[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-consumption\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-consumption":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,44,78,105,124,154,186,222,254,283,310,334,359],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100620761","comparison-of-cumulative-opioid-consumption-between-variable-rate-feedback-infusion-and-fixed-rate-basal-infusion-modes-of-intravenous-pca-following-mixed-surgery-100620761",false,"NCT07361822","Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery","Prospective Randomized Controlled Study of Individualized PCA Model Based on Multi-dimensional Strategies (Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes)","Inclusion Criteria:\n\n* aged between 18 to 65 years;\n* American Society of Anesthesiologists physical status Ⅰ - Ⅲ;\n* Patients scheduled for elective mixed surgery were enrolled. Mixed surgeries included thoracic, abdominal, spinal, orthopaedic, and cranial procedures performed using either minimally invasive or open approaches.\n\nExclusion Criteria:\n\n* Allergy to PCA medications;\n* Presence of chronic pain syndromes;\n* Presence of psychiatric disorders, or severe cardiovascular, cerebrovascular, renal, or hepatic dysfunction.","ALL","18 Years","65 Years",{"count":20,"type":21},1170,"ESTIMATED","INTERVENTIONAL",[24],"NA","Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications. Although opioids are the first-line analgesics, excessive use leads to adverse reactions. The traditional fixed-rate PCA mode is difficult to match the changes in postoperative pain. This study will compare different PCA mode optimization strategies, assuming that they can reduce opioid dosage, improve analgesic effect, and reduce adverse reactions, providing high-quality evidence-based basis for postoperative analgesia and promoting individualized and intelligent management.",[27,28,29,30],"Surgery","Pain Management","Opioid Consumption","Patient-controlled Analgesia","RECRUITING","2026-06-11",{"date":34,"type":35},"2026-06-12","ACTUAL",{"date":37,"type":35},"2025-12-30",{"date":39,"type":21},"2027-12-30",{"name":41,"class":42},"Beijing Tiantan Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":43},"100635509","the-effects-of-regional-anaesthesia-techniques-on-hemidiaphragm-paralysis-postoperative-recovery-quality-opioid-consumption-and-pain-scores-100635509","NCT07553611","The Effects of Regional Anaesthesia Techniques on Hemidiaphragm Paralysis, Postoperative Recovery Quality, Opioid Consumption, and Pain Scores","Comparion of the Effects of Ultrasound-guided Interscalene Block, Erector Spinae Plane Block, Costoclavicular Block, and Supraclavicular Block on Hemidiaphragm Paralysis, Postoperative Recovery Quality, Opioid Consumption, and Pain Scores in Patients Undergoing Arthroscopic Shoulder Surgery: a Prospective Observational Trial","Inclusion Criteria:\n\n* aged 18-65 years\n* American Society of Anaesthesiology (ASA) score I-III\n* body mass index (BMI) \\\u003C30kg\u002Fm2\n* scheduled for elective arthroscopic surgery\n\nExclusion Criteria:\n\n* ASA score ≥4\n* BMI ≥30 kg\u002Fm2\n* declining to give written informed consent\n* controendications for block application\n* history of mental or neurological disease, severe liver and\u002For kidney disease\n* history of moderate or severe pulmonary disease\n* abnormal preoperative chest X-ray findings\n* scheduled for emergency surgery",{"count":52,"type":21},88,"OBSERVATIONAL","This study aims to evaluate the effects of ultrasound-guided interscalene, erector spinae plane, costoclavicular, and supraclavicular blocks on hemidiaphragmatic paralysis, postoperative recovery quality, opioid consumption, and pain scores.",[56,57,58,59,29,60],"Regional Anaesthesia","Arthroscopic Shoulder Surgery","Hemidiaphragmatic Paralysis","Recovery Quality","Postoperative Pain Score",[62,63,64,65,66,67],"regional anaesthesia","arthroscopic shoulder surgery","hemidiaphragmatic paralysis","recovery quality","opioid consumption","postoperative pain score","2026-05-06",{"date":70,"type":35},"2026-05-11",{"date":72,"type":35},"2026-04-21",{"date":74,"type":21},"2026-11-21",{"name":76,"class":77},"Antalya Training and Research Hospital","OTHER_GOV",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":43},"100619746","phase-3-opioid-sparing-joint-replacement-100619746","NCT07348627","Opioid-Sparing Joint Replacement","Opioid-Sparing Joint Replacement - Single Site Randomized Control Trial","Inclusion Criteria:\n\n* Diagnosis of hip osteoarthritis requiring primary arthroplasty\n* Scheduled to undergo anterior total hip arthroplasty (THA)\n* Able to comply with study procedures and follow-up visits\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Concurrent significant injuries to other bones or organs\n* Local infection at or near the surgical site\n* Preoperative opioid use within 4 weeks prior to surgery\n* History of severe heart disease (NYHA Class II or higher), renal failure, or liver dysfunction\n* Chronic liver disease\n* Neurological or psychiatric conditions that may influence pain perception\n* Pregnancy\n* History of alcohol or medication abuse\n* Inability to take NSAIDs\n* Use of postoperative DVT prophylaxis other than aspirin 81 mg twice daily\n* Diabetes mellitus with HbA1c \\> 8.0%\n* Diagnosis of chronic pain syndrome or fibromyalgia\n* Pain Catastrophizing Scale (PCS) score \\> 29\n* Any condition that, in the investigator's judgment, may interfere with adherence to study procedures or follow-up",{"count":86,"type":21},120,[88],"PHASE3","The goal of this clinical trial is to evaluate whether an opioid-sparing postoperative pain regimen can reduce opioid consumption and maintain effective pain control in adults undergoing anterior total hip arthroplasty for osteoarthritis.\n\nThe main questions it aims to answer are:\n\n* Does an opioid-limited regimen result in lower postoperative opioid use compared with a standard opioid prescription?\n* Does the opioid-limited regimen provide comparable or improved postoperative pain control and patient satisfaction?",[28,29],[92,93,94,95],"Total hip arthroplasty","Numeric Rating Scale for pain","Visual Analog Scale for nausea","Life Care specialist","2026-04-14",{"date":98,"type":35},"2026-04-17",{"date":100,"type":35},"2026-03-19",{"date":102,"type":21},"2028-08",{"name":104,"class":42},"Emory University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":25,"conditions":115,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":123,"locationsCount":43},"100621784","comparison-of-the-efficacy-and-safety-of-fixed-rate-basal-infusion-mode-and-time-programmed-decremental-background-infusion-mode-of-intravenous-pca-following-mixed-surgery-100621784","NCT07375121","Comparison of the Efficacy and Safety of Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode of Intravenous PCA Following Mixed Surgery","Prospective Randomized Controlled Study of Individualized PCA Model Based on Multi-dimensional Strategies (Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode)","Inclusion Criteria:\n\n* aged between 18 to 65 years;\n* American Society of Anesthesiologists physical status Ⅰ - Ⅲ;\n* Patients scheduled for elective mixed surgery were enrolled. Mixed surgeries included thoracoscopic surgery, laparoscopic surgery, hysteroscopy surgery, laparotomy, thoracotomy, open spinal surgery, craniotomy, and so on.\n\nExclusion Criteria:\n\n* Chronic pain syndromes;\n* Psychiatric disorders;\n* Severe cardiovascular or cerebrovascular disease, renal or hepatic functional dysfunction, or allergic to PCA medications.",{"count":113,"type":21},450,[24],[27,28,29,116],"Patient Controlled Analgesia","2026-03-31",{"date":119,"type":35},"2026-04-06",{"date":37,"type":35},{"date":122,"type":21},"2026-12-30",{"name":41,"class":42},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":132,"minAge":4,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":142,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":43},"100570371","compared-reversed-us-guided-dorsal-penile-nerve-block-rusdpnb-with-dpnb-in-circumcisions-for-pediatric-patients-100570371","NCT06706375","Compared Reversed US-Guided Dorsal Penile Nerve Block (RUSDPNB) With DPNB in Circumcisions for Pediatric Patients","A Comparison of Reversed-Ultrasound-Guided Dorsal Penile Nerve Block (RUS-DPBP) and DPNB in Circumcisions for Pediatric Patients","CIRCUSPRO","Inclusion Criteria:\n\n* male\n* undergoing circumcision\n* informed consent\n\nExclusion Criteria:\n\n* other surgery than circumcision in the same time\n* contraindication to local anesthesia\n* allergy to bupivacaine\n* chronic opiates treatment","MALE","17 Years",{"count":135,"type":21},216,[24],"Circumcision is a widely performed surgical procedure. For this reason, optimal analgesic management is essential. Loco-regional anesthesia, particularly penile blocks, combined with general anesthesia is the technique of choice for managing analgesia during circumcisions.\n\nUltrasound is increasingly used in locoregional anesthesia techniques. There is already human research on penile blocks and the use of ultrasound. Studies carried out to date describe an optimization of pain relief in children after circumcision compared with the alternative technique without ultrasound, as well as a reduction in local complications due to injection. However, other studies tend to contradict these findings.\n\nIn order to provide additional knowledge and to verify whether ultrasound could provide with more optimal relief after your circumcision, the investigators are carrying out this study.\n\nThe investigators are proposing to every patient aged 0 to under 18 who is going to undergo circumcision to take part in this project. A letter is sent to all potential participants no later than 3 days before the operation. Consent can be signed no later than the day of the operation. The cooling-off period is the same regardless of age.\n\nTaking part in the study does not affect the operation in any way. The block will take place in the operating room, prior to surgery.\n\nIn this study, participants are randomized into groups. This method is important for obtaining reliable results.\n\n* Group 1 (intervention group): The penile block will be performed using ultrasound.\n* Group 2 (control group): The penile block will be performed using anatomical landmarks.\n\nThis is a \"single-blind\" study, which means that only the anaesthetists, investigators and operating room team will be aware of the allocation to one of the two groups.\n\nData on opiate consumption will be registered as well as the different durations preoperatively, intraoperatively, postoperatively, back in the recovery room and before returning home or any complications as well as pain assessment.",[139,140,29,141],"Circumcision","Ultrasound","Penile Surgery",[143,144],"circumcision","reversed ultrasound guided dorsal penile nerve block","2026-03-24",{"date":147,"type":35},"2026-03-27",{"date":149,"type":35},"2024-11-29",{"date":151,"type":21},"2027-09",{"name":153,"class":42},"Centre Hospitalier Universitaire Vaudois",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":173,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":43},"100614824","pericapsular-nerve-group-peng-block-combined-with-lateral-femoral-cutaneous-nerve-lfcn-block-or-wound-infiltration-for-postoperative-analgesia-in-anterior-approach-total-hip-arthroplasty-a-randomized-controlled-trial-100614824","NCT07284615","Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial","Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration (WI) Combined With Pericapsular Nerve Group (PENG) Block for Analgesia in Elective Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial","Peng_lfcn\u002FWI","Inclusion Criteria:\n\n* Age \\> 18 years\n* Elective total hip arthroplasty\n* Spinal (subarachnoid) anesthesia\n* Written informed consent provided by the patient or by the legal guardian, if appointed\n\nExclusion Criteria:\n\n* INR \\> 1.5\n* aPTT \\> 1.5\n* Platelet count \\\u003C 75,000\u002Fmm³\n* Signs suggestive of infection at the puncture site\n* Absence of informed consent to the procedure\n* Documented or suspected allergy to local anesthetics",{"count":163,"type":21},102,[24],"This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach. Patients will be randomized to receive either a Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block, or a PENG block combined with wound infiltration (WI).\n\nThe primary outcome is postoperative pain intensity at rest, measured by Numerical Rating Scale (NRS) at 6 hours after surgery. Secondary outcomes include dynamic pain scores at 6, 24, and 48 hours, total opioid consumption, time to first rescue analgesia, quadriceps strength, hip flexion angle, length of stay, and adverse events.\n\nAll procedures are routinely used in clinical practice and carry minimal additional risk. Safety will be continuously monitored by the Principal Investigator and the study team according to an internal Safety Monitoring Plan.",[167,168,169,170,171,172,29],"Arthropathy of Hip","Hip Arthropathy","Locoregional Anesthesia","Complication of Anesthesia","Regional Anesthesia Morbidity","Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge",[174,175,176],"Postoperative muscle weakness","ERAS","Regional Block","2026-03-21",{"date":179,"type":35},"2026-03-25",{"date":181,"type":35},"2026-01-26",{"date":183,"type":21},"2026-11",{"name":185,"class":42},"Ospedale Edoardo Bassini",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":201,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":43},"100617183","preoperative-deep-parasternal-intercostal-plane-block-and-intraoperative-opioid-use-in-cardiac-surgery-100617183","NCT07315308","Preoperative Deep Parasternal Intercostal Plane Block and Intraoperative Opioid Use in Cardiac Surgery","Preoperative Ultrasound-Guided Deep Parasternal Intercostal Plane Block Reduces Intraoperative Opioid Consumption in Adults Undergoing Cardiac Surgery Via Median Sternotomy","Inclusion Criteria:\n\nAdults aged 18 to 65 years Scheduled to undergo elective cardiac surgery via median sternotomy Planned general anesthesia Able to provide written informed consent\n\nExclusion Criteria:\n\nKnown allergy or contraindication to local anesthetics Coagulation disorders or ongoing anticoagulant therapy that contraindicates regional anesthesia Infection at or near the planned injection site Pre-existing chronic pain conditions requiring long-term opioid use Severe cognitive impairment or inability to communicate pain intensity Emergency surgery Refusal or inability to provide informed consent",{"count":194,"type":21},80,[24],"Median sternotomy is commonly used in cardiac surgery and is associated with significant intraoperative and postoperative pain, often requiring substantial opioid administration. High opioid use during cardiac surgery may contribute to adverse effects such as respiratory depression, delayed extubation, postoperative nausea and vomiting, and prolonged intensive care unit stay. Therefore, effective opioid-sparing strategies are an important component of modern perioperative care.\n\nThe deep parasternal intercostal plane (DPIP) block is a regional anesthesia technique that targets the anterior cutaneous branches of the intercostal nerves, which are responsible for transmitting pain from the sternum and adjacent tissues. When performed under ultrasound guidance, this block allows precise local anesthetic deposition while minimizing the risk of pleural or vascular injury.\n\nThe purpose of this randomized controlled study is to evaluate whether a preoperative ultrasound-guided DPIP block reduces intraoperative opioid consumption in adult patients undergoing elective cardiac surgery via median sternotomy. Patients will be randomly assigned to receive either a bilateral DPIP block in addition to standard general anesthesia or standard general anesthesia alone.\n\nThe primary outcome of the study is total intraoperative opioid consumption. Secondary outcomes include time to extubation, postoperative opioid consumption within the first 24 hours, postoperative pain scores, and the incidence of opioid-related adverse effects. The results of this study may help define the role of the DPIP block as part of a multimodal, opioid-sparing analgesic strategy in cardiac surgery.",[198,199,29,200],"Postoperative Pain","Sternotomy","Intraoperative Pain Control",[202,203,204,205,206,207,208,209,210,211,212],"Deep parasternal intercostal plane block","Parasternal block","Ultrasound-guided regional anesthesia","Sternotomy analgesia","Cardiac surgery pain management","Opioid-sparing analgesia","Multimodal analgesia","Anterior chest wall block","Regional anesthesia in cardiac surgery","Intraoperative Pain","Intraoperative Opioid Consumption","2026-03-02",{"date":215,"type":35},"2026-03-04",{"date":217,"type":35},"2026-02-12",{"date":219,"type":21},"2027-01-01",{"name":221,"class":42},"Gaziantep City Hospital",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":132,"minAge":17,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":238,"overallStatus":244,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":43},"100626246","effect-of-rectus-block-timing-on-opioid-use-100626246","NCT07433140","Effect of Rectus Block Timing on Opioid Use","The Effect of Timing of Rectus Sheath Blockade During Robotic Prostate Surgery on Opioid Consumption: A Randomized Double-Blind Study","PROSTIMERSBOP","Inclusion Criteria:\n\n-ASA (American Society of Anesthesiologists) I-III adult patients with prostate cancer and benign prostate diseases scheduled for robotic surgery at Koç University Hospital.\n\nExclusion Criteria:\n\n* \\\u003C18 years of age\n* ASA (American Society of Anesthesiologists) IV, V patients\n* Non-elective emergency cases\n* Previous major abdominal\u002Fpelvic surgery\n* History of significant psychiatric disorders\n* Patients who may have contraindications to nerve blocks (bleeding diathesis, infection, and local anesthetic allergy).",{"count":231,"type":21},50,[24],"The aim of this study is to observe the effect of administering local anesthetic to the abdominal wall at the beginning or end of surgery under general anesthesia on opioid consumption during surgery. The hypothesis of this study is to demonstrate that administering a rectus sheath block before the surgical procedure under general anesthesia is effective in reducing intraoperative opioid consumption and opioid-related side effects compared to administering it after the surgery is completed.",[235,28,236,237,29],"Prostate Cancer","Nociception Level Index(NoL)","Nociception Monitoring",[239,240,241,242,243],"Robot Surgery","Rectus sheath block","Nociception","opioid","Cancer of Prostate","NOT_YET_RECRUITING","2026-02-19",{"date":247,"type":35},"2026-02-25",{"date":249,"type":21},"2026-03-15",{"date":251,"type":21},"2026-07-01",{"name":253,"class":42},"Koc University Hospital",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":268,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":43},"100587831","effects-of-erector-spinae-plane-block-on-opioid-consumption-anesthetic-consumption-and-hemodynamics-in-lumbar-disc-herniation-surgeries-100587831","NCT06933498","Effects of Erector Spinae Plane Block on Opioid Consumption, Anesthetic Consumption and Hemodynamics in Lumbar Disc Herniation Surgeries.","Comparison of the Effects of Preoperative and Intraoperative Erector Spinae Plane Block on Opioid Consumption, Anesthetic Consumption and Hemodynamics in Lumbar Disc Herniation Surgeries.","Inclusion Criteria:\n\n* Those over 18 and under 75 years of age,\n* Those with an American Society of Anesthesiologists (ASA) score of I-II-III,\n* Those with a body mass index (BMI) between 18-40 kg\u002Fm2\n* Patients undergoing surgery with general anesthesia\n* Patients undergoing LDH surgery (levels 1, 2, and 3)\n* Patients with informed consent\n\nExclusion Criteria:\n\n* Patients with severe cardiovascular system disease,\n* Patients with coagulation disorders,\n* Those allergic to the anesthetic and analgesic drugs to be administered,\n* Patients with infection at the injection site,\n* Patients with severe renal failure, gastrointestinal ulceration or severe asthma that prevents standard analgesia protocol\n* Patients who have previously undergone LDH surgery at the same level,\n* Patients who are planned to have surgery at more than 3 levels\n* Patients with ASA 4 and above,\n* Patients who are planned with total intravenous anasthesia(TIVA)","75 Years",{"count":263,"type":21},60,[24],"Lumbar disc herniation (LDH) is an increasingly common spine disorder . In patients treated surgically, inhalation anesthesia and the use of opioids for analgesic purposes are generally the chosen anesthetic methods. Surgical techniques such as discectomy, microdiscectomy, and stabilization (REF) are used to treat LDH. Although discectomy is considered the primary option in the treatment of LDH, less invasive techniques such as microdiscectomy have been applied in recent years . However, despite the use of less invasive techniques, patients experience pain after surgery . Clinicians want to avoid complications such as thromboembolism and hemodynamic deterioration that may occur due to postoperative pain, and to apply effective pain treatment for patient comfort and rapid discharge from the hospital. It has also been stated that inadequate postoperative pain treatment may increase the risk of developing chronic pain. Therefore, the use of opioids for analgesic purposes in the intraoperative and postoperative periods is quite common. However, opioid use may cause side effects that negatively affect postoperative recovery and may delay discharge. Some of these situations include delayed recovery from anesthesia, failure to perform early postoperative neurological examination due to delayed recovery, postoperative nausea and vomiting (PONV), pruritus, urinary retention, respiratory depression, gastrointestinal dysfunction, and addiction.\n\nAnother important issue is the difficulty of applying effective treatment to patients, the side effects that develop due to the applied treatments, and the increase in healthcare costs, which are important problems. Therefore, it is also very important to take a cost-effective approach while trying to treat patients at the highest level. The applied anesthesia and analgesia methods can also significantly affect the cost of surgical treatments. In particular, inhalation anesthetics used in patients receiving general anesthesia and opioids used for intraoperative and postoperative analgesia constitute a significant portion of the anesthesia cost. Therefore, strategies that will provide cost savings by reducing the use of both inhalation anesthetics and opioids are emphasized. In this context, nerve blocks or fascial plane blocks applied with local anesthetics come to the fore. With the widespread use of ultrasonography in regional anesthesia practice, regional plane blocks have also become widespread in parallel with this development and have begun to take more place in the literature. Erector spinae plane block (ESPB) is also among these blocks that are increasingly gaining ground in the literature. ESPB is a technique defined for both acute and chronic pain. ESPB is performed by administering local anesthetic (LA) to the fascial plane between the transverse process of the vertebra and the overlying erector spinae muscle. When literature data are examined, ESPB can be applied from the thoracic or lumbar levels in LDH surgery, before and after preoperative anesthesia induction, intraoperatively, at the end of surgery, before extubation or in the postoperative period. ESPB can be applied with the patient in the prone position, sitting or lateral decubitus position.\n\nIn studies conducted on patients undergoing laparoscopic cholecystectomy, it was found that ESPB reduced the amount of intraoperative inhalation anesthetic and opioid consumption. In another study examining the effect of ESPB on lumbar spine surgeries, it was found that ESPB reduced the use of intraoperative fentanyl and isoflurane and significantly shortened the recovery time. In addition, ESPB is thought to provide more effective analgesia in postoperative pain management and reduce opioid consumption and opioid-related side effects after lumbar spine surgeries. According to the results of published studies, it has been stated that ESPB is more effective for postoperative analgesia in patients undergoing lumbar surgery, significantly reduces pain scores at rest (static) and during activity (dynamic), provides a significant decrease in 24-hour opioid consumption, prolongs the first analgesic requirement period and is associated with fewer side effects.\n\nAnother important issue is to keep intraoperative hemodynamics stable within normal limits in patients under general anesthesia. Hemodynamic stability is very important to ensure that the amount of bleeding from the surgical site is kept at a minimum level, especially during LDH surgeries. It has been stated that the combined application of regional anesthesia and general anesthesia in spinal surgery provides better pain control as well as better hemodynamic stability.\n\nThis study aimed to compare the effects of preoperative and intraoperative ESPB on opioid consumption, anesthetic drug consumption, and hemodynamics in LDH surgeries.",[267,29,198],"Erector Spina Plan Block",[269,270,271,272,273],"Lumbar disc herniation surgery.","Erector spinae plane block","Anesthetic drug consumption","Opioid consumption","Perioperative hemodynamics","2025-09-17",{"date":276,"type":35},"2025-09-18",{"date":278,"type":35},"2025-04-15",{"date":280,"type":21},"2026-01-30",{"name":282,"class":77},"Ankara Ataturk Sanatorium Training and Research Hospital",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":296,"overallStatus":244,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":4},"100573832","single-level-and-two-level-serratus-posterior-superior-intercostal-plan-block-spsipb-100573832","NCT06751407","Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB)","Comparison of Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB) Applications in the Treatment of Acute Pain After Mastectomy","Inclusion Criteria:\n\n1-Those between the ages of 18-80\n\n2.Those with ASA score I-II-III\n\n3.Those with body mass index (BMI) between 18-40\n\n4.Patients who underwent Single-Level or Two-Level SPSIPB together with mastectomy in the operating room\n\nExclusion Criteria:\n\n1. Those under 18 and over 80\n2. Those with ASA score IV and above\n3. Those with advanced co-morbidities\n4. Those with a history of bleeding diathesis\n5. Patients with infection in the area where the block will be performed\n6. Those with BMI under 18 and over 40\n7. Patients who underwent surgery under emergency conditions","80 Years",{"count":231,"type":21},[24],"Breast cancer is the most common malignancy in women; one of the mainstays of breast cancer treatment is surgery, and modified radical mastectomy is one of the standard treatments. Postoperative pain can seriously reduce the quality of life in patients, and acute pain can even trigger chronic pain syndrome. Thoracic paravertebral, thoracic epidural, intercostal nerve, and interscalene brachial plexus blocks have been used for anesthesia and abrigation during modified radical mastectomy, but their applications are limited due to the complex nature of the procedures and serious complications. In recent years, regional nerve blocks, including intercostal nerve block, erector spinae plane block (ESPB), and paravertebral block, PECS I-II block, serratus anterior plane block (SAPB), and Serratus Posterior Superior Intercostal Plane Block (SPSIPB), have been applied for the treatment of postmastectomy pain in breast cancer patients. SPSIPB has been frequently used for the treatment of acute pain in the postoperative period following surgeries in the thoracic region. SPSIPB is placed on the spine of the scapula in the sagittal plane to identify the second and third ribs under USG guidance. After visualizing the trapezius and serratus posterior superior (SPS) by moving medially to the upper medial border of the scapula, a block is applied to the depths of the SPS from above the 3rd rib. The applied local anesthetic solution spreads under the SPS muscle. Ipsilateral postoperative analgesia is provided with SPSIPB. SPSIPB can be applied on the 3rd rib in one go, or on the 3rd and 4th ribs in two go. Thus, the local anesthetic solution can be distributed more effectively and more effective postoperative analgesia can be provided.",[29,295],"Demographic Data",[297,298,299,300],"serratus posterior superior intercostal plane block","pain","breast cancer","mastectomy","2025-06-30",{"date":303,"type":35},"2025-07-03",{"date":305,"type":21},"2025-07-15",{"date":307,"type":21},"2025-09-10",{"name":309,"class":77},"Ankara Etlik City Hospital",{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":261,"enrollmentInfo":317,"targetDuration":4,"studyType":22,"phases":319,"briefSummary":320,"conditions":321,"keywords":323,"overallStatus":244,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":4},"100578734","the-effects-of-esp-block-and-mid-transverse-process-to-pleura-block-on-postoperative-opioid-consumption-and-quality-of-recovery-100578734","NCT06815146","The Effects of ESP Block and Mid-Transverse Process to Pleura Block on Postoperative Opioid Consumption and Quality of Recovery","Comparison of the Effects of Erector Spinae Area (ESP) Block and Mid-Transverse Process to Pleura Block(MTP) on Postoperative Opioid Consumption and Quality of Recovery in Lumbar Spinal Surgery","Inclusion Criteria:\n\n* Elective Lumbar Spinal surgery performed\n* ASA I-III\n* 18-75 years old\n\nExclusion Criteria:\n\n1. Refusal at enrollment\n2. Request for withdrawal from the study\n3. Inability to give informed consent\n4. Emergency surgery\n5. Bleeding diathesis\n6. Presence of contraindications to the LA agents used in this study\n7. Use of chronic opioids\n8. Psychiatric disorders\n9. Presence of infection at the injection site",{"count":318,"type":21},126,[24],"Erector Spinae Area (ESP) Block and Mid-Transverse Process to Pleura Block(MTP) have recently been described for the treatment of pain after lumbar spinal surgery. Although these blocks have been shown to be effective in the treatment of pain after lumbar spinal surgery when compared with postoperative pain, they have not been compared in terms of the quality of recovery and opioid consumption after lumbar spinal surgery.\n\nThe aim of this clinical trial is to compare the effects of Erector Spinae Area (ESP) Block and Mid-Transverse Process to Pleura Block(MTP) on quality of recovery and opioid consumption in patients scheduled for lumbar spinal surgery. The effects of the 2 blocks on postoperative pain will also be compared and recorded.",[29,322],"Quality of Recovery(QoR-40), Preoperative and Postoperative",[66,324],"quality of recovery","2025-02-03",{"date":327,"type":35},"2025-02-07",{"date":329,"type":21},"2025-02-15",{"date":331,"type":21},"2026-02-15",{"name":333,"class":42},"Aydin Adnan Menderes University",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":341,"enrollmentInfo":342,"targetDuration":4,"studyType":22,"phases":343,"briefSummary":344,"conditions":345,"keywords":347,"overallStatus":244,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":358,"locationsCount":4},"100573122","comparison-of-bi-level-erector-spinae-plane-block-espb-and-modified-thoraco-abdominal-plane-block-m-tapa-100573122","NCT06742177","Comparison of Bi-Level Erector Spinae Plane Block (ESPB) and Modified Thoraco Abdominal Plane Block (M-TAPA)","Comparison of Bi-Level Erector Spinae Plane Block (ESPB) and Modified Thoraco Abdominal Plane Block (M-TAPA) in Laparoscopic Abdominal Surgery","Inclusion Criteria:\n\n1-Patients over 18 years of age\n\n2.Those with ASA score I-II-III\n\n3.Those with body mass index (BMI) between 18-40\n\n4.Patients who underwent LAS in the operating room with Bi-level ESPB or M-TAPA\n\nExclusion Criteria:\n\n1. Those under 18 years of age\n2. Those with ASA score IV and above\n3. Those with advanced co-morbidities\n4. Those with a history of bleeding diathesis\n5. Patients with infection in the area where the block will be performed\n6. Those with BMI below 18 and above 40\n7. Patients who underwent surgery under emergency conditions\n\n8- Patients with advanced liver and kidney failure","110 Years",{"count":231,"type":21},[24],"Laparoscopy is a surgical technique used for basic diagnosis and treatment. The advantages of laparoscopic techniques compared to open surgery have been demonstrated by studies. With the developing medicine and technology, minimally invasive approaches have been targeted in interventional procedures. In laparoscopic surgeries, access to the abdomen is provided with the help of a trocar and a temporary pneumoperitoneum is created with gas insufflation. Despite all these developments, even when laparoscopic techniques are used, postoperative pain is the most disturbing issue for patients. Postoperative pain can seriously reduce the quality of life in patients and acute pain can even trigger chronic pain syndromes. Epidural analgesia, paravertebral, erector spinae plane, intercostal nerve, transverse abdominis plane, external oblique, modified thoracoabdominal plane, rectus sheath block are used for anesthesia and analgesia during laparoscopic abdominal surgeries (LAS). In recent years, regional nerve blocks, including erector spinae plane block (ESPB) and modified thoraco-abdominal plane block (M-TAPA), have been applied for the treatment of pain in patients undergoing LAS due to various causes. ESPB was first described by Forero et al. in 2016 and has been frequently used for the treatment of acute pain in the postoperative period following abdominal surgeries. ESPB can be applied at any level from cervical to sacral, covering dermatomes appropriate for the surgical area under USG guidance. Cadaver studies for the ESPB mechanism have shown that local anesthetic spreads ipsilaterally and contralaterally and that it has analgesic efficacy both on the side where it is applied and on the opposite side. This peripheral nerve block, which is usually applied at a single level, can also be applied at bi-level. Studies have also shown that when ESPB is applied at bi-level, analgesic efficacy increases due to local anesthetic spread.\n\nM-TAPA is a new peripheral nerve block technique defined by Tulgar et al. It has high analgesic efficacy in thoraco-abdominal surgery. It has been shown to be advantageous in upper umbilical surgeries by involving more dermatomes compared to the transverse abdominis plane block. Lateral and anterior branches of thoraco-abdominal nerves are blocked with M-TAPA. It provides analgesia in a wide area between T5 and T12 and can also be applied for LAS. In our clinic, Bi-level ESPB or M-TAPA is routinely applied to suitable patients after anesthesia induction, and intraoperative anesthesia is maintained with inhalation and intravenous anesthetic agents. Multimodal analgesia management has been adopted as postoperative analgesia management.",[29,346,295],"Numerical Rating Scale",[348,349,350,351],"Modified Thoraco Abdominal Block","Erector Spinae Plane Block","Abdominal surgery","Pain","2024-12-16",{"date":354,"type":35},"2024-12-19",{"date":356,"type":21},"2024-12-30",{"date":329,"type":21},{"name":309,"class":77},{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":11,"sex":16,"minAge":366,"maxAge":17,"enrollmentInfo":367,"targetDuration":4,"studyType":22,"phases":369,"briefSummary":371,"conditions":372,"keywords":376,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":43},"100559378","phase-4-magnesium-sulfate-in-children-undergoing-laparoscopic-appendectomy-100559378","NCT06563349","Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy","The Effect of Intravenous Magnesium Infusion on the Opioid Consumption, the Circulatory, Metabolic and Hormonal Response to Intubation and Surgical Trauma During Anaesthesia for Laparoscopy in Children. Randomized Clinical Trial.","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) physical status class 1E, 2E, 3E (E - emergency)\n* Patients undergoing laparoscopic appendectomy\n\nExclusion Criteria:\n\n* Allergy to the magnesium sulfate or the excipient\n* Hypermagnesemia\n* Renal failure (GFR \\\u003C30 ml\u002Fmin)\n* Myasthenia gravis\n* Preoperative atrioventricular block\n* Hypotension\n* The use of digitalis glycosides\n* The use of oral anticoagulants\n* ASA physical status class 4E or higher\n* Chronic treatment with analgesics\n* Legal guardians or patient refusal","18 Months",{"count":368,"type":21},188,[370],"PHASE4","Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the concentration of IL-6 (interleukin 6) and tumor necrosis factor alpha. In adult patients, the need for morphine in the perioperative period is reduced when magnesium infusion is used. In current guidelines for treatment of acute pain in children, magnesium sulfate may be considered as a co-analgetic. However, the strength of such a recommendation is low due to the lack of reliable scientific research confirming the effectiveness of magnesium infusion in the pediatric population. The aim of this study is to evaluate the efficacy of intravenous magnesium sulfate infusion on the opioid consumption, the circulatory, metabolic and hormonal response to intubation and surgical trauma during anesthesia for laparoscopic appendectomy in children.",[29,373,374,375],"Multimodal Analgesia","Acute Appendicitis","Complication of Treatment",[377,378,379,380,381,382,383,384,385],"multimodal analgesia","magnesium sulfate","laparoscopic appendectomy","children","pediatric population","adjuvant","metabolic stress response","hormonal response","inflammatory response","2024-11-09",{"date":388,"type":35},"2024-11-12",{"date":390,"type":35},"2024-09-09",{"date":392,"type":21},"2027-10-01",{"name":394,"class":42},"Medical University of Warsaw"]