[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,74,107,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100644263","evaluation-of-masticatory-performance-in-patients-with-periodontitis-100644263",false,"NCT07665489","Evaluation of Masticatory Performance in Patients With Periodontitis","PAROCHEW","Inclusion Criteria:\n\n* Patients followed at the university hospital (CHU) with a diagnosis of periodontitis.\n* No objection from the patient to participate in the study.\n* Patients able to speak and understand French.\n\nExclusion Criteria:\n\n* Minors.\n* Patients under legal protection (guardianship, trusteeship, or judicial protection measures).\n* Pregnant or breastfeeding women.\n* Patients who refuse to participate in the study.","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","The objective of this observational study is to assess the correlation between the severity of periodontal involvement and masticatory performance in patients with periodontitis.\n\nThe secondary objectives are to identify periodontal parameters that may be associated with a reduction in masticatory performance.\n\nThis study includes a single group.\n\nParticipants will be asked to perform a masticatory performance test consisting of chewing a piece of gum for 20 cycles.",[24,25,26],"Periodontitis, Adult","Periodontitis","Oral Disease","NOT_YET_RECRUITING","2026-06-30",{"date":30,"type":31},"2026-07-01","ACTUAL",{"date":33,"type":20},"2026-06-01",{"date":35,"type":20},"2027-06-01",{"name":37,"class":38},"University Hospital, Clermont-Ferrand","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":39},"100540758","systematical-trained-learning-algorithms-for-oral-carcinogenesis-interpretation-by-optical-coherence-tomography-100540758","NCT06321003","SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography","Single-blind Clinical Trial Assessing the Validity of Optical Coherence Tomography (OCT) in Diagnosing Potentially Malignant Oral Lesions and Oral Cancer","SYMILIS OCT","Inclusion Criteria:\n\n1. Adult patients with clinical suspicion of potentially malignant oral disorders (OPMDs) and oral squamous cell carcinoma (OSCC).\n2. Patients able to provide informed consent for participation in the study.\n3. Availability of complete clinical data and medical records.\n\nExclusion Criteria:\n\n1. Patients with a previous diagnosis of OSCC\u002FOPMDs and\u002For who have already undergone treatment.\n2. Patients with contraindications to the OCT examination for nonpermissive oral localization using the probe.\n3. Pregnant or breastfeeding women.\n4. Patients with disabilities, reluctance or difficulties of understanding to follow the procedures of the study and who have not provided a consent.","99 Years",{"count":50,"type":20},200,"This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma (OSCC). Despite the availability of oral screening, diagnostic delays persist, underscoring the importance of exploring non-invasive methodologies. The OCT technology provides cross-sectional analysis of biological tissues, enabling a detailed evaluation of ultrastructural oral mucosal features.\n\nThe trial aims to compare OCT preliminary evaluation with traditional histology, considered the gold standard in oral lesion diagnosing. It seeks to create a database of pathological OCT data, facilitating the non invasive identification of carcinogenic processes. The goal is to develop a diagnostic algorithm based on OCT, enhancing its ability to detect characteristic patterns such as the keratinized layer, squamous epithelium, basement membrane, and lamina propria in oral tissues affected by OPMDs and OSCC.\n\nFurthermore, the trial aims to implement Artificial Intelligence (AI) in OCT image analysis. The use of machine learning algorithms could contribute to a faster and more accurate assessment of images, aiding in early diagnosis. The trial aims to standardize the comparison between in vivo OCT images and histological analysis, adopting a site-specific approach in biopsies to improve correspondence between data collected by both methods.\n\nIn summary, the trial not only evaluates OCT as a diagnostic tool but also aims to integrate AI to develop a standardized approach that enhances the accuracy of oral cancer diagnosis, providing a significant contribution to clinical practice.",[53,54,55,56,57,58,59,60,61,62,63,26],"Oral Squamous Cell Carcinoma","Oral Potentially Malignant Disorder","Oral Leukoplakia","Proliferative Verrucous Leukoplakia","Oral Lichen Planus","Oral Lichenoid Lesion","Graft-versus-host-disease","Oral Erythroplakia","Actinic Keratoses","Actinic Cheilitis","Oral Cancer","RECRUITING","2025-05-19",{"date":67,"type":31},"2025-05-23",{"date":69,"type":31},"2024-03-13",{"date":71,"type":20},"2028-04-01",{"name":73,"class":38},"University of Palermo",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":86,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":39},"100585324","phase-2-role-of-kefir-mouth-wash-in-oral-health-status-amelioration-100585324","NCT06900881","Role of Kefir Mouth Wash in Oral Health Status Amelioration","Role of Kefir Mouth Wash in Oral Health Status Amelioration: An in Vivo Study","Inclusion Criteria:\n\n* Age range 18-28 years.\n* Systemically healthy people without a history of chronic illness.\n* Those suffering with moderate gingivitis.\n* Not using any antibiotics over three months\n\nExclusion Criteria:\n\n* History of systemic diseases.\n* Pregnant, lactating females.\n* History of antibiotic therapy in the past 3 months.\n* History of oral prophylaxis within the last 6 months prior to the study as this can confound the results, making it difficult to determine the real effect of the mouthwash.\n* Subjects with mouth breathing habits.\n* Subjects with orthodontic and prosthodontic appliances.\n* Subjects with deleterious habits such as smoking, because it may affect oral health status, causing periodontal disease, altered oral microbiota, and impaired healing. This can confound the study results, making it difficult to observe the mouthwash effect .\n* Failure to follow the prescription regimen.\n* Failure to follow the research protocol.",true,"28 Years",{"count":84,"type":20},60,"INTERVENTIONAL",[87,88],"PHASE2","PHASE3","The present research aims to evaluate the efficiency of kefir mouthwash in enhancing oral health status by employing an in vivo experimental approach. Specifically, the study will assess how kefir mouthwash influences key oral health indicators, including gingival inflammation, plaque development, oral hygiene status, and halitosis. The study will be conducted over a 28-day period, with follow-up assessments every 14 days. The study will include systemically healthy adults with moderate gingivitis. Clinical parameters such as the Gingival Index (GI), Plaque Index (PI), and Simplified Oral Hygiene Index (OHI-S) will be measured, along with inflammatory biomarkers, including Interleukin-1β (IL-1β) and Interleukin-10 (IL-10). Halitosis will be evaluated using a Hali meter device. All of these will be measured at base line and day 14 and day 28 end of the study. Chlorhexidine 0.12% will be used as a comparative control to evaluate the efficacy of kefir mouthwash in improving oral health. This research intends to provide scientific evidence supporting the use of kefir as a probiotic-based mouthwash, offering a natural alternative to chemical mouthwashes and potentially reducing the negative consequences commonly associated with their use.",[91,92,26],"Plaque Induced Gingivitis","Halitosis",[94,95,92,96,97],"Kefir","Moderate gingivitis","Plaque","Oral Health Status","2025-04-22",{"date":100,"type":31},"2025-04-24",{"date":102,"type":31},"2025-04-06",{"date":104,"type":20},"2025-10-10",{"name":106,"class":38},"Al-Mustansiriyah University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":81,"sex":16,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":85,"phases":118,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":39},"100545422","effectiveness-of-mysmile-app-for-improving-the-oral-health-of-secondary-school-children-100545422","NCT06381700","Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children:","Effectiveness of MySmile App for Improving the Oral Health of Secondary School Children: A Cluster Randomised Controlled Trial","1. Inclusion criteria for school\n\n   * Government-funded secondary school\n   * Received SDS from the mobile dental squad\u002Fschool dental clinic at least once a year.\n   * High-risk schools with all indicators not meeting the district's benchmark.\n2. Inclusion criteria for the participants:\n\n   * Secondary school children aged 15-17 years old.\n   * Medium to high dental plaque level - Plaque score more than 50%\n   * Healthy with no chronic medical history and physical disabilities\n   * Understand the English language.\n   * Own a smartphone\u002F\u002F have access to an Android-based smartphone","15 Years","17 Years",{"count":117,"type":20},303,[119],"NA","The goal of this cluster-randomised control trial is to assess the effectiveness of the MySmile app for improving oral health in secondary school children. The main questions it aims to answer are:\n\n1. Will the MySmile app be more effective in improving secondary school children's dental plaque and gingival health over and above the existing school dental service (SDS)?\n2. Will the MySmile app be more effective in improving secondary school children's oral health knowledge, attitudes, and behaviours over and above the existing SDS?\n3. Is the MySmile app easy to use by secondary school children?\n4. Is the MySmile app acceptable to use from the perspective of secondary school children?\n\nParticipants in the intervention group will receive the SDS and MySmile app. The control group will receive SDS only. Therefore the researcher will compare between the intervention and control group in terms of dental plaque, gingival health, oral health knowledge, oral health attitudes and oral health behaviours.",[26,122],"Gingival Diseases",[124,125,126,127],"Mobile apps","Prevention","Oral Health Promotion","Schoolchildren","2025-03-11",{"date":130,"type":31},"2025-03-12",{"date":132,"type":20},"2025-03",{"date":134,"type":20},"2025-08",{"name":136,"class":38},"University of Malaya",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":85,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":39},"100571016","evaluation-of-the-galea-pericranium-flap-in-reconstruction-of-oral-cavity-defects-100571016","NCT06714760","Evaluation of the Galea-pericranium Flap in Reconstruction of Oral Cavity Defects","Inclusion Criteria:\n\n* Patients aged ≥18 years;\n* Patients with mandibular gingival defects involving the anterior or lateral aspect of the mandible;\n* Patients in whom basal structural integrity of the mandibular bone is maintained;\n* Patients with a minimum follow-up of 3 months;\n* Obtaining informed consent.\n\nExclusion Criteria:\n\n• Patients with history of previous surgery that bilaterally altered the superficial temporal vasculature.",{"count":5,"type":20},[119],"The overall objective of this study is to evaluate the safety of using the galea and pericranium (fascio-periosteal) temporal flap in the reconstruction of mandibular gingival defects.",[26],"2024-12-03",{"date":149,"type":31},"2024-12-04",{"date":151,"type":20},"2025-01-11",{"date":153,"type":20},"2026-11-11",{"name":155,"class":38},"IRCCS Azienda Ospedaliero-Universitaria di Bologna"]