[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"open-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:open-fracture":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,64,92,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642249","phase-3-implementation-of-vancomycin-powder-application-in-the-emergency-department-for-open-fractures-100642249",false,"NCT07659886","Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures","Inclusion Criteria:\n\n* Participants aged 18 years or older presenting to the Emergency Department with Gustilo-Anderson Type I, II, or III open fractures.\n\nExclusion Criteria:\n\n* Known allergy to vancomycin\n* Ballistic open fractures\n* Pregnancy\n* Currently breastfeeding\n* Age younger than 18 years.","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","INTERVENTIONAL",[22],"PHASE3","To evaluate the feasibility, safety, and potential efficacy of applying vancomycin powder locally to open fractures in the emergency department prior to definitive surgical intervention.",[25],"Open Fracture",[27],"open fracture","NOT_YET_RECRUITING","2026-06-17",{"date":31,"type":32},"2026-06-22","ACTUAL",{"date":34,"type":19},"2026-06-10",{"date":36,"type":19},"2027-06-10",{"name":38,"class":39},"Atlantic Health System","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":20,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":40},"100626569","phase-4-volume-reduction-for-open-fracture-irrigation-100626569","NCT07437339","Volume Reduction for Open Fracture Irrigation","Volume Reduction for Open Fracture Irrigation: A Randomized Prospective Feasibility Trial","Inclusion Criteria:\n\n* Age 18 or older\n* Patient diagnosed with a Type I, II, or III open fracture of the appendicular skeleton by a study surgeon\n* For the purposes of this study, an open fracture is a fracture associated with a soft tissue wound which may or may not be contiguous with the fracture.\n* Open fractures of the carpals, tarsals, metacarpals, metatarsal, and\u002For phalanges without the involvement of a long bone or the hindfoot will not be considered.\n\nExclusion Criteria:\n\n* Patient is unable to understand Informed Consent and\u002For HIPAA Authorization Form\n* Patient does not speak English\n* Patient is pregnant\n* Patient is unable or (in the judgment of research personnel) unlikely to attend follow-up visits.\n* Patient was previously enrolled in a study which has the same primary outcomes or may influence infection rate or bone healing\n* Patient declines to participate in study",{"count":49,"type":19},200,[51],"PHASE4","The purpose of this study is to help doctors who treat open fractures understand how much fluid is required when cleaning out the wound. Participants will spend about 12 months in this study and will be asked to answer study questions about your recovery at your typical follow up clinic visits with your surgeon. After the surgeon has determined a participant's bone has healed, any remaining study visits can be conducted over the phone, email, and\u002For mail. Participants will not be asked to attend additional clinic visits as part of this study. Researchers will compare two different fluid volume protocols to determine if one results in better fracture and\u002For wound healing.",[25],"RECRUITING","2026-04-08",{"date":57,"type":32},"2026-04-13",{"date":59,"type":32},"2026-03-02",{"date":61,"type":19},"2027-12-31",{"name":63,"class":39},"Inova Health Care Services",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":20,"phases":74,"briefSummary":75,"conditions":76,"keywords":77,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100344507","phase-4-placement-of-antibiotic-powder-in-wounds-during-the-emergency-room-100344507","NCT03765567","Placement of Antibiotic Powder in Wounds During the Emergency Room","Placement of Antibiotic Powder in Wounds During the Emergency Room (POWDER) Study","POWDER","Inclusion Criteria:\n\n* Subject or Legal Authorized Representative (LAR) is willing and able to provide written informed consent.\n* Adult 18 years of age or older.\n* Open fracture of the humerus, radius, ulna, femur, tibia, and\u002For fibula.\n* 24 hours or less has elapsed from the estimated time of injury to study intervention.\n\nExclusion Criteria:\n\n* Time from injury \\> 24 hours.\n* Subjects who have received acute operative care (e.g., washout in the operating room or fixation) of the open fracture at an outside facility.\n* Subject or LAR speaks neither English nor Spanish. Note that subjects that are unable to participate in the consent process (e.g. intoxication, poly-trauma, will be enrolled into the observational arm where passive data collection will occur).\n* High-potency antibiotic powder or solution applied to the wound prior to enrollment. Simple ointment (i.e., bacitracin ointment) or antibiotic-impregnated dressings will be permitted.\n* Documented allergies or serious reactions to vancomycin. History of uncomplicated \"red man syndrome\" will not be considered a reason for exclusion.\n* Pregnant subjects. If the subject is a female of childbearing potential, and she states that she is likely to be pregnant, a pregnancy test will be performed; if negative, the subject will be eligible for enrollment.\n* Prisoners.\n* Participation in other clinical research involving investigational antimicrobial products within 30 days of randomization.","89 Years",{"count":49,"type":19},[51],"This is the first prospective controlled study to determine whether the topical application of vancomycin powder reduces infection-related complications when applied to open fracture injuries in the acute emergency department setting.",[25],[78,79,80,81],"infection","vancomycin","topical antibiotic","antibiotic prophylaxis","2025-07-30",{"date":84,"type":32},"2025-08-01",{"date":86,"type":32},"2020-10-05",{"date":88,"type":19},"2027-07",{"name":90,"class":39},"The University of Texas Health Science Center at San Antonio",2,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":40},"100499586","oct-in-open-fracture-and-infected-fracture-100499586","NCT05785182","OCT in Open Fracture and Infected Fracture","Optical Coherence Tomography Imaging to Visualize Bacteria or Biofilm on Hardware, Bone and Soft Tissue in Open Fracture and Infected Fracture","Inclusion Criteria:\n\n* Age 18 years or older\n* Open fracture\n* Fracture Related Infection\n\nExclusion Criteria:\n\n* Metatarsal fractures",{"count":100,"type":19},40,"OBSERVATIONAL","This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.",[104,105,25,106],"Trauma Injury","Trauma","Fracture Infection","2025-06-24",{"date":109,"type":32},"2025-06-27",{"date":111,"type":32},"2023-03-27",{"date":113,"type":19},"2027-06",{"name":115,"class":39},"Dartmouth-Hitchcock Medical Center",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":20,"phases":126,"briefSummary":127,"conditions":128,"keywords":134,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":40},"100554892","phase-4-powdered-intrawound-vancomycin-in-open-fractures-trial-100554892","NCT06504992","Powdered Intrawound Vancomycin in Open Fractures Trial","Powdered Intrawound Vancomycin in Open Fractures: a Randomized Controlled Trial","PIVOT","Inclusion Criteria:\n\n* 18 years or older at time of surgery\n* Patients with an open fracture classified as Gustilo Type I to IIIc in the clavicle, humerus, radius, ulna, metacarpals, upper extremity phalanges (fingers), femur, tibia, fibula and metatarsals and lower extremity phalanges (toes).\n* Open fracture treated operatively with plate(s) and screw(s) hardware fixation and intramedullary fixation (IM nail).\n* Able to attend standard of care follow up for six months post-operatively\n\nExclusion Criteria:\n\n* Patients with known vancomycin allergy, drug administration reaction, or other sensitivities to vancomycin.\n* Patients who have already had definitive fracture fixation before enrollment in the study\n* Patients with open fracture already infected at time of enrollment\n* Patients with current positive blood cultures (bacteremia) at time of enrollment (current, meaning they have not received treatment and now have negative most-recent blood cultures).\n* Patients who have other forms of local antibiotics that are left in place at the end of the definitive fixation surgery (e.g., antibiotic loaded cement or polymethyl methacrylate (PMMA) beads)\n* Patients who do not speak English\n* Patients who are currently pregnant\n* Patients who are unable to provide consent and do not have a substitute decision maker able to provide consent\n* Patients who will have severe difficulty with follow up",{"count":125,"type":19},350,[51],"The purpose of this randomized control trial is to compare the rate of post-operative infection in patients with open fractures in upper or lower extremity long bones randomized to receive intra-operative intrawound topical vancomycin powder on their open fractures in addition to the current best practice of intravenous antibiotics with irrigation and debridement compared to intravenous antibiotics with irrigation and debridement alone during definitive operative fixation of the fracture.",[25,105,129,130,131,132,133],"Infection, Surgical Site","Fractures, Open","Wound Infection","Fractures, Bone","Post-Operative Wound Infection",[27,79,78,135,136],"trauma","intrawound","2024-09-17",{"date":139,"type":32},"2024-09-19",{"date":141,"type":19},"2024-11-01",{"date":143,"type":19},"2029-09-01",{"name":145,"class":39},"University of Manitoba"]