[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthopaedic-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthopaedic-surgery":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,38,64,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100631413","the-influence-of-perioperative-strategies-on-the-extent-of-in-orthopaedic-prosthetic-surgery-100631413",false,"NCT07500350","The Influence of Perioperative Strategies on the Extent of in Orthopaedic Prosthetic Surgery","Influence of Perioperative Strategies on the Extent of Total Blood Loss in Orthopaedic Prosthetic Surgery","IPECO","Inclusion criteria:\n\n\\- Adult patients in ASA Class I-II-III undergoing prosthetic surgery, as a first-time implant\n\nExclusion criteria:\n\n* Patients who did not receive tranexamic acid prophylaxis (pre-operative and post- operative doses) and are therefore not comparable with the vast majority of cases.\n* Reintervention, as bleeding depends on a variable that is not constant, namely the initial implant","ALL",{"count":19,"type":20},1683,"ESTIMATED","OBSERVATIONAL","To assess the extent of blood loss in prosthetic surgery, considering whether possible variables may influence, either positively or negatively, the extent of such loss. The assessment will be carried out by analysing parameters (haemoglobin - haematocrit) in the immediate preoperative period and then on days 1-3 and 7.\n\nNumerous clinical studies have examined blood loss - both intraoperative and, above all, total blood loss - in shoulder, hip and knee replacement surgery.\n\nAnaesthetic and surgical techniques, relevant medications, the use of pneumatic tourniquets and, more simply, intraoperative positioning, as well as blood-sparing and blood recovery methods, have been the subject of extensive literature. Our study aims to retrospectively evaluate a full year of prosthetic surgery, analysing all the factors involved in the search for a definitive answer regarding the best method for this purpose, if feasible \\[1,2,3,4,5\\].\n\nPrior to admission, the patient undergoes a standardised series of tests, which also include a complete blood count, serum iron, transferrin and ferritin levels.\n\nThis series of tests concerning haematocrit and haematopoietic function is then repeated on the 1st, 3rd and 7th post-operative days to assess overall blood loss\n\n. Patients of both sexes who have undergone total knee replacement (unilateral or bilateral), unicompartmental and total knee replacement (unilateral or bilateral), and total shoulder replacement.\n\nThe above patients operated on between January 2025 and December 2025 at the San Siro Clinic.",[24],"Orthopaedic Surgery","NOT_YET_RECRUITING","2026-06-19",{"date":28,"type":29},"2026-06-24","ACTUAL",{"date":31,"type":20},"2026-07-08",{"date":33,"type":20},"2028-03",{"name":35,"class":36},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":17,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":37},"100643831","phase-4-effect-of-liposomal-bupivacaine-on-rebound-pain-after-peripheral-nerve-block-in-orthopedic-surgery-100643831","NCT07606911","Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery.","Liposomal Bupivacaine Combined With Plain Bupivacaine for Peripheral Nerve Block to Reduce Rebound Pain After Orthopedic Extremity Surgery: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* 18-65 years old;\n* ASA Physical Status 1-3;\n* Scheduled for elective unilateral orthopedic surgery of the upper or lower extremity.\n\nExclusion Criteria:\n\n* Women who are pregnant or breastfeeding;\n* Bupivacaine sensitivity or known allergy;\n* Contraindication for nerve blocks;\n* Enrollment in another clinical trial that could confound pain evaluation;\n* Other conditions that preclude study participation.","18 Years","65 Years",{"count":48,"type":20},668,"INTERVENTIONAL",[51],"PHASE4","This study will prospectively compare the preventive effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine alone on rebound pain after nerve block in patients undergoing orthopedic extremity surgery. The primary aim is to assess whether the combination reduces the incidence or severity of rebound pain (i.e., more effectively covers the postoperative inflammatory peak on days 2-3 and provides a smoother regression curve of sensory blockade). Secondary aims include evaluation of upper limb functional scores, occurrence of chronic pain, and health-related quality of life. All aims will be assessed over 72 hours or the duration of hospitalization if shorter.",[54,24],"Acute Pain","2026-06-07",{"date":57,"type":29},"2026-06-09",{"date":59,"type":20},"2026-07-01",{"date":61,"type":20},"2027-12-01",{"name":63,"class":36},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":45,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":49,"phases":74,"briefSummary":76,"conditions":77,"keywords":86,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":37},"100630348","mindfulness-in-fracture-recovery-and-reduction-of-opioid-reliance-evaluating-the-feasibility-of-implementing-a-brief-mindfulness-based-intervention-to-manage-pain-and-anxiety-before-and-after-fracture-surgery-100630348","NCT07486505","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance (MIRROR): Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","MIRROR","The inclusion criteria are:\n\n1. Adults 18 years of age or older; and\n2. Presenting to the hospital with an open or closed appendicular fracture requiring internal fixation. Patients with multiple fractures may be included.\n\nThe exclusion criteria are:\n\n1. Does not have the English-language skills required to participate in trial interventions (in the judgement of site research personnel);\n2. Cognitive impairment (including traumatic brain injury);\n3. Auditory or visual impairment that would inhibit ability to receive intervention;\n4. Current incarceration;\n5. Concomitant injury which, in the opinion of the attending surgeon, is likely to impair function for as long as or longer than the patient's extremity fracture;\n6. Previously completed a standardized mindfulness program (e.g., MBSR) or regularly (e.g., daily) practice mindfulness;\n7. Active psychosis;\n8. Active suicidality;\n9. Stress fracture;\n10. Fragility fracture;\n11. Currently enrolled in a study that does not permit co-enrolment in other trials;\n12. Not willing to participate in the intervention;\n13. No provision of informed consent; or\n14. Other reason as approved by the Data Coordinating Centre.",{"count":73,"type":20},50,[75],"NA","Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for surgery. After surgery, many continue to struggle with pain and rely on opioid medications, which carry serious risks including addiction. In the context of our current opioid epidemic, it's critical that alternative treatment strategies are urgently evaluated.\n\nMindfulness is a practice that helps people focus on the present and has been shown to reduce stress and pain in other settings. In this trial, patients with broken arms or legs who need surgery at Hamilton General Hospital will be randomly assigned to one of two groups who will listen to a two-part, audio recording before and after surgery. Those in the interventional group will engage in a 7-minute audio-guided mindfulness exercise before surgery to help reduce anxiety, and another 7-minute audio-guided mindfulness exercise after surgery to help manage pain. Those in the control group will listen to a 7-minute educational audio recording before surgery and again after surgery.\n\nThe main goal is to see if this approach is practical-can enough patients be recruited, and will they complete the audio recordings? The study will also look at early signs of whether the intervention helps reduce pain, anxiety, and opioid use six weeks after surgery. If feasible, a larger study can be conducted to determine if these exercises can help patients manage pain and reduce their need for opioids after surgery.\n\nIf successful, this simple, low-cost approach could be widely used in hospitals to support recovery and reduce reliance on pain medications.",[78,79,80,24,81,82,83,84,85],"Orthopaedic Fractures","Orthopaedic Trauma Fractures and Non-unions","Orthopaedic Trauma","Orthopaedic Related Pain (Musculoskeletal Pain)","Anxiety Acute","Anxiety After Surgery","Opioid Use","Opioid Use After Surgery",[87,88,89,90,91,92],"fractures","mindfulness","pain management","fracture surgery","opioid use","anxiety","2026-04-06",{"date":95,"type":29},"2026-04-07",{"date":97,"type":20},"2026-05-01",{"date":99,"type":20},"2026-10-30",{"name":101,"class":36},"McMaster University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100620384","ligamentum-teres-in-management-of-developmental-hip-dysplasia-100620384","NCT07356921","Ligamentum Teres in Management of Developmental Hip Dysplasia","Function of Ligamentum Teres in Management of Developmental Hip Dysplasia (DDH)","Inclusion Criteria:\n\n* Virgin developmental dysplasia of the hip (DDH)\n* failed closed reduction in the management of DDH and failed open reduction through medial approach in the management of DDH\n\nExclusion Criteria:\n\n* cases that managed previously through anterior approach\n* old neglected cases above 5 years old children","9 Months","5 Years",{"count":73,"type":20},"Treatment of developmental dysplasia of the hip (DDH) is still challenging, till now there is no any recent advances have refined our understanding of how best to survey for the condition during infancy and refine the selection of patients who can best benefit from hip preservation surgery.",[24],"2026-01-13",{"date":116,"type":29},"2026-01-21",{"date":118,"type":20},"2026-01-20",{"date":120,"type":20},"2026-10-01",{"name":122,"class":36},"Assiut University"]