[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oral-squamous-cell-carcinomas\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oral-squamous-cell-carcinomas":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637326","heterogeneity-of-oral-carcinogenesis-from-preneoplasia-to-invasive-squamous-cell-carcinoma-100637326",false,"NCT07579507","Heterogeneity of Oral Carcinogenesis: From PrEneoplasia to Invasive Squamous Cell Carcinoma","HOPES","Inclusion Criteria:\n\n* I1: Male or female at least 18 years old.\n* I2: For Cohort A: patients with OSCC who undergo surgery. For cohorts B and C: patients with OPMD.\n* I3: Patient who has agreed to participate in this research and sign consent.\n* I4: Patient affiliated to a medical insurance.\n* I5: Patient who have not previously received any anticancer treatment (radiotherapy, chemotherapy, or immunotherapy)\n\nExclusion Criteria:\n\n* NI1: For cohorts B and C: Patient at high risk of bleeding, such as those receiving anticoagulant or antiplatelet therapy, those with coagulation disorders, or those with a history of severe bleeding within the two weeks prior to enrollment.\n* NI2: Pregnant or nursing woman.\n* NI3: Contraindication to general anesthesia.\n* NI4: Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...).\n* NI5: Patient under curatorial or guardianship or placed under the protection of justice.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and OPMD) counterparts by scRNAseq in OSCC patients. Additionally, the study will evaluate the effectiveness of non-invasive cytobrushes as a diagnostic tool compared to traditional biopsies.",[26,27],"Oral Squamous Cell Carcinomas","Oral Potentially Malignant Disorder",[29,30,31,32,33,34],"scRNAseq","Heterogeneity of all cell population","OPMD","OSCC","cytobrush","RNAseq bulk","NOT_YET_RECRUITING","2026-05-05",{"date":38,"type":39},"2026-05-12","ACTUAL",{"date":41,"type":20},"2026-06",{"date":43,"type":20},"2035-03",{"name":45,"class":46},"Centre Leon Berard","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":5},"100498763","sentinel-node-biopsy-versus-limited-elective-neck-dissection-in-early-cancers-of-oral-cavity-node-negative-100498763","NCT05774483","Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative","Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative (SECOND N0): Non-inferiority Phase III Trial","SECOND N0","Inclusion Criteria:\n\n1. Age \\>18 years of age\n2. Biopsy-proven invasive squamous cell carcinoma involving the site tongue and buccal mucosa\n3. T1 and T2 lesions as per AJCC TNM 8 edition\n4. Clinicoradiologically node negative\n5. Amenable to per oral excision\n6. Treatment naïve\n7. No other site of malignancy\n\nExclusion Criteria:\n\n1. Previous surgery in the head and neck region,\n2. Upper alveolar or palatal lesions\n3. Large heterogeneous leukoplakia or other premalignant lesions\n4. Previous malignancy in the head and neck region\n5. Patients requiring the free flap reconstruction","80 Years",{"count":58,"type":20},508,[23],"The goal of this clinical trial is to compare the survival outcomes, morbidity and cost-effectiveness of sentinel node biopsy versus limited elective neck dissection in node-negative early oral cancers.\n\nThe main questions it aims to answer are:\n\n* Survival outcomes\n* Morbidity outcomes\n* Cost-effectiveness\n\nParticipants will either undergo sentinel node biopsy followed by completion neck dissection if sentinel node is reported to be metastatic (SNB) or limited elective neck dissection where level IIb will be cleared only if level IIa is metastatic (limited END). The study will compare the outcomes in the two cohorts.",[62,63,64,26,65,66,67],"Mouth Neoplasms","Oral Cancers","Oral Squamous Cell Carcinoma (OSCC)","Sentinel Lymph Node Biopsy","Sentinel Lymph Node Biopsy (SLNB)","Sentinel Lymph Node",[69,70,71,72,73,74,75],"mouth neoplasms","neck dissection","sentinel lymph node biopsy","survival","morbidity","oral cancers","oral squamous cell carcinoma","RECRUITING","2025-07-14",{"date":79,"type":39},"2025-07-17",{"date":81,"type":39},"2025-04-16",{"date":83,"type":20},"2034-04",{"name":85,"class":86},"Tata Memorial Hospital","OTHER_GOV",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":96,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":47},"100582263","heterogeneity-of-oral-squamous-cell-carcinoma-analysis-by-single-cell-rna-sequencing-100582263","NCT06861036","Heterogeneity of Oral Squamous Cell Carcinoma Analysis by Single Cell RNA Sequencing","HOASIS","Inclusion Criteria:\n\n* I1. Male or female at least 18 years old.\n* I2. Patient with OSCC and undergoing surgery at the Centre Léon Bérard.\n* I3. Patient who has agreed to participate in this research and sign consent.\n* I4. Patient affiliated to a medical insurance.\n\nExclusion Criteria:\n\n* NI1. Pregnant or nursing woman.\n* NI2. Contraindication to general anesthesia.\n* NI3. Suspicion of rare tumor of particular histology other than squamous cell carcinoma (Sarcoma...).\n* NI4. Patient under curatorial or guardianship or placed under the protection of justice.",{"count":95,"type":20},50,[23],"The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and leucoplasic) counterparts by scRNAseq in OSCC patients.",[26],[29,30,32],"2025-02-28",{"date":102,"type":39},"2025-03-06",{"date":104,"type":20},"2025-05-15",{"date":106,"type":20},"2028-05-15",{"name":45,"class":46}]