[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthodontic-tooth-movement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthodontic-tooth-movement":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,78,106,129,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100641094","micro-osteoperforation-versus-photobiomodulation-therapy-for-accelerating-maxillary-canine-retraction-100641094",false,"NCT07658235","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction","Micro-osteoperforation Versus Photobiomodulation Therapy for Accelerating Maxillary Canine Retraction: A Three-Arm Parallel Randomized Controlled Clinical Trial.","MOP-PBMT","Inclusion Criteria:\n\n* Age 18 to 40 years at the time of enrollment\n* Systemically healthy with no chronic medical conditions affecting bone metabolism or wound healing\n* Requiring bilateral maxillary first premolar extraction as part of a comprehensive fixed orthodontic treatment plan\n* Class I or mild Class II malocclusion requiring maximum anchorage canine retraction\n* Fully erupted maxillary permanent dentition with no missing teeth other than planned extraction teeth\n* Good oral hygiene (Plaque Index ≤ 1) and healthy periodontal status (probing depth ≤ 3 mm, no bleeding on probing)\n* No previous orthodontic treatment\n* Willing to attend all scheduled appointments and comply with study protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Systemic diseases affecting bone metabolism including osteoporosis, osteopenia, diabetes mellitus, thyroid disorders, or autoimmune conditions\n* Current use of medications affecting bone remodeling including corticosteroids, bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), or vitamin D supplements\n* Current or recent smokers (within the past 6 months)\n* Pregnant or breastfeeding women\n* History of head and neck radiation therapy\n* Periodontal disease or active dental infection at the time of enrollment\n* Skeletal Class III malocclusion or severe Class II requiring surgical intervention\n* Previous orthodontic treatment or orthognathic surgery\n* Craniofacial syndromes or cleft lip and palate\n* Photosensitivity disorders or use of photosensitizing medications (relevant to LLLT group)\n* Coagulation disorders or anticoagulant therapy (relevant to MOP group)\n* Uncooperative patients or those unable to maintain adequate oral hygiene throughout treatment\n* Parafunctional habits such as severe bruxism or tongue thrusting'",true,"ALL","18 Years","40 Years",{"count":22,"type":23},75,"ESTIMATED","INTERVENTIONAL",[26],"NA","Orthodontic treatment often requires moving the upper canine teeth (the pointed teeth) into the spaces left after removing premolar teeth. This process is usually slow and can take many months, making the total treatment time longer.This study will compare two techniques that may speed up this tooth movement:\n\nMicro-osteoperforation (MOP): A minimally invasive procedure in which a small device is used to create tiny holes in the jawbone near the canine tooth under local anesthesia. These micro-perforations stimulate the bone to remodel faster, which allows the tooth to move more quickly.\n\nPhotobiomodulation therapy (PBMT) \u002F Low-Level Laser Therapy (LLLT): A painless, non-invasive technique that uses a low-power laser light applied to the gum tissue near the canine tooth. The laser energy stimulates cells in the bone and supporting tissues to accelerate tooth movement without any cutting or drilling.\n\nThis trial will randomly assign eligible patients into one of three groups: MOP, LLLT, or a control group receiving standard orthodontic treatment only. Each group will contain 25 participants (75 total). The main goal is to measure and compare how fast the upper canine tooth moves in each group over the first month and until the space is fully closed. The study will also measure the effect of age and sex on the results. The findings will help orthodontists choose the best, fastest, and most comfortable method for each patient to shorten overall treatment time",[29,30,31],"Malocclusion","Orthodontic Tooth Movement","Maxillary Canine Retraction",[33,34,35,36],"Micro-osteoperforation","Photobiomodulation therapy","low-level laser therapy","acceleration of tooth movement","NOT_YET_RECRUITING","2026-06-16",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":23},"2026-07-01",{"date":45,"type":23},"2027-05-28",{"name":47,"class":48},"Kufa University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100640184","comparison-of-rate-of-tooth-movement-between-mops-vs-mops--lllt-combined-100640184","NCT07626580","Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined","Comparison of Rate of Tooth Movement Between Micro-osteoperforations Versus Micro-osteoperforations and Low Level Laser Therapy Combined","Inclusion Criteria:\n\n* • Patients aged 12-30 years requiring fixed orthodontic treatment.\n\n  * Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.\n  * No history of previous orthodontic treatment.\n  * Patients with indications for the extraction of the first premolars on both sides of the maxilla.\n\nExclusion Criteria:\n\n* • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).\n\n  * Smokers and individuals with poor oral hygiene.\n  * Pregnant or lactating women.","30 Years",{"count":59,"type":23},33,[26],"Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance.\n\nTo address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement.\n\nStudies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored.\n\nThis study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.",[30,63,64],"Low Level Laser Therapy","Canine Retraction",[63,66,67,64,68],"LLLT","Micro-Osteoperforations","Maxillary Scan","2026-06-01",{"date":71,"type":41},"2026-06-04",{"date":73,"type":23},"2026-06",{"date":75,"type":23},"2026-12",{"name":77,"class":48},"Riphah International University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":18,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":49},"100636514","maxillary-incisor-intrusion-using-utility-arch-assisted-with-micro-osteoperforations-100636514","NCT07566676","Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations","Evaluation of Dentoalveolar Changes Following Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations in Deep Bite Cases: A Randomized Clinical Trial","MOPs","Inclusion Criteria:\n\n1. Patients age between 15-25 years.\n2. Patients with overbite ≥ 4 mm.\n3. All permanent teeth erupted (excluding 3rd molars).\n4. No previous orthodontic treatment.\n5. Patients with good oral hygiene and good periodontal health.\n\nExclusion Criteria:\n\n1. Skeletal discrepancies.\n2. Missing maxillary anterior teeth or any kind of tooth\u002Froot shape anomaly.\n3. Patients with root resorption or impacted canines.\n4. Previous history of orthodontic treatment.\n5. Systemic disease interferes with orthodontic tooth movement.\n6. History of trauma affecting the maxillary incisors.\n7. Poor oral hygiene or periodontally compromised patient.\n8. Endodontically treated upper anterior teeth.","15 Years","25 Years",{"count":89,"type":23},18,[26],"Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases.",[93,94,30,95],"Deep Bite Malocclusion","Intrusion of Tooth","Root Resorption","RECRUITING","2026-04-30",{"date":99,"type":41},"2026-05-05",{"date":101,"type":23},"2026-05",{"date":103,"type":23},"2029-06",{"name":105,"class":48},"Al-Azhar University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":18,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":24,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":49},"100633021","nano-coated-orthodontic-miniscrews-for-en-mass-retraction-of-the-upper-arch-100633021","NCT07521267","Nano Coated Orthodontic Miniscrews for en Mass Retraction of the Upper Arch","Evaluation of Silver-Hydroxyapatite Nano-coated Versus Uncoated Orthodontic Miniscrews for en Masse Retraction of the Upper Anterior Segment: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Class I orthodontic cases with bimaxillary protrusion of the anterior segment of the upper jaw that need at least extraction for orthodontic treatment.\n* Age 14-20 years.\n* Good oral hygiene with healthy periodontium.\n* Need for an absolute skeletal anchorage.\n* Systemically healthy patients.\n\nExclusion Criteria:\n\n* Patient with craniofacial anomalies (e.g, cleft lip and palate)\n* Presence of systemic diseases or syndromes affecting bone metabolism (e.g, osteoporosis, rickets)\n* Poor oral hygiene or uncooperative patients.\n* Extensive dental caries or untreated periodontal disease.\n* History of trauma or surgery affecting the maxilla or mandible.","14 Years","20 Years",{"count":116,"type":23},14,[26],"study will be directed to evaluate silver-hydroxyapatite nano-coated versus uncoated orthodontic miniscrews for en masse retraction of the upper anterior segment.",[120,121,30],"Class I Malocclusion","Maxillary Prognathism","2026-04-08",{"date":124,"type":41},"2026-04-13",{"date":101,"type":23},{"date":127,"type":23},"2029-11",{"name":105,"class":48},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":17,"sex":18,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":24,"phases":140,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100608345","clinical-evaluation-of-local-calcitriol-delivery-on-maxillary-canine-retraction-100608345","NCT07200349","Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction","CALCR25","Inclusion Criteria:\n\n1. Presence of class I malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.\n2. Presence of class II malocclusion requiring bilateral extraction of the maxillary first premolars and subsequent canine retraction.\n3. Age range between 13 and 35 years to include both adolescent and adult patients suitable for orthodontic treatment.\n4. Presence of permanent dentition.\n5. Good oral hygiene.\n\nExclusion Criteria:\n\n1. History of chronic systemic disease.\n2. Presence of active gingival or periodontal disease.\n3. Known allergy or hypersensitivity to vitamin D.\n4. Pregnancy or lactation.\n5. History of previous orthodontic treatment.\n6. Presence of craniofacial anomalies affecting bone physiology.","13 Years","35 Years",{"count":139,"type":23},22,[26],"This study will evaluate the effect of locally applied Calcitriol on dental and skeletal changes during upper canine retraction. It is a split-mouth randomized clinical trial, where Calcitriol will be locally applied on one side of the maxilla, and the other side will serve as control.",[31,143,30],"Local Calcitriol Delivery",[145,146,64,147],"Calcitriol","Vitamin D3","Split-mouth Trial","2025-09-30",{"date":150,"type":41},"2025-10-01",{"date":152,"type":23},"2025-11-01",{"date":154,"type":23},"2026-10",{"name":105,"class":48},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":24,"phases":167,"briefSummary":168,"conditions":169,"keywords":171,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":49},"100521336","effect-of-mops-during-orthodontic-movement-in-periodontitis-patients-100521336","NCT06068270","Effect of MOPs During Orthodontic Movement in Periodontitis Patients","Randomized Clinical Trial on the Effect of Micro-osteoperforations (MOPs) During Intrusion of Flared Upper Anterior Teeth in Stage IV Periodontitis Patients","MOPorthoperi","Inclusion Criteria:\n\nPatients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria:\n\n* adult patients older than 18-year-old;\n* systemically healthy (see exclusion criteria);\n* diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;\n* the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \\\u003C5mm) (experimental teeth);\n* in need of orthodontic therapy.\n\nExclusion Criteria:\n\n* systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);\n* any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers);\n* pregnant or lactating woman;\n* inability to respond questions or to attend follow-up visits;\n* extreme skeletal malocclusions requiring orthognathic surgery;\n* patients smoking more than 10 cigarettes\u002Fday; and\n* the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy","80 Years",{"count":166,"type":23},28,[26],"Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \\\u003C5mm)",[170,30],"Stage IV Periodontitis",[172,173,174],"Stage IV periodontitis","Orthodontic tooth movement","Micro-osteoperforations","2025-03-24",{"date":177,"type":41},"2025-03-27",{"date":179,"type":41},"2023-12-15",{"date":181,"type":23},"2026-01",{"name":183,"class":48},"Universidad Complutense de Madrid"]