[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthopedic-procedures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthopedic-procedures":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,85,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100053344","phase-4-comparison-of-low-dose-versus-standard-dose-hyperbaric-bupivacaine-in-spinal-anesthesia-100053344",false,"NCT07684989","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia","Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia: Hemodynamic Stability and Recovery Profile in Elderly Patients Undergoing Lower Limb Orthopedic Surgery","Inclusion Criteria:\n\n* Male or female patients aged 65 years and above.\n* Patients scheduled for elective lower limb orthopedic surgery under spinal anesthesia.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Patients willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal to participate in the study.\n* Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy, severe hypovolemia, raised intracranial pressure).\n* Known hypersensitivity or allergy to bupivacaine.\n* Severe valvular heart disease.\n* Significant cardiac arrhythmias.\n* Uncontrolled hypertension.\n* Severe hepatic or renal impairment.\n* Pre-existing neurological disorders affecting lower limb motor or sensory function.\n* Severe spinal deformity or previous lumbar spine surgery interfering with spinal anesthesia.\n* Cognitive impairment or inability to provide informed consent.\n* Emergency orthopedic procedures.","ALL","65 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly patients undergoing lower limb orthopedic surgery under spinal anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does low-dose hyperbaric bupivacaine reduce the incidence of intraoperative hypotension and bradycardia compared with standard-dose hyperbaric bupivacaine?\n* Does low-dose hyperbaric bupivacaine improve postoperative recovery profile compared with standard-dose hyperbaric bupivacaine?\n\nResearchers will compare elderly patients receiving low-dose hyperbaric bupivacaine with those receiving standard-dose hyperbaric bupivacaine to determine whether a lower intrathecal dose improves cardiovascular stability and recovery without compromising the effectiveness of spinal anesthesia.\n\nParticipants will:\n\n* Provide written informed consent before enrollment.\n* Undergo elective lower limb orthopedic surgery under spinal anesthesia.\n* Be randomly assigned to receive either low-dose or standard-dose hyperbaric bupivacaine.\n* Have their blood pressure, heart rate, and other vital signs monitored throughout the surgical procedure.\n* Be assessed for intraoperative hypotension and bradycardia according to predefined study criteria.\n* Be evaluated for postoperative recovery parameters, including motor recovery and readiness for postoperative recovery and mobilization.\n\nThe information obtained from this study may help identify a safer and more effective spinal anesthetic technique for elderly patients undergoing orthopedic surgery.",[26,27,28,29,30],"Anesthesia, Spinal","Orthopedic Procedures","Postoperative Recovery in Elderly Patients","Hemodynamics","Bupivacaine",[32,33,34,35,36,37],"Low-Dose Hyperbaric Bupivacaine","Standard-Dose Hyperbaric Bupivacaine","Spinal Anesthesia","Geriatric Anesthesia","Lower Limb Orthopedic Surgery","Hemodynamic Stability","NOT_YET_RECRUITING","2026-07-10",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":20},"2026-07-01",{"date":46,"type":20},"2027-06-30",{"name":48,"class":49},"Mayo Hospital Lahore","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":81,"leadSponsor":83,"locationsCount":50},"100601668","phase-3-remimazolam-vs-midazolam-for-sedation-and-cognitive-outcomes-in-orthopedic-surgery-100601668","NCT07113483","Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery","Randomized, Double-Blind, 2x2 Factorial Trial of Remimazolam vs. Midazolam on Sedation and Early Cognitive Outcomes in Patients Undergoing Traumatic or Non-Traumatic Orthopedic Surgery With Regional Anesthesia","REMIND-ORTHO","Inclusion Criteria:\n\n* Adults aged 65 years or older.\n* Scheduled for traumatic or non-traumatic orthopedic surgery under regional anesthesia.\n* Able to provide informed consent or have a legally authorized representative provide consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n* Mini-Cog score less than 3 (indicative of significant cognitive impairment).\n* Severe hepatic or renal failure.\n* Known allergy to benzodiazepines or propofol.\n* History of benzodiazepine dependence.",{"count":60,"type":20},120,[62],"PHASE3","This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia. We want to find out which medication provides better sedation during the procedure and which one affects early recovery of brain function after surgery.\n\nOlder adults (65 years and above) undergoing surgery for bone injuries or conditions will participate. We will monitor their sedation levels, blood pressure, heart rate, side effects, and how quickly they recover after surgery. We also want to see if either medication causes fewer problems with thinking and memory shortly after surgery.\n\nThe study is designed so neither the patients nor the medical staff know which medication is being given, to ensure unbiased results. Participants will be randomly assigned to receive either Remimazolam or Midazolam.\n\nThe information gathered will help doctors choose the safest and most effective sedative for older patients undergoing orthopedic surgeries, potentially improving patient comfort and recovery.",[65,27,66,67],"Postoperative Cognitive Dysfunction","Postoperative Pain Management","Hip Fracture",[69,70,71,72,73,74,75],"Remimazolam","Midazolam","Regional Anesthesia","Sedation","Cognitive dysfunction","Elderly patients","Trauma","RECRUITING","2025-09-26",{"date":79,"type":42},"2025-10-01",{"date":79,"type":20},{"date":82,"type":20},"2026-02-15",{"name":84,"class":49},"Romanian Society for Enteral and Parenteral Nutrition",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":92,"maxAge":17,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":50},"100544194","physiotherapy-vs-telerehabilitation-after-volar-plating-of-distal-radius-fracture-100544194","NCT06365710","Physiotherapy vs Telerehabilitation After Volar Plating of Distal Radius Fracture","A Randomized Controlled Trial Comparing Traditional Physiotherapy vs Telerehabilitation After Volar Plating of Distal Radius Fracture: a Study Protocol","Inclusion Criteria:\n\n* Distal radius fracture, which applies the surgical requirements\n* age between 18 to 65 years\n* Non concomitant injuries including ligament injuries and distal ulna fractures, however ulnar styloid avulsion is accepted\n* No significant comorbidities\n* No previous problems with the examined hand\n* Ability to understand Finnish fluently\n\nExclusion Criteria:\n\n* High energy or multiple injuries\n* Open fractures\n* Injury of both upper extremities\n* Other operative injury on the same side\n* Rheumatoid arthritis of other inflammatory joint disease\n* Heavy smoker (over 20 cigarettes per day)\n* Disease of medication slowing ossification\n* Alcohol or drug abuse\n* Psychiatric disorder with poor treatment balance\n* Neurological disorder which affects the function of the injured extremity\n* Fixation material other than a volar locking plate\n* Fracture fixation is not stable enough to start rehabilitation after 14 days","18 Years",{"count":94,"type":20},84,[96],"NA","Trial purpose is to research the outcome comparing traditional physiotherapy vs telerehabilitation after volar plating of distal radius fracture.\n\nPatients with distal radius fracture that meet the operative criteria set by the Finnish Current Care guidelines are randomized (1:1 computer generated sequence with random block size) to two parallel groups and will undergo operative treatment and traditional physiotherapy vs telerehabilitation.\n\nBaseline data is collected preoperatively and patients are followed at 1, 3 and 12 months after enrollment. The primary end-point is 3 months and the primary outcome is the Patient-Rated Wrist Evaluation (PRWE).",[27,99,100,101,102],"Physical Therapy Modalities","Postoperative Care","Rehabilitation","Wrist Fractures","2024-10-29",{"date":105,"type":42},"2024-10-31",{"date":107,"type":42},"2022-11-24",{"date":109,"type":20},"2026-01-31",{"name":111,"class":49},"Töölö Hospital",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":92,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":50},"100558694","post-surgical-multimodal-analgesia-with-oral-strong-opioids-100558694","NCT06554457","Post Surgical Multimodal Analgesia With Oral Strong Opioids","Study on the Clinical Effectiveness of Oral Strong Opioids for Common Orthopedic Surgeries Following Multimodal Analgesia","ORORA","Inclusion Criteria:\n\n1. Aged 18 or older\n2. Must undergo one of the following treatments:\n\n(1) Fracture of upper or lower limbs or pelvis requiring internal fixation surgery (2) Spinal fusion surgery (3) Joint replacement surgery 3. Requiring multimodal analgesics for postoperative pain control, with oral strong opioids as the primary opioid analgesic, as assessed by his\u002Fher physician.\n\n4\\. Voluntarily sign the informed consent form and agree to the collection of clinical questionnaires and medical-related information for this study.\n\nExclusion Criteria:\n\n1. Patients who have not received any or have only received oral potent opioids for no more than 1 day during the postoperative hospitalization period (including those known to be intolerant or allergic to opioid medications).\n2. Patients who have received or are expected to use long-acting opioid injections within 7 days before surgery or during the postoperative hospitalization period.\n3. Patients who use patient-controlled analgesics for pain control after surgery.\n4. Patients with a history of substance abuse or who require continuous treatment with other opioid receptor agonists or antagonists (such as naloxone or methadone).\n5. Patients with a history of mental illness who continue to require medication control from 28 days before surgery and until discharge.\n6. Other cases deemed ineligible by the study investigator.",{"count":121,"type":20},200,"OBSERVATIONAL","This is a prospective observational case study, focusing on the clinical effectiveness of oral strong opioids for pain management following common orthopedic surgeries.The study aims to evaluate the effectiveness of multimodal analgesia with oral strong opioids, reduce common opioid-related side effects, and improve patient compliance and satisfaction.",[27,125,126],"Arthroplasty","Fracture Fixation","2024-08-14",{"date":129,"type":42},"2024-08-15",{"date":131,"type":20},"2024-08-12",{"date":133,"type":20},"2025-07-31",{"name":135,"class":49},"Tri-Service General Hospital"]