[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthodontics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthodontics":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,80,105,134,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100588957","exploration-of-the-utility-of-dental-dedicated-mri-for-dentistry-100588957",false,"NCT06948162","Exploration of the Utility of Dental-dedicated MRI for Dentistry","Inclusion Criteria:\n\n1. Patient Age: 18 years old or older\n2. Receiving imaging for routine dental care\n3. Does not have a serious medical condition\n4. Is not pregnant or is not potentially pregnant\n5. Is willing and able to give consent in English\n6. Has the ability to manage their own calendar and schedule appointments\n7. Willing to have a separate 2-hour appointment to have an MRI\n\nExclusion Criteria:\n\n1. Unable to consent to participant in English\n2. Serious health condition, which includes but not limited to renal failure\u002Fon dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and\u002For unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and\u002For stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure\n3. Pregnant and\u002For intending to become pregnant,\n4. Prisoner and\u002For not able to manage their own scheduling\n5. Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposure to metal particles and have the potential for such particles to be embed within them.",true,"ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.",[24,25,26,27,28,29,30,31],"Dental Crowding","Dental Occlusion, Traumatic","Dental Pain","TMD\u002FOrofacial Pain","TMD","Orthodontics","Endodontic Disease","Orthodontic Treatment",[33,34],"Diagnosis","Magnetic resounance imaging","RECRUITING","2026-05-18",{"date":38,"type":39},"2026-05-20","ACTUAL",{"date":41,"type":39},"2025-03-14",{"date":43,"type":20},"2027-12-31",{"name":45,"class":46},"University of Minnesota","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100594126","evaluation-of-a-novel-lip-bumper-with-integrated-distal-shoe-appliance-in-preventing-second-molar-impaction-in-children-with-anterior-deep-bite-100594126","NCT07015385","Evaluation of a Novel Lip Bumper With Integrated Distal Shoe Appliance in Preventing Second Molar Impaction in Children With Anterior Deep Bite","Novel Lip Bump","Inclusion Criteria:\n\n* Age between 8 and 11 years\n* In mixed dentition stage (presence of permanent first molars and incisors; unerupted second molars)\n* Presence of an anterior deep bite of ≥ 2 mm (measured vertically between upper and lower incisors)\n* Class I or mild Class II malocclusion\n* Good general health with no systemic conditions that may affect dental development or treatment\n* Written informed consent obtained from the parent or legal guardian and assent from the child\n\nExclusion Criteria:\n\n* History of previous orthodontic treatment\n* Presence of craniofacial anomalies (e.g., cleft lip\u002Fpalate) or syndromic conditions\n* Diagnosis of systemic diseases that affect bone metabolism or craniofacial growth (e.g., juvenile rheumatoid arthritis, osteogenesis imperfecta)\n* Evidence of poor oral hygiene or active caries requiring urgent dental care\n* Use of any medication known to affect dental development (e.g., long-term corticosteroids, antiepileptics)\n* Behavioral or developmental disorders that would preclude cooperation with appliance wear or study procedures","8 Years","11 Years",{"count":58,"type":20},40,"INTERVENTIONAL",[61],"NA","The goal of this clinical trial is to evaluate the effectiveness of a novel lip bumper with an integrated distal shoe in preventing second molar impaction in children aged 8-10 years with anterior open bite during the mixed dentition stage.\n\nThe main questions it aims to answer are:\n\n* Does the integrated distal shoe significantly reduce the risk of second molar impaction compared to conventional lip bumpers?\n* Does the appliance improve anterior open bite correction and influence lower incisor inclination?\n\nResearchers will compare Group I (lip bumper with distal shoe) to Group II (conventional lip bumper) to see if the modified appliance prevents mesial drift of first molars and improves eruption outcomes of second molars.\n\nParticipants will:\n\n* Undergo initial records including panoramic and cephalometric radiographs, study models, and intraoral photos\n* Be fitted with one of the two appliances and followed up every 6 weeks over a 12-month period\n* Receive radiographic and clinical evaluation of second molar eruption\n* Complete assessments related to overbite changes, incisor inclination, comfort, and compliance This trial seeks to inform early orthodontic protocols and may offer a dual-function solution for both molar guidance and open bite correction.",[64,29],"Bite",[66,67,68,69],"Malocclusion","Angle Class II","Deep Bite","Child","NOT_YET_RECRUITING","2025-08-18",{"date":73,"type":39},"2025-08-22",{"date":75,"type":20},"2025-09-15",{"date":77,"type":20},"2026-11",{"name":79,"class":46},"Dar Al Uloom University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":15,"sex":16,"minAge":86,"maxAge":17,"enrollmentInfo":87,"targetDuration":89,"studyType":21,"phases":4,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100579453","orthodontic-treatment-on-oral-microbiota-and-salivary-proteins-100579453","NCT06824493","Orthodontic Treatment on Oral Microbiota and Salivary Proteins","Inclusion Criteria:\n\n* No carries and White spot\n* No missing teeth\n* No history of oral treatment\n* No malocclusion\n* No systemic diseases\n\nExclusion Criteria:\n\n* Antibiotic use in the past three months\n* A history of long-term medication use\n* A history of dental fillings\n* Unable to attend regular follow-ups","6 Years",{"count":88,"type":20},150,"2 Years","Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.",[29,92,93],"White Spot Lesions [Initial Caries] on Smooth Surface of Tooth","Caries, Dental",[95],"microbiota","2025-05-28",{"date":98,"type":39},"2025-06-04",{"date":100,"type":20},"2025-07-01",{"date":102,"type":20},"2027-09-01",{"name":104,"class":46},"Xi'an Jiaotong University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":59,"phases":117,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100573947","personalised-prevention-of-microbiological-homeostasis-in-the-oral-cavity-during-fixed-orthodontic-treatment-100573947","NCT06752902","Personalised Prevention of Microbiological Homeostasis in the Oral Cavity During Fixed Orthodontic Treatment","Impact of a Personalised Prevention Approach on the Microbiological Homeostasis of the Oral Cavity During Fixed Orthodontic Treatment: Randomised Interventional Study","PREPERMIO","Inclusion Criteria:\n\n* Patients aged 12 to 20 (permanent dentition) requiring fixed orthodontic treatment.\n\nExclusion Criteria:\n\n* Tobacco;\n* Overcrowded restorations, untreated caries,\n* lack of tooth mineralisation;\n* Medical pathologies;\n* Known immunodepression (congenital or acquired);\n* Taking a treatment that may induce general immunodepression;\n* Taking a probiotic;\n* Taking a concomitant treatment that may interact with oral health","12 Years","20 Years",{"count":116,"type":20},80,[61],"Oral dysbiosis systematically develops during orthodontic treatment \\[35\\]\\[36\\]. Orthodontic appliances interfere with oral hygiene procedures and cause biofilm to accumulate, creating new retention zones, even in subjects who maintain correct oral hygiene \\[37\\]:\n\n* A group benefiting from intensive personalised prevention\n* A \"conventionally monitored\" group, with no personalised prevention. The hypothesis is that personalised prevention prevents dysbiosis from taking hold. If this hypothesis is confirmed, the concept could be extended to all patients, beyond orthodontics.\n\nBased on the \"biological signature\" (microbiological and immune), a \"risk profile\" of patients could be defined, making it possible to better personalise the prevention message, the method applied and the frequency of follow-up. The aim would be to rebalance dysbiosis through a personalised prevention approach tailored to the profile defined.\n\nIt was decided to explore this hypothesis initially with orthodontic patients because they are \"captive\", i.e. in the course of treatment requiring regular visits. Prevention is aimed first and foremost at healthy patients, with the aim of maintaining them in good health. The project focuses on young patients undergoing orthodontic treatment",[29],[121,122,123],"oral dysbiosis","orthodontics","oral microbiotis","2025-05-20",{"date":126,"type":39},"2025-05-23",{"date":128,"type":20},"2025-06-01",{"date":130,"type":20},"2028-06-06",{"name":132,"class":46},"Centre Hospitalier Universitaire de Nice",2,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":59,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":47},"100489226","study-of-the-use-of-orthopulse-photobiomodulation-100489226","NCT05650359","Study of the Use of Orthopulse Photobiomodulation","A Randomized and Controlled Study of the Use of Orthopulse Photobiomodulation for Acceleration of Orthodontic Tooth Movement With Fixed Appliances","Inclusion Criteria:\n\n* Age: at least 18 years\n* Indication for an orthodontic treatment with fixed appliances\n* Presence of a written declaration\n* Permanent dentition\n* Class I-III malocclusion\n* Between 4-10mm of crowding (estimated traditionally) in anterior teeth in mandibular arch (This will depend on the time we choose for the endpoint)\n\nExclusion Criteria:\n\n* Simultaneous participation in another clinical investigation or study\n* Prior participation in this study\n* Persons who have been placed in an institution as a result of an administrative or judicial order\n* Persons who are dependent on the sponsor, Investigator or the investigation site\n* Anterior cross bite\n* Spaces between anterior teeth\n* Extractions or missing permanent teeth (except for third molars)\n* No anticipated requirement of auxiliary appliances and\u002For elastics during treatment during alignment phase\n* Acute oral infection or periodontal disease\n* Active caries\n* Pregnant patients or patients planning to become pregnant",{"count":142,"type":20},42,[61],"This PMCF study evaluates the safety and performance of OrthoPulse photobiomodulation to accelerate tooth movement during alignment with fixed appliances.",[29],"2024-08-06",{"date":148,"type":39},"2024-08-07",{"date":150,"type":39},"2022-10-13",{"date":152,"type":20},"2028-05-15",{"name":154,"class":155},"Biolux Technology GmbH","INDUSTRY",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":15,"sex":16,"minAge":113,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100442244","the-effect-of-malocclusions-on-oral-health-related-quality-of-life-100442244","NCT05038865","The Effect of Malocclusions on Oral Health Related Quality of Life","Oral Health Related Quality of Life - The Effect of Malocclusions, Gender, Socioeconomic Differences and Orthodontic Treatment Among Adolescents","Inclusion Criteria:\n\n* Adolescents 12-19 years of age with malocclusion (IOTN grade 4 and 5) referred to specialist orthodontic clinics\n* Adolescents 12-19 years of age without malocclusion (IOTN grad 1, 2 or 3) at general dentistry clinics\n\nExclusion Criteria:\n\n* Previous orthodontic treatment\n* Cleft lip and palate\n* ASA ≥ III\n* Intellectual and\u002For physical inability to answer questionnaires","19 Years",{"count":165,"type":20},675,"Malocclusions in adolescents may affect oral health related quality of life. The study aims at;\n\n1. Evaluating two instruments measuring oral health related quality of life; \"Child Perceptions Questionnaire 11-14\" (CPQ 11-14) short form and \"Psychosocial Impact of Dental Aesthetics Questionnaire\" (PIDAQ).\n2. Comparing differences in oral health related quality of life in;\n\n   1. adolescents with different types of malocclusion and without malocclusions\n   2. individuals of different genders and socioeconomic status\n3. Longitudinally evaluating differences in oral health related quality of life;\n\n   1. before, during and after orthodontic treatment\n   2. in untreated individuals (without malocclusion) over time",[66,168,29,169,170],"Quality of Life","Adolescent","Socioeconomic Factors","2023-03-31",{"date":173,"type":39},"2023-04-04",{"date":175,"type":39},"2021-12-01",{"date":177,"type":20},"2027-12",{"name":179,"class":46},"Malmö University",3]