[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-melatonin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-melatonin":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100619522","oral-melatonin-versus-nebulized-dexmedetomidine-on-emergence-agitation-in-children-undergoing-adenotonsillectomy-100619522",false,"NCT07345715","Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy","Comparison Between Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy: A Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged between 3 and 7 years.\n* Both sexes.\n* Classified as American Society of Anesthesiologists (ASA) physical status I or II according to the American Society of Anesthesiologists.\n* Scheduled for elective adenotonsillectomy under general anesthesia.\n\nExclusion Criteria:\n\n* Parental refusal to participate in the study.\n* Known allergy or hypersensitivity to dexmedetomidine, melatonin or midazolam.\n* Presence of developmental delay.\n* Central nervous system disorders.\n* Intellectual disability (formerly termed mental retardation).\n* Neurological or psychiatric conditions associated with anxiety or agitation (e.g., cerebral palsy, epilepsy, separation anxiety disorder, attention-deficit\u002Fhyperactivity disorder).\n* Current or recent treatment with anticonvulsants or sedative medications","ALL","3 Years","7 Years",{"count":20,"type":21},96,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to compare the efficacy of using oral Melatonin versus nebulized Dexmedetomidine in limitation of emergence agitation in children undergoing adenotonsillectomy.",[27,28,29,30,31],"Oral Melatonin","Nebulized Dexmedetomidine","Emergence Agitation","Children","Adenotonsillectomy","RECRUITING","2026-01-07",{"date":35,"type":36},"2026-01-16","ACTUAL",{"date":38,"type":36},"2025-07-01",{"date":40,"type":21},"2027-07-01",{"name":42,"class":43},"Tanta University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100575153","effect-of-oral-melatonin-versus-intraoperative-lidocaine-infusion-on-incidence-of-postoperative-delirium-in-elderly-patients-undergoing-total-hip-arthroplasty-100575153","NCT06768580","Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty","Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty: Prospective Randomized Controlled Blinded Study","Inclusion Criteria:\n\n* Elderly patients aged \\>65 years old undergoing unilateral total hip arthroplasty.\n* Patients with body mass index (BMI) (18-30) kg\u002Fm2.\n* American Society of Anesthesiologists (ASA) physical status I-III, scheduled to undergo unilateral total hip arthroplasty.\n\nExclusion Criteria:\n\n* History of mental illness or scoring less than 8 using abbreviated mental test (AMT) before operation.\n* Obvious sinus bradycardia (heart rate of \\\u003C50 beats per minute) or other serious cardiovascular diseases.\n* Symptomatic cerebrovascular disease (such as previous stroke).\n* History of liver and kidney dysfunction.\n* Allergy to lidocaine or melatonin.\n* Metabolic disorders and fluid, electrolytes disturbances.\n* Alcohol dependence or drug abuse.\n* Redo surgery or infectious complications.\n* CNS medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).\n* History of deep vein thrombosis.","65 Years",{"count":54,"type":21},135,[24],"The aim of this study is to assess the effect of oral melatonin versus intraoperative lidocaine infusion on incidence of postoperative delirium in elderly patients undergoing total hip arthroplasty under spinal anesthesia.",[27,58,59,60,61],"Lidocaine Infusion","Postoperative Delirium","Elderly Patients","Total Hip Arthroplasty","2025-04-12",{"date":64,"type":36},"2025-04-15",{"date":66,"type":36},"2025-01-15",{"date":68,"type":21},"2026-10-01",{"name":42,"class":43}]