[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"open-nephrectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:open-nephrectomy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100642736","rhomboid-intercostal-sub-serratus-plane-block-versus-external-oblique-intercostal-block-in-open-nephrectomy-100642736",false,"NCT07642193","Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy","Ultrasound Guided Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy: Randomized Controlled Study","Inclusion Criteria:\n\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status II, III.\n* Body mass index (BMI): \\> 20 kg\u002F m2 and \\\u003C 35 kg\u002F m2.\n* Patients undergoing open nephrectomy.\n\nExclusion Criteria:\n\n* Patient refusal.\n* BMI \\\u003C20 kg\u002Fm2 and \\>35 kg\u002Fm2\n* Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).\n* History of psychiatric and cognitive disorders or chronic pain.\n* Contraindication to regional anesthesia e.g pre- existing peripheral neuropathies.\n* Severe respiratory or cardiac disorders.\n* Advanced liver or kidney disease.\n* Pregnancy.\n* Physical status ASA IV.\n* Coagulopathy with INR ≥ 1.6: hereditary (e.g. hemophilia, fibrinogen abnormalities \\& deficiency of factor II) - acquired (e.g. impaired liver functions with prothrombin concentration less than 60 %, vitamin K deficiency \\& therapeutic anticoagulants drugs).","ALL","18 Years",{"count":19,"type":20},90,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy.",[26,27,28],"Rhomboid Intercostal Sub-serratus Plane Block","External Oblique Intercostal Block","Open Nephrectomy","RECRUITING","2026-06-07",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":33},"2026-05-02",{"date":37,"type":20},"2026-12-30",{"name":39,"class":40},"Cairo University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100635734","comparison-of-serratus-intercostal-plane-blcok-with-erector-spinae-plane-block-for-open-nephrectomy-100635734","NCT07556536","Comparison of Serratus Intercostal Plane Blcok With Erector Spinae Plane Block for Open Nephrectomy","Analgesic Efficacy of Ultrasound-Guided Serratus Intercostal Plane Block Versus Erector Spinae Plane Block for Postoperative Pain Control After Open Nephrectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients scheduled for elective open nephrectomy under general anesthesia via flank incision .\n2. Adult patients aged 18-65 years.\n3. Patients with an American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n1. Patient refusal.\n2. Allergy to local anesthetics and patient with infection at the injection site of block.\n3. Coagulation disorders or ongoing anticoagulant therapy.\n4. Patients receiving opioids for chronic analgesic therapy (cancer, addiction).\n5. Cognitive impairment preventing pain scoring.\n6. Neurological or psychiatric disorders affecting pain assessment.","65 Years",{"count":51,"type":20},132,[23],"Effective postoperative pain management following open nephrectomy remains a significant clinical challenge.\n\nInadequate pain control after this procedure may lead to impaired respiratory function, delayed mobilization, prolonged hospital stay, increased opioid consumption, and a higher incidence of postoperative complications. Therefore, optimizing postoperative analgesia while minimizing opioid-related adverse effects is a key objective in perioperative care for patients undergoing open nephrectomy Traditionally, postoperative pain following open nephrectomy has been managed using systemic opioids, epidural analgesia, or paravertebral blocks.\n\nUltrasound-guided fascial plane blocks have emerged as valuable alternatives in modern regional anesthesia due to their simplicity, safety profile, and effectiveness. Among these techniques, the erector spinae plane (ESP) block has gained widespread popularity.\n\nThis block has been shown to provide effective analgesia for thoracic, abdominal, and urologic surgeries, including nephrectomy The ultrasound-guided serratus intercostal plane block (SIPB) is a more recently described regional anesthetic technique targeting the lateral cutaneous branches of the intercostal nerves by injecting local anesthetic between the serratus anterior muscle and the intercostal muscles or ribs By blocking these nerves, SIPB provides analgesia to the lateral thoracic wall and upper abdominal regions, which are particularly relevant to flank incisions used in open nephrectomy.\n\nPatients will be randomly allocated into two equal groups. Patients in group (S) will receive serratus intercostal plane block and those in group (E) will receive Erector spinae plane block . Both of these blocks will be performed after induction of general anaesthesia by an experienced anaesthesiologist The aim of this study is to to compare the analgesic efficacy of ultrasound-guided serratus intercostal plane block and erector spinae plane block in patients undergoing open nephrectomy.",[55,28],"Post Operative Pain",[57,58,59],"serratus intercostal plane block","Erector spinae plane block","open nephrectomy","2026-04-22",{"date":62,"type":33},"2026-04-29",{"date":64,"type":33},"2026-04-10",{"date":66,"type":20},"2027-06-01",{"name":68,"class":40},"Fayoum University Hospital",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":41},"100584488","bilateral-ultrasound-guided-intramuscular-quadratus-lumborum-plane-block-versus-bilateral-lateral-quadratus-lumborum-plane-block-in-controlling-postoperative-pain-in-cancer-patients-undergoing-open-nephrectomy-100584488","NCT06889987","Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy","Efficacy of Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block (Ql4) Versus Bilateral Lateral Quadratus Lumborum Plane Block (Ql1) in Controlling Post-Operative Pain in Cancer Patient Undergoing Open Nephrectomy: A Randomized Control Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status II-III.\n* Body mass index (BMI): (20- 40) kg\u002Fm2.\n* Type of surgery: midline incision for unilateral open nephrectomy.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Age \\\u003C18 years or \\>65 years\n* BMI \\\u003C20 kg\u002Fm2 and \\> 40 kg\u002Fm2\n* Known sensitivity or contraindication to drugs used in the study\n* Contraindication to regional anesthesia, e.g. local infection at the introduction site, pre-existing peripheral neuropathies and coagulopathy.\n* Physical status ASA IV\n* Patients on chronic analgesic therapy (daily morphine ≥30 mg or equivalent dose of other opioids or tramadol or any medication for neuropathic pain)\n* Patients with a history of drug abuse\n* Patients with neuropsychiatric diseases; patients with a history of chronic pain syndromes that may enhance sensitivity to pain, for example, fibromyalgia\n* All patients who are going to have severe intra- or post-operative bleeding or will require postoperative mechanical ventilation are also excluded from the study.",{"count":19,"type":20},[23],"This study aims to evaluate the efficacy of bilateral ultrasound-guided intramuscular quadratus lumborum plane block (QL4) versus bilateral lateral quadratus lumborum plane block (QL1) in controlling postoperative pain in cancer patients undergoing open nephrectomy.",[80,81,82,83,84,85,28],"Bilateral","Ultrasound","Intramuscular Quadratus Lumborum Plane Block","Lateral Quadratus Lumborum Plane Block","Postoperative Pain","Cancer Patients","2025-03-16",{"date":88,"type":33},"2025-03-21",{"date":90,"type":33},"2024-12-10",{"date":92,"type":20},"2025-12-06",{"name":94,"class":40},"National Cancer Institute, Egypt"]