[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-health-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-health-care":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,41,69,93,122,143,174,208,231,261],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100635388","dental-management-of-patients-with-hiv-in-pays-de-la-loire-100635388",false,"NCT07552038","Dental Management of Patients With HIV in Pays de la Loire","Dental Management of Patients Living With HIV: A Retrospective Study Using COREVIH Data in Pays de la Loire","VIH-ODONTO","Inclusion Criteria:\n\n* Adult patients aged ≥18 years\n* Confirmed diagnosis of HIV infection\n* Followed at participating hospital centers\n* Available clinical and biological data relevant to dental care management (CD4 count, viral load, blood count)\n\nExclusion Criteria:\n\n* Patients with missing key biological data required for analysis\n* Patients not followed in participating centers\n* Patients with incomplete medical records preventing assessment of outcomes","ALL","18 Years",{"count":20,"type":21},5603,"ESTIMATED","OBSERVATIONAL","Dental care for people living with HIV has evolved with the widespread use of antiretroviral therapy, which has improved life expectancy and disease control. However, uncertainty remains about whether specific adaptations are still needed during dental procedures due to potential biological abnormalities that may increase infectious or bleeding risks.\n\nThis study aims to evaluate the proportion of patients living with HIV in the Pays de la Loire region who may require adapted dental management based on biological parameters such as immune status, hematological values, and comorbidities.\n\nA retrospective descriptive study will be conducted using anonymized data from 5,603 patients followed in the COREVIH Pays de la Loire database. The results are expected to provide objective data to better inform dental practice and reduce unnecessary precautions or stigmatization in the management of patients living with HIV.",[25,26,27],"HIV Infection","Acquired Immune Deficiency Syndrome","Oral Health Care","RECRUITING","2026-06-23",{"date":31,"type":32},"2026-06-25","ACTUAL",{"date":34,"type":32},"2026-05-02",{"date":36,"type":21},"2027-05-30",{"name":38,"class":39},"Nantes University Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100643026","theranovis-dental-gel-in-patients-with-gingivitis-100643026","NCT07641192","Theranovis Dental Gel in Patients With Gingivitis","The Effects of Theranovis Dental Gel in Patients With Gingivitis: A Prospective Pilot Study","Inclusion Criteria:\n\n* Male and female participants aged over 18 years\n* At least 12 teeth per jaw (natural teeth, including restorations such as crowns and implants)\n* Smokers (less than 10 cigarettes per day)\n* Gingivitis with intact periodontium (probing depth ≤ 3.0 mm, bleeding on probing \\> 10%)\n* Gingivitis with intact periodontium (probing depth ≤ 4 mm, no bleeding on probing at these sites)\n* Periodontal screening index (PSI) up to grade 2\n\nExclusion Criteria:\n\n* Male and female participants under 18 years of age\n* Fewer than 12 teeth per jaw\n* Individuals not capable of giving informed consent\n* Individuals with hypersensitivity or allergies to any of the study product ingredients\n* Patients with periodontitis\n* Patients with non-plaque-induced gingivitis\n* Periodontal screening index (PSI) grade 3 or higher\n* Current antibiotic prophylaxis",{"count":49,"type":21},20,"INTERVENTIONAL",[52],"NA","The aim of this randomized, blinded, controlled study is to compare the theranovis dental gel with a placebo product in order to determine whether an improvement in oral health can be achieved in patients with gingivitis.",[55,27],"Gingivitis",[57,58],"theranovis dental gel","gingivitis","NOT_YET_RECRUITING","2026-06-08",{"date":62,"type":32},"2026-06-11",{"date":64,"type":21},"2026-06",{"date":66,"type":21},"2027-04",{"name":68,"class":39},"Medical University of Graz",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100637675","oral-health-education-in-nursing-training-programs-in-germany-100637675","NCT07584616","Oral Health Education in Nursing Training Programs in Germany","Oral Health in Nursing Education: A Nationwide Survey on Teaching Content, Competencies, and Needs in Vocational Schools and Primary Qualifying Nursing Degree Programs in Germany","Inclusion Criteria:\n\n* Age ≥18 years\n* Educational leaders (e.g., school directors, curriculum coordinators, or program leads) in vocational nursing schools or primary qualifying nursing degree programs in Germany- OR\n* Nursing trainees enrolled in vocational nursing training programs in Germany, OR\n* Students enrolled in primary qualifying nursing degree programs in Germany\n* Ability to understand German\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Not belonging to one of the defined target groups\n* Inability to understand the German language sufficiently to complete the questionnaire\n* No provision of informed consent",true,{"count":78,"type":21},7600,"This study aims to assess the current state of oral health education in nursing training programs in Germany. Good oral health is an important component of general health, yet it is often insufficiently addressed in nursing practice and education.\n\nThis cross-sectional study uses self-developed standardized online questionnaires to collect data from educational leaders (such as school directors and program coordinators) as well as nursing trainees and students.\n\nThe survey examines how oral health topics are integrated into curricula, which content is taught, how teaching is delivered, and how learners assess their own competence and educational needs in this area.\n\nThe results of this study will provide a comprehensive overview of current practices and help identify gaps and opportunities to improve oral health education in nursing programs.",[27,81,82,83],"Nursing Education","Health Education","Oral Health Education","2026-05-07",{"date":86,"type":32},"2026-05-13",{"date":88,"type":21},"2026-05-06",{"date":90,"type":21},"2026-09-01",{"name":92,"class":39},"University Medical Center Goettingen",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":50,"phases":102,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":121},"100629114","the-mouth-matters-in-mental-health-trial--2-100629114","NCT07470437","The Mouth Matters in Mental Health Trial -2","A Link Work Intervention to Support Dental Visiting in People With Severe Mental Health Difficulties: The Mouth Matters in Mental Health Effectiveness and Cost-Effectiveness Trial","Inclusion Criteria:\n\n* Aged ≥18 years.\n* Receipt of care from community mental health or early intervention teams at the point of referral.\n* No routine dental appointment (e.g. high street dentist, special care dentist service) in the past three years. This would include any dental examination, diagnosis, advice or treatment (e.g. fillings, root canal, extractions, crowns, dentures, bridges) resulting from a routine (non-emergency) appointment at a dental service. Emergency dental care (e.g. emergency attendance at an Accident \\& Emergency Appointment or a dental hospital) is not included within this definition, although any follow-up routine and planned appointments with a dentist would exclude the person from taking part.\n* Able to provide informed consent as determined by trained researchers in consultation with the clinical team.\n\nExclusion Criteria:\n\n* Current inpatient status on psychiatric ward. This does not include people in rehabilitation homes or supported accommodation in the community.\n* Immediate risk to self or others operationalised as the presence of active intent or planning to harm oneself or others in the near future (e.g. next month). Where individuals are excluded on this basis, with the person's consent, the researcher will aim to re-contact them and\u002For the referrer in approximately one-months' time to determine if risk has subsided to a point where they are now eligible.\n* Enrolled in another dental randomised controlled trial.",{"count":101,"type":21},480,[52],"This clinical trial will evaluate the effectiveness and cost-effectiveness of a link work intervention for supporting people with severe mental health difficulties to attend a routine dental appointment. There are two main outcomes, namely: i) attendance at a routine dental appointment; and ii) oral health quality of life.\n\nThe main predictions are that:\n\n1. The link work intervention plus treatment as usual will lead to greater likelihood of attendance at a routine dental appointment, compared with treatment as usual alone.\n2. The link work intervention plus treatment as usual will lead to better oral health quality of life, compared with treatment as usual alone.\n3. The link work intervention plus treatment as usual will be cost-effective compared with treatment as usual alone.",[105,27,106],"Mental Health","Psychosis",[108,109,110],"Mouth Matters","Dentistry","mental health","2026-03-13",{"date":113,"type":32},"2026-03-17",{"date":115,"type":21},"2026-05-01",{"date":117,"type":21},"2029-07-31",{"name":119,"class":120},"Lancashire and South Cumbria NHS Foundation Trust","NETWORK",5,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":76,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":141,"leadSponsor":142,"locationsCount":40},"100617892","oral-health-in-palliative-care-a-survey-study-100617892","NCT07324525","Oral Health in Palliative Care: A Survey Study","Oral Health and Dental Care in Palliative Medicine: A Survey Study Among Patients and Members of the German Society for Palliative Medicine","OH-PAL","Inclusion Criteria:\n\n* consent-capable patients receiving palliative care\n* patients whose health status allows completion of a questionnaire\n* consent-capable members of the German Society for Palliative Medicine\n\nExclusion Criteria:\n\n* Participants under 18 years of age\n* Individuals who are unable or unwilling to provide informed consent",{"count":131,"type":21},151,"Oral health problems such as xerostomia or oral infections are common in palliative care patients and can significantly impair quality of life. Adequate dental care may contribute substantially to symptom control and well-being; however, oral health and dental services are often insufficiently integrated into palliative care practice. In addition, little is known about the level of awareness, knowledge, and interprofessional collaboration regarding oral health among palliative care professionals.\n\nThis prospective, non-interventional survey study aims to assess the relevance of oral health in palliative care by surveying both palliative care patients and healthcare professionals who are members of the German Society for Palliative Medicine. The study investigates patients' oral health status, oral health-related quality of life, and access to dental care, as well as professionals' knowledge, attitudes, and current practices related to oral health and dental care in palliative settings. The findings are intended to identify existing gaps and inform strategies for improved integration of dental expertise into palliative care.",[27,134,135,136],"Oral Health-Related Quality of Life","Palliative Care","Palliative Care, Patient Care","2026-02-24",{"date":139,"type":32},"2026-02-27",{"date":137,"type":32},{"date":64,"type":21},{"name":92,"class":39},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":151,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":50,"phases":154,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":173},"100624191","evaluation-of-efficacy-of-coconut-oil-mouth-care-for-non-autonomous-hospitalised-elderly-people-100624191","NCT07406425","Evaluation of Efficacy of Coconut Oil Mouth Care for Non-autonomous Hospitalised Elderly People.","Evaluation of Efficacy of Coconut Oil Mouth Care for Non-autonomous Hospitalised Elderly People: a Multicentric Randomised Controlled Trial","COCO-CARE","Inclusion Criteria:\n\n* Patients aged 75 and over\n* Patients hospitalised in geriatric medicine and geriatric SMR departments\n* Patients able to open their mouths for treatment\n* Patients not able to carry out their oral hygiene on their own\n* Patients who have given their written consent (consent of the patient or patient consent accompanied by the designated representative if the patient is unable to give written consent)\n\nExclusion Criteria:\n\n* Patients with a known allergy to coconut\n* Patients requiring medicated mouth care as prescribed by a doctor\n* Patients under guardianship, tutorship or curatorship\n* Confused patients who have had medically diagnosed dehydration for less than 48 hours\n* Patients with swallowing difficulties\n* Patients in the terminal phase of end of life\n\nSecondary exclusion criteria:\n\n* Patients leaving the department between D1 and D8 (whatever the reason for discharge, and including in the event of death)\n* Patients whose condition progresses towards a terminal phase of the end of life between D1 and D8\n* Patients experiencing an allergic reaction to Coconut Oil during the study\n* Patients who may present with dehydration during the study","75 Years",{"count":153,"type":21},94,[52],"This is a prospective, longitudinal, randomised, open-label, multicentric, interventional, comparative superiority study.\n\nThe main objective is to demonstrate the superiority of oral care with coconut oil on the oral status of elderly people hospitalised in geriatrics, versus oral care with glycerol sticks.",[157,27],"Geriatrics",[159,160,161,162,163],"geriatrics","oral health care","elderly","coconut oil","palliative care","2026-02-05",{"date":166,"type":32},"2026-02-12",{"date":168,"type":21},"2026-03-15",{"date":170,"type":21},"2026-10-15",{"name":172,"class":39},"University Hospital, Limoges",2,{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":76,"sex":17,"minAge":182,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":50,"phases":186,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":40},"100614176","ul-smile-a-mobile-health-application-to-promote-oral-health-in-portuguese-adolescents-100614176","NCT07276191","UL Smile: A Mobile Health Application to Promote Oral Health in Portuguese Adolescents","UL Smile - Mobile Application for Oral Health Promotion: Development and Effectiveness Evaluation in Adolescents Living in Portugal: A Randomized Controlled Field Trial","UL Smile","Inclusion Criteria:\n\n* Be aged between 15 and 18 years at baseline.\n* Be fluent in Portuguese.\n* Have access to a mobile phone or computer\u002Ftablet with internet.\n* Be willing to participate in the study by providing signed assent\u002Fconsent. For participants under 18 years old, consent must be signed by a legal guardian.\n* Use of the app at least twice during the first month of the study.\n\nExclusion Criteria:\n\n* Current or previous use of any oral health-related mobile application.\n* Not being responsible for their own oral hygiene.","15 Years","19 Years",{"count":185,"type":21},150,[52],"This study is part of a doctoral research project in Oral Health Sciences and Technologies, with a specialization in Dental Hygiene, at the Faculty of Dental Medicine, University of Lisbon.\n\nWith the advancement of technology, smartphones and mobile applications (apps) have become an integral part of daily life, especially among adolescents and young adults, who are the main users of these devices. In 2023, global app downloads reached an estimated 257 billion, including a growing number of health-related apps, known as Mobile Health or mHealth, and, more specifically, apps targeting oral health.\n\nOral diseases, such as dental caries and periodontal disease, remain a major public health issue due to their high prevalence and impact on quality of life. Although these conditions are preventable, the adoption and maintenance of healthy behaviors continues to be challenging. Mobile apps may serve as an effective complement to oral health consultations, promoting motivation, adherence to recommendations, and communication with healthcare professionals.\n\nDespite the increasing availability of oral health apps, evidence regarding their effectiveness is still limited. Many of these tools lack scientific rigor and fail to adequately meet users' needs.\n\nIn this context, an original Portuguese-language mobile application for promoting oral health was developed, based on current scientific evidence and preliminary exploratory studies involving adolescents and oral health professionals. These studies aimed to identify the most relevant features for this type of tool. The app was designed using the Behaviour Change Wheel (BCW) model, widely recognized for structuring effective behavior change interventions in health.\n\nThis mobile app was developed by a multidisciplinary team from the University of Lisbon, involving experts from various faculties, including Psychology, Sciences, Dental Medicine, and Fine Arts. As an original tool, it is not yet available on app stores.\n\nThe main aim of this study is to test the effectiveness of this app as a complement to oral health consultations in a population of adolescents living in Portugal, contributing to the advancement of knowledge in this field and to the promotion of more innovative and user-centered clinical practices.\n\nThese are the specific objectives of the study:\n\n1. To assess the effectiveness of the app when used as a complement to dental hygiene consultations in relation to several oral health indicators, namely risk of dental caries, gingival inflammation, dental plaque presence, and oral self-care behaviors.\n2. To analyze the level of satisfaction and usability of the app's features.\n\nThe main hypotheses are:\n\n1. The app will significantly improve oral health indicators, including plaque levels, gingival inflammation, and caries risk, compared to a control group.\n2. The app will increase adherence to recommended oral hygiene behaviors (e.g., brushing frequency, interdental cleaning).\n3. Adolescents using the app will report higher motivation and self-efficacy for oral self-care.\n4. The app will demonstrate high usability and user satisfaction, supporting its potential for broader implementation.",[27,189,190],"Oral Health Behavior Change","Oral Health Self-efficacy",[192,193,194,195,196,197,198],"Adolescent","Mobile Applications","Oral Health","Health Promotion","MHealth","Health Behavior","Behavior change techniques","2026-01-30",{"date":201,"type":32},"2026-02-03",{"date":203,"type":21},"2026-02-02",{"date":205,"type":21},"2026-12-31",{"name":207,"class":39},"University of Lisbon",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":76,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":50,"phases":218,"briefSummary":219,"conditions":220,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":228,"leadSponsor":230,"locationsCount":40},"100618186","improving-dental-care-for-patients-with-head-and-neck-tumors-100618186","NCT07328347","Improving Dental Care for Patients With Head and Neck Tumors","A Simulation Experiment to Improve Dental Care for Patients With Head and Neck Tumors","OncoDent","Inclusion Criteria:\n\n* Patients aged 18 years or older with head and neck cancer whose health status allows completion of a questionnaire\n* Practicing dentists in Germany registered in the OAK-Verlag address database\n\nExclusion Criteria:\n\n* Lack of consent to participate\n* Insufficient German language skills that prevent completion of the questionnaire",{"count":217,"type":21},132,[52],"This prospective survey study investigates knowledge, attitudes, experiences, and practices related to dental care in patients with head and neck cancer among affected patients and dentists. Participants complete an anonymous online questionnaire before and after receiving written, guideline-based information. The study aims to evaluate whether targeted educational materials improve knowledge and perceptions regarding dental care in the context of head and neck cancer treatment.",[27,189,221,222,223],"Head & Neck Cancer","Dentist's Role","Dentist-Patient Relations","2026-01-13",{"date":226,"type":32},"2026-01-15",{"date":224,"type":32},{"date":229,"type":21},"2026-05",{"name":92,"class":39},{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":76,"sex":17,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":50,"phases":242,"briefSummary":243,"conditions":244,"keywords":250,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":259,"locationsCount":40},"100618087","intraoral-camera-assisted-parent-training-100618087","NCT07327060","Intraoral Camera-Assisted Parent Training","Effect of Intraoral Camera-Assisted Parent Training on Children's Oral Hygiene and Parent Oral Health Literacy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy children\n* Age between 5-7 years, with at least one first permanent molar in the eruption stage\n* No urgent treatment needs (e.g., dental trauma or pain)\n* Voluntary participation with signed and verbal informed consent from parents, and willingness to attend follow-up visits regularly\n\nExclusion Criteria:\n\n* Children with special healthcare needs, intellectual disabilities, or autism spectrum disorder\n* Children with a Frankl Behavior Rating Scale score of 1 (Definitely negative)","5 Years","7 Years",{"count":241,"type":21},40,[52],"The aim of this randomized controlled trial is to test the null hypothesis that parent education using an intraoral camera has no effect on children's oral hygiene levels, parental oral health literacy, or plaque accumulation on first permanent molars compared with standard verbal education. 40 children aged 5-7 and their parents will be randomly assigned to two groups. The intervention group will receive real-time visualization of dental conditions and brushing techniques using an intraoral camera, while the control group will receive standard verbal education using a brushing model. Outcomes include children's plaque and gum health and ICDAS caries scores. Secondary outcomes include Occlusal Plaque Index (OPI) on first molars. Assessments will be conducted at baseline and 1-month follow-up. This study tests whether intraoral camera-assisted education leads to better oral hygiene outcomes in children, improves parents' oral health literacy, and reduces plaque accumulation on the first permanent molars compared to standard verbal education.",[245,27,246,247,248,249],"Oral Health Literacy","Intraoral Images","Periodontal Index","Gingival Index","Caries",[251,27,252],"Oral health literacy","İntraoral camera","2026-01-07",{"date":255,"type":32},"2026-01-09",{"date":257,"type":32},"2025-02-05",{"date":229,"type":21},{"name":260,"class":39},"Aydin Adnan Menderes University",{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":76,"sex":17,"minAge":18,"maxAge":269,"enrollmentInfo":270,"targetDuration":4,"studyType":50,"phases":272,"briefSummary":273,"conditions":274,"keywords":275,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":40},"100613636","the-effect-of-supplementary-foods-containing-trypsin-chymotrypsin-and-serratia-peptidase-on-healing-after-impacted-wisdom-tooth-surgery-100613636","NCT07269171","The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery","Evaluation of the Effects of Dietary Supplements Containing Trypsin, Chymotrypsin and Serratia Peptidase on Postoperative Edema, Pain and Trismus After Mandibular Impacted Third Molar Extraction.","Trypsin","Inclusion Criteria:\n\n* Having a mandibular third molar with a unilateral or bilateral Class 2, Position A or B impaction according to the Pell and Gregory classification\n* Being systemically healthy (ASA Class I)\n* Aged between 18 and 45 years (young adult age group)\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Age outside the specified range\n* Pregnancy\n* Currently breastfeeding\n* Presence of infection in the third molar region (e.g., acute pericoronitis)\n* Presence of cystic or tumoral lesions associated with the impacted third molar\n* History of allergic reactions\n* Presence of any systemic disease\n* Unwillingness to participate in the study\n* Poor oral hygiene that may negatively affect healing\n* Smoking or alcohol addiction","45 Years",{"count":271,"type":21},15,[52],"Introduction: The aim of this study was to determine the effects of a dietary supplement containing trypsin, chymotrypsin, and serratia peptidase (Tripser Forte N30, Incir Pharma, Turkey) on postoperative healing and to determine the differences between the groups. The aim was to identify differences between the groups regarding postoperative pain, edema, and trismus levels.\n\nMaterial and Method: Demographic data before surgery will be recorded on the patient follow-up form (Appendix 1). All surgical procedures will be performed under sterile conditions following the administration of local anesthesia (80 mg articaine hydrochloride and 0.02 mg epinephrine, Maxicaine Fort ampoule, Vem Pharmaceuticals, Istanbul, Turkey) with inferior alveolar block anesthesia and buccal mucosa anesthesia. Procedure monitoring will begin after the incision is made and will conclude with suturing. Osteotomy (bone removal) and, if necessary, root dissection will be performed using a surgical handpiece, accompanied by irrigation with sterile saline solution. Following tooth extraction, the socket will be examined, and any sharp bony prominences will be removed. The area will be closed primarily using non-resorbable silk suture material (3\u002F0 surgical silk suture, Doğsan, Turkey). A sterile tampon will be applied to the procedure area, and the patient will be instructed to bite on the tampon for 20 minutes before removing it and replacing it with another material. As a standard postoperative approach, all patients in group 1 received antibiotics (875 mg Amoxicillin+125 mg clavulonic acid, Augmentin-BID film coated tablets, GlaxoSmithKline, Istanbul, Turkey), analgesics (25 mg dexketoprofen, Arveles tb, UFSA Pharmaceutical Industry and Trade Inc. Davutpasa Cad. No.12 (34473) Topkapi\u002FIstanbul) and mouthwash (100 ml solution containing 120 mg (%0.12) chlorhexidine gluconate and 150 mg (%0.15) benzydamine hydrochloride) for use after surgery. Drogsan Pharmaceutical Industry and Trade Inc. Oguzlar neighborhood, 1370.sokak 7\u002F3 Balgat 06520 Cankaya\u002FAnkara). Patients will be instructed to take antibiotics morning and evening for 5 days, use mouthwash for 7 days starting the day after the procedure, and use mouthwash only when deemed necessary. They will be asked to record the amount they use on the provided home assessment form (Appendix 2). Patients in Group 2 will be given a dietary supplement containing trypsin, chymotrypsin, and serratia peptidase (Tripser Forte N30, Incir Pharma, Turkey) in addition to the medications mentioned above. Patient follow-up procedures will be the same.\n\nAll patients will be evaluated on the 1st, 2nd, 3rd, and 7th postoperative days, and pain, edema, and trismus will be recorded.",[27],[276,277,278,279],"nutritional supplements","oral and maxillofacial surgery","wisdom teeth","trypsin, chymotrypsin and serratia peptidase","2025-11-25",{"date":282,"type":32},"2025-12-08",{"date":284,"type":21},"2025-12-01",{"date":286,"type":21},"2026-03-10",{"name":288,"class":39},"Saglik Bilimleri Universitesi"]