compare VRH with a control group (usual sedation) on propofol consumption during oocyte retrieval.\n\nSecondary objectives are to compare preoperative anxiety, APAIS score, catastrophizing score, remifentanil consumption, intra- and\u002For post-operative nausea and vomiting, post-procedural analgesic consumption, time perception during the procedure, fertilization parameters, and pregnancy rate at 12 weeks. The degrees of absorption, dissociation, immersion, and presence for the VRH group will also be noted.",[28],[85,86,32],"virtual reality","hypnosis","2025-08-05",{"date":89,"type":37},"2025-08-11",{"date":91,"type":21},"2025-09-01",{"date":93,"type":21},"2027-02-01",{"name":95,"class":44},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain"]