[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ophthalmopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ophthalmopathy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100640174","assessing-agreement-between-acuvera-capture-and-paper-based-methods-for-bcva-data-recording-in-ophthalmic-trials-100640174",false,"NCT07613580","Assessing Agreement Between Acuvera Capture and Paper-Based Methods for BCVA Data Recording in Ophthalmic Trials","An Observational Comparative Study Assessing Agreement Between Acuvera Capture and Paper-Based Methods for Best Corrected Visual Acuity (BCVA) Data Recording in Ophthalmic Clinical Trials","VALiCAPTURE","90 adult participants (≈180 eyes) with the following BCVA levels, will be included:\n\n* 30 participants (33%) in the normal\u002Fnear-normal BCVA range (≤0.3 logMAR ≥70 letters); ≈20\u002F40 or better);\n* 30 participants (33%) with mid-range BCVA (0.4-0.9 logMAR (36-69 letters); 20\u002F50 to 20\u002F200)\n* 30 participants (33%) with low vision BCVA (≥ 1.0 logMAR (≤35 letters); worse than 20\u002F200) including off-chart acuities using protocol low-vision procedures).\n\nInclusion Criteria:\n\n* Adults ≥18 years old\n* Able and willing to provide written informed consent\n* Capable of performing BCVA testing procedures according to study requirements\n* All BCVA ranges are eligible, including off-chart acuities (e.g., count fingers, hand motion, light perception) irrespective of the presence or absence of ocular disease.\n\nExclusion Criteria:\n\n* Any condition preventing reliable completion of BCVA testing (e.g., severe cognitive impairment, language barriers)\n* Inability or unwillingness to comply with study requirements\n* Non-ophthalmic condition that precludes safe or reliable testing (e.g., immediate post-operative systemic status preventing cooperation).\n* Any circumstance that, in the investigator's opinion, makes the eye\u002Fparticipant unsuitable for accurate BCVA testing or for completing both data-capture methods during the same visit.\n\nNumber of Sites: 2 ophthalmic clinical research centers Portugal)\n\nNumber of Countries: Portugal\n\nNumber of Visits: One study visit per participant\n\nDuration: 2 months\n\nParticipants will undergo BCVA testing at a single visit using both paper-based recording and electronic capture with Acuvera Capture. Testing order will be randomized to minimize bias. Paper data will be inserted by the examiners or study coordinator into the study eCRF. Electronic capture data will be exported directly from the app.",true,"ALL","18 Years",{"count":21,"type":22},90,"ESTIMATED","OBSERVATIONAL","Study Purpose: To evaluate the level of agreement between the Acuvera Capture application and traditional paper-based methods for recording Best Corrected Visual Acuity (BCVA) in ophthalmic clinical trials. The study aims to determine whether the electronic capture system provides equivalent or improved accuracy, consistency, and error reduction compared with paper-based recording, thereby supporting its potential adoption as a reliable method for BCVA data collection in clinical research.",[26],"Ophthalmopathy",[28,29,30],"BCVA","ETDRS Protocol","Electronic Capture","RECRUITING","2026-05-21",{"date":34,"type":35},"2026-05-29","ACTUAL",{"date":37,"type":35},"2026-01-12",{"date":39,"type":22},"2026-06-30",{"name":41,"class":42},"OptymEdge, LLC","INDUSTRY",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100471140","assessment-of-the-ocular-microbiome-in-health-and-disease-100471140","NCT05414994","Assessment of the Ocular Microbiome in Health and Disease","Inclusion Criteria:\n\nWe will include subjects who meet all of the following criteria:\n\n* 18 years of age or older\n* Provide informed consent\n* Cohort A - normal eyes with no ocular disease\n* Cohort B - primary open angle glaucoma\u002FOcular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months\n* Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)\n* Cohort D - Dry AMD (age related macular degeneration)\n* Cohort E - Wet AMD\n* Cohort F - diabetic retinopathy\n\nExclusion Criteria:\n\nWe will exclude subjects who meet all of the following criteria:\n\n* Prior ocular disease either of the anterior or posterior segment\n* Any medical comorbidities except well controlled DH and HTN\n* Unable to follow up with study procedures as described",{"count":50,"type":22},500,"The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.",[53,54,26],"Microbial Colonization","Eye Diseases","2026-01-19",{"date":57,"type":35},"2026-01-22",{"date":59,"type":35},"2023-09-07",{"date":61,"type":22},"2027-12-30",{"name":63,"class":64},"Vanderbilt University Medical Center","OTHER",1]