[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orofacial-myofunctional-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orofacial-myofunctional-disorders":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,69,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100602934","oromyofunctional-training-an-innovative-rehabilitation-program-for-pediatric-obstructive-sleep-apnea-100602934",false,"NCT07129967","Oromyofunctional Training: an Innovative Rehabilitation Program for Pediatric Obstructive Sleep Apnea","OROFIT","Inclusion Criteria:\n\n* Children aged between 6-12\n* Diagnosed with Obstructive Sleep Apnea on Polysomnography (AHI\\\u003C1)\n\nExclusion Criteria:\n\n* History of Orofacial Myofunctional Therapy\n* Undergoing an orthodontic procedure during the study period\n* Undegoing an OSA treatment during the study period\n* Orofacial congenital deformities\n* Mental retardation (\\>2 SD above P50)","ALL","6 Years","12 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Obstructive sleep apnea (OSA) is a prevalent medical condition with important implications for overall health and quality of life in both children. Therefore, it is important to treat OSA early and effectively. However, adenotonsillectomy, the standard therapeutic approach for children with OSA, is often inadequate. Research shows that 20-40% of children still have residual OSA symptoms after surgery. Therefore, exploring other treatment options, specifically for those patients who currently have insufficient therapeutic options, is an interesting and relevant avenue for research.\n\nThis study will evaluate the effectiveness of orofacial myofunctional therapy as a treatment option for children with obstructive sleep apnea (OSA). Orofacial myofunctional therapy consists of a set of oropharyngeal exercises to correct abnormal orofacial functions and strengthen upper airway muscles that are involved in maintaining airway patency. Both objective and subjective\u002Fpatient-reported outcomes are collected to obtain a comprehensive understanding of the potential of orofacial myofunctional therapy as a treatment for OSA.",[27,28],"Obstructive Sleep Apnea (OSA)","Orofacial Myofunctional Disorders",[30,31],"Orofacial myofunctional therapy","obstructive sleep apnea","RECRUITING","2025-08-11",{"date":35,"type":36},"2025-08-19","ACTUAL",{"date":38,"type":36},"2024-08-08",{"date":40,"type":21},"2027-01-01",{"name":42,"class":43},"University Ghent","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":13,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":68,"locationsCount":44},"100602361","oromyofunctional-therapy-a-rehabilitation-program-for-osa-in-children-with-down-syndrome-and-prader-willi-syndrome-100602361","NCT07122505","Oromyofunctional Therapy: a Rehabilitation Program for OSA in Children With Down Syndrome and Prader-Willi Syndrome","OROFIT-P","Inclusion Criteria:\n\n* Children aged between 4-18\n* Diagnosed with Down syndrome or Prader-Willi syndrome\n* Diagnosed with Obstructive Sleep Apnea on Polysomnography (AHI\\\u003C1)\n\nExclusion criteria:\n\n* History of Orofacial Myofunctional Therapy\n* Undergoing an orthodontic procedure during the study period\n* Undegoing an OSA treatment during the study period\n* Orofacial congenital deformities (not related to Down syndrome or Prader-Willi syndrome)","4 Years","18 Years",{"count":55,"type":21},60,[24],"Obstructive sleep apnea (OSA) is a prevalent medical condition with important implications for overall health and quality of life in both children. Therefore, it is important to treat OSA early and effectively. Children with Down syndrome and Prader-Willi syndrome have many predisposing factors for OSA, including mouth breathing, narrow upper airways resulting from craniofacial abnormalities, and generalized hypotonia, which increases UA collapsibility and multilevel obstructions. Adenotonsillectomy is the first-line treatment. Unfortunately, up to 55% of children with Down syndrome and up to 79% of children with Prader-Willi syndrome suffer from residual OSA after adenotonsillectomy. Therefore, exploring other treatment options for these children is an interesting and relevant avenue for research.\n\nThis study will evaluate the effectiveness of orofacial myofunctional therapy as a treatment option for children with Down syndrome or Prader-Willi syndrome and obstructive sleep apnea. Orofacial myofunctional therapy consists of a set of oropharyngeal exercises to correct abnormal orofacial functions and strengthen upper airway muscles that are involved in maintaining airway patency. Both objective and subjective\u002Fpatient-reported outcomes are collected to obtain a comprehensive understanding of the potential of orofacial myofunctional therapy as a treatment for OSA.",[27,28],[30,60,61,62],"Obstructive sleep apnea","Down syndrome","Prader-Willi syndrome",{"date":64,"type":36},"2025-08-14",{"date":66,"type":36},"2024-04-15",{"date":40,"type":21},{"name":42,"class":43},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":97},"100599712","trial-to-compare-the-effects-of-myo-munchee-therapy-and-oral-motor-therapy-omt-in-pediatric-patients-to-treat-maxillary-deficiency-and-orofacial-myofunctional-dysfunction-omd-100599712","NCT07088055","Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).","Multi-center, 6-month, Randomized, and Controlled Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients (Aged 3-5 Years) to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).","Inclusion Criteria:\n\n* Aged between 36 - 60 (3-5 yrs) months old and will not turn 6 years of age before the study completion\n* Diagnosed with having at least two maxillary skeletal-dental malocclusion traits as determined by the dentist\n* At least one of the identified Orofacial Myofunctional Dysfunction (OMD) traits determined by the Speech-Language Pathologist (CCC-SLP)\n\nExclusion Criteria:\n\n* A patient must be considered healthy to be included in this study. Definition of health: the patient does not have ongoing treatment, medication or specialized assessments (more than routine follow up exams) with health care providers regarding a condition. If they have had treatment for a condition (e.g. treated by respiratory physician for acute asthma hospitalization), it must have been 12 months or more since their last appointment with a health provider related to that condition.\n\nOf particular consideration:\n\nOngoing care from a sleep physician or respiratory physician Current use of Continuous Positive Airway Pressure (CPAP), nasal sprays, sleeping or behavioral medication to treat diagnosed sleep disorder or behavioral disorder Adenectomy or tonsillectomy within last 12 months\n\n* Any previous or current tumors or traumas in the head, neck and jaw region Patients with any known genetic or congenital conditions that impair oral motor muscle function, oral motor coordination, or speech articulation, such as but not limited to muscular dystrophy, cerebral palsy, will be excluded from the study.\n* Patients with any known syndromic conditions to affect oral motor function, including but not limited to syndromes that involve craniofacial anomalies, neuromuscular disorders, or developmental delays affecting oral motor muscle control, speech articulation, or swallowing, such as Down Syndrome, Pierre Robin sequence, or Moebius syndrome.\n* Children that do not have their 2nd molars by 36 months of age\n* Overweight, Z-scores Body Mass Index (BMI) above 85th percentile (z score of 1) Boys: https:\u002F\u002Fwww.cdc.gov\u002Fgrowthcharts\u002Fdata\u002Fextended-bmi\u002FBMI-Age-percentiles-BOYS-Z-Scores.pdf Girls: https:\u002F\u002Fwww.cdc.gov\u002Fgrowthcharts\u002Fdata\u002Fextended-bmi\u002FBMI-Age-percentiles-GIRLS-Z-Scores.pdf\n* History of prescription for therapeutic gum chewing and\u002For use of edibles in treatment program\n* Previous tongue tie releases (frenuloplasty and frenectomy)\n* Any therapeutic oral device treatment\n* Previous or current treatment from any other dental, Oral Motor Therapy (OMT) or orthodontic provider\n* Gross neglect of patient's oral health and presence of dental caries\n* Grade 4 tonsils on Brodsky scale",true,"3 Years","5 Years",{"count":80,"type":21},48,[24],"Multi-center, 6-month, randomized, and controlled trial to compare the effects of Myo Munchee therapy and Oral Motor Therapy (OMT) in pediatric patients (aged 3-5 years) to treat maxillary deficiency and orofacial myofunctional dysfunction (OMD).",[28,84,85,86],"Myo Munchee","Oral Motor Therapy","Maxillary Deficiency","2025-07-19",{"date":89,"type":36},"2025-07-28",{"date":91,"type":21},"2025-08-20",{"date":93,"type":21},"2027-06",{"name":95,"class":96},"Myo Munchee (Operations) Pty Ltd","INDUSTRY",2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":44},"100596463","oral-myofunctional-pattern-in-children-with-anterior-open-bite-100596463","NCT07045779","Oral Myofunctional Pattern in Children With Anterior Open Bite","The OMBIT Study: Oral Myofunctional Pattern in Children With Anterior Open Bite","OMBIT","Inclusion Criteria:\n\n* Presence of anterior open bite (AOB)\n* Early or intermediate mixed dentition phase\n\nExclusion Criteria:\n\n* History of or active engagement in orofacial myofunctional therapy (OMT)\n* History of or active engagement in orthodontic therapy\n* Congenital abnormalities, syndromes, or surgical needs affecting the oral and maxillofacial region\n* Disorders affecting motor or cognitive development\n* Current or recent (\\\u003C 3 months) non-nutritive sucking habits",{"count":107,"type":21},33,[24],"Oral myofunctional disorders (OMD) are a key, internationally acknowledged environmental factor causing dental and skeletal malocclusion. For the past 15 years, research regarding the efficacy of orofacial myofunctional therapy (OMT) to reduce OMD and to contribute to the treatment of malocclusions has been significantly increased. Despite the growing interest, high-quality evidence is still lacking because studies show a lack of standardized assessment techniques, outcome measures, and inclusion criteria, important methodological limitations such as small sample sizes, a variety of content and service delivery models and a lack of long-term follow-up.\n\nThe goal of this clinical trial is to evaluate the effects of structured OMT on anterior open bite (AOB) in children in early or intermediate mixed dentition. The main questions it aims to answer are:\n\n* Does a structured OMT program affect orofacial myofunctional patterns, dental occlusion, and oral health-related quality of life (OHRQoL) in children with AOB?\n* Are there differences in treatment outcomes between children receiving a traditional OMT program, a reduced OMT program, and a sham treatment?\n\nParticipants will undergo baseline and follow-up assessments of dental occlusion, orofacial myofunctional patterns, and OHRQoL. They will follow a structured OMT protocol tailored to their assigned group and participate in weekly therapy sessions over a defined intervention period.",[28,111],"Anterior Open Bite Malocclusion","2025-06-23",{"date":114,"type":36},"2025-07-01",{"date":116,"type":36},"2023-02-22",{"date":118,"type":21},"2026-05",{"name":42,"class":43}]