[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-use\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-use":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,82,0,25,[9,42,74,101,125,144,165,196,233,263,288,310,340,367,391,416,445,469,491,511,538,565,590,614,636],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100053994","sex-hormones-postoperative-pain-and-opioid-use-100053994",false,"NCT06023225","Sex Hormones, Postoperative Pain and Opioid Use","Relationship Between Sex Hormones, Postoperative Pain and Opioid Use: the Role of Immune Factors","SPO","Inclusion Criteria:\n\nPediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking\n\nExclusion Criteria:\n\nPregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).","FEMALE","11 Years","16 Years",{"count":22,"type":23},210,"ESTIMATED","OBSERVATIONAL","Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use.\n\nAim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors",[27,28],"Postoperative Pain","Opioid Use","RECRUITING","2026-07-10",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":33},"2023-09-01",{"date":37,"type":23},"2029-07-01",{"name":39,"class":40},"Washington University School of Medicine","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":41},"100484569","phase-1-sleep-disordered-breathing-with-opioid-use-100484569","NCT05589753","Sleep Disordered Breathing With Opioid Use","Targeting Chemoreceptor Control of Breathing During Sleep to Mitigate Opioid-Associated Sleep Disordered Breathing","SDB","Inclusion Criteria:\n\n* Veterans, age 18-89 years\n* Veterans with prescription opioids\n\nExclusion Criteria:\n\n* Patients with BMI\\>40kg\u002Fm2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control\n* Patients with history of unresolved\u002Funtreated cardiac disease, including recent myocardial infarction, recent bypass surgery, untreated atrial and ventricular tachy-bradycardias\n* Congestive heart failure with Cheyne-Stokes respiration (CSR)\n* Current unstable angina\n* Recent stroke\n* Untreated schizophrenia\n* Untreated hypothyroidism\n* Unresolved seizure disorder\n* Severe respiratory, neurological, liver and renal diseases\n* Unstable psychiatric disorders\u002Funtreated PTSD\n* Traumatic brain injury\n* Pregnant women\n* Significant sleep disorder such as narcolepsy, parasomnias disorder\n* Failure to give informed consent\n* Patients on tramadol and suboxone\u002Fbuprenorphine",true,"ALL","18 Years","89 Years",{"count":55,"type":23},150,"INTERVENTIONAL",[58,59],"PHASE1","PHASE2","There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.",[62,28,63],"Sleep Apnea","Sleep Disordered Breathing","2026-06-29",{"date":66,"type":33},"2026-07-01",{"date":68,"type":33},"2019-05-02",{"date":70,"type":23},"2027-03-31",{"name":72,"class":73},"VA Office of Research and Development","FED",{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":18,"minAge":52,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":56,"phases":85,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":41},"100644956","spsip-block-versus-esp-block-for-chronic-pain-after-unilateral-breast-surgery-100644956","NCT07674836","SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery","Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block for the Prevention of Chronic Postoperative Pain After Unilateral Breast Surgery: A Prospective, Randomized, Assessor-Blinded Trial","SPES-CPSP","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* ASA physical status I-III\n* Body mass index (BMI) between 18 and 35 kg\u002Fm²\n* Scheduled for elective unilateral breast surgery (mastectomy with or without sentinel lymph node biopsy)\n* Ability to understand and provide written informed consent\n\nExclusion Criteria:\n\n* Infection at the site of block application\n* Known allergy to local anesthetics\n* Coagulopathy or anticoagulant therapy\n* Chronic opioid use\n* Pregnancy\n* Inability to communicate or cooperate\n* Refusal to participate\n* Failed block\n* Requirement of additional intraoperative analgesia outside the study protocol\n* Development of serious intraoperative complications","65 Years",{"count":84,"type":23},90,[86],"NA","This prospective, randomized, assessor-blinded study will compare serratus posterior superior intercostal plane block and erector spinae plane block in adult female patients undergoing unilateral breast surgery. The primary outcome is chronic postoperative pain at 3 months, assessed using the Brief Pain Inventory-Short Form.",[27,28],[90,28],"Post Operative Pain","NOT_YET_RECRUITING","2026-06-25",{"date":94,"type":33},"2026-06-30",{"date":66,"type":23},{"date":97,"type":23},"2026-12-01",{"name":99,"class":100},"Engin Çetin","OTHER_GOV",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":56,"phases":110,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":41},"100644752","phase-2-leveraging-mhealth-to-promote-opioid-use-recovery-and-mental-health-among-residents-of-a-medium-sized-midwestern-city-100644752","NCT07673380","Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City","Leveraging mHealth to Promote Recovery From Opioid Use Disorder and Commonly Occurring Mental Health Disorders Among Residents of a Medium-Sized Midwestern City","Inclusion Criteria:\n\n* Have a history of opioid and\u002For stimulant use\n* Identify as Black and\u002For African American\n* Seek treatment at local substance use treatment centers\n* Fluent in English\n* U.S. resident\n* 18 years of age or older at the time of data collection.\n\nExclusion Criteria:\n\n* Self-reported cognitive impairment that would limit ability to participate in research.",{"count":109,"type":23},300,[59],"The sequential trial compares recovery and mHealth engagement outcomes among Black participants who participated in the mHealth intervention uMAT-R or uMAT-R + enhanced community engagement. The mHealth intervention seeks to support people in various stages of recovery who are also seeking other forms of substance use treatment. Participants are recruited from community-based substance use treatment facilities and recovery services. Participants must be adults who have or are currently using opioids and\u002For stimulants.",[28,113,114],"Stimulant Use","Depression and Anxiety Symptoms",[116,117],"Digital health","Community engagement","2026-06-22",{"date":64,"type":33},{"date":121,"type":33},"2025-08-31",{"date":123,"type":23},"2027-02-28",{"name":39,"class":40},{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":18,"minAge":52,"maxAge":82,"enrollmentInfo":131,"targetDuration":4,"studyType":56,"phases":133,"briefSummary":134,"conditions":135,"keywords":136,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":41},"100634542","serratus-vs-esp-block-for-postoperative-pain-in-unilateral-breast-surgery-100634542","NCT07541040","Serratus vs ESP Block for Postoperative Pain in Unilateral Breast Surgery","Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block for Postoperative Analgesia in Unilateral Breast Surgery: A Prospective, Randomized, Assessor-Blinded Trial",{"count":132,"type":23},54,[86],"This prospective, randomized, assessor-blinded trial compares serratus posterior superior intercostal plane block (SPSIPB) and erector spinae plane block (ESPB) for postoperative analgesia in unilateral breast surgery. 54 patients will be randomized to receive either SPSIPB or ESPB before general anesthesia.\n\nThe primary outcome is postoperative pain scores within the first 24 hours. The secondary outcome is opioid consumption.",[90,28],[90,28],{"date":138,"type":33},"2026-06-23",{"date":140,"type":33},"2026-05-01",{"date":142,"type":23},"2026-08-01",{"name":99,"class":100},{"id":145,"slug":146,"hasResults":12,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":56,"phases":153,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":41},"100644386","targeting-alcohol-opioid-co-use-among-young-adults-using-a-novel-mhealth-intervention-100644386","NCT07663448","Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention","Inclusion Criteria:\n\n1. Ages 18 to 25 years, inclusive\n2. Self-report interest in reducing their alcohol-opioid co-use - outside a research study, people who do not wish to change their co-use are unlikely to download and use an mHealth app designed to reduce co-use. It is important to recruit participants who most closely resemble the intended users of the eventual mHealth intervention. This is defined as reporting any alcohol-opioid co-use goal (i.e., not selecting \"No goal\" in response to the alcohol-opioid co-use goal question at the screening visit).\n3. Self-report engaging in simultaneous alcohol-opioid co-use (i.e., use of both substances within two hours) ≥ 1 day\u002Fweek on average in the past 28 days (i.e., at least 4 co-use events in the past 28 days). This requirement will ensure that we observe sufficient use episodes where the pharmacological effects of alcohol and opioids overlap to evaluate project aims.\n4. Able to understand written and oral instructions in English, communicate understanding of the consent form, and provide written informed consent.\n5. Complete all assessments required at screening.\n6. Agree to the schedule of visits, verbally acknowledge that he\u002Fshe\u002Fthey will be able to attend each scheduled visit, participate in phone visits and that he\u002Fshe\u002Fthey does not have any already scheduled events or a job that may substantially interfere with study participation.\n7. Own a smartphone with data plan. Almost all participants (98%) in our preliminary work owned a smartphone with data plan.\n8. Currently reside in the United States of America.\n\nExclusion Criteria:\n\n1. Pregnant or nursing\n2. Current suicidality\n3. History of psychosis","25 Years",{"count":152,"type":23},30,[86],"The goal of this treatment development project is to develop and pilot an adaptive mobile health (mHealth) intervention that targets the co-use of alcohol and opioids in young adults.",[156,28],"Alcohol Drinking","2026-06-17",{"date":138,"type":33},{"date":160,"type":33},"2026-06-08",{"date":162,"type":23},"2027-04-30",{"name":164,"class":40},"Brown University",{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":56,"phases":174,"briefSummary":175,"conditions":176,"keywords":180,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":41},"100578043","machine-learning-prediction-and-reducing-overdoses-with-ehr-nudges-100578043","NCT06806163","Machine-Learning Prediction and Reducing Overdoses With EHR Nudges","mPROVEN","Inclusion Criteria:\n\n* Received an opioid prescription within the past year\n* Age 18 years or older at the time of the opioid prescription\n* At least one visit to an internal medicine or family care practice within the past year\n\nExclusion Criteria:\n\n* Diagnosis of malignant cancer within the past year\n* Enrollment in hospice care",{"count":173,"type":23},1350,[86],"The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction model as having an elevated risk for an opioid overdose.\n\nThe clinical trial will evaluate the effectiveness of providing a flag in the EHR to identify individuals at elevated risk with and without behavioral nudges\u002Fbest practice alerts (BPAs) as compared to usual care by primary care clinicians.\n\nThe primary goals of the study are to improve opioid prescribing safety and reduce overdose risk.",[177,28,178,179],"Opioid Overdose","Opioid Use Disorder","Opioids",[181,182,183,184,185,186,187,177,179],"Machine learning","Risk prediction","Behavioral nudge","Best Practice Alert","Artificial intelligence","Primary care","Electronic Health Record Platforms","2026-06-16",{"date":157,"type":33},{"date":191,"type":33},"2025-03-10",{"date":193,"type":23},"2027-02",{"name":195,"class":40},"University of Pittsburgh",{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":51,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":56,"phases":207,"briefSummary":209,"conditions":210,"keywords":217,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":41},"100431190","phase-4-opioid-free-anesthesia-analgesia-strategy-and-surgical-stress-in-elective-open-abdominal-aortic-aneurysm-repair-100431190","NCT04894864","Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study","Inclusion Criteria:\n\n1. Patient Consent\n2. Age between 40 and 85 years old\n3. Patients undergoing Elective Open Abdominal Aortic Infrarenal Aneurysm Repair\n\nExclusion Criteria:\n\n1. Immunocompromised patients\n2. Patients with active infection\n3. Reoperation on the aorta\n4. Inflammatory bowel Disease\n5. Malignancy\n6. Chronic Inflammatory conditions (e.g. Rheymatoid arthritis, Psoriatic arthritis)\n7. Chronic corticosteroid or immunosuppressive drug use\n8. Intraoperative transfusion with \\>2 units of packed Red Blood Cells","40 Years","85 Years",{"count":206,"type":23},40,[208],"PHASE4","Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and acute-phase protein release, and bone marrow activation. There is a proven correlation of surgical stress, which patients undergoing open AAA repair are subjected to, with patient outcome, morbidity\u002Fmortality, intensive care unit stay and overall length of stay. Modern general anesthetic techniques have been revised and rely on perioperative multimodal anesthetic and analgesic strategies for improved overall patient outcome. Based on this context of a multimodal anesthetic technique and having taken into consideration the international \"opioid-crisis\" epidemic, an Opioid Free Anesthesia-Analgesia (OFA-A) strategy started to emerge. It is based on the administration of a variety of anesthetic\u002Fanalgesic agents with different mechanisms of action, including immunomodulating and anti-inflammatory effects.\n\nOur basic hypothesis is that the implementation of a perioperative multimodal OFA-A strategy, involving the administration of pregabalin, ketamine, dexmedetomidine, lidocaine, dexamethasone, dexketoprofen, paracetamol and magnesium sulphate, will lead to attenuation of surgical stress response compared to a conventional Opioid-Based Anesthesia-Analgesia (OBA-A) strategy. Furthermore, the anticipated attenuation of the inflammatory response, is pressumed to be associated with equal or improved analgesia, compared to a perioperative OBA-A technique.",[211,27,212,28,213,214,215,216],"Elective Surgical Procedures","Anesthesia","Abdominal Aortic Aneurysm Without Rupture","Vascular Surgical Procedure","Interleukin 6","Immunomodulators",[218,219,220,221,222,223,224],"Opioid-free Anesthesia-Analgesia","Cytokines","Opioid-based Anesthesia-Analgesia","Haemodynamic Stability","Open Abdominal Aortic Aneurysm Repair","Immunomodulation","Inflammatory Markers","2026-06-13",{"date":188,"type":33},{"date":228,"type":33},"2020-10-08",{"date":230,"type":23},"2027-09-01",{"name":232,"class":40},"University of Crete",{"id":234,"slug":235,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":56,"phases":243,"briefSummary":244,"conditions":245,"keywords":248,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":41},"100619275","better-experiences-in-substance-treatment-a-brief-alcohol-focused-intervention-tailored-for-patients-in-opioid-agonist-treatment-100619275","NCT07342504","Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment","Better Experiences in Substance Treatment: A Brief Alcohol-Focused Intervention Tailored for Patients in Opioid Agonist Treatment","Project BEST","Inclusion Criteria for the RCT:\n\n* Participants must be taking prescribed buprenorphine for at least 2 weeks\n* Participants must be 18 years or older.\n* Meet DSM-5 criteria for alcohol use disorder (AUD)\n* Participants must report alcohol use ≥ 1 day\u002Fweek on average in the past 28 days\n* Participants must be able to read simple English\n\nExclusion Criteria:\n\n* Currently receiving formal alcohol use treatment.\n* Currently experiencing psychosis",{"count":242,"type":23},60,[86],"This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes related to alcohol use. The results of this proof-of-concept study will inform whether a future larger clinical trial is warranted.",[246,178,247,28],"Alcohol Use Disorder","Alcohol Use",[246,249,250,178,251,252,253],"Alcohol Use Disorder (AUD)","Cognitive Behavioral Therapy","Opioid Use Disorder (OUD)","Motivational Enhancement Therapy","Cognitive Behavior Therapy (CBT)","2026-06-05",{"date":256,"type":33},"2026-06-09",{"date":258,"type":33},"2026-03-24",{"date":260,"type":23},"2027-03-01",{"name":262,"class":40},"University of Notre Dame",{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":56,"phases":273,"briefSummary":274,"conditions":275,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":41},"100636109","erector-spinae-block-versus-paravertebral-block-on-chronic-pain-after-mastectomy-100636109","NCT07561411","Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy","The Effect of Erector Spinae Block Versus Paravertebral Block on the Incidence of Chronic Pain After Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients between 18 and 80 years old.\n* Scheduled to total mastectomy with or without axillary dissection\n* Willing to receive regional anesthesia in addition to GA\n* ASA classification 1-3\n\nExclusion Criteria:\n\n* Previous thoracic surgery with an incision of \\>2 cm\n* Patient's refusal\n* Allergy to local anesthetics\n* Pregnant women\n* Any contraindications to thoracic PVB, including intrathoracic infection, infection at the puncture site, cancer invasion of the puncture site, severe spinal deformity, history of spinal surgery, and severe coagulopathy; anticoagulants intake.\n* American Society of Anesthesiologists (ASA) classification of 4 or higher,\n* History of chronic pain or untreated clinical severe depression","80 Years",{"count":272,"type":23},132,[86],"The goal of this clinical trial is to learn if the erector spinae block can reduce the incidence of chronic pain compared to the paravertebral block in adult patients undergoing total mastectomy. The study includes patients aged 18 to 80 years scheduled for mastectomy, with or without axillary dissection. The main questions it aims to answer are:\n\n* Does erector spinae block reduce the incidence of chronic pain at 3 months after mastectomy compared to paravertebral block?\n* Does erector spinae block affect postoperative outcomes such as opioid consumption at 48 hours, pain scores (in PACU, 24 and 48 hours), block performance time, and the incidence of complications, anxiety or depression, and pain intensity at 3 months?\n\nResearchers will compare patients receiving erector spinae block to those receiving paravertebral block to determine if erector spinae block provides equivalent or improved outcomes in terms of chronic pain and perioperative measures.\n\nParticipants will:\n\n* Be randomly assigned to receive either erector spinae block or paravertebral block prior to surgery\n* Undergo total mastectomy (with or without axillary dissection)\n* Have their pain assessed in the PACU and at 24 and 48 hours postoperatively\n* Have opioid consumption measured during the first 48 hours after surgery\n* Be followed up at 3 months to assess chronic pain, pain intensity, and psychological outcomes (anxiety or depression)",[276,277,278,28],"Mastectomy; Lymphedema","Chronic Pain","Regional Anesthesia Morbidity","2026-06-01",{"date":281,"type":33},"2026-06-02",{"date":283,"type":33},"2026-05-19",{"date":285,"type":23},"2028-05-01",{"name":287,"class":40},"American University of Beirut Medical Center",{"id":289,"slug":290,"hasResults":12,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":50,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":56,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":41},"100549454","phase-4-opioid-use-after-laparoscopic-salpingectomy-100549454","NCT06434233","Opioid Use After Laparoscopic Salpingectomy","A Randomized Control Trial for Opioid Use After Laparoscopic Salpingectomy","Inclusion Criteria:\n\n* Individuals with a fallopian tube (unilateral and\u002For bilateral)\n* Age 18 years old and above\n* Undergoing minimally invasive (laparoscopic or robotic) unilateral or bilateral salpingectomy or other tubal sterilization procedure as the primary procedure\n* Benign indications for salpingectomy\u002Ftubal sterilization\n* Agreeing to participate\n\nExclusion Criteria:\n\n* Chronic pain syndromes patients including fibromyalgia\n* Patients currently on long-term (i.e. for more than three months) opioid use\n* Conversion to laparotomy\n* Allergy or other contraindication to the prescribed medications such as acetaminophen or oxycodone\n* Salpingectomy that occurs in conjunction with a major Gyn surgery (i.e. hysterectomy, etc)\n* Salpingectomy performed for treatment of ectopic pregnancy\n* Patients with a history of gastritis and\u002For GI bleeding",{"count":296,"type":23},38,[208],"The purpose of this study is to evaluate patient-reported post-operative pain scores following minimally invasive tubal sterilization procedures to determine if a multimodal, non-opioid pain control regimen is non-inferior to a pain control regimen including opioids.\n\nThe study team hypothesizes that with extensive counseling on pain management, multimodal medication use, and expectation with non-opioid methods can effectively eliminate the need for opioid prescriptions after laparoscopic salpingectomy.",[28,300,301],"Post-operative Pain","Sterility, Female",{"date":303,"type":33},"2026-06-03",{"date":305,"type":33},"2024-04-25",{"date":307,"type":23},"2026-11",{"name":309,"class":40},"Johns Hopkins University",{"id":311,"slug":312,"hasResults":12,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":50,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":56,"phases":320,"briefSummary":321,"conditions":322,"keywords":323,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":333,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":41},"100508822","neuroimaging-of-opioid-phase-opal-100508822","NCT05905419","Neuroimaging of Opioid Phase (OPAL)","Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord","OPAL","Inclusion Criteria for Healthy Controls:\n\n1. female and ages 18+\n2. ability to read\u002Funderstand English and give consent to participate\n3. no current or history of chronic pain\n4. not regularly taking any pain-relieving or mood-altering medications (per PI discretion)\n5. absence of use of opioid medications\n\nInclusion Criteria for Individuals with Chronic Pain:\n\n1. female and ages 18 +\n2. ability to read\u002Funderstand English and give consent to participate\n3. self-reported or physician diagnosis of fibromyalgia and\u002For chronic pain\n4. current use of opioid medication(s) for inclusion in the opioid patient group -OR- absence of use of opioid medications for inclusion in the non-opioid patient group\n\nExclusion Criteria (for both groups):\n\n1. limited ability to participate fully in behavioral tasks, longitudinal follow-up\n2. MRI contraindication\n3. any factors that at the discretion of the investigators would adversely affect the participant or the integrity of the study\n4. male",{"count":319,"type":23},140,[86],"The purpose of this study is to compare activity in the brains of female adults with chronic pain and\u002For opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.",[277,28],[324,325,326,327,328,329,330,331,332],"fibromyalgia","women","brain","functional MRI","opioid","opiate","narcotic","chronic pain","pain",{"date":303,"type":33},{"date":335,"type":33},"2023-06-01",{"date":337,"type":23},"2027-06-30",{"name":339,"class":40},"Duke University",{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":349,"conditions":350,"keywords":353,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":41},"100551965","understanding-the-acute-pain-phenotype-in-patients-undergoing-surgery-100551965","NCT06466941","Understanding the Acute Pain Phenotype in Patients Undergoing Surgery","Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain","Inclusion Criteria:\n\n* Age ≥ 18\n* English speaking\n* Surgical or procedural patient who will be admitted postoperatively\n* Willingness to answer psychosocial survey and\u002For audio recorded semi-structured interview\n\nExclusion Criteria:\n\n-Cognitive dysfunction that precludes communication",{"count":348,"type":23},1000,"The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery.\n\nThe main questions are:\n\n1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia?\n2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery?\n3. Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?",[351,352,28],"Acute Pain","Chronic Post Operative Pain",[354,355,356,357],"regional anesthesia","peripheral nerve blocks","psychosocial phenotype","pain catastrophizing","2026-05-20",{"date":360,"type":33},"2026-05-22",{"date":362,"type":33},"2024-07-03",{"date":364,"type":23},"2028-12-31",{"name":366,"class":40},"Brigham and Women's Hospital",{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":50,"sex":51,"minAge":150,"maxAge":82,"enrollmentInfo":374,"targetDuration":4,"studyType":56,"phases":376,"briefSummary":378,"conditions":379,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":41},"100639167","phase-2-dexa-vs-dexmedetomidine-with-bupivacaine-in-tap-block-for-laparotomy-analgesia-100639167","NCT07590752","\"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia","Comparison Of Dexamethasone Versus Dexmedetomidine As An Adjuvant To 0.25% Bupivacaine In Ultrasound Guided Tap Block On Post-Op Analgesia Duration In Patients Undergoing Laparotomy","Inclusion Criteria:\n\n* Patients undergoing laparotomy.\n* Patients aged 25 to 65 years.\n* Both genders.\n* Patients with ASA Class I, II.\n\nExclusion Criteria:\n\n* Patients who do not give consent.\n* Patients with Comorbidities like DM, HTN, CKD, CLD.\n* Patients with bleeding disorders.\n* Infection at site of injection.\n* Allergy to any drug, local anaesthetic, or other drugs used.\n* Patients with polytrauma.",{"count":375,"type":23},96,[59,377],"PHASE3","Transversus abdominis plane block is a regional anesthetic technique which blocks the abdominal neural afferents by introducing local anesthetic into the neuro-fascial plane between the internal oblique and the transversus abdominis muscle and gives analgesia from the skin to parietal peritoneum. There are studies showing evidence of improved post operative analgesia with addition of adjuvants such as dexmedetomidine or dexamethasone in comparison with plane local anesthesia in terms of time to rescue analgesia and the overall quantity of analgesic used post operatively.",[380,28,381],"Pain, Postoperative","Laparotomy","2026-05-08",{"date":384,"type":33},"2026-05-15",{"date":386,"type":33},"2024-03-03",{"date":388,"type":23},"2026-07-04",{"name":390,"class":100},"Sahiwal medical college sahiwal",{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":397,"targetDuration":4,"studyType":56,"phases":399,"briefSummary":400,"conditions":401,"keywords":402,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":41},"100575171","overdose-recovery-and-care-access-orca-qualitative-stakeholder-interviews-and-county-level-data-100575171","NCT06768814","Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data","Inclusion Criteria:\n\n1. Verbally consents to transfer of care to SASC.\n2. Awake and oriented to person and place, with no significant deficits in mental status or neurological function.\n3. Age \\>=18\n4. Patent airway and effective respirations with adequate oxygenation.\n5. Stable heart rate and blood pressure, with no evidence of cardiac arrhythmias or other significant cardiovascular disfunction.\n6. Vitals:\n\n   * Heart rate: 45-130\n   * Blood pressure: systolic 95-190, diastolic 50-120\n   * Respiratory rate: 10-24\n   * SpO2: \\>92 on room air or supplemental O2 via nasal cannula.\n   * SpO2 \\\u003C92% with supplemental O2 requires ED transfer.\n   * EtCO2: \\\u003C50\n   * Temperature: 95.5-100.3 F\n   * Blood glucose (if indicated): 60-300\n7. No signs of head trauma:\n\n   * Dizziness or loss of balance\n   * Blurred vision or double vision\n   * Sensitivity to light or noise\n   * Seizures or convulsions\n   * Weakness or numbness in the arms or legs\n   * Persistent or worsening headache\n   * CSF or blood leaking from the nose or ears\n   * Unequal pupils or pupils that are slow to react to light.\n8. No signs of other traumatic injury or medical needs requiring immediate treatment.\n9. No signs of respiratory infection. Screen for COVID-19. See COVID-19 Screening protocol.\n\nExclusion Criteria:\n\n\\- People under 18 and who do not meet SASC admission criteria will be excluded.",{"count":398,"type":23},40000,[86],"The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical services (EMS) in Seattle, WA. Those transported to the SASC are the intervention participants and two comparison groups will be utilized: eligible Seattle EMS patients who opt not to go to the SASC and King County residents, outside of Seattle, who meet the same eligibility criteria. A comparative interrupted time series analysis is planned to study the main effectiveness outcomes.\n\nSeattle Fire EMS will assess, refer, and arrange transport for participants to the SASC. The SASC will offer an array of services including post-overdose monitoring, utilization of buprenorphine and methadone for the treatment opioid use disorder and opioid withdrawal, linkage to ongoing care for OUD, and provision of harm reduction services and supplies. The length of stay in the SASC will be limited to less than 24 hours. A continuous process improvement (CPI) approach will monitor and refine the intervention. Characterization of the interventions will be based upon analysis of service utilization patterns over time along with interviews and surveys with stakeholders.",[178,28],[403,404,405,406],"opioid overdose","opioid poisoning","harm-reduction","sub-acute stabilization","2026-05-04",{"date":409,"type":33},"2026-05-06",{"date":411,"type":33},"2024-12-15",{"date":413,"type":23},"2029-05-31",{"name":415,"class":40},"University of Washington",{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":82,"enrollmentInfo":423,"targetDuration":4,"studyType":56,"phases":425,"briefSummary":426,"conditions":427,"keywords":431,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":438,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":41},"100636688","evaluation-of-the-stress-response-in-anesthesia-use-inhalation-anesthetic-desflurane-versus-tiva-for-bariatric-surgery-100636688","NCT07568938","Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery","Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA TCI ELEVELD Model for Bariatric Surgery","Inclusion Criteria:\n\n* Signed Informed Consent\n* ASA II-III\n* Morbid obesity confirmed diagnosis and approval for surgical treatment\n* Laparoscopic sleeve gastrectomy (LSG) or Gastric By pass (R-Y By pass \u002FSASI\u002FSADI AND one anastomosis by pass )\n* Preop respiratrory assessment conducted\n* Adequate organ and bone marrow function\n\nExclusion Criteria:\n\n* Patients declining or withdrawing consent\n* Patients unsuitabe with regards to compliance to treatment, according to the researcher's assessment\n* Bradycardia, AV block, , postural hypotension\n* QTcF\\>470msec\n* Known allergy or hypersensitiity to any of the medications administered\n* Stop-BANG score \\>6\n* Intraoperative administration of more than 8mg of prednisolone or equivalent\n* Patients who have received corticosteroids for durations \\>3 weeks at any point in their lifetime\n* Participation in other clinical trial for experimental product administered post operatively\n* Diagnosis of depression",{"count":424,"type":23},70,[86],"The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer :\n\n-Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane?\n\nParticipants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.",[28,428,429,430],"Bariatric Surgery Candidate","TCI Eleveld","Obesity",[432,433,434,435,436,437],"Morbid Obesity","Opioid Free Anesthesia","Nociception Level","Analgesia","Bariatric Surgery","Eleveld Model TCI",{"date":409,"type":33},{"date":440,"type":33},"2024-01-10",{"date":442,"type":23},"2027-05-30",{"name":444,"class":40},"G.Gennimatas General Hospital",{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":4,"eligibilityCriteria":451,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":452,"targetDuration":4,"studyType":56,"phases":454,"briefSummary":455,"conditions":456,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":468},"100518673","phase-3-motivational-interviewing-and-mindfulness-oriented-recovery-enhancement-100518673","NCT06033599","Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement","Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE) for Tobacco Dependence and Other Drug Use in Methadone Treatment","Inclusion Criteria:\n\n* English-speaking\n* Age ≥18\n* Currently on methadone; and 4) currently smoke cigarettes.\n\nExclusion Criteria:\n\n* Severe cognitive impairment (score \\>23 on Mini Mental Status Exam) or psychosis (positive SCID Psychotic Screen)\n* Suicidal risk (score ≥7 on Suicidal Behaviors Questionnaire)\n* Inability to attend or fully participate in intervention sessions or assessments\n* Previous formal mindfulness training (e.g., MBSR, MBRP) or MORE (from the R21 or R33\n* Currently taking smoking cessation pharmacotherapy or participating in smoking cessation counseling\n* Any contraindications for NRT\n* Currently or soon planning to be pregnant or breastfeeding.",{"count":453,"type":23},420,[377],"The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient outcomes related to the effectiveness of MORE decreasing opioid, tobacco, and other drug use.",[457,28,458],"Polysubstance Abuse","Tobacco Use","2026-04-27",{"date":461,"type":33},"2026-04-28",{"date":463,"type":33},"2023-09-05",{"date":465,"type":23},"2028-06-30",{"name":467,"class":40},"Rutgers, The State University of New Jersey",2,{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":475,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":56,"phases":478,"briefSummary":479,"conditions":480,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":41},"100337587","reducing-opioid-use-for-chronic-pain-patients-following-surgery-100337587","NCT03675386","Reducing Opioid Use for Chronic Pain Patients Following Surgery","Ontario Transitional Pain and Opioid Safety Program: Improving Pain and Opioid Practices for Complex Chronic Pain Patients Following Surgery","RECOUP","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Taking 10 -- 400 mg of preoperative oral morphine equivalents daily\n* Any type of surgical procedure, with the exception of those with palliative intent or organ transplantation\n* Able to read and understand English as posed on the questionnaire surveys prior to informed consent\n* Must be taking opioids for at least one month prior to their operation\n* Must have a personal email address for the set-up of the Manage My Pain (MMP) App or online multimedia tool\n\nExclusion Criteria:\n\n• Subjects who are undergoing palliative care or procedures, organ transplantation, or prescribed with Methadone\u002FBuprenorphine will be excluded from the trial",{"count":22,"type":23},[86],"Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use. The Toronto General Hospital has created the world's first multidisciplinary perioperative Transitional Pain Service Program (TPSP) aimed at reducing the incidence and severity of chronic post-surgical pain. The TPSP incorporates a variety of mechanisms and interventions to help patients manage pain and to wean off opioids. The approach consists of: pain education, Acceptance and Commitment Therapy (ACT), and an e-mobile self- management tool to help patients manage chronic pain more effectively. With the TPSP team, the investigators hope to continually assist patients to achieve a balance between the benefits and potential harms of opioid use to promote long-term health and well-being.",[277,28,27,481],"Opioid Dependence","2026-04-24",{"date":484,"type":33},"2026-04-30",{"date":486,"type":33},"2018-10-15",{"date":488,"type":23},"2026-12-31",{"name":490,"class":40},"University Health Network, Toronto",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":204,"enrollmentInfo":498,"targetDuration":4,"studyType":56,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":506,"completionDateStruct":508,"leadSponsor":509,"locationsCount":41},"100443736","phase-3-lumbar-steroid-use-in-patients-undergoing-posterior-lumbar-decompression-100443736","NCT05058287","Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression","Topical Epidural Steroid Usage in Patients Undergoing Posterior Lumbar Decompression: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients scheduled to undergo 1 to 2 level laminectomy\n* Between the ages of 18-85\n\nExclusion Criteria:\n\n* Minimally invasive surgery\n* Prior daily opioid usage within 6 months.\n* Use of concomitant procedures such as spinal fusion, revision procedure at the same level.\n* History of a chronic pain syndrome, uncontrolled diabetes defined as A1C \\> 6.5, immunocompromised condition such as active cancer treatment, history of transplant, benign prostatic hyperplasia or history of urinary retention, and other conditions which require chronic steroid therapy or immunosuppressants.\n* Non-English speakers\n* Patients allergic to Depo-Medrol and\u002For glucocorticoids, or other steroids",{"count":55,"type":23},[377],"This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy. The study will examine post-operative opioid usage, length of stay, return to work, and patient reported outcomes following these procedures.",[28,502,380,503],"Lumbar Spinal Stenosis","Pain, Back","2026-04-23",{"date":461,"type":33},{"date":507,"type":33},"2021-11-05",{"date":488,"type":23},{"name":510,"class":40},"Hospital for Special Surgery, New York",{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":518,"targetDuration":4,"studyType":56,"phases":520,"briefSummary":521,"conditions":522,"keywords":524,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":536,"locationsCount":41},"100542669","improving-sleep-and-reducing-opioid-use-in-individuals-with-chronic-pain-100542669","NCT06345872","Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain","SPIN Opioid: Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain","Inclusion Criteria:\n\n* 18+ yrs\n* willing to be randomized,\n* can read\u002Funderstand English\n* diagnosed with chronic widespread pain and insomnia (as described below)\n* prescribed opioid medication for 1+ mo, 3+ times per week\n* desire to reduce or eliminate opioid use\n* written agreement from physician prescribing opioid medication\n* no prescribed or OTC sleep meds for 1+ mo, or stabilized on meds for 6+ wks\n\nExclusion Criteria:\n\n* unable to provide informed consent\n* cognitive impairment (MMSE \\\u003C26)\n* sleep disorder other than insomnia \\[i.e., sleep apnea (apnea\u002Fhypopnea index, AHI \\>15)\n* Periodic Limb Movement Disorder (myoclonus arousals per hour \\>15)\\]\n* bipolar or seizure disorder (due to risk of sleep restriction treatment)\n* other severe, untreated major psychopathology except for depression or anxiety (e.g.,suicidal ideation\u002Fintent, psychotic disorders)\n* psychotropic or other medications (e.g., beta-blockers) that alter pain or sleep (medications prescribed for pain or sleep are allowed)\n* participation in other non-pharmacological treatment for pain, sleep, or mood outside the current trial\n* internal metal objects or electrical devices\n* pregnancy\n* presumptive\u002Fconfirmed lumbar nerve root compression\n* confirmed lumbar spinal stenosis\n* \\\u003C6 mos post-back surgery\n* other spinal disorders",{"count":519,"type":23},165,[86],"The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.",[277,523,28],"Chronic Insomnia",[525,526,527,528],"Chronic pain","Chronic insomnia","Opioid use","CBT-I","2026-04-17",{"date":531,"type":33},"2026-04-21",{"date":533,"type":33},"2024-12-11",{"date":535,"type":23},"2028-07-01",{"name":537,"class":40},"University of South Florida",{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":544,"targetDuration":4,"studyType":56,"phases":545,"briefSummary":546,"conditions":547,"keywords":552,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":563,"locationsCount":41},"100348956","phase-3-post-op-pain-control-for-prophylactic-intramedullary-nailing-100348956","NCT03823534","Post-Op Pain Control for Prophylactic Intramedullary Nailing.","Inclusion Criteria:\n\n1. Femoral Shaft or Neck bone lesion\n2. 18 years old or greater\n3. Plan to undergo prophylactic intramedullary nailing of one femur\n\nExclusion Criteria:\n\n1. Concurrent pathologic fracture\n2. History of advanced renal impairment (eGFR\\\u003C30mL\u002Fmin)\n3. History of Peptic Ulcer Disease with bleeding or requiring hospitalization\n4. History of NSAID or aspirin allergy\n5. Concurrent chemotherapy regimen that prevents NSAID use\n6. History of liver disease that precludes use of toradol\n7. History of heart failure or cardiovascular disease that precludes toradol usage\n8. Pregnancy\n9. History of narcotic allergy resulting in anaphylaxis\n10. Patients with coagulation disorders or those who require concomitant use of anticoagulant or anti- platelet therapy during the treatment phase of the study.\n11. Patients with acetaminophen allergies resulting in anaphylaxis\n12. Current use of the medication probenecid\n13. Current use of the medication Pentoxifylline\n14. History of aspirin induced asthma.\n15. Known history of opioid dependence, abuse, or addiction.\n16. Bilateral IMN of the femurs",{"count":242,"type":23},[377],"Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a unique subset of patients that undergo prophylactic placement of intramedullary femoral nails. Because no fracture is present, these patients do not rely on inflammatory healing factors, allowing for post-op NSAID use. This study sets out to determine the effect of post-op toradol use in addition to opioids compared to solely opioids in patients undergoing prophylactic nailing of the femur.",[548,549,550,28,551],"Bone Metastases","Lymphoma","Multiple Myeloma","Pain",[553,554,555,556,527,557],"Toradol","Ketorolac","Prophylactic intramedullary nail","bone metastases","post-operative pain",{"date":559,"type":33},"2026-04-22",{"date":561,"type":33},"2019-02-20",{"date":70,"type":23},{"name":564,"class":40},"St. Louis University",{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":571,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":573,"minAge":52,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":56,"phases":575,"briefSummary":576,"conditions":577,"keywords":579,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":583,"startDateStruct":585,"completionDateStruct":587,"leadSponsor":589,"locationsCount":41},"100423791","phase-2-pain-alleviation-with-testosterone-in-opioid-induced-hypogonadism-100423791","NCT04798469","Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism","Androgen Replacement to Improve Patient-Important Outcomes in Men With Opioid-Induced Hypogonadism","PATH","Inclusion Criteria:\n\n* Men, age 18 years and older.\n* Chronic non-cancer spinal pain.\n* Use of opioid analgesics for at least 6 months.\n* Serum total testosterone (measured by mass spectrometry) \\\u003C348 ng\u002FdL and\u002For free testosterone \\\u003C70 pg\u002FmL.\n* Ability and willingness to provide informed consent.\n\nExclusion Criteria:\n\n* History of prostate cancer or breast cancer.\n* Known history of organic hypogonadism (e.g., due to hypothalamic, pituitary or testicular disease).\n* Use of testosterone within the past 6 months.\n* Baseline hematocrit \\>48%.\n* Prostate-specific antigen (PSA) level \\>4 ng\u002FmL in Caucasians or \\>3 ng\u002FmL in African-Americans.\n* Presence of prostate nodule or induration on digital rectal examination.\n* Uncontrolled congestive heart failure.\n* Myocardial infarction, acute coronary syndrome, revascularization surgery or stroke within 3 months.\n* Serum creatinine \\>2.5 mg\u002FdL.\n* Alanine aminotransferase (ALT) level 3 times above the upper limit of normal.\n* Diagnosis of bipolar disorder or schizophrenia.\n* Presence of metallic implants (pacemakers, aneurysm clips, etc.) that preclude the patient from undergoing functional magnetic resonance imaging (MRI). In subjects who are otherwise eligible and either do not qualify for MRI or are reluctant to undergo imaging, the investigators may consider enrolling such participants on a case-by-case basis.","MALE",{"count":55,"type":23},[59],"The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism (low testosterone).",[28,551,578],"Hypogonadism, Male",[551,580,581],"Opioid Analgesics","Testosterone","2026-04-11",{"date":584,"type":33},"2026-04-14",{"date":586,"type":33},"2022-01-10",{"date":588,"type":23},"2027-12-30",{"name":366,"class":40},{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":594,"acronym":595,"eligibilityCriteria":596,"healthyVolunteers":50,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":597,"targetDuration":4,"studyType":56,"phases":599,"briefSummary":600,"conditions":601,"keywords":603,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":607,"completionDateStruct":609,"leadSponsor":611,"locationsCount":613},"100468495","personalized-perioperative-analgesia-platform-ppap-for-cesarean-section-100468495","NCT05380531","Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section","PPAP C-Section","Inclusion Criteria:\n\nAdult women (\\>18 yr) All races American Society of Anesthesiologists Classification (ASA) physical status: 1 to 3 undergoing elective Cesarean section that are willing to receive in-patient opioids.\n\nExclusion Criteria:\n\n1. Health conditions including uncontrolled diabetes (gestational or pre-existing) or hypertension (pre-eclampsia, eclampsia, or chronic)\n2. Any history of opioid misuse before or during pregnancy-per self-report and clinical notes\n3. Preoperative severe pain and opioid use\u002Fmisuse, allergy to oxycodone\n4. Allergy to oxycodone\n5. Significant neurological disorders, liver and renal diseases",{"count":598,"type":23},700,[86],"The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants",[602,28],"Cesarean Section Complications",[604],"Opioid Exposure","2026-04-08",{"date":584,"type":33},{"date":608,"type":33},"2022-12-05",{"date":610,"type":23},"2027-10-30",{"name":612,"class":40},"Senthil Sadhasivam",4,{"id":615,"slug":616,"hasResults":12,"nctId":617,"briefTitle":618,"officialTitle":618,"acronym":4,"eligibilityCriteria":619,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":270,"enrollmentInfo":620,"targetDuration":4,"studyType":56,"phases":622,"briefSummary":623,"conditions":624,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":627,"lastUpdatePostDateStruct":628,"startDateStruct":630,"completionDateStruct":632,"leadSponsor":634,"locationsCount":41},"100524782","phase-4-nonopioid-pain-control-regimen-after-open-reduction-and-internal-fixation-of-traumatic-fractures-100524782","NCT06113211","Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures","Inclusion Criteria:\n\n* All adult patients over age eighteen and scheduled for primary open reduction internal fixation following a traumatic fracture at Henry Ford Hospital (Detroit, Michigan, United States), and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan, United States) will be eligible for inclusion in this study. All patients will be met in our abulatory orthopedic clinics. All surgeries will be performed by a fellowship trained truama surgeons.\n\nExclusion Criteria:\n\n* patients with a medical history of known allergies or intolerance to allergies or intolerance to Motrin, Lyrica, Tylenol, tramadol, Zanaflex\n* substantial alcohol or drug abuse\n* pregnancy\n* history of narcotics within 6 months of surgery\n* renal impairment, peptic ulcer disease, GI bleeding.",{"count":621,"type":23},75,[208],"An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is advantageous to use alternate forms of analgesia. Multimodal pain control captures the effectiveness of different analgesic modalities and maximizes analgesia while minimizing side effects. The theory behind their use is that agents with different mechanisms of action work synergistically in preventing acute pain.\n\nObjective: To measure postoperative pain control in patients in two treatment arms of ORIF of the clavicle: a treatment group given a nonopioid pain control regimen, and a standard of care control group given standard opioid pain control regimen.\n\nStudy Design: A randomized single blinded standard of care controlled clinical trial comparing pain management interventions. All adult patients scheduled for an ORIF following a traumatic fracture by fellowship trained Trauma surgeons will be eligible for inclusion. Patients will be excluded if their medical history presents known allergies or intolerance to Motrin, Lyrica, Tylenol, Zanaflex, substantial alcohol or drug abuse, and pregnancy, history of narcotics within 6 months of surgery, renal impairment, peptic ulcer disease, GI bleeding.\n\nOn the day of surgery, patients will be randomized to receive a nonopioid pain control regimen or an opioid regimen using a computer-generated sequence.\n\nIf pain is uncontrolled, patients will also be sent home with a prescription with 10 pills of 5 mg of Oxycodone for breakthrough pain. The amount of oxycodone taken will be recorded. Patients can call the resident on call, available 24-hours per day, if additional pain control is needed.\n\nTreatment: All patients will undergo previously scheduled ORIF of the clavicle in standard fashion and be randomized to the non-narcotic pain regimen vs the narcotic pain regimen.",[28,625,626],"Fractures, Bone","Trauma","2026-04-07",{"date":629,"type":33},"2026-04-13",{"date":631,"type":33},"2024-10-01",{"date":633,"type":23},"2026-09-15",{"name":635,"class":40},"Henry Ford Health System",{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":642,"eligibilityCriteria":643,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":644,"targetDuration":4,"studyType":56,"phases":646,"briefSummary":647,"conditions":648,"keywords":657,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":664,"lastUpdatePostDateStruct":665,"startDateStruct":666,"completionDateStruct":667,"leadSponsor":669,"locationsCount":41},"100630348","mindfulness-in-fracture-recovery-and-reduction-of-opioid-reliance-evaluating-the-feasibility-of-implementing-a-brief-mindfulness-based-intervention-to-manage-pain-and-anxiety-before-and-after-fracture-surgery-100630348","NCT07486505","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance (MIRROR): Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","MIRROR","The inclusion criteria are:\n\n1. Adults 18 years of age or older; and\n2. Presenting to the hospital with an open or closed appendicular fracture requiring internal fixation. Patients with multiple fractures may be included.\n\nThe exclusion criteria are:\n\n1. Does not have the English-language skills required to participate in trial interventions (in the judgement of site research personnel);\n2. Cognitive impairment (including traumatic brain injury);\n3. Auditory or visual impairment that would inhibit ability to receive intervention;\n4. Current incarceration;\n5. Concomitant injury which, in the opinion of the attending surgeon, is likely to impair function for as long as or longer than the patient's extremity fracture;\n6. Previously completed a standardized mindfulness program (e.g., MBSR) or regularly (e.g., daily) practice mindfulness;\n7. Active psychosis;\n8. Active suicidality;\n9. Stress fracture;\n10. Fragility fracture;\n11. Currently enrolled in a study that does not permit co-enrolment in other trials;\n12. Not willing to participate in the intervention;\n13. No provision of informed consent; or\n14. Other reason as approved by the Data Coordinating Centre.",{"count":645,"type":23},50,[86],"Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for surgery. After surgery, many continue to struggle with pain and rely on opioid medications, which carry serious risks including addiction. In the context of our current opioid epidemic, it's critical that alternative treatment strategies are urgently evaluated.\n\nMindfulness is a practice that helps people focus on the present and has been shown to reduce stress and pain in other settings. In this trial, patients with broken arms or legs who need surgery at Hamilton General Hospital will be randomly assigned to one of two groups who will listen to a two-part, audio recording before and after surgery. Those in the interventional group will engage in a 7-minute audio-guided mindfulness exercise before surgery to help reduce anxiety, and another 7-minute audio-guided mindfulness exercise after surgery to help manage pain. Those in the control group will listen to a 7-minute educational audio recording before surgery and again after surgery.\n\nThe main goal is to see if this approach is practical-can enough patients be recruited, and will they complete the audio recordings? The study will also look at early signs of whether the intervention helps reduce pain, anxiety, and opioid use six weeks after surgery. If feasible, a larger study can be conducted to determine if these exercises can help patients manage pain and reduce their need for opioids after surgery.\n\nIf successful, this simple, low-cost approach could be widely used in hospitals to support recovery and reduce reliance on pain medications.",[649,650,651,652,653,654,655,28,656],"Orthopaedic Fractures","Orthopaedic Trauma Fractures and Non-unions","Orthopaedic Trauma","Orthopaedic Surgery","Orthopaedic Related Pain (Musculoskeletal Pain)","Anxiety Acute","Anxiety After Surgery","Opioid Use After Surgery",[658,659,660,661,662,663],"fractures","mindfulness","pain management","fracture surgery","opioid use","anxiety","2026-04-06",{"date":627,"type":33},{"date":140,"type":23},{"date":668,"type":23},"2026-10-30",{"name":670,"class":40},"McMaster University"]