[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthodontic-appliance-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthodontic-appliance-complication":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,81,125,155,182],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100495628","comparison-of-mi-paste-plus-and-resin-infiltration-in-white-spot-lesions-following-orthodontic-treatment-100495628",false,"NCT05733676","Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment","Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals in the age range of 12-21 years who had undergone fixed orthodontic appliance therapy for a duration of 12-36 months.\n* Should have at least one white spot lesion on the labial surface of either maxillary or mandibular anterior teeth after debonding. Lesion visible with or without drying the lesion surface.\n* Patients with mild to moderate plaque accumulation. Fair oral hygiene. With a simplified Oral Hygiene Index of no more than 1.3-3.0\n\nExclusion Criteria:\n\n* Poor oral hygiene Simplified Oral Hygiene Index of 3.1-6.0 or more\n* Patients with hypoplasia or any developmental defects on the buccal of upper or lower incisors\n* Patients with any restorations on the buccal of upper or lower incisors\n* Patients that have presented WSL on the buccal of upper or lower incisors before orthodontic treatment was initiated.\n* Patients that have received any re-mineralizing agent other than regular toothpaste during the last three months\n* Patient with allergy to milk or any of their products\n* Patient with any medical \u002F oral or mental condition\n* Patients or legal guardians that does not speak or read English",true,"ALL","12 Years","21 Years",{"count":21,"type":22},62,"ESTIMATED","INTERVENTIONAL",[25],"NA","Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances. The white spot lesion (WSL) is the first clinical sign of cavities that presents itself as a milky-white opacity when located on the front face of the tooth. The aim to manage these early lesions focuses on promoting natural remineralization and preventing further demineralization. Various materials have been introduced for management of WSLs including MI paste and MI paste combined with fluoride (MI paste plus). Recently, a new material called resin infiltration has been found to treat these lesions with high esthetic results and great performance. According to the few numbers of in-vivo studies investigating the effectiveness of remineralization products, the aim of the current study is to clinically compare the outcome of the resin-infiltration and etching + MI paste plus to stop and improve the appearance of the WSL on front teeth in patients after treatment with braces.",[28,29,30,31],"White Spot Lesions","Orthodontic Appliance Complication","Caries Arrested","Smooth Surface Caries",[33,34,35,36],"White spot lesion","caries","arrested","orthodontic","RECRUITING","2026-06-25",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":43,"type":41},"2023-05-30",{"date":45,"type":22},"2028-10-01",{"name":47,"class":48},"University of Alberta","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":49},"100560196","the-effect-of-intraoral-transcutaneous-electrical-nerve-stimulation-in-orthodontics-pain-100560196","NCT06573996","The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain","The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation (TENS) on Pain Perception During Orthodontic Alignment and Leveling: A Randomized Clinical Trial","Inclusion Criteria:\n\nGeneral Health: Patients who are generally healthy.\n\nOrthodontic Treatment: Patients undergoing orthodontic treatment that requires the use of full-fixed appliances.\n\nNo Pain Medication: Patients not currently taking any medications for pain management.\n\nExclusion Criteria:\n\nPatients with a history of seizures\n\nPatients with or with a history of cardiac arrhythmias or pacemaker treatment\n\nPatients taking any over-the-counter or prescription pain medication during the testing period.",{"count":58,"type":22},150,[25],"The goal of this clinical trial is to determine whether an intraoral Transcutaneous Electrical Nerve Stimulation (TENS) device can reduce pain during orthodontic alignment and leveling in adolescents and adults. The study aims to compare the effectiveness of the TENS device in reducing pain on one side of the mouth, where the device is used, to the other side, where a non-functioning (placebo) device is applied.\n\nThe primary questions this study aims to answer are:\n\nDoes the TENS device effectively reduce pain during orthodontic treatment compared to the placebo? How do patients pain levels differ between the treated and untreated sides of the mouth?\n\nParticipants will:\n\nHave an orthodontic appliance placed on their teeth. Experience the TENS device being applied to one side of their mouth for 2.5 minutes immediately after the appliance placement (brackets and wires).\n\nReport their pain levels at various intervals after the procedure (immediately, 2 hours, 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours).\n\nThis study includes up to 150 participants who are undergoing routine orthodontic treatment. The findings will help researchers understand whether the TENS device can effectively reduce discomfort during orthodontic procedures, potentially leading to better patient care and comfort.",[62,63,64,29],"Orthodontic Appliance","Pain","Transcutaneous Electric Nerve Stimulation",[66,67,68,69,70,71],"Orthodontic Pain","TENS Therapy","Orthodontic Alignment","Randomized Clinical Trial","Transcutaneous Electrical Nerve Stimulation (TENS)","Dental Pain Eraser","2026-02-11",{"date":74,"type":41},"2026-02-17",{"date":76,"type":41},"2024-09-16",{"date":78,"type":22},"2029-09-01",{"name":80,"class":48},"University of the Pacific",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":49},"100620261","comparison-of-a-3-step-bonding-system-transbond-xt-and-a-2-step-system-gc-ortho-connect-on-demineralization-around-maxillary-orthodontic-brackets-100620261","NCT07355322","Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets","Comparison of a 3-step Bonding System (TRANSBOND™ XT) Versus a 2-step System (GC ORTHO CONNECT™) on Demineralization Around Maxillary Orthodontic Brackets: a Randomized Split-mouth Clinical Trial.","ORTHOCOLLAGE","Inclusion Criteria:\n\n* Patient aged 10 to 16 years included,\n* Patient attending their first dentofacial orthopedics consultation at the Montpellier Dental Care Center, in adolescent or young adult dentition (according to Démogé classification),\n* Patient requiring the placement of a bimaxillary multi-bracket treatment and opting for a metallic vestibular technique.\n\nExclusion Criteria:\n\n* Syndromic patient (all syndromes included, e.g., cleft lip) or with a severe long-term condition (ALD),\n* Patient previously treated with a multi-bracket orthodontic treatment using a mixed, lingual, or vestibular technique,\n* Any medical condition deemed incompatible with bracket placement by the investigator,\n* Patient with severe MIH (molar-incisor hypomineralization) and\u002For severe demineralization on one or more teeth (including severe amelogenesis imperfecta or dentinogenesis imperfecta),\n* Patient with restorations such as metal crowns, ceramic crowns, porcelain-fused-to-metal crowns, inlays, onlays, or amalgam on one or more vestibular surfaces,\n* Patient with oral hygiene incompatible with orthodontic treatment,\n* Agenesis of lateral incisors,\n* Subject already participating in another interventional clinical trial that could interfere with this study,\n* Uncontrolled psychiatric disorder,\n* Lack of written informed consent from a legal representative after a reflection period,\n* Lack of cooperation or difficulty in communication\u002Fcomprehension, or refusal of participation by the minor,\n* Subject with a dependency or employment relationship with the sponsor or investigator,\n* Subject participating in another research study with an ongoing exclusion period,\n* Subject not affiliated with the French social security system or not a beneficiary of such a system,\n* Protected populations according to the French Public Health Code:\n\nPregnant or breastfeeding women Subjects deprived of liberty (by judicial, administrative decision, or involuntary hospitalization) Subjects under guardianship or curatorship","10 Years","16 Years",{"count":92,"type":22},34,[25],"White spot lesions (WSLs) are one of the most common adverse effects of fixed orthodontic treatments, affecting up to 97% of patients treated with labial appliances. These early enamel demineralizations, caused by microleakage between enamel and adhesive, can appear as early as the fourth week of treatment. They not only pose aesthetic concerns but also increase the risk of bracket failure.\n\nThis randomized split-mouth clinical trial compares two bonding systems : the traditional three-step system (Transbond™ XT) and the simplified two-step system (GC Ortho Connect™) to assess their impact on enamel demineralization around orthodontic brackets. The degree of demineralization will be measured using the Enamel Decalcification Index (EDI) based on intraoral photographs and confirmed with a fluorescence camera (C50 Acteon).\n\nThe aim of the study is to determine whether the simplified bonding protocol can reduce clinical time and saliva contamination risk without increasing enamel demineralization, thus offering a potentially more efficient and conservative approach for orthodontic bonding procedures.",[96,97,98,29,99],"Tooth Demineralization","White Spot Lesion","Demineralization","Dental Braces Complication",[101,102,103,104,105,106,107,108,109,110,111,112,113,114],"White spot lesions","Orthodontic bonding","Enamel demineralization","Transbond XT","GC Ortho Connect","Split-mouth trial","Orthodontic Brackets","Fixed Orthodontic Appliances","Adolescents","Oral Hygiene","Dental Plaque","Orthodontic Adhesives","Bracket detachment","Bracket debonding","NOT_YET_RECRUITING","2026-01-12",{"date":118,"type":41},"2026-01-21",{"date":120,"type":22},"2026-01",{"date":122,"type":22},"2028-04",{"name":124,"class":48},"University Hospital, Montpellier",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":135,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":49},"100588704","microbial-adherence-surface-roughness-effectiveness-and-impact-on-patients-between-conventional-and-3d-printed-twin-block-appliances-100588704","NCT06944860","Microbial Adherence, Surface Roughness, Effectiveness and Impact on Patients Between Conventional and 3D Printed Twin Block Appliances","Microbial Adherence, Surface Roughness, Effectiveness and Impact on Patients Between Conventional and 3D Printed Twin Block Appliances: An Open-Label Prospective Clinical Trial","Inclusion Criteria:\n\n1. Patients with Class II Division 1 incisor relationship\n2. Overjet of ≥ 7mm\n3. Age range of children: 10-12 years in females, 12-14 years in males\n4. All permanent incisors and molars erupted\n5. ICDAS ≥ score 3 and BPE ≥ 3\n6. Able to understand English or Bahasa Melayu\n\nExclusion Criteria:\n\n1. Patients with craniofacial syndromes (example: cleft lip and palate)\n2. Patients with previous history of orthodontic treatment\n3. Patients with hyperdivergent facial type (MMPA \\> 40º)\n4. Untreated gingival disease (e.g.: gingivitis, periodontitis)","14 Years",{"count":134,"type":22},32,[25],"The Twin Block appliance is a removable orthodontic appliance that is used to help correct a backward positioned lower jaw in growing children. This appliance works by guiding the lower jaw forward to a specific position over a certain period of time. After completing the treatment, patients often experience improvements in their appearance, such as an improved bite, a more balanced facial profile and improved lip posture.\n\nThe investigators' interest is to compare two types of Twin Block appliances; traditional (conventional) and 3D-printed, by examining several factors, including the amount of bacteria that stick to them, the surface roughness, and the overall effectiveness of each type.\n\nSurface roughness refers to the texture of the appliance's surface, which could influence how much bacteria can accumulate. Rougher surfaces may trap more bacteria, potentially leading to oral health issues such as bad breath, tooth decay, and gum problems. The study will also assess the effectiveness of both the conventional and 3D-printed Twin Block appliances, focusing on factors like how well they perform in improving jaw position and achieving the desired treatment outcomes.\n\nAdditionally, the investigators want to assess how these appliances affect the quality of life related to oral health. Participants will answer questions about their experience to help understand how the type of appliance impacts their daily lives, comfort, and overall well-being during the course of treatment.",[138,29,139],"Orthodontic Appliances, Removable","Class II Malocclusion, Division 1",[141,142,143,144,145],"Twin block appliance","Microbial adherence","Surface roughness","Effectiveness","Oral Health Related Quality of Life (OHRQoL)","2025-06-15",{"date":148,"type":41},"2025-06-18",{"date":150,"type":41},"2025-05-01",{"date":152,"type":22},"2027-01-17",{"name":154,"class":48},"University of Malaya",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":16,"sex":17,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":23,"phases":166,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":49},"100574962","chios-mastic-toothpaste-and-halitosis-and-oral-hygiene-in-orthodontic-patients-100574962","NCT06766097","Chios Mastic Toothpaste and Halitosis and Oral Hygiene in Orthodontic Patients","The Effect of Chios' Mastic Toothpaste on Halitosis and Oral Hygiene in Orthodontic Patients: a Randomized Clinical Trial","Inclusion Criteria:\n\nPatients eligible for the trial must comply with all of the following at randomization:\n\n• Age between 13 and 18 years for the group with conventional orthodontic appliances.\n\nThis age group represents the majority of patients seeking orthodontic treatment and is homogeneous regarding occupational status (high-school and lyceum students in Greece). Younger patients might present with cooperation problems.\n\n* Good general health.\n* Orthodontic fixed labial appliances on the maxillary and mandibular arch, brackets at least on 20 teeth for more than 4 months before enrollment and estimated duration of the treatment more than 1 month, bands on the first molars, extraction cases patients could be enrolled at least two months after the last extraction.\n* Total initial VSCs levels above the baseline level of 150ppb.\n\nExclusion Criteria:\n\nPatients will be excluded for any of the following reasons:\n\n* Active caries\n* Periodontitis\n* Dental fluorosis \u002F dysplasia of the teeth\n* Syndromes, mental disabilities and craniofacial deformities\n* Smoking or use of other tobacco products\n* Allergy to mastic\n* Antibiotics during the last 2 months\n* Chlorhexidine in the previous 3 weeks\n* Participation in other trials","13 Years","18 Years",{"count":165,"type":22},30,[25],"The aim of this trial was to investigate the effect of mastic toothpaste on halitosis using as proxy the levels of the Volatile Sulfur Compounds (VSCs), and the effect on plaque and gingival indices in adolescents undergoing orthodontic treatment with fixed conventional labial appliances.",[169,29],"Halitosis",[169,171,172],"Mastic","Orthodontic appliance","2025-01-03",{"date":175,"type":41},"2025-01-09",{"date":177,"type":22},"2025-01-07",{"date":179,"type":22},"2025-02-28",{"name":181,"class":48},"University of Athens",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":16,"sex":17,"minAge":163,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":49},"100554730","evaluation-of-the-stability-of-orthodontic-treatment-after-first-premolar-extraction-using-combined-retention-protocol-100554730","NCT06502886","Evaluation of The Stability of Orthodontic Treatment After First Premolar Extraction Using Combined Retention Protocol","Evaluation of The Stability of Orthodontic Treatment After First Premolar Extraction in Adult Patients Using Bonded Retainer Versus Bonded Retainer Combined With Vacuum Formed Retainer : A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Adult patients at the end of comprehensive orthodontic treatment after extraction of upper and lower first premolars and requiring subsequent application of a lingual and palatal bonded retainers\n2. Good oral hygiene\n3. Patients whom the pre-treatment records (models) are available\n4. Good finishing criteria (ABO grading system)\n\nExclusion Criteria:\n\n1. Non-extraction orthodontic treatment\n2. Poor oral hygiene\n3. Dental\u002Fcongenital anomalies ex: Missing laterals, transposed canines, Cleft lip and palate\u002Fcraniofacial syndromes\n4. Poor finishing criteria (ABO grading system)",{"count":190,"type":22},24,[25],"The aim of this study is to compare between the stability of anterior and posterior segments in both arches using bonded lingual retainers versus a combined protocol of retention (bonded lingual retainer and vacuum formed retainers). The effect of different treatment changes achieved on the post-treatment stability will be studied in both groups.\n\nHypothesis: No difference between BR and BR+VFR regarding the stability of anterior segment alignment and posterior segment alignment and interdigitation",[29],"2024-07-09",{"date":196,"type":41},"2024-07-16",{"date":198,"type":41},"2024-03-10",{"date":200,"type":22},"2025-03-01",{"name":202,"class":48},"Cairo University"]