[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-overdose\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-overdose":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,48,81,107,132,153,187,214,235,256],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630258","phase-4-a-bundled-intervention-to-end-opioid-overdoses-100630258",false,"NCT07485335","A Bundled Intervention to End Opioid Overdoses","Implementation and Effectiveness of A Bundled Intervention to End Opioid Overdoses by Increasing Treatment Uptake Post Discharge","B-CARE","Inclusion Criteria:\n\n1. discharged from the ED and inpatient settings at the UAB hospital\n2. 19 years or older (the age of majority in Alabama);\n3. diagnosis of OUD and experiencing opioid overdose in the last 12 months;\n4. prescribed buprenorphine in the ED and willing to continue buprenorphine post-ED discharge;\n5. English speaking;\n6. not actively psychotic and suicidal, or cognitively impaired.\n7. Patients who are admitted to the hospital from the ED will be eligible for enrollment.\n\nExclusion Criteria:\n\n1. living in a restricted environment (e.g., prison or jail facility, etc.);\n2. currently enrolled in other clinical studies;\n3. anticipated to take other prescribed opioids except buprenorphine for a medical condition longer than three months;\n4. known allergic reaction to buprenorphine;\n5. critically ill or injured;\n6. females with pregnancy (they are anticipated to request a higher level of care).\n7. living outside of Alabama","ALL","19 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge. Evidence-based treatment modules to reduce repeat opioid overdose and mortality are lacking in this patient population. A bundled intervention is proposed, including telehealth, peer support specialist, buprenorphine, and linkage for definitive care, that is designed to increase treatment uptake in this patient population post-ED discharge, reduce repeat opioid overdoses, and end overdose deaths.",[27,28],"Opioid Use Disorder","Opioid Overdose",[30,31,32,33,34],"Emergency department","post discharge","buprenorphine","peer support specialist","telehealth","NOT_YET_RECRUITING","2026-06-16",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":21},"2026-09-07",{"date":43,"type":21},"2030-09-30",{"name":45,"class":46},"University of Alabama at Birmingham","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":47},"100578043","machine-learning-prediction-and-reducing-overdoses-with-ehr-nudges-100578043","NCT06806163","Machine-Learning Prediction and Reducing Overdoses With EHR Nudges","mPROVEN","Inclusion Criteria:\n\n* Received an opioid prescription within the past year\n* Age 18 years or older at the time of the opioid prescription\n* At least one visit to an internal medicine or family care practice within the past year\n\nExclusion Criteria:\n\n* Diagnosis of malignant cancer within the past year\n* Enrollment in hospice care","18 Years",{"count":57,"type":21},1350,[59],"NA","The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction model as having an elevated risk for an opioid overdose.\n\nThe clinical trial will evaluate the effectiveness of providing a flag in the EHR to identify individuals at elevated risk with and without behavioral nudges\u002Fbest practice alerts (BPAs) as compared to usual care by primary care clinicians.\n\nThe primary goals of the study are to improve opioid prescribing safety and reduce overdose risk.",[28,62,27,63],"Opioid Use","Opioids",[65,66,67,68,69,70,71,28,63],"Machine learning","Risk prediction","Behavioral nudge","Best Practice Alert","Artificial intelligence","Primary care","Electronic Health Record Platforms","RECRUITING",{"date":74,"type":39},"2026-06-17",{"date":76,"type":39},"2025-03-10",{"date":78,"type":21},"2027-02",{"name":80,"class":46},"University of Pittsburgh",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":47},"100551893","unityphilly-response-app-for-overdose-reversal-100551893","NCT06466005","UnityPhilly Response App for Overdose Reversal","UnityPhilly Response App for Overdose Reversal: Assessing Citywide Effectiveness and Sustainability","Inclusion Criteria:\n\n* owning a smartphone with a data package;\n* living or working in one of three identified Philadelphia neighborhoods;\n* aged 18 or older.\n\nExclusion Criteria:\n\n* persons aged under 18 years of age",true,{"count":90,"type":21},450,"OBSERVATIONAL","The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app. The main hypotheses to answer are:\n\nHypothesis 1: UnityPhilly signal rates relative to EMS calls will increase over time. The primary outcome will be assessed as the total number of overdoses signaled by participants relative to all overdose-related EMS calls, per year.\n\nHypothesis 2: The number of cases where a nearby UnityPhilly participant successfully reverses an overdose with naloxone will increase over time. The primary outcome will be assessed as the number of successful reversals relative to the total number of responder arrivals, per year.\n\nParticipants will be supplied with the UnityPhilly app, training on how to use the app and respond to an opioid overdose using naloxone, and respond to follow up surveys about their experiences.",[28],[95,96,97],"overdose prevention","Philadelphia","UnityPhilly","2026-05-07",{"date":100,"type":39},"2026-05-12",{"date":102,"type":39},"2025-09-16",{"date":104,"type":21},"2028-07",{"name":106,"class":46},"Drexel University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":88,"sex":17,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100556590","evaluation-of-clinical-decision-support-in-opioid-tapering-100556590","NCT06527079","Evaluation of Clinical Decision Support in Opioid Tapering","Inclusion Criteria: Primary care patients being tapered from an opioid. Tapering patients:\n\n* Have an active opioid prescription for more than 3 months and\n* Prescribed more than 90 morphine milligram equivalents (MME) per day or\n* Co-prescribed an opioid and benzodiazepine or\n* Received a reduction in opioid dosage by more than 5% MME per day\n\nExclusion Criteria:\n\n* Patients \\\u003C12 and \\>89\n* Patients with active cancer diagnosis in last 1 year\n* Patients with hospice care\u002Fpalliative care order\n* Patients with sickle cell disease diagnosis","12 Years","89 Years",{"count":116,"type":21},200000,"The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. This project will evaluate a clinical decision support (CDS) tool in the form of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering. Primary care providers will be randomized at the clinic location to a control arm or intervention arm. The control arm will have the clinical care pathway available, but will not be reminded of the pathway when tapering a patient. The intervention arm will receive a nudge when prescribing a tapering opioid strategy to a patient to use the clinical care pathway. The rate of opioid tapering in line with CDC guidelines will be examined as well as long-term patient outcomes of opioid overdose or poisoning using existing patient health records. The study period will be approximately 18 months.",[119,120,27,121,28,122],"Medication Abuse","Harm Reduction","Opioid Prescribing","Prevention","2026-04-20",{"date":125,"type":39},"2026-04-23",{"date":127,"type":21},"2026-08",{"date":129,"type":21},"2027-06",{"name":131,"class":46},"University of Colorado, Denver",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":25,"conditions":143,"keywords":144,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":47},"100561663","phase-1-a-bundled-intervention-100561663","NCT06593093","A Bundled Intervention","A Bundled Intervention to End Opioid Overdose by Increasing Treatment Uptake Post Emergency Department Discharge",{"count":139,"type":21},190,[141,142],"PHASE1","PHASE2",[27,28],[30,31,32],"2026-02-19",{"date":147,"type":39},"2026-02-23",{"date":149,"type":39},"2025-02-13",{"date":151,"type":21},"2030-11-30",{"name":45,"class":46},{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":88,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":47},"100599034","a-model-to-save-lives-through-a-volunteer-first-responder-service-providing-antidote-treatment-in-opioid-overdose-100599034","NCT07079241","A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose","REgion Skåne Preventing Overdose Through Naloxone Distribution With Emergency Runners: a Feasibility Study for a Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose","RESPONDER","Inclusion Criteria for volunteer first responder:\n\n1. Give informed written consent to participate in the study\n2. Successfully complete an opioid overdose and naloxone course in addition to a first aid course, following current first aid guidelines from the Swedish Resuscitation Council and the European Resuscitation Council.\n3. Download and register oneself as a user on the project-specific volunteer first responder app on a smartphone\n4. Purchase naloxone from a pharmacy and receive reimbursement for the full cost of the purchase upon submission of the pharmacy receipt\n\nExclusion Criteria for volunteer first responder:\n\n1\\. Displaying inappropriate behavior during the education day (or otherwise in time, as witnessed or experienced by course instructors or the project team). Such conduct could for example be to not follow the guidelines of low-arousal (non-confrontational) approach in emergencies.\n\nInclusion Criteria for overdose alerts:\n\n1. Victim being ≥15 years old\n2. Any naloxone-responder being up to 10.000 meters from the situation, in Skåne\n\nExclusion Criteria for overdose alerts:\n\n1. Any trauma behind the condition\n2. Dispatcher impression of the scene to be unsafe for lay persons",{"count":162,"type":21},1000,[59],"Opioids are responsible for the greatest drug-related global health burden. Prevention and treatment programs for people with opioid use disorder are widely implemented, but further actions are required to reduce the mortality and morbidity caused by opioid use and dependence. We suggest a novel and unique approach with a volunteer first responder system for suspected opioid overdoses, integrated with national emergency call services. The idea derives from the success of volunteer first responder systems for out-of-hospital cardiac arrests. Several reports exist globally with results of increased survival rates, less complications and a beneficial time-gain to start of cardiopulmonary resuscitation before emergency services (like ambulance and fire fighters) arrival.\n\nOur model aims to investigate feasibility, acceptability and safety of a smartphone-based volunteer first responder system for suspected opioid overdoses. The volunteer responders will be equipped with an emergency kit including two doses of the opioid antidote naloxone, which can reverse life-threatening respiratory arrest caused by intoxication of opioids. The responders will, prior to registration, accomplish an in-depth overdose and naloxone education, as well as a first aid course aligned with current European and Swedish resuscitation guidelines. The results will be collected through questionnaires to the responder participants, technical data from the responder application, and dispatcher, pre-medical\u002Fparamedical and hospital records among others. Both quantitative and qualitative methods will be used. The major question is if the model is feasible in alerting lay persons with naloxone to suspected overdose situations and successfully administer naloxone prior to emergency service arrival. Furthermore, experiences of safety during alerts among volunteer first responders and overdose victims will also be studied.\n\nOur model is unique in its integration with emergency medical dispatch service along with overdose and first aid education prior to participant registration. The respiratory arrest of opioids is an acute life-threatening condition, which - in similarity to cardiac arrests - need emergent actions for survival. A reduced time to naloxone administration through volunteer first responders prior to ambulance arrival could save lives.",[28],[167,168,169,170,171,172,173,174,175,176,177],"Opioid overdose","Community first responder","Volunteer first responder","Medical emergency","Dispatcher","Naloxone","Overdose","Intoxication","Smartphone applications","First responder system","Emergency medical dispatcher","2025-12-16",{"date":180,"type":39},"2025-12-17",{"date":182,"type":39},"2025-09-01",{"date":184,"type":21},"2027-08-31",{"name":186,"class":46},"Region Skane",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":195,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":47},"100424754","phase-4-young-houston-emergency-opioid-engagement-system-100424754","NCT04811014","Young Houston Emergency Opioid Engagement System","Houston Emergency Engagement System for Youths and Adolescents","YHEROES","Inclusion Criteria:\n\n* In otherwise good health based on physician assessment and medical history\n* Drug screen positive for opioids\n* Patients express a willingness to stop opioid use\n* Meet Diagnostic and Statistical Manual of Mental Disorders - Text Revision (DSM-IV-TR) criteria for opioid dependence\n* Patients must be able to speak English\n* Be agreeable to and capable of signing the informed consent and assent (parent or guardian must consent, minor must assent)\n\nExclusion Criteria:\n\n* Non-English-speaking patients\n* Have a known sensitivity to buprenorphine or naloxone\n* Be physiologically dependent on alcohol, benzodiazepines, or other drugs of abuse that require immediate medical attention. Other substance use diagnoses are not exclusionary.\n* Have a medical condition that would, in the opinion of the study physician, make participation medically hazardous, including unstable cardiovascular disease, neurological deficits, trauma, acute hepatitis, stroke, and liver or renal disease)\n* Be acutely psychotic, severely depressed, and in need of inpatient treatment, or is an immediate suicide risk\n* Be a nursing or pregnant female","13 Years","17 Years",{"count":198,"type":21},250,[24],"The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral counseling, and peer recovery support. The objective is to compare differences in engagement and retention in treatment for individuals with opioid use disorder. The investigators also intend to understand the prevalence of opioid overdoses and OUD among youth in Houston.",[202,203,28,62,204],"Opioid-use Disorder","Opioid Dependence","Substance Use Disorders","2025-09-26",{"date":207,"type":39},"2025-10-01",{"date":209,"type":39},"2021-04-19",{"date":211,"type":21},"2030-08-31",{"name":213,"class":46},"The University of Texas Health Science Center, Houston",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":223,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":47},"100535421","phase-2-naloxone-for-opioid-associated-out-of-hospital-cardiac-arrest-100535421","NCT06251609","Naloxone for Opioid Associated Out of Hospital Cardiac Arrest","NOPACA","Inclusion Criteria:\n\nPatients will be eligible if all the following criteria are met:\n\n• Adults (age ≥ 18 years) in OHCA per EMS protocol. ACLS interventions have been initiated by EMS: chest compressions, ventilation; • 1st dose of epinephrine given via IV or IO.\n\n•. At risk of OA-OHCA (EMS presumed drug-related OHCA or NACARDI positive for occult OA-OHCA) as described above.\n\nExclusion Criteria:\n\n* EMS plans to administer naloxone, or administration of naloxone by EMS during the same encounter\n* Cardiac arrest apparently caused by trauma, choking, or drowning.\n* Known or apparent pregnancy\n* Patient experiences ROSC prior to study drug administration\n* Prior inclusion in the study\n* Patient has an opt out bracelet or family member states exclusion •. Children less than 18 years old",{"count":222,"type":21},98,[142],"The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of Hospital Cardiac Arrest. The investigative team plan to randomize patients in OHCA to early naloxone administration vs. placebo after initial resuscitation and measure ROSC and survival. Challenges to designing NOPACA include uncertainty regarding: 1) the available pool of participants and number of EMS agencies needed to meet enrollment targets; 2) acceptability among patients, EMS and Emergency Medicine provider stakeholders, and 3) estimates of the study outcomes needed for sample size estimates. Toward obtaining the necessary information to design NOPACA, the investigators propose a pilot RCT of participants at high risk for OA-OHCA to verify a reasonable recruitment rate; treatment fidelity and acceptability; and adequate retention and measurement of outcomes at follow up. The investigators propose incorporating hypothesis testing of the feasibility outcomes to determine progression to a definitive trial.",[226,28,172],"Heart Arrest, Out-Of-Hospital","2025-03-07",{"date":76,"type":39},{"date":230,"type":21},"2026-11",{"date":232,"type":21},"2028-12-31",{"name":234,"class":46},"University of California, San Francisco",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":88,"sex":17,"minAge":113,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":22,"phases":244,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":4},"100572017","phase-2-serious-game-to-teach-opioid-overdose-response-100572017","NCT06727786","Serious Game to Teach Opioid Overdose Response","Using a Serious Game to Teach People How to Recognize and Respond to Opioid Overdose","Inclusion Criteria:\n\n* Student at participating school, enrolled in Health or Science Class\n\nExclusion Criteria:\n\n* None",{"count":243,"type":21},850,[142],"This study evaluates the efficacy of a serious game to teach students how to recognize and respond to opioid overdose",[28],"2024-12-05",{"date":249,"type":39},"2024-12-11",{"date":251,"type":21},"2026-02-01",{"date":253,"type":21},"2027-12-01",{"name":255,"class":46},"University of Nevada, Reno",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":17,"minAge":263,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":267,"briefSummary":268,"conditions":269,"keywords":270,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":281},"100506648","improving-availability-of-intranasal-naloxone-100506648","NCT05877118","Improving Availability of Intranasal Naloxone","Improving Availability of Intranasal Naloxone Rescue for Opioid Overdose","Inclusion Criteria:\n\n-Patients will be in the process of being discharged from Hartford Hospital ED with a naloxone kit prescription following opiate or opioid intoxication\u002Fpoisoning, use of illicit opioids or prescription opioids, or opioid injection use-related conditions\n\nExclusion Criteria:\n\n* Patient has previously received the standard naloxone kit education or has a known allergy to naloxone and\u002For kit constituents\n* Patient or support network does not speak English\n* Patient is in police custody\n* Patient is not being discharged home from the ED.","21 Years","65 Years",{"count":266,"type":21},84,[59],"While there is a lifesaving medication called naloxone that can reverse the deadly effects of opioid overdose, patients often fail to fill the prescription at the pharmacy when it is prescribed. This is particularly concerning and true in those at the highest risk of death-those who end up in the emergency department for opioid overdose. The goal of this study is to compare the impact of different overdose education on naloxone prescription fill rates in opioid users being discharged from our hospital emergency department. You will receive either (a) written education about naloxone through their MyChart account, or (b) a concise one-page handout and 4-minute video clip reviewed with the participant and a support individual (family\u002Ffriend) prior to discharge.",[28],[172,271],"Overdose education","2024-06-06",{"date":274,"type":39},"2024-06-07",{"date":276,"type":39},"2024-03-01",{"date":278,"type":21},"2025-12-31",{"name":280,"class":46},"Hartford Hospital",2]