[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-free-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-free-anesthesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,40,68,96,125,174,204,225,247],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100622859","phase-4-opioid-free-anesthesia-versus-opioid-based-anesthesia-for-adolescent-idiopathic-scoliosis-100622859",false,"NCT07389096","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis A Prospective Randomized Double-Blind Controlled Trial","Inclusion Criteria:Patients younger than 18 years of age, classified as American Society of Anesthesiologists (ASA) Physical Status I or II, and will be scheduled for surgical correction of adolescent idiopathic scoliosis.\n\n\\-\n\nExclusion Criteria:• Refusal to participate in the study or to allow use of personal data\n\n* Non-idiopathic scoliosis\n* Contraindications to commonly used perioperative medications\n* ASA Physical Status ≥ III\n* Presence of neuromuscular disorders or severe cardiac dysfunction\n* Requirement for postoperative mechanical ventilation\n* Regular use of analgesics or opioids\n* History of allergy to opioids or dexmedetomidine\n* Diagnosed mental disorders\n* Severe hepatic or renal dysfunction\n* Coagulopathy or significant pulmonary disease\n* Preoperative or postoperative neurological deficits\n* Occurrence of serious arrhythmia, hypotension, or bradycardia necessitating discontinuation of dexmedetomidine infusion","ALL","8 Years","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids. This technique employs a combination of antinociceptive agents targeting various pathways within the central and peripheral nervous systems to achieve effective analgesia.\n\nDexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive and anxiolytic properties. Only a few prospective randomized controlled trials have specifically examined the postoperative analgesic efficacy of intraoperative dexmedetomidine infusion in patients undergoing spinal surgery, with limited data focusing on this as a primary endpoint. Importantly, no clinical studies have investigated its analgesic impact in patients undergoing spinal surgery under general anesthesia.",[27],"Opioid Free Anesthesia","RECRUITING","2026-01-30",{"date":31,"type":32},"2026-02-05","ACTUAL",{"date":29,"type":21},{"date":35,"type":21},"2027-01-31",{"name":37,"class":38},"Nashwa Ahmed","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100620646","role-of-opioid-free-anaesthesia-in-elderly-patients-undergoing-elective-coronary-artery-bypass-graft-surgeries-with-cardiopulmonary-bypass-in-enhanced-recovery-after-surgeries-100620646","NCT07360327","Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries","Inclusion Criteria:\n\n* Age group: above 65 years old of both sex. Undergoing an elective coronary artery bypass graft surgeries with cardiopulmonary bypass.\n\nExclusion Criteria:\n\n* Past or ongoing history of drug abuse.\n* Psychiatric disease and cognitive disorders.\n* Inability to perform the confusion assessment method for the intensive care unit (CAM-ICU) test.\n* EF\\\u003C40 %.\n* 1st or 2nd degree Heart block.\n* HR \\\u003C50 bpm.\n* Allergy from drugs used in this study.\n* Use of a left ventricular assist device, IAB or ECMO pri","65 Years","90 Years",{"count":49,"type":21},60,[51],"NA","The introduction of synthetic opioids in 1960 to general anesthesia together with sedative hypnotics and muscle relaxants allowed the appearance of the concept of multimodal balanced anesthesia. Although they help in achieving hemodynamic stability during anesthesia of open heart surgeries, their administration consequences are neither scarce nor benign to the patient. Perioperative opioids are associated with increased incidence of respiratory depression, prolonged mechanical ventilation, nausea and vomiting, prolonged sedation, Postoperative ileus (POI), urine retention, Postoperative cognitive dysfunction (POCD), immune depression and hyperalgesia (Beloeil et al., 2018).\n\nCoronary artery bypass graft surgery with cardiopulmonary bypass (CPB) is particularly vulnerable to the above-mentioned complications. Indeed, some of the side effects of this surgery overlap with the adverse effects of opioids. Postoperative pulmonary complications are observed in up to 50% of patients (Fisscher et al., 2022) and POCD or delirium in 4-54% according to studies (Bhushan et al., 2021). Whereas major gastrointestinal complications are estimated to occur in around 3% of patients, essentially acute pancreatitis, postoperative ileus (Marsoner et al., 2019).\n\nOpioid-free anesthesia (OFA) strategies have emerged to avoid intraoperative opioid use. It is based on the fact that a sympathetic reaction evidenced by hemodynamic changes in an anesthetised patient does not systematically reflect pain. In addition, a sleeping patient will not recall pain, while hormonal stress and sympathetic and inflammatory reactions can be controlled by therapeutic classes",[54,55,56,27,57],"CABG","Dexmedetomidine","Ketamine","Opioid Based Anesthesia","NOT_YET_RECRUITING","2026-01-14",{"date":61,"type":32},"2026-01-22",{"date":63,"type":21},"2026-01-01",{"date":65,"type":21},"2026-12-01",{"name":67,"class":38},"Ain Shams University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":16,"minAge":18,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100616538","effect-of-opioid-free-anesthesia-ofa-on-postoperative-pain-and-perioperative-nausea-and-vomiting-in-elective-laparoscopic--100616538","NCT07306910","Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic .","Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic Cholecystectomy.","OFA","Inclusion Criteria:\n\n* Adults aged 18 to 60 years scheduled for elective laparoscopic cholecystectomy. Elective must be included in title.\n* ASA (American Society of Anesthesiologists) physical status I or II.\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Chronic opioid use (\\>30 MME\u002Fday for \\>3 months).\n* Contraindications to study medications (e.g., severe hepatic impairment; allergy\u002Fcontraindication to lidocaine, dexmedetomidine, ketamine, fentanyl, or NSAIDs).\n* Renal dysfunction (eGFR \\\u003C60 mL\u002Fmin\u002F1.73 m²).\n* Significant cardiac conduction abnormalities.\n* Pregnancy or lactation.\n* Emergency surgery or conversion to open cholecystectomy",true,"60 Years",{"count":79,"type":21},110,[51],"1. To evaluate the efficacy of a standardized multimodal Opioid Sparing (OS) protocol versus conventional opioid-based analgesia in reducing acute postoperative\n2. To quantify opioid consumption reduction achievable through OS strategies\n3. To assess the impact of OS on hemodynamic parameters during critical surgical phases\n4. To compare recovery metrics (PONV, bowel function, ambulation)\n5. To evaluate the safety profile of OS anesthesia",[83,84],"Opioid-Free Anesthesia","Elective Laparoscopic Cholecystectomy",[86],"opa","2025-12-13",{"date":89,"type":32},"2025-12-29",{"date":91,"type":21},"2025-12-30",{"date":93,"type":21},"2028-12-30",{"name":95,"class":38},"Assiut University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":107,"conditions":108,"keywords":112,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":39},"100613282","effect-of-ofa-osa-versus-opioid-based-anesthesia-on-nets-and-cancer-cell-malignancy-after-colorectal-cancer-surgery-100613282","NCT07264556","Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","Effect of Opioid-Free, Opioid-sparing Versus Opioid-based Anesthesia on Perioperative NETs and Cancer Cell Malignancy in Patients Undergoing Surgery for Colorectal Cancer: A Randomized, Controlled Trial","Inclusion Criteria:\n\n* aged 18-80 years old,\n* American Society of Anesthesiologists physical status I-III,\n* elective colorectal cancer surgery under general anesthesia\n\nExclusion Criteria:\n\n* previous history of colorectal surgery,\n* addicted to opioids,\n* serious major mental or physical illness (heart, pulmonary, hepatic, or renal diseases),\n* radiotherapy or chemotherapy history within 8 weeks prior to the surgery,\n* contraindications to anesthetic agents or epidural.","80 Years",{"count":105,"type":21},90,[51],"Adult patients aged 18-80 years old, American Society of Anesthesiologists physical status I-III, who were scheduled for elective colorectal cancer surgery under general anesthesia were recruited for this study. They were randomized to receive opioid-free anesthesia (OFA), opioid-sparing anesthesia (OSA) and opioid-based anesthesia (OA) group.\n\nBlood samples were collected pre-surgery and 24h post-surgery. As primary endpoint, serum neutrophil myeloperoxidase (MPO) and citrullinated histone3 (CitH3) was measured. The secondary endpoints included the effects of postoperative serum on colorectal cancer (CRC) cells malignancy, numerical rating scale (NRS) scores, postoperative adverse events and recovery profiles.\n\nFor OA group, intraoperative remifentanil and sufentanil were used and postoperative patient controlled intravenous analgesia (PCIA) was performed with 0.5μg\u002Fml of sufentanil and 0.75 mg\u002FmL flurbiprofen, and the PCIA was stopped 48 h after surgery.\n\nFor OSA group, remifentanil and sufentanil were used only for anesthetic induction and the patient received ultrasound-guided transversus abdominis plane (TAP) nerve blockwas performed. Patient controlled intravenous analgesia (PCIA) was performed with 1mg\u002FmL of oxycodone and 0.75 mg\u002FmL flurbiprofen after surgery, and the PCIA was stopped 48 hours after surgery.\n\nFor OFA group, intraoperative epidural anesthesia combined with general anesthesia was used, and esketamine, lidocaine and dexmedetomidine for analgesia. Patient controlled epidural analgesia (PCEA) was used and terminated 48 hours after surgery.",[109,110,111],"Colorectal Cancer","Opioid-free Anesthesia","NETs",[113,114,115],"Opioid free anesthesia","Neutrophil extracellular trapping markers","colorectal cancer","2025-11-24",{"date":118,"type":32},"2025-12-04",{"date":120,"type":32},"2025-11-01",{"date":122,"type":21},"2025-12-15",{"name":124,"class":38},"Fudan University",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":146,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":39},"100599458","non-opioid-anesthesia-based-on-thoracic-paravertebral-block-during-laparoscopic-sleeve-gastrectomy-100599458","NCT07084753","Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","Comparison of Opioid-based Anesthesia, Opioid-free Anesthesia Based on Intravenous Drugs and Opioid-free Anesthesia With Thoracic Paravertebral Block, in Patients Undergoing Laparoscopic Gastric Bypass Surgery for Obesity","Inclusion Criteria:\n\n-. patients with a prior history of treatment by a multidisciplinary obesity team scheduled for laparoscopic sleeve gastrectomy (LSG)\n\n* body mass index of 30 kg\u002Fm² or greater\n* patients classified as ASA status 2-3.\n\nExclusion Criteria:\n\n* allergies to the intended medications\n* patient refusal\n* uncontrolled psychiatric disorders\n* intracranial pathology\n* cerebrovascular damage\n* any factors impairing effective communication\n\nAdditional Exclusion Criteria:\n\n1. For patients receiving thoracic paravertebral block (TPVB):\n\n   \\- the presence of infection at the puncture site\n2. For the OFA group:\n\n   * 2nd or 3rd-degree atrioventricular block\n   * bradycardia with a heart rate below 50 beats per minute\n   * coronary artery disease,\n   * cardiomyopathy.","70 Years",{"count":134,"type":21},36,[51],"Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain. In this study, an ultrasound-guided paravertebral block will be used, with careful consideration of all positive and negative factors and possible complications. A thoracic paravertebral block is performed by inserting a needle into the intercostal spaces on the back, approximately 4 cm lateral to the spine. Many studies support excellent pain control with this technique, during and after surgery in thoracic and abdominal surgery. Investigators aim to achieve faster patient mobility after surgery, rapid recovery of bowel function, reduced nausea and vomiting, and maximum pain control. The use of opioids, which can additionally cause respiratory suppression and drowsiness, is avoided.\n\nAt any time in case of need to switch from laparoscopic to open surgery, equally adequate anesthesia and postoperative analgesia are ensured without the need to change the approach to the same. In this study, the basic scientific assumption (hypothesis) of the researchers is that non-opioid anesthesia with thoracic paravertebral block provides adequate pain control during and long-term after the surgical procedure, without the side effects of opioid anesthesia.\n\nThe main goal of the study is to determine which type of anesthesia results in the best pain control and most significantly reduces complications of anesthesia and surgery in overweight patients who are scheduled for laparoscopic longitudinal gastrectomy and partial\u002Ftotal gastrectomy.",[138,139,140,141,142,143,144,145,27],"Obese Patients","Bariatric Surgical Pain","Bariatric Surgery (Sleeve Gastrectomy )","Non-Opioid Pain Management","PONV","Postoperative Analgesia","Postoperative Pain","Thoracic Paravertebral Block",[147,148,149,150,151,152,153,154,155,156,157,158,113,159,74,160,141,142,161,162,163,164],"thoracic paravertebral block","obese patients","bariatric surgery","sleeve gastrectomy","postoperative pain management","anesthesia recovery period","non-opioid anesthesia","recovery after bariatric surgery","TPVB","OFA based on thoracic paravertebral block","Visceral pain, Postoperative","Opioid based anesthesia","OBA","Recovery Period, Anesthesia","Postoperative analgesia","Postoperative pain","Bariatric Surgery, Pain","Opioid free anesthesia, dexmedetomidine, ketamine, lidocaine","2025-07-17",{"date":167,"type":32},"2025-07-24",{"date":169,"type":21},"2025-07-30",{"date":171,"type":21},"2025-10",{"name":173,"class":38},"IVO JURISIC",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":46,"enrollmentInfo":182,"targetDuration":4,"studyType":183,"phases":4,"briefSummary":184,"conditions":185,"keywords":190,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":39},"100586452","modulation-of-the-inflammatory-response-in-bariatric-surgery-100586452","NCT06915558","Modulation of the Inflammatory Response in Bariatric Surgery","Modulation of the Inflammatory Response to Surgical Trauma: Comparison of Three Anesthetic Techniques in Bariatric Surgery Patients","MRICBx3","Inclusion Criteria:\n\n* Patients scheduled for bariatric surgery.\n* Age 18-65 years.\n* BMI ≥ 30 kg\u002Fm².\n* ASA physical status II-III.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Chronic opioid use before surgery.\n* Severe renal or hepatic failure.\n* Uncontrolled psychiatric disorders.\n* Significant intraoperative complications requiring protocol deviation.",{"count":105,"type":21},"OBSERVATIONAL","This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids.\n\nThe study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response.\n\nThe results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.",[186,187,188,144,83,189],"Obesity","Bariatric Surgery Candidate","Inflammation","Heart Rate Variability",[83,191,192,193,194],"Opioid-Based Anesthesia","Inflammatory Markers","Surgical Stress Response","heart rate variability","2025-04-04",{"date":197,"type":32},"2025-04-08",{"date":199,"type":32},"2024-12-02",{"date":201,"type":21},"2025-12-02",{"name":203,"class":38},"Hospital HM Nou Delfos",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":211,"targetDuration":212,"studyType":183,"phases":4,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":4},"100581132","opioid-free-anesthesia-and-quality-of-recovery-after-general-anesthesia-100581132","NCT06846333","Opioid-free Anesthesia and Quality of Recovery After General Anesthesia","Effect of Opioid-free Anesthesia Protocol on Quality of Recovery After Major Surgery in Geriatric Patients","Inclusion Criteria:\n\n* Patients aged 65 and older\n* Undergoing major elective non-cardiac surgery under general anesthesia\n* Classified as ASA I-II-III\n* With sufficient cognitive ability to complete a questionnaire were included in the study\n\nExclusion Criteria:\n\n* Patients requiring rapid sequence induction for emergency cases\n* Those with severe psychiatric or cognitive disorders preventing questionnaire evaluation\n* A body mass index \\\u003C 18 or \\> 39 kg\u002Fm²\n* Allergy or contraindication to any drug included in the study\n* A history of chronic pain or chronic opioid use\n* Uncontrolled epilepsy, decompensated heart failure\n* Chronic kidney or liver failure\n* Preoperative bradycardia with atrioventricular block (2nd or 3rd degree)\n* Heart rate \\\u003C 50 bpm due to chronic beta-blocker therapy\n* Those using medications that prolong the QT interval\n* Patients whose anesthesia regimen was intraoperatively changed (from opioid-free to opioid-containing anesthesia)",{"count":49,"type":21},"3 Days","This study aimed to evaluate the effect of an opioid-free anesthesia protocol on postoperative recovery quality in patients aged 65 years and older undergoing major surgery. Recovery quality was assessed using the Quality of Recovery-15 (QoR-15) questionnaire. Findings are expected to contribute to optimizing anesthesia practices in the elderly population by improving recovery quality and reducing opioid-related side effects.",[110,215],"Geriatric Population","2025-02-25",{"date":218,"type":32},"2025-02-26",{"date":220,"type":21},"2025-02-20",{"date":222,"type":21},"2025-04-30",{"name":224,"class":38},"Selcuk University",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":46,"enrollmentInfo":232,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":4},"100566068","opioid-free-anesthesia-versus-opioid-based-anesthesia-100566068","NCT06650371","Opioid Free Anesthesia Versus Opioid Based Anesthesia","Comparative Study Between the Performance of Opioid Free Anesthesia Versus Conventional Opioid Based Anesthesia Regarding Achievement of Enhanced Recovery in Laparoscopic Bariatric Surgeries","Inclusion Criteria:\n\n* Undergoing a scheduled laparoscopic bariatric surgery under general anesthesia.\n* Age group: 18-65 years old.\n* BMI greater than 35 to 50 Kg\u002Fm2\n* ASA physical status classes I and II.\n\nExclusion Criteria:\n\n* Patient refusal.\n* ASA physical status classes III and IV.\n* Anticipated difficult intubation.\n* Hypersensitivity to any drugs used in this study. Inability to extubate the patient at the end of the operation. Conversion to laparotomy. Patients for whom the anesthetic regimen is changed intraoperatively (from OFA to OBA or vice versa).",{"count":134,"type":21},[51],"This Study aims to evaluate the efficacy of opioid free general anesthesia in achieving enhanced recovery after surgery (ERAS) in laparoscopic bariatric surgery in terms of post-operative recovery time, cumulative pethidine consumption and number of episodes of postoperative nausea and vomiting(PONV).",[27,236],"Laparoscopic Bariatric Surgeries",[113,238],"laparoscopic bariatric surgeries","2024-10-18",{"date":241,"type":32},"2024-10-21",{"date":243,"type":21},"2024-11-20",{"date":245,"type":21},"2025-08-01",{"name":67,"class":38},{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":22,"phases":255,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":4},"100554000","effect-of-opioid-free-anesthesia-on-sleep-quality-cognitive-function-and-recovery-quality-after-general-anesthesia-in-elderly-patients-100554000","NCT06493396","Effect of Opioid-free Anesthesia on Sleep Quality, Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients","Inclusion Criteria:\n\n* Elderly patients to undergo elective non-cardiac surgery\n\n  * ASA grade I or III;\n\n    * volunteered in this trial and signed informed consent;\n\n      * age 60 years;\n\n        * BMI 18-30kg \u002F m2.\n\nExclusion Criteria:\n\n* Chronic pain;\n\n  * severe liver dysfunction (total bilirubin 2 mg dl-1);\n\n    * severe renal dysfunction (glomerular filtration rate 60ml min-1 1.73m-2);\n\n      * preoperative heart rate \\\u003C50 beats \u002F min, sick sinus syndrome, severe heart block;\n\n        * dementia or significant neurological disease (such as stroke, epilepsy, intracranial tumor, Parkinson disease, etc);\n\n          * history of alcohol or drug abuse;\n\n            * preoperative or PSQI score 7 or sleep disturbance;\n\n              * Cannot cooperate with the scale survey\n\n                * Allergic to the trial drug",{"count":254,"type":21},88,[51],"Postoperative cognitive dysfunction (POCD)is a common well disorder of the central nervous system after surgery, mainly manifested by impaired memory, spirit, language ability or other aspects of brain function. POCD, which often occurs in elderly patients over 65 years, The recent phase is recommended to be changed to perioperative neurocognitive impairment ( PND), The PND is used to describe the cognitive function changes that occur before and within 1 year after surgery, Based on the time of disease onset, It can be divided into neurocognitive impairment existing before surgery, postoperative delusion (POD) occurring hours to days after surgery, neurocognitive recovery delay (DNR) within 30 days after surgery, and postoperative neurocognitive impairment occurring weeks to months after surgery (POND). With the acceleration of the aging process of Chinese social population, the frequency of surgical treatment for elderly inpatients has also increased, and the elderly patients have postoperative sleep disorders, and POCD is relatively common. Surgical patients after surgical trauma, the body inflammation, sympathetic excitation and endocrine disorders, make postoperative sleep structure or pattern change, often lead to postoperative sleep disorders (PSD) , the main performance for patients with postoperative complaint difficult to enter and maintain sleep, frequent nightmares, total sleep quantity and quality reduction, etc. PSD is not only the most common manifestation of postoperative brain dysfunction, but also an important risk factor for inducing postoperative fatigue, postoperative hyperalgesia, metabolic dysfunction, and cardiovascular and cerebrovascular diseases. Moreover, it is considered to promote the development of postoperative delusion. At present, the common mode of general anesthesia is still mainly opioids, and opioids are an important part of general anesthesia and perioperative analgesia. Perioperative use of opioids is not only associated with adverse effects such as postoperative nausea and vomiting, excessive sedation, and ileus, but also leads to the occurrence of postoperative hypoxemia, hyperalgesia and postoperative chronic pain, and cognitive impairment. Therefore, the Association of Accelerated Rehabilitation Surgery indicates that the use of a multimodal analgesic regimen during the perioperative period reduces pain and reduces opioid-related adverse effects, and that opioid-free anesthesia ( OFA) is used in clinical work. At present, most clinical studies of OFA focus on adults aged 18-65 or 18 years old, and few studies focus OFA solely on the elderly population to observe its application effect. Therefore, it is necessary to conduct clinical studies to observe postoperative recovery in elderly patients with different types of anesthetics, investigate the incidence and severity of POCD, and determine the efficacy and safety of each anesthetic agent.",[83,258,259,260],"POCD","Recovery Quality","Sleep Quality","2024-07-02",{"date":263,"type":32},"2024-07-10",{"date":265,"type":21},"2024-08-01",{"date":267,"type":21},"2025-08-31",{"name":269,"class":38},"Beijing Friendship Hospital"]