[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-potentially-malignant-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-potentially-malignant-disorders":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,72,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100633675","artificial-intelligence-for-the-diagnosis-of-oral-lesions-100633675",false,"NCT07529769","Artificial Intelligence for the Diagnosis of Oral Lesions","AID-OraL","Inclusion Criteria:\n\n* Patient aged ≥ 18 years\n* Patients followed up in the Oral Mucosa Pathology Department (Maxillofacial Surgery and Stomatology Department, Pitié-Salpêtrière Hospital, AP-HP, Paris) between January 1, 1970, and December 31, 2023, with a diagnosis of potentially malignant oral lesion and\u002For oral cavity cancer.\n\nExclusion Criteria:\n\n* Photograph of the lesion unavailable (in standard care)","ALL","18 Years",{"count":19,"type":20},5000,"ESTIMATED","OBSERVATIONAL","Squamous cell carcinomas of the upper aerodigestive tract are among the most common cancers worldwide, with the oral cavity being the most frequent site. Oral cavity squamous cell carcinomas (OCSCC) represent a major cause of morbidity and mortality, mainly due to high rates of locoregional or metastatic recurrence and the frequent occurrence of second primary tumors. Unlike oropharyngeal squamous cell carcinomas, human papillomavirus (HPV) is not involved in the carcinogenesis of OCSCC.\n\nIn some cases, OCSCC develop from oral potentially malignant disorders (OPMDs), such as leukoplakia and erythroplakia, which have a worldwide incidence of 3-5%. The malignant transformation rate of OPMDs ranges from 3% to 50%, reflecting their marked heterogeneity. Although several clinical, histological, and molecular factors have been proposed to identify patients at high risk of malignant transformation, none have demonstrated sufficient clinical utility to date. In other cases, OCSCC arise from clinically normal oral mucosa in patients with OPMDs located at a distance and\u002For with established risk factors, particularly tobacco and alcohol use.\n\nCurrently, no chemopreventive or preventive strategy has been established as a standard of care to prevent malignant transformation of OPMDs. Improving the prognosis of OCSCC therefore requires the development of tools to better identify high-risk OPMDs and to enable the earliest possible diagnosis. Early detection of OPMDs is essential for secondary prevention of OCSCC. However, conventional oral examination based on visual inspection and palpation has limited sensitivity, and clinical recognition of OPMDs remains challenging. Consequently, there is a clear need for improved methods to enhance early detection and risk stratification of OPMDs.\n\nMain objective:\n\nTo develop a tool to aid in the diagnosis of cancerous lesions in the oral cavity using Artificial Intelligence (AI). This tool appears promising in meeting the current needs of the oral cavity practitioner community.",[24,25],"Oral Potentially Malignant Disorders","Oral Cavity Squamous Cell Carcinoma",[24,25,27,28,29],"diagnosis","oral cancer","Artificial Intelligence","NOT_YET_RECRUITING","2026-04-13",{"date":33,"type":34},"2026-04-14","ACTUAL",{"date":36,"type":20},"2026-04",{"date":38,"type":20},"2026-12",{"name":40,"class":41},"Assistance Publique - Hôpitaux de Paris","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100582369","application-and-validation-of-a-smartphone-based-deep-learning-system-for-oral-potentially-malignant-disorders-and-oral-cancer-screening-100582369","NCT06862414","Application and Validation of a Smartphone-based Deep Learning System for Oral Potentially Malignant Disorders and Oral Cancer Screening","Application and Validation of a Smartphone-based Deep Learning System for Oral Potentially Malignant Disorders (OPMD) and Oral Cancer Screening","Inclusion Criteria:\n\n* Adult patients (age ≥18) visiting cancer screening center\n\nExclusion Criteria:\n\n* Unable to cooperate to fully open mouth\u002F navigate tongue\n* Unable to cooperate for the assessment",true,"19 Years",{"count":52,"type":20},954,"INTERVENTIONAL",[55],"NA","The goal of this clinical trial is to learn if smartphone-based deep learning system works to accurately detect oral potentially malignant disorders and oral cancer in adults. It will also learn about if it is as effective as assessments conducted by dentists and non-certified health provider.\n\nWe expect that the deep learning system will have higher sensitivity in detecting oral potentially malignant disorders and oral cancer, where as the dentists and non-certified health providers will exhibit higher specificity in screening.\n\nParticipants will be grouped into three arms: deep learning system (arm A) or board-certified dentist with deep learning system (arm B) or non-certified health providers (general practitioners) with deep learning system (arm C).\n\nOral cancer risk factors, such as habits of smoking or having chewed betel nut or alcohol drinking, would be recorded by anonymous questionnaires.",[58,59,24],"Cancer Screening","Oral Cancer",[61,29],"Deep learning systems","2025-03-02",{"date":64,"type":34},"2025-03-06",{"date":66,"type":20},"2025-03",{"date":68,"type":20},"2025-12",{"name":70,"class":41},"National Taiwan University Hospital",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":49,"sex":16,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":53,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":71},"100407354","role-of-the-dentist-in-the-control-of-the-alcoholic-habit-in-patients-with-potentially-malignant-oral-lesions-100407354","NCT04584333","Role of the Dentist in the Control of the Alcoholic Habit in Patients with Potentially Malignant Oral Lesions","Randomised Clinical Trial on the Role of the Dentist in the Control of the Alcoholic Habit, in Elderly Patients with Potentially Malignant Oral Lesions","ALCODENT","Inclusion Criteria:\n\n1. Patients with a clinical and histopathological diagnosis of oral lichen planus (OPL) and\u002For oral leukoplakia (LO) (in all its clinical forms) as chronic LOPMs according to the WHO 2017 classification.\n2. Patients over 40 years old\n3. Patients in follow-up, with chronic injuries, without medical and\u002For surgical treatment for at least 1 month\n4. Patients with frequent daily alcohol consumption \\> 1 Standard Beverage Unit (more than two glasses of wine\u002Fbeer per day or one glass of liquor\u002Fdistilled drink per day)\n\nExclusion Criteria:\n\n1. Participants who do not sign the informed consent.\n2. Patients with a score above 20 in the AUDIT.\n3. Patients undergoing treatment for problems with alcohol and other drugs.\n4. Patients with systemic pathology associated with alcohol consumption\n5. Pregnant patients.\n6. Patients undergoing active pharmacological treatment for OPL.\n7. Patients who have undergone surgical resection and\u002For CO2 laser treatment for LO in the last month.\n8. Patients with a history of malignant oral lesions.","40 Years",{"count":82,"type":20},206,[55],"Introduction: Alcohol is the most consumed psychoactive substance, its consumption is very prevalent and there is a low perception of the risk it poses in our society. Alcohol is a risk factor and a causal factor for multiple pathologies, including cancer and potentially malignant oral lesions (LOPM). The dentist can play a relevant role in the evaluation of consumption, as well as provide brief interventions (BI) to assist them in the cessation of the habit.\n\nObjectives: The main objective is to evaluate the efficacy of the intervention, carried out by dentists, to stop or reduce alcohol consumption in a patient with LOPM.\n\nMaterial and methods: clinical trial, randomized, with balanced randomization, single-blind (for the evaluator of the results) with 1 experimental arm and a control group, carried out in a single-center manner. Group 1 incident brief intervention and Group 2 no incident intervention (only usual clinical information). 200 patients from the Unit of Oral Medicine, Oral Surgery and Implantology of the University of Santiago de Compostela will participate in this study, they will make an initial visit, one month, three months, six months and one year. In these visits, evaluations related to alcohol consumption, the evolution of injuries, quality of life and satisfaction with the BI were carried out.\n\nPredictable results: If IB contributes to the cessation or reduction of alcohol consumption, and improves the clinical evolution of LOPM, it could be implemented immediately in our Oral Medicine unit and could lay the foundations for its implementation in different public centers and private.",[24,86],"Alcohol Drinking",[88,89,90,91,92,93],"Alcohol Abuse","Substance Abuse","Monitoring Program","Dentistry","Health Promotion","Clinical trial","RECRUITING","2024-10-15",{"date":97,"type":34},"2024-10-17",{"date":99,"type":34},"2021-03-01",{"date":101,"type":20},"2026-09-30",{"name":103,"class":41},"University of Santiago de Compostela",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":53,"phases":113,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":127,"locationsCount":71},"100482464","predictive-value-of-goccles-device-for-early-diagnosis-of-oral-potentially-malignant-disorders-100482464","NCT05562375","Predictive Value of GOCCLES® Device for Early Diagnosis of Oral Potentially Malignant Disorders","Predictive Value of GOCCLES® (Glasses for Oral Cancer Curing Light Exposed Screening), Device for Early Diagnosis of Oral Potentially Malignant Disorders","Inclusion Criteria:\n\n* Patients older than 18.\n* Patients that present oral mucosa injuries compatible with OPMD.\n* Patients that understand the purpose of the study and express consent\n\nExclusion Criteria:\n\n* Patients that don't have the capability to express consent.\n* Patients with systemic pathologies that contraindicate a biopsy.\n* Patients with a recent biopsy at the oral cavity",{"count":112,"type":20},73,[55],"Oral potentially malignant disorders (OPMDs) are chronic pathologies which can suffer dysplastic alterations and evolve into oral cancer.\n\nThe diagnosis of those pathologies is commonly done by visual inspection, which is not capable of determining the presence or not of dysplasia. Furthermore, this type of diagnosis depends greatly on the expertise and training of the professional.\n\nIn recent years, new methods that can help early oral cancer diagnosis have been developed. A new device has been commercialized, named GOCCLES® (Glasses for Oral Cancer Curing Light Exposed Screening), based on the autofluorescence principle.\n\nThe hypothesis of this study is that GOCCLES® device could be an effective tool to help in early detection of oral cancer.",[24,59],[117,118,119,120],"GOCCLES","Autofluorescence","Oral cancer","Oral dysplasia","2022-09-30",{"date":123,"type":34},"2022-10-04",{"date":125,"type":34},"2022-01-08",{"date":101,"type":20},{"name":128,"class":41},"Universidad Rey Juan Carlos"]