[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioids":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,78,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100578043","machine-learning-prediction-and-reducing-overdoses-with-ehr-nudges-100578043",false,"NCT06806163","Machine-Learning Prediction and Reducing Overdoses With EHR Nudges","mPROVEN","Inclusion Criteria:\n\n* Received an opioid prescription within the past year\n* Age 18 years or older at the time of the opioid prescription\n* At least one visit to an internal medicine or family care practice within the past year\n\nExclusion Criteria:\n\n* Diagnosis of malignant cancer within the past year\n* Enrollment in hospice care","ALL","18 Years",{"count":19,"type":20},1350,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction model as having an elevated risk for an opioid overdose.\n\nThe clinical trial will evaluate the effectiveness of providing a flag in the EHR to identify individuals at elevated risk with and without behavioral nudges\u002Fbest practice alerts (BPAs) as compared to usual care by primary care clinicians.\n\nThe primary goals of the study are to improve opioid prescribing safety and reduce overdose risk.",[26,27,28,29],"Opioid Overdose","Opioid Use","Opioid Use Disorder","Opioids",[31,32,33,34,35,36,37,26,29],"Machine learning","Risk prediction","Behavioral nudge","Best Practice Alert","Artificial intelligence","Primary care","Electronic Health Record Platforms","RECRUITING","2026-06-16",{"date":41,"type":42},"2026-06-17","ACTUAL",{"date":44,"type":42},"2025-03-10",{"date":46,"type":20},"2027-02",{"name":48,"class":49},"University of Pittsburgh","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":50},"100581738","early-phase-1-impacts-of-opioids-on-respiratory-drive-during-sleep-100581738","NCT06854211","Impacts of Opioids on Respiratory Drive During Sleep","Mechanisms of Opioid-induced Respiratory Depression (OIRD) During Sleep","OIRD","Inclusion Criteria:\n\n* Healthy controls: Apnea Hypopnea Index (AHI) \\\u003C 5 events\u002Fhr on in-laboratory PSG within 3 months of enrollment\n* OSA group: AHI \\> 10 events\u002Fhr on in-laboratory PSG within 3 months of enrollment; treated or untreated.\n\nExclusion Criteria:\n\n* Sleep disordered breathing or respiratory disorders (other than OSA in the OSA group), such as central sleep apnea (\\>50% of respiratory events scored as central), chronic hypoventilation\u002Fhypoxemia (awake SaO2 \\\u003C 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions.\n* Other sleep disorders: periodic limb movements (periodic limb movement index \\> 20\u002Fhr), narcolepsy, or parasomnias.\n* Any unstable major medical condition.\n* Medications expected to stimulate or depress respiration (including other opioids taken at home, barbiturates, benzodiazepines, doxapram, almitrine, theophylline, 4-hydroxybutanoic acid).\n* History of allergy to lidocaine or oxymetazoline.\n* Contraindications for morphine, including:\n* allergy to morphine or opioids\n* chronic obstructive pulmonary disease, asthma, or other significant respiratory disorders\n* kidney or liver dysfunction, as this can affect the metabolism and excretion of morphine, leading to increased risk of toxicity.\n* women who are pregnant or breastfeeding will be excluded due to potential risks to the fetus or infant.\n* history of substance abuse, particularly opioid abuse, will be excluded to prevent potential misuse or relapse.\n* current use of central nervous system depressants.\n* individuals with gastrointestinal obstruction. Constipation is not an exclusion criterion because morphine is only administered for one night.\n* recent head injury, brain tumors, or other conditions leading to increased intracranial pressure.\n* unstable heart disease, particularly those with risk factors for or a history of heart rhythm disorders.\n* epilepsy or a history of seizures, as morphine can lower the seizure threshold.\n* severe psychiatric conditions, particularly those with a history of psychosis, as opioids can exacerbate these conditions.\n* medications that interact with morphine, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), Monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants buproprion and trazodone.\n* untreated or unstable endocrine disorders like adrenal insufficiency or thyroid dysfunction.",true,"65 Years",{"count":62,"type":20},26,[64],"EARLY_PHASE1","The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.",[29,67],"Obstructive Sleep Apnea (OSA)","NOT_YET_RECRUITING","2026-01-28",{"date":71,"type":42},"2026-01-29",{"date":73,"type":20},"2026-07-01",{"date":75,"type":20},"2027-01-31",{"name":77,"class":49},"Brigham and Women's Hospital",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":50},"100572751","phase-4-bupivacaine-liposomes-or-bupivacaine-for-cmb-on-postoperative-analgesia-in-laparoscopic-hepatobiliary-pancreatic-surgery-100572751","NCT06737341","Bupivacaine Liposomes or Bupivacaine for CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery","Effect of Bupivacaine Liposomes or Bupivacaine for Ultrasound-guided CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery: a Prospective, Single Blind, Completely Randomized, Active Controlled Clinical Trial","Inclusion Criteria:\n\n* 18-80 years old ASA Level I-III Laparoscopic Hepatobiliary Pancreatic Surgery\n\nExclusion Criteria:\n\n* Body Mass Index (BMI) ≥ 30 kg\u002Fm ² or ≤ 15 kg\u002Fm ² Known alcohol or drug abuse History of upper abdominal surgery Congenital coagulation dysfunction Localized or systemic infection Peripheral neuropathy Unable to understand the research plan","80 Years",{"count":87,"type":20},60,[89],"PHASE4","Numerous studies have confirmed that regional analgesia using peripheral nerve block has great potential for perioperative analgesia in abdominal surgery. Ultrasound guided costal margin block (CMB) is a new regional anesthesia technique that has been proven to compensate for the analgesic effects of regional analgesia techniques such as transverse abdominal muscle plane (TAP) and rectus abdominis sheath (RSB) on mid abdominal incisions, but it is difficult to meet the analgesic needs of anterior and outer abdominal wall incisions. According to relevant anatomy and research, the application of local anesthetics along the rib margin under the rectus abdominis muscle or under the external oblique muscle on the rib surface can block the lateral and anterior cutaneous branches of the thoracoabdominal nerve, known as CMB. Ultrasound guided CMB requires the injection of local anesthetics onto the surface of the rib along the plane below the rectus abdominis and oblique muscles, covering most of the upper abdominal incision pain. However, there are few reports on other types of upper abdominal surgeries such as liver, gallbladder, and pancreas surgeries.\n\nBupivacaine liposomes are an important innovation, which encapsulate bupivacaine in polycystic liposomes using DepoFoam technology to achieve slow drug release and effectively prolong pain relief time by up to 72 hours. This ultra long acting local anesthetic has significant advantages in reducing opioid use, improving analgesic satisfaction, reducing complications, and shortening hospital stays, and has been applied in the ERAS concept.\n\nThe investigators designed a prospective, single blind, randomized, active controlled clinical trial to investigate the effect of bupivacaine liposomes in combination with bupivacaine mixture or bupivacaine alone for ultrasound-guided bilateral CMB on postoperative analgesia in patients undergoing laparoscopic hepatobiliary pancreatic surgery. Our main hypothesis is that the use of bupivacaine liposomes and a mixture of bupivacaine for ultrasound-guided CMB in a multimodal analgesia regimen can more effectively reduce the dosage of intravenous patient-controlled analgesia (PCA) opiates within 72 hours after laparoscopic hepatobiliary pancreatic surgery compared to using bupivacaine alone. Secondary outcomes include the dosage of PCA opiates within 24-48 hours, pain score values, patient satisfaction, adverse reactions, and complications.",[92,93,94,29],"Bupivacaine","Ultrasound-Guided","Analgesia, Postoperative",[96,97,98],"Bupivacaine Liposome","Costal Margin Block","Laparoscopic Hepatobiliary Pancreatic Surgery","2025-09-30",{"date":101,"type":42},"2025-10-03",{"date":103,"type":20},"2025-10-08",{"date":105,"type":20},"2026-02-01",{"name":107,"class":49},"Huazhong University of Science and Technology",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":4},"100591617","phase-1-acupuncture-versus-compound-diclofenac-sodium-for-pain-relief-in-non-traumatic-acute-abdominal-100591617","NCT06982755","Acupuncture Versus Compound Diclofenac Sodium for Pain Relief in Non-Traumatic Acute Abdominal","Effect of Acupuncture on Early Analgesia of Non-traumatic Acute Abdomen is Discussed Based on the Experience of Sanli Acupoint for Du-fu Diseases :A Prospective Randomized Controlled pRCT Study","ACU-NTAA","Inclusion Criteria:\n\n1. The diagnostic criteria of NTAA were as follows: ① abdominal pain was the main symptom; ② The onset time was less than 1 week; ③ The cause of abdominal pain could be traced to intra-abdominal abdominal wall chest or systemic diseases;\n2. Patients with NRS scores ≥4 (mild pain and above) were evaluated before inclusion; （3）16 years \\\u003C age \\\u003C75 years;\n\n（4）Those who were considered not to need surgery within 2 hours after initial assessment by a specialist.\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria were excluded from the study:\n\n1. Acute abdomen caused by trauma;\n2. Super sudden diseases (e.g. acute myocardial infarction rupture of abdominal aortic aneurysm pulmonary embolism aortic dissection pericardial tamponade);\n3. Emergent conditions requiring surgical treatment within 3 hours (e.g. rupture of liver cancer ectopic pregnancy ischemic bowel disease severe acute cholangitis peritonitis with septic shock);\n4. Extremely severe pain (NRS ≥ 8) with an undetermined diagnosis and requiring further assessment for a super sudden disease;\n5. Inability to select acupuncture points due to skin injury or ulceration at Zusanli (ST36) on the lower limb;\n6. Induration or infection at the hip injection site;\n7. Patients with altered consciousness mental illness other severe chronic diseases or those who are unlikely to cooperate with acupuncture treatment;\n8. Contraindications to Western medicine:\n\n   * Known allergies to diclofenac sodium or acetaminophen; ②History of asthma urticaria or allergic reactions induced by aspirin or other NSAIDs.\n\n     * Undergoing coronary artery bypass grafting (CABG) surgery. ④History of gastrointestinal bleeding or perforation following non-steroidal anti-inflammatory drugs (NSAIDs).\n\n       * Active gastrointestinal ulcers or bleeding or a history of recurrent ulcers or bleeding.\n\n         * Severe heart failure.\n9. Use of any pain medication or acupuncture within the past 6 hours;\n10. Previous participation in this study;\n11. Pregnant or lactating individuals.","16 Years","75 Years",{"count":119,"type":20},176,[121,122],"PHASE1","PHASE2","The investigators designed this clinical study to evaluate the efficacy and safety of semi-standardized acupuncture and moxibustion combined with compound diclofenac sodium injection in the emergency department (ED) compared with acupuncture or compound diclofenac sodium injection alone.",[125,126,127,29],"Acute Abdominal Pain","Acupuncture Therapy","Acupuncture",[129,130,131,132,127,133,134,135,29,136,137],"Acute abdominal pain","Non-Traumatic Acute Abdomen","Non-traumatic acute abdomen early analgesia","Acupuncture therapy","Zusanli point, ST36","Diclofenac sodium","Emergency environment","Non-steroidal anti-inflammatory drugs ，NSAIDs","Acetaminophen","2025-05-20",{"date":140,"type":42},"2025-05-21",{"date":142,"type":20},"2025-06-01",{"date":144,"type":20},"2026-12-31",{"name":146,"class":49},"The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine"]