[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"optimal-volume-of-liposomal-bupivacaine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:optimal-volume-of-liposomal-bupivacaine":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100588537","phase-4-determination-of-the-optimal-volume-of-liposomal-bupivacaine-in-adductor-canal-block-for-knee-joint-surgery-100588537",false,"NCT06942689","Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery","Determination of the Optimal Volume of Liposomal Bupivacaine in Single-Shot Adductor Canal Block for Knee Joint Surgery-A Phase I\u002FII Trial","Inclusion Criteria:\n\n* Patients undergoing elective general anesthesia for unilateral knee joint surgery.\n* Patients who provide informed consent.\n* Aged between 18 and 65 years old, regardless of gender.\n* American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ\n* Body mass index (BMI) ≤ 35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Femoral neuropathy.\n* Coagulation dysfunction.\n* Allergy to local anesthetics.\n* Infection at the puncture site.\n* History of chronic pain or opioid use.\n* Pregnancy.\n* Diabetes mellitus and peripheral neuropathy.","ALL","18 Years","85 Years",{"count":20,"type":21},63,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN\u002FBOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.",[27],"Optimal Volume of Liposomal Bupivacaine",[29,30,31,32,33],"Liposomal Bupivacaine","Adductor Canal Block","Knee Surgery","Maximum Tolerated Volume","Quadriceps Muscle Strength","RECRUITING","2025-08-31",{"date":37,"type":38},"2025-09-08","ACTUAL",{"date":40,"type":38},"2025-06-01",{"date":42,"type":21},"2027-12-31",{"name":44,"class":45},"Nanjing First Hospital, Nanjing Medical University","OTHER"]