[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-analgesic-adverse-reaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-analgesic-adverse-reaction":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":38,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100607351","incidence-of-pruritus-using-intrathecal-fentanyl-versus-epidural-fentanyl-to-initiate-labour-analgesia-100607351",false,"NCT07187427","Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.","Randomized Trial Comparing the Injection of Intrathecal Fentanyl Versus Epidural Fentanyl for the Initiation of Labour Analgesia on the Incidence of Pruritis.","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Vaginal delivery\n* Gestational age ≥ 37 weeks\n* Requesting neuraxial analgesia\n* French or English language\n\nExclusion Criteria:\n\n* ASA score \\> 3\n* Allergy or contraindication to receiving opioids\u002Flocal anesthesia (morphine or fentanyl)\n* BMI \\> 40 kg\u002Fm²\n* Hepatic or renal failure,\n* Severe preeclampsia and signs of severity according to the criteria of the American College of Obstetricians and Gynecologists\n* Maternal hemorrhage (placental abruption, hepatic subcapsular hematoma,...)\n* Severe scoliosis\n* Biliary cholestasis or polymorphic eruption of pregnancy\n* Inability to provide informed consent, either secondary to mental or physical disability or a significant language barrier (inability to understand English or French)\n* Prior administration of an opioid or opioid misuse","FEMALE","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women. Specifically, this study aim to compare intrathecal fentanyl with epidural fentanyl in order to determine whether the epidural route is associated with a lower occurrence and severity of pruritus. By clarifying these differences, the research seek to optimize analgesic strategies during labor while minimizing opioid-related side effects",[26,27,28,29,30,31,32,33,34,35,36,37],"Pruritis","Hypotension Drug-Induced","Urinary Retention","Fetal Bradycardia During Labor","Nausea and Vomitting","Satisfaction, Patient","Labor Analgesia","Neuraxial Opioid","Opioid Analgesic Adverse Reaction","Term Labour","Fentanyl Analgesia","Fentanyl Adverse Reaction",[39,40],"neuraxial opioid induced pruritus during labor","Intrathecal fentanyl versus Epidural fentanyl","NOT_YET_RECRUITING","2025-11-20",{"date":44,"type":45},"2025-11-26","ACTUAL",{"date":47,"type":20},"2026-01",{"date":49,"type":20},"2027-05",{"name":51,"class":52},"St. Justine's Hospital","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":17,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":21,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":53},"100556857","phase-4-the-efficacy-and-safety-of-oliceridine-fumarate-injection-for-acute-pain-after-abdominal-surgery-100556857","NCT06530563","the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery","the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery: a Randomized, Double-blind, Positive-drug Parallel-controlled, Multi-center Clinical Study","Inclusion Criteria:\n\n1.Preoperative inclusion criteria\n\n1. aged ≥18 years and ≤75 years at screening;\n2. Plan to undergo open or laparoscopic abdominal surgery, and the estimated operative time more than 2 hours.\n3. able to understand and comply with research procedures and requirements, and can provide a written informed consent.\n\n2.postoperative inclusion criteria:\n\n1. patients who required open or laparoscopic surgery;\n2. According to the investigator's judgment, the patient had recovered sufficiently from the intraoperative anesthesia protocol to accurately complete the protocol-specified questionnaire;\n\nExclusion Criteria:\n\n1.preoperative exclusion criteria:\n\n1. ASA grade \\>III\n2. existing other acute or chronic pain conditions;\n3. body mass index (BMI) \\\u003C 18 or \\> 30 kg\u002Fm2;\n4. with sleep apnea syndrome; 5 ) long-term opioid treatment, defined as receiving more than 15mg morphine equivalent units per day on more than 3 days per week for a period of more than 1 month in the 12 months prior to surgery;\n\n6\\) suffering from mental or nervous system diseases (such as epilepsy, depression, schizophrenia, etc.), chronic obstructive pulmonary disease or pulmonary heart disease, heart failure, severe arrhythmia, etc; 7) with severe liver and kidney dysfunction; 8) Other conditions considered by the investigator to be inappropriate for enrollment.\n\nPostoperative exclusion criteria:\n\n1. intraoperative, postoperative or anesthetic deviations that may affect the efficacy and safety evaluation in the study;\n2. evidence of hemodynamic instability or respiratory insufficiency.","ALL","75 Years",{"count":64,"type":20},606,[66],"PHASE4","The goal of this clinical trial is to learn if Oliceridine fumarate injection works to treat acute pain after abdominal surgery. It will also learn about the safety of Oliceridine fumarate injection. The main questions it aims to answer are:\n\n1. Does Oliceridine fumarate injection works to treat acute pain after abdominal surgery?\n2. Does Oliceridine fumarate injection lead to less adverse effect?\n\nResearchers will compare Oliceridine fumarate injection to a positive-drug (Sufentanil Citrate) to see if Oliceridine fumarate injection not inferior to sufentanil in the efficacy and safety for acute pain after abdominal surgery.\n\nParticipants will:\n\n1. Receive patient controlled analgesia treat using Oliceridine or sufentanil after surgery\n2. Be followed up every 6 hours until 48 hours after surgery or before discharge",[69,34],"Acute Pain",[71,72,73],"Oliceridine","acute pain after surgery","abdominal surgery","2025-08-18",{"date":76,"type":45},"2025-08-19",{"date":78,"type":20},"2025-08",{"date":80,"type":20},"2026-05",{"name":82,"class":52},"Xiangya Hospital of Central South University",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":61,"minAge":17,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":53},"100555073","postoperative-analgesia-intervention-with-non-opioid-alternatives-pain-alt-trial---breast-surgery-100555073","NCT06507345","Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery","Comparative Effectiveness of Opioid Versus Opioid-free Post-discharge Analgesia After Outpatient Breast Surgery: A Protocol for a Randomized Controlled Trial (PAIN-Alt Trial)","PAIN-Alt","Inclusion Criteria:\n\n* Undergoing mastectomy (i.e., total, modified radical, radical, or skin\u002Fnipple sparing) or lumpectomy (i.e., excisional biopsy, partial or segmental mastectomy, oncoplastic breast-conserving surgery) for malignant (cancer) and non-malignant diseases (i.e., ductal carcinoma in situ)\n* Planned discharge on the day of the operation.\n\nExclusion Criteria:\n\n* Immediate breast reconstruction, i.e., implant, tissue-expander, or autologous\u002Fflap-based (often leads to higher levels of pain and analgesia requirements)\n* Contraindications to the drugs used in the trial in accordance with Health Canada Monographs (i.e., opioid use disorder, pregnancy, breastfeeding, heart failure, allergy\u002Fhypersensitivity, peptic ulcer, bleeding disorders, renal or liver impairment)\n* Taking opioids preoperatively\n* Cognitive impairment precluding patient-reported outcome assessment\n* Need for postoperative hospitalization decided before randomization (i.e., same-day discharge cancelled for medical \\[e.g., intra-operative complications\\] or non-medical reasons \\[e.g., lack of support at home\\]).",{"count":92,"type":20},540,[23],"North America is experiencing a crisis of opioid use and abuse, partially caused by excessive prescribing by doctors. People often receive their first opioid prescription for pain treatment after outpatient breast surgery (i.e., surgery to remove all or parts of the breast(s), where patients leave the hospital the same day). Many patients misuse these drugs and become addicted. Additionally, many of the opioid pills prescribed to patients are left unused and may be misused by family members, friends, or other community members. To prevent this problem, surgeons can avoid prescribing opioids by prioritizing opioid-free analgesia (i.e., pain treatment using only non-opioid interventions). Prescribing only non-opioid pain medications after surgery is very common in many countries outside of North America; however, few studies have assessed whether opioid-free analgesia is as effective as opioid analgesia after breast surgery. Therefore, the main question driving this study is: For patients who undergo outpatient breast surgery, is pain treatment without opioids as good as pain treatment with opioids?\n\nThe proposed trial will compare two groups of patients: one group will receive opioids to treat pain after surgery, while the other group will receive only non-opioid medications. The impact of these different medication strategies will be measured on pain intensity, pain interference with daily activities, medication side effects, and other outcomes. An expert team of scientists, surgeons, pain specialists, nurses, and patients has been assembled to maximize the success of this study. The results will provide important information to guide surgeons' decisions to prescribe (or not to prescribe) opioids. If opioid-free analgesia is found to be effective, doctors may be able to substantially reduce opioid prescribing after breast surgery and prevent more people from misusing opioids.",[96,34,97,98,99],"Post Operative Pain","Surgery","Postoperative Pain","Breast Disease",[97,101,102,103,104,105],"Postoperative analgesia","Breast surgery","Opioids","Postoperative pain","Postoperative care","RECRUITING","2025-01-10",{"date":109,"type":45},"2025-01-13",{"date":111,"type":45},"2024-11-26",{"date":113,"type":20},"2026-02-28",{"name":115,"class":52},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre"]