[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-prescribing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-prescribing":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100636476","reducing-post-operative-opioid-prescribing-in-southeastern-north-carolina-100636476",false,"NCT07566182","Reducing Post-Operative Opioid Prescribing in Southeastern North Carolina","Building an Implementation Science Network to Reduce Post-Operative Opioid Prescribing in Southeastern North Carolina","Inclusion Criteria:\n\nSurgeon champions and identified change team members must be currently practicing at one of the sites participating in this study.\n\nPatient representatives must be:\n\nProficient in the English language Prescribed opioids following a qualifying general surgery procedure (inpatient or outpatient laparoscopic appendectomy, inguinal\u002Ffemoral hernia repair, umbilical hernia, bariatric\u002Fweight loss surgery, mastectomy, laparoscopic cholecystectomy, laparoscopic colectomy, lipoma\u002Fsoft tissue tumor excision, and anal\u002Frectal procedures).\n\nNo patients will be enrolled for this trial. However, claims data will be used to assess the claims based outcome measure (opioid prescribing).\n\nInclusion criteria for the claims analysis includes:\n\nPatients greater than or equal to 18 at the time of a qualifying general surgery procedure either inpatient or outpatient (laparoscopic appendectomy; umbilical\u002Fventral\u002Finguinal\u002Ffemoral hernia repair; bariatric\u002Fweight loss surgery; mastectomy; laparoscopic cholecystectomy; laparoscopic colectomy; lipoma\u002Fsoft tissue tumor excision; anal\u002Frectal procedures) based on procedure codes Patients must have continuous insurance coverage (including prescription drug coverage), 6 months before to 60 days post discharge to assess comorbidities and prescription drug fills.\n\nExclusion Criteria:\n\nPatients with an opioid fill 6 months before the procedure. Patients who undergo a significant operation during the stay associated with their index procedure that would require additional pain management.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this stepped-wedge cluster randomized trial is to evaluate whether an opioid stewardship intervention improves post-operative opioid prescribing practices. Participants will include surgeon champions and identified change team members (e.g., pharmacists, hospitalists, nurses, advanced practice providers, anesthesiologists, etc.) and patient representatives at designated hospital sites in North Carolina.\n\nThe main questions it aims to answer are:\n\nI. Does the intervention reduce postoperative opioid prescribing behavior at the surgeon and hospital level? II. Is the intervention acceptable, feasible, and effective for implementation among participating hospitals?\n\nResearchers will compare opioid prescribing and implementation outcomes across sites before and after implementation using a stepped-wedge cluster randomized design, in which sites are randomly assigned to different intervention start times.\n\nParticipants will attend educational sessions delivered, introduce the Standard Opioid Prescribing (SOPS) Toolkit into their clinical practice, review benchmarked, deidentified opioid prescribing performance reports that use administrative claims data (secondary data source, data not collected or shared between hospitals), and complete surveys assessing intervention acceptability, feasibility, and effectiveness. Preliminary effectiveness will be assessed through reduction of opioid prescriptions using administrative claims data.",[26],"Opioid Prescribing",[28,29,30,31,32,33,34],"Opioid Stewardship","Postoperative opioid prescribing","Cluster randomized trial","Implementation science","Audit and feedback","Performance reporting","Quality Improvement","NOT_YET_RECRUITING","2026-04-28",{"date":38,"type":39},"2026-05-04","ACTUAL",{"date":41,"type":20},"2026-05-01",{"date":43,"type":20},"2027-12-31",{"name":45,"class":46},"University of North Carolina, Chapel Hill","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100556590","evaluation-of-clinical-decision-support-in-opioid-tapering-100556590","NCT06527079","Evaluation of Clinical Decision Support in Opioid Tapering","Inclusion Criteria: Primary care patients being tapered from an opioid. Tapering patients:\n\n* Have an active opioid prescription for more than 3 months and\n* Prescribed more than 90 morphine milligram equivalents (MME) per day or\n* Co-prescribed an opioid and benzodiazepine or\n* Received a reduction in opioid dosage by more than 5% MME per day\n\nExclusion Criteria:\n\n* Patients \\\u003C12 and \\>89\n* Patients with active cancer diagnosis in last 1 year\n* Patients with hospice care\u002Fpalliative care order\n* Patients with sickle cell disease diagnosis",true,"12 Years","89 Years",{"count":57,"type":20},200000,"OBSERVATIONAL","The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. This project will evaluate a clinical decision support (CDS) tool in the form of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering. Primary care providers will be randomized at the clinic location to a control arm or intervention arm. The control arm will have the clinical care pathway available, but will not be reminded of the pathway when tapering a patient. The intervention arm will receive a nudge when prescribing a tapering opioid strategy to a patient to use the clinical care pathway. The rate of opioid tapering in line with CDC guidelines will be examined as well as long-term patient outcomes of opioid overdose or poisoning using existing patient health records. The study period will be approximately 18 months.",[61,62,63,26,64,65],"Medication Abuse","Harm Reduction","Opioid Use Disorder","Opioid Overdose","Prevention","2026-04-20",{"date":68,"type":39},"2026-04-23",{"date":70,"type":20},"2026-08",{"date":72,"type":20},"2027-06",{"name":74,"class":46},"University of Colorado, Denver"]