[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthodontic-aligners\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthodontic-aligners":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100639840","bone-metabolism-in-patients-treated-with-3d-printed-aligners-versus-thermoformed-aligners-100639840",false,"NCT07617571","Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners","Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners (Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Minor malocclusion (2 to 4 mm of crowding) .\n* Patients in need for Antero-posterior expansion and labial tipping of incisors without interproximal reduction\n* No use of anti-inflammatory drugs or antibiotics in the past 6 months.\n* Periodontal parameters of gingival index \\\u003C1 and no pocketing with a generalized pocketing depth of \\\u003C3mm.\n* Radiographic parameters of no crestal bone loss.\n* No history of smoking.\n\nExclusion Criteria:\n\n* Signs of inflammation of the gingiva, and periodontitis.\n* Systemic conditions (kidney disease, HIV, and liver disease).\n* Teeth missing or poor oral hygiene.\n* Bone disease e.g.; osteoporosis.","ALL","18 Years","25 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Orthodontic forces induce tissue reactions by triggering perturbations from orthodontic appliances, which lead to the modelling and remodelling of alveolar bone. Despite the growing popularity of 3D-printed aligners, no studies have compared their effects on bone metabolism in comparison with thermoformed aligners. Aim: This study aims to assess bone metabolism in patients undergoing treatment with 3D-printed aligners versus thermoformed aligners.",[27,28],"Bone Metabolism","Orthodontic Aligners","NOT_YET_RECRUITING","2026-05-24",{"date":32,"type":33},"2026-06-01","ACTUAL",{"date":32,"type":21},{"date":36,"type":21},"2026-07-01",{"name":38,"class":39},"Alexandria University","OTHER"]