[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"optic-nerve-sheath-diameter\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:optic-nerve-sheath-diameter":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,74,107,138,165,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100634449","effects-of-menstrual-cycle-on-optic-nerve-sheath-diameter-in-patients-undergoing-laparoscopic-gynecologic-surgery-100634449",false,"NCT07539831","Effects of Menstrual Cycle on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery","The Effect of Menstrual Cycle Phase on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Gynecologic Surgery","Inclusion Criteria:\n\n* Female patients aged 18 to 45 years\n* Scheduled for elective laparoscopic gynecologic surgery\n* Menstrual cycle in the follicular phase or luteal phase\n* American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n* Irregular menstrual cycle (e.g., polycystic ovary syndrome, early menopause, hypothalamic amenorrhea)\n* Pregnancy or breastfeeding\n* Neurological disease associated with intracranial pressure changes\n* Glaucoma or another eye disease associated with high intraocular pressure\n* Previous brain surgery\n* Uncontrolled hypertension or severe cardiovascular disease","FEMALE","18 Years","45 Years",{"count":20,"type":21},110,"ESTIMATED","OBSERVATIONAL","This observational study aims to evaluate the effect of menstrual cycle phase on optic nerve sheath diameter (ONSD) in women undergoing elective laparoscopic gynecologic surgery. Patients will be grouped according to menstrual cycle phase as follicular or luteal. ONSD measurements will be performed perioperatively, and postoperative nausea and vomiting as well as postoperative cognitive function will also be assessed. The study is designed to investigate whether hormonal variations during the menstrual cycle are associated with differences in intracranial pressure reflected by ONSD measurements and postoperative outcomes",[25,26,27],"Menstrual Cycle","Optic Nerve Sheath Diameter","Postoperative Nausea and Vomiting",[26,29,30,31,32,33],"Laparoscopic Gynecologic Surgery","Mini-Mental State Examination","Verbal Descriptive Scale","Follicular Phase","Luteal Phase","RECRUITING","2026-04-20",{"date":37,"type":38},"2026-04-21","ACTUAL",{"date":35,"type":38},{"date":41,"type":21},"2027-04-05",{"name":43,"class":44},"Konya City Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100630709","effect-of-trendelenburg-position-and-pneumoperitoneum-on-optic-nerve-sheath-diameter-in-robot-assisted-prostatectomy-100630709","NCT07491198","Effect Of Trendelenburg Position And Pneumoperitoneum On Optic Nerve Sheath Diameter In Robot-Assisted Prostatectomy","Effect of Steep Trendelenburg Position and Pneumoperitoneum on Optic Nerve Sheath Diameter in Robot-Assisted Laparoscopic Radical Prostatectomy: A Prospective Study","ONSD-RALP","Inclusion Criteria:\n\n* Age ≥ 18 years\n* ASA physical status I-III\n* Patients scheduled for robot-assisted laparoscopic radical prostatectomy or open radical prostatectomy under general anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* History of intracranial surgery or intracranial lesion\n* Known ocular disease (glaucoma, retinal detachment, diabetic retinopathy, previous ocular surgery, etc.)\n* Intraocular pressure greater than 30 mmHg\n* Refusal to participate in the study","MALE",{"count":56,"type":21},50,"This prospective study aims to evaluate the effect of steep Trendelenburg position and pneumoperitoneum on optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic radical prostatectomy and open radical prostatectomy under general anesthesia. Increased intracranial pressure may occur during robotic surgery due to pneumoperitoneum and head-down positioning. Optic nerve sheath diameter measured by ocular ultrasonography is a non-invasive method used to assess intracranial pressure changes. Hemodynamic and respiratory parameters will also be recorded during surgery. The results of this study may help to better understand the physiological effects of surgical position and pneumoperitoneum during prostatectomy procedures.",[59,26,60,61],"Prostate Cancer","Robot-Assisted Radical Prostatectomy","Steep Trendelenburg Position With Penumoperitoneum in Robot Assisted Laparoscopic Prostatectomy",[26,63,64,60],"Trendelenburg Position","Pneumoperitoneum","2026-03-18",{"date":67,"type":38},"2026-03-24",{"date":69,"type":38},"2026-01-05",{"date":71,"type":21},"2026-09",{"name":73,"class":44},"Ege University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":82,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":85,"conditions":86,"keywords":94,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100591382","early-wake-up-predictors-after-out-of-hospital-cardiac-arrest-100591382","NCT06979700","Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest","Early Wake-up Predictors After Out-of-hospital Cardiac Arrest - an Observational, Multicenter Substudy of the DANOHCA Trial","WAKE-OHCA","Inclusion Criteria:\n\n* Age ≥18 years\n* OHCA of presumed cardiac cause\n* Sustained ROSC, defined as persistent signs of circulation and no need for chest compressions or mechanical circulatory support for 20 minutes\n* Unconsciousness (GCS \\\u003C9) (patients not able to obey verbal commands) after sustained ROSC at the time of randomization\n\nExclusion Criteria:\n\n* Females of childbearing potential if pregnancy is suspected (unless a negative HCG test can rule out pregnancy within the inclusion window)\n* Known bleeding diathesis (medically induced coagulopathy (e.g. warfarin, NOAC, clopidogrel) does not exclude the patient)\n* Suspected or confirmed acute intracranial bleeding\n* Suspected or confirmed acute stroke\n* Unwitnessed asystole\n* Known limitations in therapy and Do Not Resuscitate-order\n* Known disease making 180 days survival unlikely\n* Known pre-arrest CPC 3 or 4 functional status\n* \\>3 hours (180 minutes) from ROSC to screening\n* Systolic blood pressure \\\u003C80 mm Hg despite fluid loading\u002Fvasopressor and\u002For inotropic medication (If the systolic blood pressure is recovering during the inclusion window of 180 minutes the patient may be included)\n* Use of intra-aortic balloon pump\u002Faxial flow device\u002FECMO (If the patient is weaned and the device is removed during the inclusion window of 180 minutes the patient may be included)\n* Temperature on admission \\\u003C30°C\n* Known allergy for dexamethasone or olanzapine\n* Ongoing (within 48 h) treatment with olanzapine or dexamethasone\n* Known back or hip condition that precluded the patients from being positioned with backrest from 0 to 45-degree angle\n* Known or suspected Long QT Syndrome (LQTS)\n* Known active fungal disease. Localized skin lesions do not exclude patients from inclusion\n* Estimated body weight \\\u003C45kg","ALL",{"count":84,"type":21},250,"WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838. The aim is to collect early neuromonitoring data to identify key predictors of successful wake-up.",[87,88,89,90,91,26,92,93],"Cardiac Arrest (CA)","Anoxic Brain Injury","Comatose Survivors of Cardiac Arrest","EEG","Pupillometry","Transcranial Doppler Ultrasound","Neurological Outcome",[95,96],"wakeup","sedation","2025-11-14",{"date":99,"type":38},"2025-11-18",{"date":101,"type":38},"2025-05-13",{"date":103,"type":21},"2027-12",{"name":105,"class":44},"University of Aarhus",2,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":82,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":4},"100592519","comparison-of-the-effects-of-endotracheal-intubation-and-laryngeal-mask-applications-on-optic-nerve-diameter-in-pediatric-patients-100592519","NCT06994481","Comparison of the Effects of Endotracheal Intubation and Laryngeal Mask Applications on Optic Nerve Diameter in Pediatric Patients","Inclusion Criteria:\n\n1. Classified as American Society of Anesthesiologists (ASA) physical status I or II,\n2. Aged between 1 and 11 years,\n3. Scheduled to receive general anesthesia,\n4. Planned to be ventilated via endotracheal intubation or laryngeal mask airway (LMA).\n\nExclusion Criteria:\n\n1. Families who do not provide informed consent,\n2. Patients with a tracheostomy,\n3. History of previous intracranial surgery (e.g., tumor resection or shunt placement),\n4. History of preoperative seizures,\n5. Presence of craniofacial deformities that may prevent accurate optic nerve sheath diameter (ONSD) measurement,\n6. Infection, wound, or any other condition in the measurement area that may interfere with ONSD assessment,\n7. Presence of conditions that may increase intracranial pressure and affect ONSD measurement (e.g., tumor, encephalitis, meningitis, or intracranial infection),\n8. Patients who require a change in the endotracheal tube or laryngeal mask airway (LMA) size during the operation, or who undergo a second intubation or insertion attempt,\n9. Patients who withdraw from the study.",true,"1 Year","11 Years",{"count":117,"type":21},200,"This clinical study aims to investigate the effects of breathing tubes, which we use to connect children aged 1-11 to a respiratory device under general anesthesia in the operating room, on intracranial pressure after they are inserted. No changes will be made to routine anesthesia practices for this purpose, and eye examinations will be performed with an USG device. This study has no undesirable effects or risks. This study does not include any invasive procedures. You have the right to refuse to participate in the study. You have the right to withdraw from the study at any time. If you decide not to participate in the study for any reason, there will be no disruption to your treatment. You will not be liable for any financial loss if you participate in the study, and you will not be paid. Your identity will be kept confidential if you participate in the study.",[26,120,121,122],"Pediatric Anesthesia","Intubation","Laryngeal Mask Airways",[124,125,126,127],"optic nerve sheath diameter","pediatric patients","intubation","laryngeal mask airway","NOT_YET_RECRUITING","2025-05-20",{"date":131,"type":38},"2025-05-29",{"date":133,"type":21},"2025-06-01",{"date":135,"type":21},"2026-06-01",{"name":137,"class":44},"Marmara University Pendik Training and Research Hospital",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":82,"minAge":17,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":148,"phases":149,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":45},"100535646","lidocaine-dexmedetomidine-esmolol-and-magnesium-effect-on-optic-nerve-sheath-diameter-after-laryngoscopy-100535646","NCT06254534","Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy","Effect of Lidocaine, Dexmedetomidine, Esmolol and Magnesium Use on Optic Nerve Sheath Diameter and Hemodynamic Response After Laryngoscopy: Randomized, Controlled, Double-blind Trial","Inclusion Criteria:\n\n* Patients aged 18 to 80 years who will receive endotracheal intubation for general anesthesia and have an American Society of Anesthesiologists (ASA) Physical Status classification of I to III.\n\nExclusion Criteria:\n\n* Patients allergic to dexmedetomidine, esmolol, lidocaine, and magnesium; patients with uncontrolled hypertension or advanced heart failure with EF below 35%; patients with cardiac arrhythmia, especially Type 2 and 3 blocks, supraventricular arrhythmias. Patients with renal failure (GFR below 30) or severe liver failure; patients with known acute or previous intracranial pathology and known diagnosis of epilepsy, predefined difficult airway examination. Patients who required more than one attempt at intubation or total laryngoscopy took more than 20 seconds.","80 Years",{"count":147,"type":21},100,"INTERVENTIONAL",[150],"NA","This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy.\n\nThe participants will be patients determined to need intubation and general anesthesia for any elective surgery. Each participant will receive either lidocaine, dexmedetomidine, esmolol, magnesium, or none before anesthesia induction, according to randomization. The investigator will measure the optic nerve sheath diameter by ultrasonography before and after intubation. Researchers will compare the difference between optic nerve sheath diameter, systolic blood pressure, and heart rate before and after laryngoscopy and search for the most stable group. The trial aims to determine a general anesthesia induction protocol for patients sensitive to intracranial pressure changes reflected as optic nerve sheath diameter for easy monitoring.",[153,154,26,155],"Intracranial Hypertension","Endotracheal Intubation","General Anesthesia","2025-03-16",{"date":158,"type":38},"2025-03-20",{"date":160,"type":38},"2024-02-14",{"date":162,"type":21},"2025-07",{"name":164,"class":44},"Haseki Training and Research Hospital",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":82,"minAge":17,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":148,"phases":175,"briefSummary":176,"conditions":177,"keywords":179,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":186,"leadSponsor":188,"locationsCount":45},"100583273","oropharyngeal-vs-intravenous-lidocaine-effects-on-optic-nerve-sheath-diameter-after-intubation-100583273","NCT06874179","Oropharyngeal Vs Intravenous Lidocaine Effects on Optic Nerve Sheath Diameter After Intubation","Effects of Oropharyngeal-topical and Intravenous Lidocaine on the Optic Nerve Sheath Diameter Changes After Endotracheal Intubation: a Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* ASA class I or II\n* Age 18-65 years\n* BMI 18-30\n* No history or expected difficult intubation\n* No glaucoma or ocular pathology\n* No intracranial pressure increase\n\nExclusion Criteria:\n\n* ASA class III and above\n* Obesity (BMI \\> 30)\n* Difficult intubation history or risk\n* Glaucoma or other ophthalmic pathology\n* History of intracranial pressure increase or prior ophthalmic\u002Fintracranial surgery\n* Preoperative sedation\n* Active malignancy or ongoing radiotherapy\u002Fchemotherapy","65 Years",{"count":174,"type":21},190,[150],"This study aims to evaluate the effects of pre-intubation oropharyngeal topical lidocaine on optic nerve sheath diameter (ONSD) post-endotracheal intubation. The study will measure the ONSD using ultrasonography before intubation, and at 1, 5, and 10 minutes post-intubation. The results will be compared between patients receiving %10 lidocaine topically and %2 intravenous lidocaine.",[178,26],"Endotracheal Intubation During Surgery",[180,124,181],"endotracheal intubation","lidocaine","2025-03-08",{"date":184,"type":38},"2025-03-13",{"date":158,"type":21},{"date":187,"type":21},"2025-11-30",{"name":189,"class":44},"Ankara City Hospital Bilkent",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":82,"minAge":17,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":148,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":45},"100554326","effect-of-spinal-needle-type-on-optic-nerve-sheath-diameter-100554326","NCT06497634","Effect of Spinal Needle Type on Optic Nerve Sheath Diameter","Effect of Needle Types and Diameters Using in Spinal Anesthesia on Optic Nerve Sheath Diameter; Prospective Randomized Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I-II Risk Classification\n* Elective orthopedic lower extremity surgery\n* Using a tourniquet\n* Spinal anesthesia\n\nExclusion Criteria:\n\n* Bilateral tourniquet usage\n* History of orbital trauma\n* Optic nerve pathology\n* Glaucoma\n* Asthma\n* Coronary obstructive or pulmonary disease\n* Previous corneal or intraocular surgery\n* Increased intracranial pressure\n* Coagulopathy\n* Local site infection\n* Refusing to participate in the study","40 Years",{"count":199,"type":21},165,[150],"The optic nerve sheath is a continuation of the dura mater, extending along the subarachnoid space surrounding the optic nerve. Consequently, changes in intracranial pressure cause an augmentation or contraction in the diameter of the optic nerve sheath, which is coreleted with intracranial pressure. Participants undergoing lower extremity operations (ankle, distal tibia and fibula surgeries) using a tourniquet under spinal anesthesia will be investigated. Spinal anesthesia will be performed with a 25 G Whitacre, 25 G Quincke, or 27 G Quincke needle, depending on the study group. Optic nerve sheath diameter (ONSD) measurements will be performed before spinal anesthesia; and 5 minutes, 15 minutes,,24 hours after spinal block, respectively.The 4th measurement will be performed after tourniquet is opened. Measurements will be done with 15 MHz linear ultrasound (US) probe in B mode, 3 mm behind the posterior globe in the transverse plane from both eyes, on upper eyelid. Values will be recorded numerically. The impact of spinal anesthesia administered using various needle designs (Quincke and Whitacre) and sizes (25G-27G) on intracranial pressure will be investigated.",[203,204,26,205,206],"Spinal Anesthesia","Intracranial Pressure Change","Orthopedic Surgery","Cerebrospinal Fluid Leak","2024-07-29",{"date":209,"type":38},"2024-07-30",{"date":211,"type":21},"2024-08-15",{"date":213,"type":21},"2024-12-30",{"name":215,"class":216},"Bagcilar Training and Research Hospital","OTHER_GOV"]