[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"operable-breast-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:operable-breast-cancer":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100639113","expander-based-versus-direct-to-implant-pre-pectoral-breast-reconstruction-a-comparative-analysis-of-surgical-outcomes-100639113",false,"NCT07593651","EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes","EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes : the EXPRESsO Study","EXPRESSO","Inclusion Criteria:\n\n* Female patients ≥18 years\n* Patients undergoing unilateral or bilateral therapeutic mastectomy for breast cancer\n* Patients undergoing pre-pectoral implant-based breast reconstruction, either:\n\n  * One-stage DTI, or\n  * Two-stage TE-I\n* Use of implant with or without biological or synthetic mesh\n* Contralateral prophylactic mastectomy allowed if a therapeutic mastectomy was performed on one side\n\nExclusion Criteria:\n\n* Male patients\n* Subpectoral implant-based reconstruction\n* Autologous breast reconstruction\n* Delayed reconstructions not performed at the time of mastectomy\n* Incomplete clinical or follow-up data for primary endpoint analysis","FEMALE","18 Years",{"count":20,"type":21},276,"ESTIMATED","OBSERVATIONAL","Recent advances in breast surgery, together with the increasing adoption of conservative surgical approaches, have renewed interest in pre-pectoral implant-based breast reconstruction. Within this reconstructive paradigm, surgeons may employ two distinct strategies:\n\n(i) immediate reconstruction using a direct-to-implant approach (DTI), or (ii) a two-stage reconstruction consisting of tissue expander placement followed by definitive implant insertion (TE-I).\n\nEach approach is associated with specific indications, advantages, and inherent limitations.\n\nThe EXPRESSO study aims to retrospectively compare surgical outcomes between pre-pectoral DTI and TE-I breast reconstruction. By providing real-world evidence on these reconstructive strategies, this study seeks to inform surgical decision-making and to optimize reconstructive outcomes in contemporary breast cancer care.",[25,26],"Breast Cancer","Operable Breast Cancer",[28,29,30],"breast cancer","Mastectomy","Pre-pectoral reconstruction","NOT_YET_RECRUITING","2026-05-11",{"date":34,"type":35},"2026-05-18","ACTUAL",{"date":37,"type":21},"2026-06",{"date":39,"type":21},"2027-12",{"name":41,"class":42},"IRCCS San Raffaele","OTHER"]