[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-mucosal-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-mucosal-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,88,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100318690","biospecimen-procurement-for-head-and-neck-disorders-100318690",false,"NCT03429036","Biospecimen Procurement for Head and Neck Disorders","Biospecimen Procurement for the Study of Head and Neck Disorders","* INCLUSION CRITERIA:\n* Age 3 and older.\n* Able to provide their own consent, or for minors, a parent or guardian is able to consent on their behalf.\n* Diagnosis of a condition of the head and neck for which removal of biological specimens was indicated for clinical care or for research purposes under a separate Review Board (IRB) approved protocol.\n* Ability of subject (or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\n* Part 1:\n\n  --Are unwilling to share waste specimens for research purposes\n* Part 2: Additional exclusion criteria for the Part 2 prospective sample collection part of this protocol these criteria may be assessed prior to collection of the samples but will not affect overall eligibility for the trial (i.e., Part 1):\n\n  * have active symptomatic major organ disorders that would increase the risk of biopsy for research, including but not limited to bleeding disorders, ischemic heart disease, a recent myocardial infarction, active congestive heart failure or severe pulmonary dysfunction\n  * have specific medical condition, such as a bleeding tendency where additional biopsies or phlebotomy procedures may increase the participants risk in participating. This will be determined at the discretion of the principal investigator\n  * Individuals under the age of 18 are excluded from oral mucosal biopsies and skin biopsies","ALL","3 Years","120 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","Background:\n\nResearchers want to learn more about head and neck disorders. Understanding these disorders could help them find better treatments. To do this, they are collecting tissue samples for research.\n\nObjective:\n\nTo create a repository of tissue samples and data to better study conditions of the head and neck.\n\nEligibility:\n\nPeople who had or will have tissue samples taken because of a head or neck disorder. They must be ages 3 and older and not pregnant to join Part 2.\n\nDesign:\n\nParticipants will be screened with a questionnaire, medical history, and physical exam.\n\nPart 1. Participants will give permission for any of their tissue samples leftover from private care or other research protocols to be used.\n\nIf participants tissue did not contain normal tissue or if they have a condition that suggests a genetic issue, they will be invited to join Part 2.\n\nPart 2: Participants will have additional samples collected. These could be:\n\n* Blood: Blood is drawn through a needle in the arm.\n* Cheek swab or brushing: A cotton swab or small brush is rubbed inside the cheek.\n* Saliva: They rinse their mouth with water and spit into a tube or cup.\n* Skin biopsy: They are injected with a numbing drug. A biopsy tool removes a small piece of skin.\n* Mucosal biopsy: They are injected in the mouth with a numbing medication. A small piece of tissue from the inside of the cheek is removed.\n\nParticipants samples will be used for future research, including genetic testing.",[25,26,27,28,29],"Hearing Disorder","Oral Mucosal Disease","Pharyngeal Neoplasm","Head and Neck Neoplasms","Laryngeal Disease",[31,32,33,34,35,36],"Genomic DNA","DNA Banking","Tissue Sample","Saliva","Blood Collection","Natural History","RECRUITING","2026-06-10",{"date":40,"type":41},"2026-06-11","ACTUAL",{"date":43,"type":41},"2018-05-23",{"date":45,"type":21},"2029-12-02",{"name":47,"class":48},"National Cancer Institute (NCI)","NIH",9,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":70,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":87},"100629572","oral-health-dento-facial-condition-and-ohrqol-in-subjects-with-mowat-wilson-syndrome-an-epidemiologic-study-100629572","NCT07476417","Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.","ORALMOWAT26","Inclusion Criteria:\n\n* individuals affected by MWS with confirmed molecularly diagnosis of ZEB2 gene variation.\n* written informed consent statement signed by parents\u002Flegal guardians for participation in the study\n\nExclusion Criteria:\n\n* individuals not affected by MWS\n* refusal of parents\u002Flegal guardians to participate in the study",{"count":58,"type":21},25,"Mowat-Wilson Syndrome (MWS) is a rare syndrome characterized by the presence of facial gestalt and delayed psychomotor development, variably associated with intellectual disability, epilepsy, Hirschsprung's disease (HSCR) and multiple congenital malformations.\n\nAlthough there is evidence of the presence of dental and craniofacial anomalies in MWS, little epidemiological data is available to date.\n\nThe goal of this observational study is to assess oral health and dento-facial phenotype of people affected by Mowat-Wilson Syndrome (MWS). In addition, the Oral Health Related Quality of Life (OHRQoL) will be investigated.",[61,62,63,64,65,66,67,68,69,26],"Mowat-Wilson Syndrome","Dental Caries","Periodontal Diseases","Sleep Related Breathing Disorder","Tooth Diseases","Malocclusion","Tooth Abnormalities","Oral Health Related Quality of Life (OHRQoL)","Craniofacial Abnormalities",[71,72,73,74,75,69],"Mowat-Wilson syndrome","dental caries","periodontal diseases","malocclusion","oral health","NOT_YET_RECRUITING","2026-03-19",{"date":79,"type":41},"2026-03-24",{"date":81,"type":21},"2026-04-01",{"date":83,"type":21},"2026-08-30",{"name":85,"class":86},"University of Milan","OTHER",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":16,"minAge":96,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":87},"100622943","prevalence-of-oral-mucosal-lesions-among-a-sample-of-adult-egyptian-subjects-100622943","NCT07390188","Prevalence of Oral Mucosal Lesions Among a Sample of Adult Egyptian Subjects","Prevalence of Oral Mucosal Lesions Among a Sample of Adult Egyptian Subjects: Hospital Based Cross-sectional Study.","Inclusion Criteria:\n\n* Adults, 18 years old and above, Egyptian individuals\n\nExclusion Criteria:\n\n* Individuals refusing to participate in the study. Individuals unable to give accurate or full information due to suffering from acute symptoms, requiring immediate intervention. Individuals unable to give accurate or full information due to any disease preventing them from opening their mouth.",true,"18 Years",{"count":98,"type":21},14645,"Oral mucosal lesion represents a wide array of conditions. They may be the result of a local or systemic infection or trauma or the manifestations of a medical condition or neoplastic growth weather primary or metastatic or may be mistaken for a variation of a normal structure. This study aims to estimate the prevalence of OMLs and describe the risk factors for the development of OMLs in a sample of the Egyptian population Research Question :What is the prevalence of oral mucosal lesions and their associated risk factors in a sample of adult Egyptians?",[26,101],"Oral Mucosal Disorder",[103,104,105],"Oral Mucosal Lesions","OML","OMLs","2026-01-29",{"date":108,"type":41},"2026-02-05",{"date":110,"type":41},"2025-07-08",{"date":112,"type":21},"2026-05-30",{"name":114,"class":86},"Cairo University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":96,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":125,"phases":126,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":87},"100600678","phase-2-mucoadhesive-modified-release-formulations-for-the-topical-treatment-of-symptomatic-oral-lichen-planus-100600678","NCT07100613","Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus","Efficacy of a Microparticulate Muco-adhesive Patch Containing Drug-nutraceutical Association in paTIents Affected by Oral Mucosa Alterations (EMPATIA)","EMPATIA","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Clinical suspicion of Oral Lichen Planus (OLP).\n* Histological confirmation of OLP based on World Health Organization (WHO) criteria (presence of hyperkeratosis, acanthosis, basal cell degeneration, and a band-like lymphocytic infiltrate in the lamina propria).\n* Absence of epithelial dysplasia.\n* Ability to understand and sign informed consent.\n\nExclusion Criteria:\n\n* Previous diagnosis or treatment for OLP.\n* Use of topical or systemic corticosteroids in the last 4 weeks.\n* Use of medications known to cause lichenoid reactions.\n* History of allergic reactions to dental materials (e.g., amalgam).\n* Hematological disorders or immunodeficiencies.\n* Pregnancy or breastfeeding.\n* Current use of immunosuppressive therapies.\n* Inability or unwillingness to comply with study procedures.",{"count":124,"type":21},45,"INTERVENTIONAL",[127],"PHASE2","The goal of this clinical trial is to learn if a mucoadhesive patch containing clobetasol alone or in combination with resveratrol can reduce symptoms and improve quality of life in adults with Oral Lichen Planus (OLP). The main questions it aims to answer are:\n\nDoes the patch reduce oral pain and burning sensations? Does it improve the appearance of oral lesions and patients' daily well-being?\n\nResearchers will compare:\n\nA patch containing clobetasol A patch containing clobetasol and resveratrol A standard clobetasol 0.05% ointment in an adhesive base\n\nParticipants will:\n\nApply their assigned treatment to the oral lesion daily for 30 days Attend three clinical visits for evaluations and imaging Complete questionnaires about pain, symptoms, and treatment experience",[130,131,26,132],"Oral Lichen Planus","Oral Lichen Planus Related Stress","Oral Pain",[134,135,136,137,138,139,140],"mucoadhesive patch","oral lichen planus","clobetasol","resveratrol","drug delivery system","Optical coherence tomography","Ora pain","2025-07-30",{"date":143,"type":41},"2025-08-03",{"date":145,"type":41},"2024-09-04",{"date":147,"type":21},"2027-10-01",{"name":149,"class":86},"University of Palermo"]